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Quyen Thi Tran, Jung-woo Chae 忠南大學校 醫藥品開發硏究所 2021 藥學論文集 Vol.36 No.-
Clevudine (CLV) and entecavir (ETV) were approved in Korea in 2006. While ETV is recommended as first-line monotherapies for treatment chronic hepatitis B in many countries, the application of CLV is limited in Korea and Philippine due to concern about CLV-induced myopathy. Our meta-analysis study was performed to compare the efficacy and safety of CLV to ETV based on literature reviews. Electronic databases were searched and four studies with a total of 697 patients were included in our study. Results showed that virological re- sponse at 48 weeks of treatment was not significantly different between CLV and ETV (RR: 1.05, 95% CI: 0.96-1.14, I2 = 0%). The result for alanine aminotransferase normalization rate (RR: 1.05, 95% CI: 0.96-1.14, I2 = 0%) and serological response (RR: 0.59, 95% CI: 0.27-1.29, I2 = 57%) also showed a similar between CLV and ETV. The results at 24 weeks showed no statistically significant difference between CLV and ETV as well. These results suggest that CLV may have similar efficacy as ETV.
Multi-Carrier Differential Chaos-Shift Keying with Repeated Spreading Sequence
Quyen, Nguyen Xuan The Korean Institute of Communications and Informa 2018 Journal of communications and networks Vol.20 No.3
This paper proposes a multi-carrier differential chaos-shift keying (MC-DCSK) system using repeated spreading sequence (RSS), namely RSS-MC-DCSK, for chaos-based wireless communications. In the proposed system, instead of transmitting the chaotic spreading sequence on a predefined subcarrier as in conventional MC-DCSK, a DCSK-modulated signal, of which each two-bit duration consisting of reference and data-bearing sequences is sent via this subcarrier. Meanwhile, a repeated spreading sequence is produced by copying the reference sequence of the DCSK-modulated signal to the same and next bit periods. The parallel bit streams are multiplied with this RSS and the resulting signals are then conveyed by corresponding subcarriers. In the receiver, the signal retrieved from the predefined subcarrier is DCSK-demodulated and simultaneously used to recover the repeated spreading sequence. The correlative demodulation is performed for all the signals retrieved from the remaining subcarriers to decode the data. The structure and operation of the proposed system are described. Bit error rate (BER) performance under a multipath Rayleigh fading channel is theoretically analyzed and then verified by numerical simulations. In addition, the BER performance, energy and spectral efficiencies of RSS-MC-DCSK are evaluated in comparison to those of MC-DCSK.
A simple time-to-event model with NONMEM featuring right-censoring
Quyen Thi Tran,Jung-woo Chae,Kyun-Seop Bae,Hwi-yeol Yun 대한임상약리학회 2022 Translational and Clinical Pharmacology Vol.30 No.2
In healthcare situations, time-to-event (TTE) data are common outcomes. A parametricapproach is ofen employed to handle TTE data because it is possible to easily visualizediferent scenarios via simulation. Not all pharmacometricians are familiar with the use ofnon-linear mixed efects models (NONMEMs) to deal with TTE data. Therefore, this tutorial simply explains how to analyze TTE data using NONMEM. We show how to write the codeand evaluate the model. We also provide an example of a hands-on model for training.
Quyen Van Nguyen,Hang Thi Khuat,Yen‑Ngoc Thi Nguyen,Dung Thi Vu,Thu‑Ha Bui,부경환 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.5
Drynaria bonii H. Christ is a medicinal plant that has traditionally been used for the treatment of chronic diseases and tuberculosis. However, D. bonii has not yet been cultivated or propagated. In this study, we optimized the conditions for the spore culture of D. bonii to produce sporophytes. First, we evaluated the efects of various factors, such as temperature, light intensity, potting material, and pH, on spore germination and early gametophyte development. Under optimal culture conditions, 95–99% of the spores germinated within 2 weeks of culture. Next, based on these results, we established a culture system for gametophyte development and sporophyte production. Mature gametophytes frst appeared 5 months post-germination (mpg), and at 12 mpg, the rate of production of heart-shaped gametophytes reached 56.6%. Sporophytes at the early frst-leaf stage frst appeared at 6 mpg, and at 12 mpg, the rate of formation of sporophytes reached 15.4%. Interestingly, 6.3% of all gametophytes produced multiple sporophytes. Additionally, 42–62% of the gametophytes also produced multiple secondary gametophytes, indicating a high potential of D. bonii gametophytes to generate new gametophytes and, subsequently, sporophytes. When transferred to new trays or pots, sporophytes grew well and showed 100% survival. Overall, we conclude that this spore culture system can be successfully used for the propagation of D. bonii sporophytes.
Viscous heating and temperature profiles of liquid water flows in copper nanochannel
Quyen Van Dinh,Truong Quoc Vo,김보흥 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.7
Understanding nanoscale fluidic transport becomes increasingly important due to the rapid development of nanotechnology and nanofabrication. By using molecular dynamics (MD) simulations, we investigated the viscous heating of water flows in copper nanochannels. The two scenarios that were studied are Couette flows and Poiseuille flows. We observed the scale effects on the distribution of fluid density, streaming velocity, fluid viscosity, and temperature across the channel. The results revealed the significant effects of surface forces on causing a large deviation between simulation results and classical hypothesis. We found that the energy equation coupled with the thermal-slip boundary conditions still fails to predict the temperature distributions. Hereby, further scale effects are taken into account, which leads to better predictions. The model that we developed in this study shows the relative deviation to the simulation data within 5 %, which is small compared to the conventional continuum approach (i.e., up to 51 %).