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Ming Zhang,Xing Fan,Bing Fang,Chengzhen Zhu,Jun Zhu,Fazheng Ren 한국미생물학회 2015 The journal of microbiology Vol.53 No.6
Probiotics have been suggested as a prophylactic measure in colon cancer. The aim of this study was to investigate the impact of Lactobacillus salivarius Ren (Ren) in modulating colonic microbiota structure and colon cancer incidence in a rat model after injection with 1,2-dimethyl hydrazine (DMH). The results indicated that oral administration of Ren could effectively suppress DMH-induced colonic carcinogenesis. A significant decrease in cancer incidence (87.5% to 25%) was detected in rats fed with a dose of 5 × 1010 CFU/kg bodyweight per day. Using denaturing gradient gel electrophoresis and Real-time PCR combined with multivariate statistical methods, we demonstrated that injection with DMH significantly altered the rat gut microbiota, while Ren counteracted these DMH-induced adverse effects and promoted reversion of the gut microbiota close to the healthy state. Tvalue biplots followed by band sequencing identified 21 bacterial strains as critical variables affected by DMH and Ren. Injection of DMH significantly increased the amount of Ruminococcus species (sp.) and Clostridiales bacteria, as well as decreasing the Prevotella sp. Administration of Ren reduced the amount of Ruminococcus sp., Clostridiales bacteria, and Bacteroides dorei, and increased the amount of Prevotella. Real-time PCR results were consistent with the results derived by t-value biplots. These findings suggested that Ren is a potential agent for colon cancer prevention. In conclusion, the results in the present study suggest a potential therapeutic approach based on the modulation of intestinal microflora by probiotics may be beneficial in the prevention of colorectal carcinogenesis.
Jun-fan Jiang,Hao Ying,Tang-fu Feng,Ren-bing Sun,Xie Li,Fang Wang 한국물리학회 2018 Current Applied Physics Vol.18 No.12
Gd1-xHoxNi melt-spun ribbons were fabricated by a single-roller melt spinning method. All the compounds crystallize in an orthorhombic CrB-type structure. The Curie temperature (TC) was tuned between 46 and 99 K by varying the concentration of Gd and Ho. A spin reorientation (SRO) transition is observed around 13 K. Different from TC, the SRO transition temperature is almost invariable for all compounds. Two peaks of magnetic entropy change (ΔSM) were found. One at the higher temperature range was originated from the paramagnet-ferromagnet phase transition and the other at the lower temperature range was caused by the SRO transition. The maximum of ΔSM around TC is almost same. The other maximum of ΔSM around SRO transition, however, had significantly positive relationship with x. It reached a maximum about 8.2 J kg−1 K−1 for x=0.8. Thus double large ΔSM peaks were obtained in Gd1-xHoxNi melt-spun ribbons with the high Ho concentration. And the refrigerant capacity power reached a maximum of 622 J kg−1 for x=0.6. Gd1-xHoxNi ribbons could be good candidate for magnetic refrigerant working in the low temperature especially near the liquid nitrogen temperature range.
Mathematical Simulation of Spray Forming Process
( Jun Fei Fan ),( Yin Zhang ),( San Bing Ren ),( You Duo He ),( Hai Rong Le ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-
In this paper, an integrated approach for modeling the entire spray forming process is presented and the program for the simulation is written by hand. The whole spray forming process can be divided into four calculate process and the basis for the analysis is classical k-ε turbulence model which used to simulate the flow field of gas formed in the chamber. The other three mathematical models are atomization model,deposition model and solidification model. In the atomization model coupled the flow field of gas and formation、velocity and location of droplet. By means of integrate above mathematical model the process of spraying forming was simulated in detail.
Chao-Jun Xin,Yuan-Wen Cai,Yuan Ren,Ya-Hong Fan 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.2
The aim of this paper is to design a centrifugal deformation error compensation method with guaranteed performance that allows angular velocity measurement of the magnetically suspended sensitive gyroscopes (MSSGs). The angular velocity measurement principle and the structure of the MSSG are described, and the analytical model of errors caused by MSSG rotor centrifugal deformation is established. Then, an on-line rotor centrifugal deformation error compensation method based on measurement of rotor spinning speed in real-time has been designed. The common issues caused by centrifugal deformation of spinning rotors can be effectively resolved by the proposed method. Comparative experimental results before and after compensation demonstrate the validity and superiority of the error compensation method.
Modeling and Analysis of Drift Error from Stator of A MSSG with Double Spherical Envelope Surfaces
Chao-Jun Xin,Yuan-Wen Cai,Yuan Ren,Ya-Hong Fan 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.5
For the newly developing magnetically suspended sensitive gyroscope (MSSG) with double spherical envelope surfaces, it is necessary to analyze the causes of drift error to improve sensing accuracy. This paper builds the models of disturbing torques generated by stator assembly and process errors based on the geometric construction and running regularity of the MSSG, and further reveals the generation mechanism of the drift error. Then the drift error from a single stator magnetic pole is calculated quantitatively with the established model, and the key factors producing the drift error are further discussed. It is proposed that the main approaches in reducing the drift error from stator are guaranteeing the rotor envelope surface to be an ideal spherical and improving the controlling precision of rotor displacement. The common problems associated in a gyroscope with a spherical rotor can be effectively resolved by the proposed method. This analysis provides a reference for the structure optimization and error compensation of a MSSG.
Wang, Xiao,Fan, Jin-Chuan,Wang, An-Rong,Leng, Yue,Li, Jun,Bao, Yu,Wang, Ying,Yang, Qing-Feng,Ren, Yu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Background and Objectives: Yanting in Sichuan Province is one of the highest risk areas of esophageal cancer (EC) in the world. We here summarize the epidemiology of EC in Yanting using data from the national screening programme during 2006-2011. Methods: Random cluster sampling was used to select a proportion of natural villages from six towns in Yanting, and residents aged 40-69 years old were invited for screening. Participants were screened using endoscopy with iodine staining and then confirmed by histological examinations. Results: The overall detection rates of low-grade hyperplasia (LH), moderate hyperplasia (MH), high-grade hyperplasia (HH), carcinoma in situ (CIS), intramucosal carcinoma (IC) and invasive carcinoma (INC) were 5.33%, 1.28%, 0.68%, 0.15%, 0.06% and 0.29%, respectively. The detection rates of LH, MH, HH and INC increased with age, reaching the peak among those aged 60-65 years, and the prevalences of LH and MH were higher among men than among women. In addition, the detection rates of hyperplasia were much higher in mountainous than in hilly areas. Conclusions: Among the high risk population, there are a great number of people with early-stage EC or precancerous conditions who do not have presenting symptoms. In particular, the elderly, men, or those living in mountainous areas are the most vulnerable population. It is therefore important to reinforce health education and screening services among such high risk populations.
Xin, Chao-Jun,Cai, Yuan-Wen,Ren, Yuan,Fan, Ya-Hong The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.2
The aim of this paper is to design a centrifugal deformation error compensation method with guaranteed performance that allows angular velocity measurement of the magnetically suspended sensitive gyroscopes (MSSGs). The angular velocity measurement principle and the structure of the MSSG are described, and the analytical model of errors caused by MSSG rotor centrifugal deformation is established. Then, an on-line rotor centrifugal deformation error compensation method based on measurement of rotor spinning speed in real-time has been designed. The common issues caused by centrifugal deformation of spinning rotors can be effectively resolved by the proposed method. Comparative experimental results before and after compensation demonstrate the validity and superiority of the error compensation method.
WenJing Xiao,Jun Hou,Jie Ma,BoTao Yu,JianDong Ren,WeiHua Jin,Juan Wu,DeZhi Zheng,KaiHua Fan 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8
Mangiferin is a promising effective chemopreventiveagent against various tumors. However, itsclinical use is limited by poor water solubility and lowbioavailability. In this article, mangiferin loaded magneticPCEC microspheres (MG-MS) were designed, characterizedand the antitumor activity of MG-MS was evaluatedin vitro. The magnetic nanoparticles (MNP) were synthesizedvia the high-temperature reaction of ironacetylacetonate in phenyl ether in the presence of oleic acidand oleylamine. Poly (ε-caprolactone)-poly (ethyleneglycol)-poly (ε-caprolactone) (PCL-PEG-PCL, PCEC)copolymers were formed by ring-opening copolymerizationof ε-CL initiated by PEG-diol using Sn(Oct)2 as acatalyst and MG-MS were prepared by solvent diffusionmethod. MNP, PCEC copolymer, and MG-MS werecharacterized by GPC, TEM, XRD, FT-IR, 1H-NMP andMalvern Laser Particle Sizer. Meanwhile, the antiproliferativeactivity in vitro and in vitro release behavior of thismicrospheres were studied in detail. The results indicatethat the obtained magnetic microspheres might have greatpotential as an effective carrier for mangiferin used incancer chemotherapy.