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A simple time-to-event model with NONMEM featuring right-censoring
Quyen Thi Tran,Jung-woo Chae,Kyun-Seop Bae,Hwi-yeol Yun 대한임상약리학회 2022 Translational and Clinical Pharmacology Vol.30 No.2
In healthcare situations, time-to-event (TTE) data are common outcomes. A parametricapproach is ofen employed to handle TTE data because it is possible to easily visualizediferent scenarios via simulation. Not all pharmacometricians are familiar with the use ofnon-linear mixed efects models (NONMEMs) to deal with TTE data. Therefore, this tutorial simply explains how to analyze TTE data using NONMEM. We show how to write the codeand evaluate the model. We also provide an example of a hands-on model for training.
Viscous heating and temperature profiles of liquid water flows in copper nanochannel
Quyen Van Dinh,Truong Quoc Vo,김보흥 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.7
Understanding nanoscale fluidic transport becomes increasingly important due to the rapid development of nanotechnology and nanofabrication. By using molecular dynamics (MD) simulations, we investigated the viscous heating of water flows in copper nanochannels. The two scenarios that were studied are Couette flows and Poiseuille flows. We observed the scale effects on the distribution of fluid density, streaming velocity, fluid viscosity, and temperature across the channel. The results revealed the significant effects of surface forces on causing a large deviation between simulation results and classical hypothesis. We found that the energy equation coupled with the thermal-slip boundary conditions still fails to predict the temperature distributions. Hereby, further scale effects are taken into account, which leads to better predictions. The model that we developed in this study shows the relative deviation to the simulation data within 5 %, which is small compared to the conventional continuum approach (i.e., up to 51 %).
Production of transgenic soybean plants carrying modified cry1Ac gene
Quyen Nguyen Thi,Jung Hun Pak,Mi-Jin Kim,Hye Jeong Kim,Ha Neui Hong,Yeon Ho Je,Young Soo Chung 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Cry1Ac protein is known as one of toxin crystal proteins synthesized from Bacillus thuringenesis that plays a critical role for the insect resistance. Recently, cry1Ac genes have introduced into many plants in general and soybean as well. However, the gene expression of cry1Ac genes in transgenic plants remains low that need to be improved. Several mutations we reintroduced into the cry1Ac genes in order to enhance the insecticidal effect. In this study, the cry1Ac with mutant #2, #11 and #16 were transformed into Kwangan, a Korean soybean variety by using the “half-seed” method. The plant lets carrying modified cry1Ac genes were primarily selected on media containing Phosphinothricine (PPT), a bar selective agent and Basta leaf painting. Then, the presence of introduced genes in T0 plants and the gene expression were investigated by PCR, RT-PCR and Real-time PCR. PCR and RT-PCR analysis showed expression of bar and cry1Ac genes from tested transgenic soybean plants. The number of copy of bar gene ranged from 1 to 3 by Real-time PCR analysis. These results provided a fundamental back ground for our further experiments: Confirmation of the gene expression by Southern blot and identification of the function of modified cry1Ac by insect bioessays.
Quyen Le Hoang Thuy To NGUYEN,Du Van NGUYEN,Ngoc Nguyen Mong CHU,Van Hong TRAN 한국유통과학회 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.11
The shift from elite education to mass education in Vietnam has met the demand for education for everybody as well as for quality human resource talent for an emerging nation. Under the resource constraint, understanding the quality dimensions of education and its priority level is important for effective and efficient policies. This study was carried out using both qualitative and quantitative methodologies to develop quality criteria and a ranking model. Two rounds of in-depth interviews were conducted with fifteen experts in the field, who were rectors, employers, and recruitment specialists to develop the quality framework applied in Vietnamese universities under total quality management (TQM), starting from the input of the senior secondary school leavers, through a teaching process to the output. The first round of interviews were unstructured questionnaires designed to explore the main factors in quality assessment model. The second round affirmed the experts’ agreement on the assessment model. Then, fuzzy logic was applied to rank eight criteria in the quality assessment model into priority order: cost, teaching and administrative staff, leadership, curriculum, student-related factors, internationalization, admissions, and campus. The results are critical for identifying the necessary actions to enhance the education quality and to further research on the optimal quality model.
Quyen Van Nguyen,Hang Thi Khuat,Yen‑Ngoc Thi Nguyen,Dung Thi Vu,Thu‑Ha Bui,부경환 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.5
Drynaria bonii H. Christ is a medicinal plant that has traditionally been used for the treatment of chronic diseases and tuberculosis. However, D. bonii has not yet been cultivated or propagated. In this study, we optimized the conditions for the spore culture of D. bonii to produce sporophytes. First, we evaluated the efects of various factors, such as temperature, light intensity, potting material, and pH, on spore germination and early gametophyte development. Under optimal culture conditions, 95–99% of the spores germinated within 2 weeks of culture. Next, based on these results, we established a culture system for gametophyte development and sporophyte production. Mature gametophytes frst appeared 5 months post-germination (mpg), and at 12 mpg, the rate of production of heart-shaped gametophytes reached 56.6%. Sporophytes at the early frst-leaf stage frst appeared at 6 mpg, and at 12 mpg, the rate of formation of sporophytes reached 15.4%. Interestingly, 6.3% of all gametophytes produced multiple sporophytes. Additionally, 42–62% of the gametophytes also produced multiple secondary gametophytes, indicating a high potential of D. bonii gametophytes to generate new gametophytes and, subsequently, sporophytes. When transferred to new trays or pots, sporophytes grew well and showed 100% survival. Overall, we conclude that this spore culture system can be successfully used for the propagation of D. bonii sporophytes.
Quyen Thi Tran, Jung-woo Chae 忠南大學校 醫藥品開發硏究所 2021 藥學論文集 Vol.36 No.-
Clevudine (CLV) and entecavir (ETV) were approved in Korea in 2006. While ETV is recommended as first-line monotherapies for treatment chronic hepatitis B in many countries, the application of CLV is limited in Korea and Philippine due to concern about CLV-induced myopathy. Our meta-analysis study was performed to compare the efficacy and safety of CLV to ETV based on literature reviews. Electronic databases were searched and four studies with a total of 697 patients were included in our study. Results showed that virological re- sponse at 48 weeks of treatment was not significantly different between CLV and ETV (RR: 1.05, 95% CI: 0.96-1.14, I2 = 0%). The result for alanine aminotransferase normalization rate (RR: 1.05, 95% CI: 0.96-1.14, I2 = 0%) and serological response (RR: 0.59, 95% CI: 0.27-1.29, I2 = 57%) also showed a similar between CLV and ETV. The results at 24 weeks showed no statistically significant difference between CLV and ETV as well. These results suggest that CLV may have similar efficacy as ETV.