Identification of Porcine Follicular Fluid Proteins of Mature and Immature Follicles in Using Proteomics

Shi, Quan Van,Lee, Hye-Ran,Kim, Hong-Rye,Park, Chang-Sik,Jin, Dong-Il 한국수정란이식학회 2006 한국수정란이식학회 학술대회 Vol.2006 No.1

Mixtures of Tea and Citrus maxima (pomelo) Alleviate Lipid Deposition in HepG2 Cells Through the AMPK/ACC Signaling Pathway

Ran An,Shuai Wen,Dong-Li Li,Qiu-Hua Li,Xing-Fei Lai,Wen-Ji Zhang,Ruo-Hong Chen,Jun-Xi Cao,Zhi-Gang Li,Qiu-Sheng Huang,Ling-Li Sun,Shi-Li Sun 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.9

Tea and citrus maxima are natural, medicinal homologous plants, typically used for making beverages, which have anticancer, antiobesity, and antioxidation properties. Green tea, yellow tea, and black tea were combined with citrus maxima to obtain green tea and Citrus maxima (GTCM), yellow tea and Citrus maxima (YTCM), and black tea and Citrus maxima (BTCM). The biochemical components of these mixtures were analyzed, and their possible effects and mechanisms on relieving liver lipid deposition were explored. The tea polyphenols, free amino acids, phenolamine ratio, and caffeine were comparable in YTCM and GTCM, being significantly higher than those in BTCM. In addition, the content of esterified catechins, nonesterified catechins, and total catechins in YTCM was significantly higher than those in GTCM and BTCM. All three mixtures of Citrus maxima tea significantly reduced lipid deposition in HepG2 cells, with GTCM and YTCM being slightly more effective than BTCM. Regarding the possible mechanism, Western blot analysis revealed that the three Citrus maxima tea mixtures could activate the AMPK/ACC signaling pathway, upregulate the expression of p-AMPK, p-ACC, and CPT-1 proteins, and downregulate the expression of SREBP1c and fatty acid synthase proteins to inhibit fat synthesis, thereby relieving lipid deposition in liver cells. In conclusion, as a novel and healthy beverage, Citrus maxima tea has the potential to alleviate liver lipid deposition, and further could be responsible for obesity treatment.

Application of thermally coupled energy levels in Er³⁺ doped CdMoO₄ phosphors: Enhanced solid-state lighting and non-contact thermometry

Ran, Weiguang,Noh, Hyeon Mi,Park, Sung Heum,Lee, Bo Ram,Kim, Jung Hwan,Jeong, Jung Hyun,Shi, Jinsheng Elsevier 2019 Materials research bulletin Vol.117 No.-

<P><B>Abstract</B></P> <P>Er<SUP>3+</SUP>-activated CdMoO<SUB>4</SUB> phosphors were prepared by a traditional high-temperature solid-state method. The crystal structure, photoluminescence (PL) characteristics and performance in non-contact thermometry of as-prepared phosphors were studied in detail. Benefiting from the 3D network structure of CdMoO<SUB>4</SUB> host, the desirable green emission of Er<SUP>3+</SUP>-based phosphors were observed. Especially, based on the thermally coupled energy levels, the obtained phosphors show enhanced emission intensity in high temperatures. When applied to the temperature sensor based on the fluorescence intensity ratio (FIR), the prepared CdMoO<SUB>4</SUB>:0.02Er<SUP>3+</SUP> phosphor show an excellent sensitivity (0.875% K<SUP>−1</SUP>) at 483 K. Therefore, it is demonstrated that the as-prepared Er<SUP>3+</SUP>-activated CdMoO<SUB>4</SUB> phosphors have a promising potential application in both solid-state lighting and non-contact thermometry.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Enhanced emission intensity in high temperatures has been achieved. </LI> <LI> Er<SUP>3+</SUP> doped CdMoO<SUB>4</SUB> phosphor has a potential application in solid-state lighting. </LI> <LI> High sensitivity indicates that CdMoO<SUB>4</SUB>: 0.02Er<SUP>3+</SUP> phosphor can be used in non-contact thermometer. </LI> <LI> Excellent water stability of Er<SUP>3+</SUP> doped CdMoO<SUB>4</SUB> can be used in a complex condition. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Overexpression of hARD1<SUP>235</SUP> accelerates Tumorigenesis in APC<SUP>MIN/+</SUP>Mice

Shi-Nai Lee(이시내),Mi-Ni Lee,Mi-Ran Lee,Jong-Gil Park,Ji-Young Yoo,Se-Jin Jeong,Inhyuk Jung,Goo Taeg Oh 한국실험동물학회 2009 한국실험동물학회 학술발표대회 논문집 Vol.2009 No.-

Crystal structure, electronic structure and photoluminescence properties of KLaMgWO₆:Eu³⁺ phosphors

Ran, Weiguang,Noh, Hyeon Mi,Moon, Byung Kee,Park, Sung Heum,Jeong, Jung Hyun,Kim, Jung Hwan,Liu, Guangzeng,Shi, Jinsheng Elsevier 2018 Journal of luminescence Vol.197 No.-

<P><B>Abstract</B></P> <P>A variety of Eu<SUP>3+</SUP>-activated KLaMgWO<SUB>6</SUB> phosphors were synthesized by a traditional high temperature solid state reaction method in air atmosphere. By using geometric optimization and Rietveld analysis, the detailed structural properties were derived for the first time. The band structure, electronic distribution and phonon dispersion were calculated using the plane-wave density functional theory (DFT). Meanwhile, the optical band gap of KLaMgWO<SUB>6</SUB> host was measured with an ultraviolet-visible diffuse reflection spectroscopy (UV–vis DRS). The charge transfer band (CTB) of KLaMgWO<SUB>6</SUB>:Eu<SUP>3+</SUP> phosphors is situated at ultraviolet and near-ultraviolet region from 250 to 410 nm. Combined with theoretical calculations and experimental results, the detailed luminescence process is deduced. The phosphors show intense absorption in near ultraviolet-blue region and exhibit strong red emissions with CIE coordinates of (x = 0.6474, y = 0.3360) under 344 and 394 nm excitation. Excellent luminescence properties make it have potential application in the fabrication of white light-emitting diodes (LEDs).</P> <P><B>Graphical abstract</B></P> <P>Detailed structural was derived using geometric optimization and Rietveld analysis.</P> <P>O<SUP>2-</SUP>-Eu<SUP>3+</SUP> CT band was identified through DFT calculations.</P> <P>This phosphor has great potential applications in white light-emitting diodes (LEDs).</P> <P>[DISPLAY OMISSION]</P>

Clinical Characteristics and Risk Factors for Mortality in Critical COVID-19 Patients Aged 50 Years or Younger During Omicron Wave in Korea: Comparison With Patients Older Than 50 Years of Age

Shi Hye Jin,Yang Jinyoung,Eom Joong Sik,Ko Jae-Hoon,Peck Kyong Ran,Kim Uh Jin,Jung Sook In,Kim Seulki,Seok Hyeri,Hyun Miri,Kim Hyun Ah,Kim Bomi,Joo Eun-Jeong,Cheong Hae Suk,Jun Cheon Hoo,Wi Yu Mi,Kim 대한의학회 2023 Journal of Korean medical science Vol.38 No.28

Background: The coronavirus disease 2019 (COVID-19) pandemic has caused the death of thousands of patients worldwide. Although age is known to be a risk factor for morbidity and mortality in COVID-19 patients, critical illness or death is occurring even in the younger age group as the epidemic spreads. In early 2022, omicron became the dominant variant of the COVID-19 virus in South Korea, and the epidemic proceeded on a large scale. Accordingly, this study aimed to determine whether young adults (aged ≤ 50 years) with critical COVID-19 infection during the omicron period had different characteristics from older patients and to determine the risk factors for mortality in this specific age group. Methods: We evaluated 213 critical adult patients (high flow nasal cannula or higher respiratory support) hospitalized for polymerase chain reaction-confirmed COVID-19 in nine hospitals in South Korea between February 1, 2022 and April 30, 2022. Demographic characteristics, including body mass index (BMI) and vaccination status; underlying diseases; clinical features and laboratory findings; clinical course; treatment received; and outcomes were collected from electronic medical records (EMRs) and analyzed according to age and mortality. Results: Overall, 71 critically ill patients aged ≤ 50 years were enrolled, and 142 critically ill patients aged over 50 years were selected through 1:2 matching based on the date of diagnosis. The most frequent underlying diseases among those aged ≤ 50 years were diabetes and hypertension, and all 14 patients who died had either a BMI ≥ 25 kg/m2 or an underlying disease. The total case fatality rate among severe patients (S-CFR) was 31.0%, and the S-CFR differed according to age and was higher than that during the delta period. The S-CFR was 19.7% for those aged ≤ 50 years, 36.6% for those aged > 50 years, and 38.1% for those aged ≥ 65 years. In multivariate analysis, age (odds ratio [OR], 1.084; 95% confidence interval [CI], 1.043–1.127), initial low-density lipoprotein > 600 IU/L (OR, 4.782; 95% CI, 1.584–14.434), initial C-reactive protein > 8 mg/dL (OR, 2.940; 95% CI, 1.042–8.293), highest aspartate aminotransferase > 200 IU/L (OR, 12.931; 95% CI, 1.691–98.908), and mechanical ventilation implementation (OR, 3.671; 95% CI, 1.294–10.420) were significant independent predictors of mortality in critical COVID-19 patients during the omicron wave. A similar pattern was shown when analyzing the data by age group, but most had no statistical significance owing to the small number of deaths in the young critical group. Although the vaccination completion rate of all the patients (31.0%) was higher than that in the delta wave period (13.6%), it was still lower than that of the general population. Further, only 15 (21.1%) critically ill patients aged ≤ 50 years were fully vaccinated. Overall, the severity of hospitalized critical patients was significantly higher than that in the delta period, indicating that it was difficult to find common risk factors in the two periods only with a simple comparison. Conclusion: Overall, the S-CFR of critically ill COVID-19 patients in the omicron period was higher than that in the delta period, especially in those aged ≤ 50 years. All of the patients who died had an underlying disease or obesity. In the same population, the vaccination rate was very low compared to that in the delta wave, indicating that non-vaccination significantly affected the progression to critical illness. Notably, there was a lack of prescription for Paxlovid for these patients although they satisfied the prescription criteria. Early diagnosis and active initial treatment was necessary, along with the proven methods of vaccination and personal hygiene. Further studies are needed to determine how each variant affects critically ill patients.

A Novel Non-phosgene Approach to the Synthesis of Methyl N-phenyl Carbamate by a Reaction of Methanol with Phenylurea

Shi-run Yan,Xin-kui Wang,Zhen-hua Li,Kang-nian Fan,Mao-qing Kang,Shao-yi Peng 한국화학공학회 2004 Korean Journal of Chemical Engineering Vol.21 No.2

A novel non-phosgene process for the synthesis of methyl N-phenyl carbamate (MPC) by a reaction of phenylurea with methanol was studied. The reaction between phenylurea and methanol was found to be a spontaneous reaction that took place in the absence of catalyst and gave MPC as the main product. Addition of a catalyst markedly influenced the reaction behavior. A basic catalyst greatly enhanced the yield of MPC, whereas an acidic catalyst promoted the formation of aniline and methyl carbamate. Moderate strength of basicity showed the best catalytic performance in the cases studied. The mechanism of reaction and catalyst functioning was discussed.

Poly(vinylidene fluoride)/Plasma-Treated BaTiO3 Nanocomposites with Enhanced Electroactive Phase

Ran Ding,Lei Gong,Ming-ming Li,Shu-hua Chen,Shi-ping Zhan,Xu-dong Sun,Cheng Zhang,Tao Shao 한국고분자학회 2018 Macromolecular Research Vol.26 No.11

Functional C=O and C-O groups are successfully fixated onto the surface of a high dielectric constant material barium titanate (BaTiO3) via non-thermal plasma. The strong dipole interaction exists between these functional groups and CH2 or CF2 groups of poly(vinylidene fluoride) (PVDF), resulting in the enhancement of the electroactive γ-phase of PVDF/BaTiO3 nanocomposites on one hand; on the other hand the dispersion of BaTiO3 is enhanced in the PVDF matrix, where the smaller spherulite size and better hydrophilic property are observed in the PVDF/plasmatreated BaTiO3 nanocomposite, comparing with the untreated ones. Therefore, the PVDF/plasma-treated BaTiO3 nanoparticles exhibited higher dielectric constant and lower dielectric loss than the PVDF/BaTiO3 nanoparticles.

Characteristics and significance of heterogeneity of sea−land transitional facies shale gas reservoir in North Guizhou, China

Ran Wang,Shuxun Sang,Jun Jin,Lingyun Zhao,Wei Gao,Wei Fu,Fulun Shi,Ende Deng 한국지질과학협의회 2019 Geosciences Journal Vol.23 No.1

In order to identify the characteristics of the longitudinal heterogeneity of the sea–land transitional facies shale gas reservoir in the upper Yangtze region of North Guizhou, studies on the lithological combination, rock and mineral composition, geochemical parameters and reservoir microanisotropy characteristics of Longtan Formation in the study area are conducted on the basis of core observation, testing of geochemistry and reservoir physical property and well logging interpretation. The studies show that the lithological assemblages of the Longtan Formation are diverse and form an amina interbedding of “sand-mud-coal” with obvious cyclicity characteristics. There is a large longitudinal difference in rock and mineral composition and the average mass fraction of the clay mineral is 39.83%, which is obviously higher than that of the marine shale in North America and South China; the longitudinal heterogeneity of the organic matter abundance is high, with an average of 2.17% in the upper part, and 4.51% in the lower part; in accordance with the results observed with the scanning electron microscope and results calculated through pore fractal, the microscopic pore heterogeneity of the reservoir is high. The comparison and analysis of connecting wells with different scales in the study area show that the control effect of the depositional environment on longitudinal macroscopic heterogeneity of Longtan Formation is obvious, and the longitudinal microscopic heterogeneity is controlled through diagenesis. Meanwhile, studies with main coal mining seam as the seam section division method conclude that the heterogeneity of Coal Seam Sections 4 to 5 and Coal Seam Sections 13 to 15 is significantly smaller than that in other seam sections, and the Coal Seam Sections 4 to 5 and Coal Seam Sections 13 to 15 can be considered as a priority key seam section during development of shale gas.

A Novel Authenticated Group Key Distribution Scheme

( Run-hua Shi ),( Hong Zhong ),( Shun Zhang ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.2

In this paper, we present a novel authenticated group key distribution scheme for large and dynamic multicast groups without employing traditional symmetric and asymmetric cryptographic operations. The security of our scheme is mainly based on the basic theories for solving linear equations. In our scheme, a large group is divided into many subgroups, where each subgroup is managed by a subgroup key manager (SGKM) and a group key generation center (GKGC) further manages all SGKMs. The group key is generated by the GKGC and then propagated to all group members through the SGKMs, such that only authorized group members can recover the group key but unauthorized users cannot. In addition, all authorized group members can verify the authenticity of group keys by a public one-way function. The analysis results show that our scheme is secure and efficient, and especially it is very appropriate for secure multicast communications in large and dynamic client-server networks.