hARIP2 is a Putative Growth-promoting Factor Involved in Human Colon Tumorigenesis

Gao, Rui-Feng,Li, Zhan-Dong,Jiang, Jing,Yang, Li-Hua,Zhu, Ke-Tong,Lin, Rui-Xin,Li, Hao,Zhao, Quan,Zhang, Nai-Sheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Activin is a multifunctional growth and differentiation factor of the growth factor-beta (TGF-${\beta}$) superfamily, which inhibits the proliferation of colon cancer cells. It induces phosphorylation of intracellular signaling molecules (Smads) by interacting with its type I and type II receptors. Previous studies showed that human activin receptor-interacting protein 2 (hARIP2) can reduce activin signaling by interacting with activin type II receptors; however, the activity of hARIP2 in colon cancer has yet to be detailed. In vitro, overexpression of hARIP2 reduced activin-induced transcriptional activity and enhanced cell proliferation and colony formation in human colon cancer HCT8 cells and SW620 cells. Also, hARIP2 promoted colon cancer cell apoptosis, suggesting that a vital role in the initial stage of colon carcinogenesis. In vivo, immunohistochemistry revealed that hARIP2 was expressed more frequently and much more intensely in malignant colon tissues than in controls. These results indicate that hARIP2 is involved in human colon tumorigenesis and could be a predictive maker for colon carcinoma aggressiveness.

Controversy on necessity of cobalt in nickel-rich cathode materials for lithium-ion batteries

Rui Wang,Lifan Wang,Yujie Fan,Woochul Yang,Chun Zhan,Liu Guicheng 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.110 No.-

Since the layered oxide LiCoO2 as the cathode material for commercial Li ion batteries, especially, nickelrichlayered oxide cathode materials are consolidating their status as the cathode material of choice andenabling a significant success of the passenger electric vehicle industry. Generally, cobalt in cathodes hasbeen considered necessary in enhancing electrochemical performance. However, they are still facing criticalchallenges in further commercialization. For instance, cobalt caused more severe structural degradationand capacity degradation at high potential. Additionally, it triggered O2 and heat release, whicheventually cause the interfacial instability and thermal instability of the cathode materials. Prior studiesalso confirmed that cobalt plays double-edged roles in cathodes, and questioned its necessity. Meanwhile, not only is it facing a roadblock caused by high-cost restrictions, but more importantly,50% of world mine production originates from copper-cobalt ore in the Democratic Republic of theCongo (DRC), where geopolitical instability and harsh working conditions could halt cobalt exports. Therefore, many studies have explored the possibility of cobalt-free materials. This review shed newlights on understanding the role of cobalt and reveals the perspectives of technical challenges in currentstate by the practical aspect for cobalt-free cathode materials, thereby helping to advance the futuredevelopment of next-generation low-cost and long-calendar-life batteries.

Isolation and Identification of Lipopeptide Antibiotics from Paenibacillus elgii B69 with Inhibitory Activity Against Methicillin-Resistant Staphylococcus aureus

Rui Ding,Chao-Dong Qian,Yi Teng,Ou Li,Zha-Jun Zhan,Yu-Hua Zhao,Xue-Chang Wu 한국미생물학회 2011 The journal of microbiology Vol.49 No.6

Two lipopeptide antibiotics, pelgipeptins C and D, were isolated from Paenibacillus elgii B69 strain. The molecular masses of the two compounds were both determined to be 1,086 Da. Mass-spectrometry, amino acid analysis and NMR spectroscopy indicated that pelgipeptin C was the same compound as BMY-28160, while pelgipeptin D was identified as a new antibiotic of the polypeptin family. These two peptides were active against all the tested microorganisms, including antibiotic-resistant pathogenic bacterial strains such as methicillin-resistant Staphylococcus aureus (MRSA). Time-kill assays demonstrated that pelgipeptin D exhibited rapid and effective bactericidal action against MRSA at 4×MIC. Based on acute toxicity test, the intraperitoneal LD50 value of pelgipeptin D was slightly higher than that of the structurally related antimicrobial agent polymyxin B. Pelgipeptins are highly potent antibacterial and antifungal agents, particularly against MRSA, and warrant further investigation as possible therapeutic agents for bacteria infections resistant to currently available antibiotics.

Tri-stimuli responsive carbon nanotubes covered by mesoporous silica graft copolymer multifunctional materials for intracellular drug delivery

Rui-Qian Zhang,Zhan-Qing Liu,Yan-Ling Luo,Feng Xu,Ya-Shao Chen 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-

To overcome premature drug leakage and instability in drug delivery systems, we designed tri-stimuliresponsive multiwalled carbon nanotubes covered by mesoporous silica graft poly(N-isopropylacryla-mide-block-poly(2-(4-formylbenzoyloxy) ethyl methacrylate) multifunctional materials via disulfidelinkages (MWCNTs@MSN-s-s-g-PNIPAM-b-PFBEMA). The multifunctional materials could covalentlybind and physically load anticancer drug doxorubicin (DOX), and exhibited pH-, temperature- andreductant-induced multi-stimuli responsiveness, significantly enhancing drug loading capacity andimproving the release dynamics of drug. The DOX-loaded multifunctional materials exhibited theoptimal release behavior in cancer environments compared with in normal cells upon simultaneouslytriggered by these stimuli. It meant that the MWCNTs@MSN-s-s-g-PNIPAM-b-PFBEMA could serve asefficient gatekeepers to control the mesopore on–off and thus to modulate drug release. Themultifunctional materials were proved to be low toxic, whereas the DOX-loaded counterparts had almostthe same toxicity as free DOX to cancer cells. Therefore, the developed multifunctional materials can beused as promising drug controlled delivery platforms for cancer therapy.

Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling

Zhan, Yingzhuan,Chen, Yinnan,Liu, Rui,Zhang, Han,Zhang, Yanmin 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8

It has been suggested that combined effect of natural products may improve the treatment effectiveness in combating proliferation of cancer cells. Here, we examined the combined anticancer activities of compounds of three natural origin including baicalein, curcumin, and resveratrol with chemotherapy drug paclitaxel respectively, which showed that combination of paclitaxel with curcumin exhibited synergistic growth inhibition and induced significant apoptosis in MCF-7 cell lines. Treatment of MCF-7 cell lines with paclitaxel and curcumin induced the apoptosis of regulatory protein Bcl-2 but decreased Bax expression. In addition, simultaneous treatment with paclitaxel and curcumin strongly inhibited paclitaxel-induced activities of EGFR signaling. Furthermore, the combination of paclitaxel and curcumin exerted increased anti-tumor efficacy on mouse models. Overall, our data described the promising therapeutic potential and underlying mechanisms of combining paclitaxel with curcumin in treating breast cancer.

Immunosuppressive Effects of New Cyclolanostane Triterpene Diglycosides from the Aerial Part of Cimicifuga foetida

Rui-Le Pan,Di-Hua Chen,Jian-Yong Si,Xiao-Hong Zhao,Zhan Li,Li Cao 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2

Two new cyclolanostane diglycosides, cimifoetiside A (1) and cimifoetiside B (2), were isolated from an 80% ethanolic extract of the aerial part of Cimicifuga foetida L. (Ranuculaceae). Using spectral data and chemical analysis, the structures of 1 and 2 were identified as (23R, 24S) cimicigenol 3-O-β-D-glucopyranosyl-(1"→3')-β-D-xylopyranoside and (23R, 24S) cimicigenol 3-O-β-D-glucopyranosyl-(1"→2')-β-D-xylopyranoside, respectively. The in vitro immunosuppressive effects of the two new compounds 1 and 2, as well as four other known cyclolanostane saponins 3-6 on T cells were evaluated. All the agents tested effectively inhibited the proliferation of murine splenocytes induced by Concanavalin A (ConA), with IC50 values ranging from 12.7 nM to 33.3 nM.

Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling

Yingzhuan Zhan,Yinnan Chen • Rui Liu,Han Zhang,Yanmin Zhang 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8

It has been suggested that combined effect ofnatural products may improve the treatment effectiveness incombating proliferation of cancer cells. Here, we examinedthe combined anticancer activities of compounds of threenatural origin including baicalein, curcumin, and resveratrolwith chemotherapy drug paclitaxel respectively, whichshowed that combination of paclitaxel with curcuminexhibited synergistic growth inhibition and induced significantapoptosis in MCF-7 cell lines. Treatment of MCF-7cell lines with paclitaxel and curcumin induced the apoptosisof regulatory protein Bcl-2 but decreased Baxexpression. In addition, simultaneous treatment with paclitaxeland curcumin strongly inhibited paclitaxel-inducedactivities of EGFR signaling. Furthermore, the combinationof paclitaxel and curcumin exerted increased anti-tumorefficacy on mouse models. Overall, our data described thepromising therapeutic potential and underlying mechanismsof combining paclitaxel with curcumin in treating breast cancer.

Dieless bulging and nonlinear buckling of longan-shaped pressure hull

He Rui,Zhang Jian,Kaewunruen Sakdirat,Zhan Ming,Liu Ping 대한조선학회 2023 International Journal of Naval Architecture and Oc Vol.15 No.-

In this study, the dieless bulging and nonlinear buckling behaviours of a stainless longan-shaped pressure hull were investigated. According to the Cassini oval equation, the longan shape has a shape index of 0.1. The lengths of the major and minor axes of the designed longan-shaped pressure hull were approximately 400 and 396 mm, respectively. The wall thickness of this pressure hull was 1 mm. The Huberevon Mises stress and first yielding load of the designed longan-shaped shell and its inscribed polyhedral preform were investigated analytically and experimentally. Moreover, the dieless bulging of the designed longan-shaped pressure hull was investigated numerically and experimentally by using the nonlinear finite element method and a hydrostatic test, respectively. The analytical, experimental, and numerical results exhibited good agreement with each other.

A study on decentralization and intellectual property rights(IP) construction strategies in NFT art: Focusing on the Chinese case

LIN LI,Rui Zhan 성균관대학교 트랜스미디어연구소 2024 트랜스- Vol.16 No.-

In a rapidly growing digital economic environment, NFT has emerged as a hot topic in the art field. However, in China, NFT art is developing slowly due to constraints related to China's political economy and socio-cultural situation. Due to strict management and control, the circulation of cryptocurrency is limited, and the level of public awareness and acceptance of NFT art and market maturity are still low. Despite these limitations, this paper predicts that Chinese art creators and market participants can build an online personal art IP model that suits the characteristics of the Chinese market and explores the current status and possibilities.

Sorafenib Continuation after First Disease Progression Could Reduce Disease Flares and Provide Survival Benefits in Patients with Hepatocellular Carcinoma: a Pilot Retrospective Study

Fu, Si-Rui,Zhang, Ying-Qiang,Li, Yong,Hu, Bao-Shan,He, Xu,Huang, Jian-Wen,Zhan, Mei-Xiao,Lu, Li-Gong,Li, Jia-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: Sorafenib is a promising drug for advanced hepatocellular carcinoma (HCC); however, treatment may be discontinued for multiple reasons, such as progressive disease, adverse events, or the cost of treatment. The consequences of sorafenib discontinuation and continuation are uncertain. Materials and Methods: We retrospectively analyzed 88 HCC patients treated with sorafenib from July 2007 to January 2013. Overall survival (OS), post-disease progression overall survival (pOS), and time to disease progression (TTP) were compared for survival analysis. Cox proportional hazard regression was performed to assess the effect of important factors on OS in the overall patient population and on pOS in patients who continued sorafenib treatment. Results: Sorafenib was discontinued and continued in 24 and 64 patients, respectively. The median OS (355 vs 517 days respectively; p=0.015) and median post-PD OS (260 vs 317 days, respectively; p=0.020) were statistically different between the discontinuation and continuation groups. Neither the median time to first PD nor the time to second PD were significantly different between the 2 groups. In the discontinuation group, 3 of the 24 patients (12.5%) suffered disease outbreaks. In Cox proportional hazard regression analysis after correction for confounding factors, BCLC stage (p=0.002) and PD site (p=0.024) were significantly correlated with pOS in patients who continued sorafenib treatment. Conclusions: Sorafenib discontinuation may cause HCC flares or outbreaks. It is advisable to continue sorafenib treatment after first PD, particularly in patients with Barcelona Clinic Liver Cancer stage B disease or only intrahepatic PD.