http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Ryu Gyoungah (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
Anti-inflammatory effect of metabolite A derived from plants in LPS-stimulated Raw264.7 cells
Gyoungah Ryu,Seong-Ah Shin,Minjoo Han,Jangeun An,Huiji Kim,Chang Sup Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Inflammation is a host defensive response to cellular injury, which intends to remove pathogenic factor. However, excessive inflammation induces many inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease (IBD), and sepsis. Currently, although numerous anti-inflammatory drugs are commercially available, their use is limited due to side effects. Accordingly, the need for pharmaceutical phytochemicals with fewer side effects is increasing, compared to synthetic chemicals. In this study, we demonstrated the anti-inflammatory effect of metabolite A, a product derived from plant, that could use for the treatment of inflammatory diseases. Metabolite A was not shown cell cytotoxicity in Raw264.7 cell. Also, we identified that the metabolite A inhibited the production of Nitric oxide (NO)/Reactive Oxygen Species (ROS) and decreased mRNA expression of inflammatory mediators such as interleukin (IL)-6, IL-1β, iNOS, and COX-2 in LPS-stimulated Raw264.7 cells. These results indicate that the metabolite A can reduce LPS-induced inflammatory responses. Therefore, it suggests that the metabolite A could be applied as an anti-inflammatory drug candidate.
-
The anti-inflammatory effect of plant-derived metabolite in LPS-stimulated RAW 264.7 cells
Jangeun An,Seong-Ah Shin,Gyoungah Ryu,Minjoo Han,Huiji Kim,Chang Sup Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Inflammation is an innate response towards the damage to our cells, which may be due to various stimuli (internal or external) and is essential to human health, but excessive inflammatory response may be detrimental to the host. Taking in consideration that the existing drugs for treatment of inflammatory diseases have various side effects such as allergic reactions, stomach ulcers, cardiovascular problems. There is a need for research of new anti-inflammatory drugs with low toxicity and less side effects. Therapeutic drugs made from components isolated from plants are less harmful and has potential to contribute as novel anti-inflammatory drugs. In our study, we examined phytochemicals whether they would be the candidates for anti-inflammatory drugs. At first, using MTT assay, we studied whether metabolites have cytotoxic effect in LPS-induced RAW 264.7 cells. Next, to confirm the anti-inflammatory effect, we measured the levels of nitric oxide (NO) and intracellular reactive oxygen species (ROS). We found that the levels of NO and ROS was significantly decreased. Therefore, we propose that phytochemicals isolated from plants could have anti-inflammatory activity.
-
The anti-cancer effect by phytochemical in B16F10 cell
Huiji Kim,Seong-Ah Shin,Gyoungah Ryu,Minjoo Han,Jangeun An,Chang Sup Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Cancer which is defined by abnormal growth of cells, is one of the leading causes of death worldwide. Since the anticancer drugs that are currently available elicit various adverse side effects, a need for discovering new drug candidates has become crucial. Recently, natural compounds such as phytochemicals, are attracting attention as potential anticancer agents owing to their lower adverse effects, compared to synthetic drugs. In our study in order to examine the anti-cancer effect of phytochemical, we have selected the murine melanoma cell line B16F10. Firstly, to verify the cytotoxicity of phytochemical, MTT assay was performed. We found that phytochemical reduced cell viability of B16F10 cells and thus, could have anticancer effect. In addition, we performed wound healing assays to investigate whether phytochemical affected cell migration. We idendified that phytochemical inhibited cell migration in B16F10 cells. Therefore, we suggest that phytochemical has anticancer activity and has the potential to be an anticancer agent.
-
Anti-Cancer Effects of Phytochemical A against B16F10 Melanoma Cells
Minjoo Han,Seong-Ah Shin,Gyoungah Ryu,Huiji Kim,Jangeun An,Chang Sup Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Melanoma is one of the most common cancer worldwide and is an aggressive form that accounts for most of the deaths of patients with skin cancers. If the invasion of melanoma has occurred, it is hard to be cured and can be life-threatening. Phytochemicals are the metabolic compounds that were found in plants. It has already been known to prevent various chronic diseases including cancer. The chemical “A” is the phytochemical which is one of the isoflavones that are known to inhibit tumor growth and limit the production of cancer-related hormones. We focused on the anti-cancer effects of the phytochemical A that play important roles in B16F10 melanoma cells. The phytochemical A reduced cell viability and cell numbers. We also found that these effects are because of the inhibition of proliferation rather than cytotoxicity. In addition, the phytochemical A induced cell cycle arrest at the G0/G1 phase and inhibited the migration of melanoma cells. Taken together, these results suggest that phytochemical A could exert its effect against metastasis and the cell cycle in melanoma cells. Therefore, it implies that it could work as a chemotherapeutic agent for cancer treatment.
-
Anti‑cancer effects of lucidadiol against malignant melanoma cells
Shin Seong-Ah,Lee Jun Seob,Joo Byeong Jun,Ryu Gyoungah,Han Minjoo,Kim Huiji,An Jangeun,Koo Man Hyung,Youn Ui Joung,Lee Jun Hyuck,Park Hyun Ho,이창섭 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.5
Melanoma is one of the most aggressive and lethal skin cancers. Lucidadiol is a triterpenoid isolated from Ganoderma lucidum and is known to have various biological functions, including antibacterial effects. However, the anti-cancer effects and mechanism of action of lucidadiol in malignant melanoma are unknown. In this study, lucidadiol significantly reduced B16 melanoma cell viability in a dose- and time-dependent manner. In addition, lucidadiol induced apoptosis and suppressed cell mobility in B16 melanoma cells. Moreover, our findings revealed that lucidadiol remarkably downregulated phospho-Akt/ERK/JNK, but not p38. Taken together, our results suggest that lucidadiol could exerts its anti-cancer effects by inducing apoptosis via modulation of the Akt/MAPK pathway. Therefore, lucidadiol may be a potential cancer therapeutic agent for malignant melanoma.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
