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- 저자 : RahimaBegum (검색결과 4 건)
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Hair Growth Promoting Effects of Mineral-rich Spring Water in SKH-1 Hairless Mice
Rahima Begum,Jesmin Ara,Md Faruk Ahmed,Johny Bajgai,Ailyn Fadriquela,Kyu Jae Lee 한국물학회 2017 한국물학회지 Vol.6 No.1
Mineral rich spring water has been used in spa and bathing purpose that often belong to traditional medicinal therapies. It also considered as a classical alternative medicine to cure the immunological disease. Recently, mineral rich containing medicine and cosmetics has been widely applied in hair loss purpose but not tried by mineral water. Therefore, the purpose of the present study is to observe the hair growth promoting effects of mineral rich spring water in SKH-1 hairless mice. We designed this study to evaluate the mineral water has hair growth promoting effect. The experimental SKH-1 hairless mice were divided into a normal control group (NC: No treatment), a positive control group (M: 3% Minoxidil), and different concentrations of mineral water group as a treatment group (MW: 2.5%, 5%, and 10%). All the test samples were topically sprayed on the three distinct parts of the leg, dorsal and a shoulder portion (about 1 cm2 areas) of the mice skin (100 L per application), twice a day, for μ 21 days. The number of hair and length was measured by taking a photograph of using the scale bar tools of the DinoCapture 2.0 digital microscope windows software. The thickness of the hair was measured by using scanning electron microscope. After 21 days of the experiment, mice treated with 2.5% mineral water showed the preferable effect on the number of hair, length, and thickness compared to the PC group and other concentration groups. However, the positive control minoxidil has no mineral containing ingredient but it has strong activity in hair growth. In our study, we found minoxidil had shown less active in hair growth effects in SKH-1 hairless mice. These results suggest that the using of optimum concentration of mineral rich spring water might have a remarked hair growth promoting effect, as observed morphologically. Collectively, according to our studies, we hypothesized that the topical application of mineral rich spring water might represent a novel strategy for the management and therapy for hair falling purpose. However, furthermore, studies could be more assured this hair growth promoting effects.
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Antibacterial Effects of Hydrogen Water on Human Pathogenic Bacteria
Rahima Begum,Cheol-Su Kim,Ailyn Fadriquela,Johny Bajgai,Soo-Ki Kim,Kyu-Jae Lee 한국물학회 2019 한국물학회지 Vol.7 No.1
Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including anti-oxidantion and anti-inflammation however, the antibacterial effect on human pathogenic bacteria is poorly studied. In the present study, we investigated the antibacterial effects of hydrogen water on three different types of human pathogenic bacterial species, such as Staphylococcus aureus, Escherichia coli, and S. mutans. S. aureus, S. mutans, and E. coli were cultured and diluted with hydrogen water and tap water at different ratio (9:1, 5:5 and 1:9) and inoculated on Brain Heart Infusion (BHI) and Mac Conkey agar. After inoculation, the S. aureus, E. coli culture plates were incubated at 37 ℃ in aerobic condition for 24 h, S. mutans in anaerobic condition for 48 hours. After 24 h of incubation, the total number of the colony was measured as CFU/mL. We found that the number of all three bacterial species was fully reduced at the ratio of 1:9 hydrogen water, but the tap water had no effects. We can conclude from our results, that hydrogen water may have positive and strong antibacterial effects on various human pathogenic bacteria. But, it needs other experiments to clarify the antimicrobial effects of hydrogen water.
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Rahima Begum,Cheol‑Su Kim,Ailyn Fadriquela,Johny Bajgai,Xingyu Jing,Dong‑Heui Kim,Soo‑Ki Kim,Kyu‑Jae Lee 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.2
Background Oxidative stress is involved in the development of many inflammatory, metabolic and aging diseases. Objective In this study we investigated, the protective effects of H2 on RAW 264.7 macrophage cell against LPS-and H2O2- induced oxidative stress by the inhibition of MAPK pathway and also activate the Nrf2 pathway. Results Our results showed H2 increased the macrophage cell proliferation and generated ROS and NO against LPS stimulation to exert an active immune response. Similarly, H2 protected the macrophage cell from H2O2- induced oxidative stress. H2 reduced the LPS-and H2O2- induced inflammatory cytokine production and intracellular calcium influxes. H2 inhibited the LPS-and H2O2- induced phosphorylation of MAPK pathway and its downstream signaling molecules. Furthermore, H2 protected the macrophage cell from mitochondrial apoptosis. H2 increased Nrf2 protein expression indicating its strong anti-oxidative effects against oxidative stress. Conclusion Collectively, our results indicate the strong antioxidant role of H2 against LPS-and H2O2- induced oxidative stress on macrophage cells by activating the Nrf2 pathway and inhibiting the MAPK-signaling pathway.
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Potential Therapeutic and Preventive Effect of Drinking Hydrogen-rich Water on Acute Fatigue
Md Faruk Ahmed,Jesmin Ara,AilynFadriquela,RahimaBegum,JohnyBajgai,KyuJaeLee 한국물학회 2017 한국물학회지 Vol.6 No.1
Acute fatigue is a condition defined as a sudden onset of physical and mental exhaustion particularly after a short but strenuous period of physical exercise due to effect of waste product of muscle contraction within muscle fiber and accumulation of metabolites within the muscle fiber. Until recently, it’s believed that lactic acid build-up and reactive oxygen species (ROS) resulting oxidative stress are the most common causes of muscle fatigue. With prevalence of this condition and due to the lack of effective therapeutics, fatigue-related disorders turn to alternative medicine and other non-traditional practices. Previous studies on molecular hydrogen have reported that hydrogen exerts antioxidant, anti-inflammatory and metabolic modulation properties that are beneficial to the cell. Herein we hypothesized that hydrogen-rich water (HW) might ameliorate various impairment of acute fatigue through ROS scavenging activity and elevation of metabolic profile which were related to fatigue such as blood lactate and increasing storage of muscle glycogen, thereby improving physical endurance.
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