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- 저자 : Ramiro González (검색결과 4 건)
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Copper and Zinc Bioaccumulation and Bioavailability of Ganoderma lucidum
Ramiro González Matute,Analia Serra,Debora Figlas,Néstor Curvetto 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10
Ganoderma lucidum is a widely recognized medicinal mushroom. The bioaccumulation and potential bioavailability of copper (Cu) and zinc (Zn), which are essentials for human health, were analyzed in G. lucidum mycelium and fruit bodies grown in the presence of these metals to test their potential utility as a food dietary supplement. Mycelia grown in culture medium with non-mycotoxic doses of Cu or Zn (25 and 50 mg/kg) were selected for evaluation of the bioavailability of these metals in the gastrointestinal tract by using an in vitro simulated digestion system. One gram of dried mycelium grown in the presence of 50 mg/kg Cu or Zn showed a bioavailability of 19% for Cu and 2% for Zn of the recommended daily intake (RDI). When production of fruit bodies was evaluated, the highest biological efficiency (23%) was reached when the substrate was enriched with 100 mg/kg Cu. Cu and Zn contents obtained either before or after digestion of fruit bodies from all metal-enriched treatments were substantially lower than those from metal-enriched mycelia. The metal bioavailability was also low: 1.5% of the Cu RDI and almost negligible for Zn. The results are discussed in relation to the RDI values exhibited by two commercial supplements. The potential incorporation of these mineral-enriched mycelia/fruit bodies in capsules, infusions, and dietary supplements is evaluated.
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Díaz Andrés Ramiro Lanza,Pezet Santiago Gallardo,González Osvaldo Soto,Trueba Montserrat Guraieb,Alonso Ivan Azael Martínez,Ramirez Mario Alberto López 대한대장항문학회 2023 Annals of Coloproctolgy Vol.39 No.2
Malakoplakia is a rare granulomatous inflammatory disorder. Its diagnosis depends on histopathological findings; however, high-quality literature regarding proper medical/surgical treatment is lacking. A 38-year-old diabetic female patient was admitted to the emergency room with a history of lower gastrointestinal hemorrhage. Colonoscopy revealed a lesion in the descending colon, and abdominal computed tomography revealed a splenic flexure mass involving the lower pole of the spleen and upper pole of the left kidney. Biopsies confirmed the diagnosis of malakoplakia. After completing antibiotic treatment, a restaging computed tomography revealed a discrete mass increase; hence, the patient underwent laparoscopic <i>en bloc</i> colectomy and partial nephrectomy. Postoperatively, the patient developed a pancreatic fistula, which was successfully treated with percutaneous drainage and antibiotics. The presence of pathognomonic Michaelis-Gutmann inclusions on histopathology is frequently reported as the key to diagnosing malakoplakia. Herein, we present a successful, minimally invasive surgical treatment for colonic malakoplakia.
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Joan Casals,Aurora Rull,Mauro Bernal,Ramiro González,Roser Romero del Castillo,Joan Simó 한국원예학회 2018 Horticulture, Environment, and Biotechnology Vol.59 No.5
Tomato landrace producers are adopting grafting technology to overcome agronomic deficiencies and increase plant yields. Landraces are valued for their higher organoleptic quality, so it is important to assess the impact of grafting on their sensory profile. We studied the influence of ‘Beaufort’ rootstock on agronomic, morphologic, and sensory traits using two landraces (‘Mando’ and ‘Montgri’) and one commercial cultivar (‘Egara’) as scions in two extreme management systems for tomato cultivation: conventional/greenhouse and organic/open field. Panel sensory analysis found that grafting onto ‘Beaufort’ had a negative effect on sensory attributes, reducing sweetness, acidity, and intensity of flavor in the organic system and sweetness and intensity of flavor in the conventional system. In conventional management, grafting also modified some aspects of fruit appearance. In the conventional system, grafting significantly increased yield in all the genotypes (mean increase, 52%). By contrast, in the organic system, grafting increased yield only in the ‘Mando’ landrace (mean increase, 62.3%). As many genotype × grafting interactions affecting many important commercial traits occurred in both management systems, specific studies with different rootstock-scion combinations are highly recommended before adopting this technique for producing landraces with high sensory quality.
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AURKA Gene Variants rs1047972, and rs8173 Are Associated With Breast Cancer
Eric Jonathan Maciel-Cruz,Luis Eduardo Figuera-Villanueva,Asbiel Felipe Garibaldi-Ríos,Belinda Claudia Gómez-Meda,Guillermo Moisés Zúñiga-González,Ana María Pérez,Paola B Castro-García,Ramiro Ramírez- 한국유방암학회 2023 Journal of breast cancer Vol.26 No.4
Purpose: Association between variants rs1047972 and rs8173 of the AURKA gene in healthy women and breast cancer (BC) in a Mexican population. Methods: Genomic DNA samples from 409 healthy women and 572 patients with BC were analyzed for variants rs1047972 and rs8173 of the AURKA gene by polymerase chain reaction-restriction fragment length polymorphism. Results: TT genotype (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.22–5.11; p = 0.0015) and the T allele (OR, 1.16; 95% CI, 1.23–2.12; p = 0.0007) of the rs1047972 variant were associated as risk susceptibility for BC relative to the control group. Contrarily, the GG genotype (OR, 0.64; 95% CI, 0.43–0.94; p = 0.029) was associated as a protective factor of susceptibility of BC of the variant rs8173 of the AURKA gene. Differences were observed in the patients with BC who were carriers of the CT genotype of the rs1047972 variant with overweight, obesity, estrogen receptor-positive plus obesity, Ki-67 (≥ 20%) plus history familial positive of cancer; and for variant rs8173 the BC patients who were CG carriers and presented chemotherapy gastric toxicity, hormonal receptor positive plus chemotherapy gastric toxicity, and menopause status plus chemotherapy gastric toxicity (p < 0.05). Two common haplotypes were identified in the study groups: CG and TC genotypes, were associated as a protective and risk factor, respectively (p < 0.05). Conclusion: Variants rs1047972 and rs8173 of the AURKA gene and the TC haplotype were associated as risk susceptibility factors for BC in this population.
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