Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

Triclosan과 죽염을 함유한 바디워시의 액취 등에 미치는 효과에 대한 연구

노석선 ( Seok Sun Roh ),윤우식 ( Woo Sik Yun ),정지영 ( Ji Young Jung ),유형욱 ( Hyung Uk Yu ),황동성 ( Dong Sung Hwang ),최승만 ( Seung Man Choi ),이정래 ( Jeong Rae Lee ),강상진 ( Sang Jin Kang ),장석윤 ( Sug Youn Chang ) 대한화장품학회 2009 대한화장품학회지 Vol.35 No.3

1.0 wt% triclosan과 0.4 wt% 죽염을 함유한 바디워시의 액취 등에 미치는 효과에 대한 연구를 위하여 in vitro 항균시험 및 무작위 배정, 이중맹검, 교차설계로 진행한 임상시험을 실시하였다. 1.0 wt% triclosan과 0.4 wt% 죽염을 함유한 바디워시는 Corynebacterium glutamicum, Corynebacterium xerosis, Corynebacterium jeikeium를 균주로 한 in vitro 항균 실험에서 모두 우수한 항균 효과가 있었다. 1.0 wt% triclosan과 0.4 wt% 죽염을 함유한 바디워시는 액취를 전반적으로 유의성 있게 감소시켰고 그 효과는 최소 9 h 동안 지속되었다. 1.0 wt% triclosan과 0.4 wt% 죽염을 함유한 바디워시는 액와 균수를 유의성 있게 감소시켰고 그 효과는 최소 9 h 동안 지속되었다. 임상시험 기간 동안 피시험자 전체에서 이상반응 증상은 나타나지 않았다. 결론적으로 1.0 wt% triclosan과 0.4 wt% 죽염을 함유한 바디워시는 액취에 대한 감소효과와 피부 안전성이 우수하였다. This study was performed to evaluate a deodorant body wash with 1.0 wt% of triclosan and 0.4 wt% of bamboo salt, which have an inhibitory effect on axillary malodor. In this studies, in vitro antibacterial study and the clinical study, which was designed by randomized assignment, double-blind and cross-over, were performed. In the antibacterial study, test sample, which was body wash having 1.0 wt% of triclosan and 0.4 wt% of bamboo salt, have a potent antibacterial effect on Corynebacterium glutamicum, Corynebacterium xerosis, Corynebacterium jeikeium. In the clinical study, test sample has a potent and significant deodorizing effect on axillary malodor and an antibacterial efficacy. And its efficacy was maintained for 9 h at least. There was no side effect during the period of clinical study. Consequently, body wash, containing 1.0 wt% of triclosan and 0.4 wt% of bamboo salt, has the effectiveness and the safety about axillary malodor reduction.

FC 2-9 : Genetic alterations among Korean melanoma patients with the evidence of tumor heterogeneity and evolution

( Hong Sun Jang ),( Mi Ryung Roh ),( Ji Hee Kim ),( Hee Su Kim ),( Byung Ho Oh ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Sun Young Rha ),( Kee Yang Chung ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Melanomas at different levels of sun exposure are found to have genetic alterations such as BRAF, NRAS, KIT, and GNAQ/11 mutations. Objectives: We designed this study to analyze the mutation status of primary tumors in Korean melanoma patients and to investigate the discordance rate between the primary tumors and the paired metastatic samples. Methods: Patients diagnosed with malignant melanoma from 2005 to 2012, 188 in number, at Yonsei University Health System, were enrolled for this study. Results: The most common type was acral type (n=89, 47.3%) followed by non-chronic sun damage induced type (Non-CSD type) (n=32, 17%) and mucosal type (n=31, 16.5%). The overall incidence of somatic mutation was 17.6% in the BRAF gene, 12.6% in NRAS, and KIT amplification was 28.6%. GNAQ/11 mutation in the uveal type was 66.6%. Of the non-CSD type, 41.9% had the BRAF mutation while 35.8% of the acral type had KIT amplification. Among the 43 patients who had both primary tumor and metastatic tissues, 22 patients (51.2%) showed heterogeneity, regardless of age, gender, subtype and stage. In our study, heterogeneity of the paired tumors did not affect the overall survival. Conclusion: In conclusion, the characteristics of the mutation between Korean and Caucasian melanomas are similar, but the proportion of the subtypes is distinguishable. About half of the Korean melanoma patients showed significant genetic heterogeneity which did not affect the overall survival in our study.

Long-term outcomes of concomitant chemoradiotherapy with temozolomide for newly diagnosed glioblastoma patients : A single-center analysis

Roh, Tae Hoon,Park, Hun Ho,Kang, Seok-Gu,Moon, Ju Hyung,Kim, Eui Hyun,Hong, Chang-Ki,Ahn, Sung Soo,Choi, Hye Jin,Cho, Jaeho,Kim, Se Hoon,Lee, Seung Koo,Kim, Dong Seok,Kim, Sun Ho,Suh, Chang-Ok,Lee, Ky Williams & Wilkins Co 2017 Medicine Vol.96 No.27

<P><B>Abstract</B></P><P>The present study analyzed outcomes of surgery followed by concomitant chemoradiotherapy (CCRT) with temozolomide (TMZ) in patients with newly diagnosed glioblastoma (GBM) at a single institution. Outcomes were retrospectively reviewed in 252 consecutive patients with newly diagnosed GBM who underwent surgery followed by CCRT with TMZ at the authors’ institution between 2005 and 2013. At initial operation, 126 (50.0%), 55 (21.8%), 45 (17.9%), and 26 (10.3%) patients underwent gross total resection (GTR), subtotal resection, partial resection (PR), and biopsy, respectively. Their median overall survival (OS) was 20.8 months (95% confidence interval [CI] 17.7–23.9 months) and their median progression-free survival was 12.7 months (95% CI 11.2–14.2 months). The O<SUP>6</SUP>-methylguanine-DNA methyltransferase (MGMT) promoter was methylated in 78 (34.1%) of the 229 patients assayed, and an isocitrate dehydrogenase 1 mutation was detected in 7 (6.6%) of the 106 patients analyzed. Univariate analyses showed that patient age, involvement of eloquent areas, involvement of the subventricular zone, presence of leptomeningeal seeding, Karnofsky Performance Status, extent of resection (EOR), MGMT promoter methylation, and presence of an oligodendroglioma component were prognostic of OS. Multivariate analysis showed that age, involvement of eloquent areas, presence of leptomeningeal seeding, EOR, and MGMT promoter methylation were significantly predictive of survival. OS in patients with GBM who undergo surgery followed by CCRT with TMZ is enhanced by complete resection. Other factors significantly prognostic of OS include that age, involvement of eloquent areas, presence of leptomeningeal seeding, and MGMT promoter methylation.</P>

Ferroelectric domain states of a tetragonal BiFeO ₃ thin film investigated by second harmonic generation microscopy

Roh, Chang Jae,Hamh, Sun Young,Woo, Chang-Soo,Kim, Kwang-Eun,Yang, Chan-Ho,Lee, Jong Seok Springer US 2017 Nanoscale research letters Vol.12 No.1

<P>We investigate the ferroelectric state of a tetragonal BiFeO<SUB>3</SUB> thin film grown on a LaAlO<SUB>3</SUB> (001) substrate using an optical second harmonic generation (SHG) microscope. Whereas the ferroelectric state of this material hosts nanometer-sized domains which again form micrometer-sized domains of four different configurations, we could figure out the characteristic features of each domain from the SHG mapping with various sizes of the probe beam, i.e., from 0.7 to 3.9 μm in its diameter. In particular, we demonstrate that a single micrometer-sized domain contributes to the SHG as a coherent summation of the constituent nanometer-sized domains, and multi-micrometer-sized domains contribute to the SHG as an incoherent summation of each micro-domain.</P>

벤처기업의 고객관계관리를 위한 개인화 추천 시스템 성과 분석

노희선,김광용,한경석 한국인터넷비즈니스학회 2001 인터넷비지니스연구 Vol.2 No.2

본 연구에서는 현재 벤처기업의 고객 중심의 전략을 수립하고 벤처기업의 장기성과로 연결시킬 수 있는 개인화 추천 시스템(Personalization Recommendation System)의 성과를 가시적으로 제시하는 것이 연구목적이다. 그 성과를 측정하기 위해 고객의 충성도를 인식 충성도(Perceptional Loyalty), 거래 충성도(Transactional Loyalty), 잠재적 충성도(Complex Loyalty)로 나누어 충성도 성과를 측정하었다. 위의 연구목적을 달성하기 위해 본 연구에서는 설문 데이터뿐만 아니라 웹 상의 거래데이터를 이용하였다. 또한 솔로몬 4 집단 실험설계를 통해 개인화 추천 시스템 도입과 사용여부의 요인을 모두 고려하고 가능한 모든 외생변수를 룹제하여 보다 정확한 개인화 추천 시스템의 성과를 측정하고자 하였다. 그 결과, 개인화 추천 시스템으로 인해 인식 충성도인 만족도, 거래충성도인 교차판매, 잠재적 충성도인 LTV 성과가 증가함을 보여주었고 고객의 구매패턴이 빨라지는 것을 알 수 있었다. 이로써 개인화 추천 시스템의 정성적 성과와 정량적 성과를 제시할 수 있었고, 개인화 추천 시스템이 벤처기업의 매출 향상과 고객이 한번에 많은 량을 구매함으로써 그 배송비용을 절감시켜줌으로써 벤처기업의 수익구조의 기반이 될 수 있음을 보여주었다. This research is to study the performance of the personalized recommendation system for building the customer oriented strategy and connecting into the long-term profit of the company. For measuring the performance, customer loyalty of personalized recommendation system is divide into Perceptional Loyalty, Transactional Loyalty and Complex Loyalty. For achieving the research objectives, two different kinds of data were used, One is the perception data through the web survey and the other is the transaction data in the electronic commerce cyber book store. The methodology used is not only independent sampling T-test but also Solomon four-group experimental design, for getting more accurate result. In addition, the analysis of Return of Investment(ROI) through the Life time Value(LTV) were tried. The result shows that all of the loyalty is increased by the personalized recommendation system ; the increase of customer satisfaction in the perceptional loyalty, the increase of Cress selling in transactional loyalty and the increase of LTV in the complex loyalty. The analysis of Solomen 4 group experimental design, it also shows that the sales are per each customer increased by amount 250,000 per year. The Further research, like customer pattern analysis using the log data, should be done for the more complex and varied measure of ROI in electronic commerce.

Stimulation of the Extracellular Matrix Production in Dermal Fibroblasts by Velvet Antler Extract

( Seok Seon Roh ),( Min Ho Lee ),( Yul Lye Hwang ),( Hyun Hee Song ),( Mu Hyun Jin ),( Sun Gyoo Park ),( Cheon Koo Lee ),( Chang Deok Kim ),( Tae Jin Yoon ),( Jeung Hoon Lee ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.2

Background: Fibroblasts produce many components of the extracellular matrix (ECM) and so they contribute to the maintenance of connective tissue integrity. Objective: The aim of this study is to evaluate the effect of velvet antler extract (VAE) on the ECM production of dermal fibroblasts cultured in vitro. Methods: Primary cultured human dermal fibroblasts were treated with VAE, and then the ECM production was determined by RT-PCR, ELISA and Western blot analysis. Furthermore, the change of gene expression according to VAE treatment was evaluated by cDNA microarray. Results: VAE accelerated the growth of fibroblasts in a dose-dependent manner. VAE increased the production of several ECM components, including type 1 collagen, fibronectin and elastin. In line with these results, the phosphorylations of p42/44 ERK and p38 mitogen-activated protein kinase were markedly increased by VAE, suggesting that the enhancement of ECM production may be linked to the activation of intracellular signaling cascades. VAE also significantly increased cell migration on an in vitro scratch wound test. In cDNA microarray, many genes related with connective tissue integrity were identified to be up-regulated by VAE. Conclusion: These results suggest that VAE has a potential to stimulate ECM production, and VAE may be applicable for maintaining the skin`s texture. (Ann Dermatol 22(2) 173~179, 2010)

8. Abottoir survey of kidney Lesions of Korean cattle

( Young-sun Roh ),( Yea-baek Yoon ),( Yong-jin Kim ),( Bum-seok Kim ),( Lev Kolodzieyski ),( Byung-moo Rim ),( Chae-woong Lim ) 한국가축위생학회 2001 학술대회논문집 Vol.2001 No.-

Variation of Mitochondrial DNA Restriction Fragments of Common Rats, Rattus norvegicus caraco Pallas (Mammalia, Rodentia), from Cheongju, Korea

Hung Sun Koh(고흥선),Yong Seok Roh(노용석),Sang Bok Kim(김상복),Byung Sun Yoo(유병선) 한국동물분류학회 1995 Animal Systematics, Evolution and Diversity Vol.11 No.4