A simple time-to-event model with NONMEM featuring right-censoring

Quyen Thi Tran,Jung-woo Chae,Kyun-Seop Bae,Hwi-yeol Yun 대한임상약리학회 2022 Translational and Clinical Pharmacology Vol.30 No.2

In healthcare situations, time-to-event (TTE) data are common outcomes. A parametricapproach is ofen employed to handle TTE data because it is possible to easily visualizediferent scenarios via simulation. Not all pharmacometricians are familiar with the use ofnon-linear mixed efects models (NONMEMs) to deal with TTE data. Therefore, this tutorial simply explains how to analyze TTE data using NONMEM. We show how to write the codeand evaluate the model. We also provide an example of a hands-on model for training.

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Tran Thi Le Quyen 한국디자인학회 2019 한국디자인학회 국제초대전도록 Vol.2019 No.6

Comparison of the Efficacy and Safety Between Clevudine and Entecavir for Treating Chronic Hepatitis B Infection: A Systematic Review and Meta-analysis

Quyen Thi Tran, Jung-woo Chae 忠南大學校 醫藥品開發硏究所 2021 藥學論文集 Vol.36 No.-

Clevudine (CLV) and entecavir (ETV) were approved in Korea in 2006. While ETV is recommended as first-line monotherapies for treatment chronic hepatitis B in many countries, the application of CLV is limited in Korea and Philippine due to concern about CLV-induced myopathy. Our meta-analysis study was performed to compare the efficacy and safety of CLV to ETV based on literature reviews. Electronic databases were searched and four studies with a total of 697 patients were included in our study. Results showed that virological re- sponse at 48 weeks of treatment was not significantly different between CLV and ETV (RR: 1.05, 95% CI: 0.96-1.14, I2 = 0%). The result for alanine aminotransferase normalization rate (RR: 1.05, 95% CI: 0.96-1.14, I2 = 0%) and serological response (RR: 0.59, 95% CI: 0.27-1.29, I2 = 57%) also showed a similar between CLV and ETV. The results at 24 weeks showed no statistically significant difference between CLV and ETV as well. These results suggest that CLV may have similar efficacy as ETV.

The reduced reversible phase transition field of lead–free Bi–based ceramic composites by adding nonergodic relaxor

Dinh, Thi Hinh,Tran, Vu Diem Ngoc,Nguyen, Thi Thao,Hoang, Quyen Thi Ngoc,Han, Hyoung–,Su,Lee, Jae–,Shin Elsevier 2017 CERAMICS INTERNATIONAL Vol.43 No.18

<P><B>Abstract</B></P> <P>This study investigated the microstructure, dielectric, ferroelectric, and strain properties of lead‒free 0.995Bi<SUB>1/2</SUB>(Na<SUB>0.82</SUB>K<SUB>0.18</SUB>)<SUB>1/2</SUB>TiO<SUB>3</SUB>–0.005BaZrO<SUB>3</SUB>/0.98Bi<SUB>1/2</SUB>(Na<SUB>0.78</SUB>K<SUB>0.22</SUB>)<SUB>1/2</SUB>TiO<SUB>3</SUB>–0.02LaFeO<SUB>3</SUB> (BNKT18BZ/BNKT22LF) ceramic composites. We found that the required electric field for trigging the phase transition from ergodic relaxor (ER) to ferroelectric of BNKT18BZ/BNKT22LF ceramic composites can be effectively decreased by adding BNKT18BZ as nonergodic relaxor (NER) with changes of three different stabilized regions and the highest <I>S</I> <SUB>usable</SUB> peak points as a function of the applied electric field. The highest <I>d</I> <SUB>33</SUB> <SUP>*</SUP> value of 690p.m./V was obtained at 4kV/mm for 0.3wt BNKT18BZ fraction ceramic composites. This value was higher than 575 p.m./V of BNKT22LF ceramics under an applied electric field of 5kV/mm.</P>

One-Pot Preparation of Antibacterial Electrospun Polycaprolactone Membrane Embedded with Gamma Irradiation-Induced Silver Nanoparticles

Chien Minh Tran,Ngoc Thi‑Thanh Nguyen,Minh Hieu Ho,Vinh Khanh Doan,Khanh Loan Ly,Nhi Ngoc‑Thao Dang,Nam Minh‑Phuong Tran,Hoai Thi‑Thu Nguyen,Long Phuoc Truong,Thai Minh Do,Quyen Ngoc Tran,Hien Quoc Ng 한국섬유공학회 2023 Fibers and polymers Vol.24 No.1

In this study, we proposed a straightforward electrospun polycaprolactone (PCL) loaded with silver nanoparticles (SNPs)membrane fabrication process, in which SNPs were directly synthesized from silver nitrate (AgNO3) in PCL–acetone mixtureby gamma irradiation. The insolubility of AgNO3in PCL solution was solved using an auxiliary dimethyl sulfoxide solvent. As a physical approach, gamma rays readily converted silver ions into SNPs without the addition of harmful reductionagents, which reduced the cytotoxicity of the synthesized material. By avoiding some processes such as purification, solventremoval, or redispersion of SNPs, this method was more time-saving compared to other related studies. SNPs formation wasconfirmed by both UV–Visible spectrum (UV–Vis) and X-ray diffraction analysis. Scanning electron microscopy (SEM)revealed that the addition of SNPs significantly reduced the fiber diameter of PCL–Ag membranes compared to that of rawPCL. Uniform spherical-shaped SNPs incorporated in PCL fibers were observed under transmission electron microscopy(TEM). The tensile test showed that the electrospun PCL–Ag membranes exhibited good mechanical characteristics. Moistureeasily penetrated the porous microstructure of PCL–Ag, facilitating wound humidity regulation. Inductively coupledplasma-mass spectroscopy (ICP-MS) was employed to study the release profiles of SNPs at different time intervals. Overall,the PCL–Ag 500 ppm sample exerted excellent antibacterial activity against Pseudomonas aeruginosa and Staphylococcusaureus strains and low in vitro cytotoxicity.

Enzyme-mediated fabrication of an oxidized chitosan hydrogel as a tissue sealant

Phuong, Nguyen Thi,Anh Ho, Viet,Hai Nguyen, Dai,Khoa, Nguyen Cuu,Quyen, Tran Ngoc,Lee, Yunki,Park, Ki Dong Technomic Pub. Co 2015 Journal of bioactive and compatible polymers Vol.30 No.4

<P>Oxidized polysaccharide-based hydrogels have recently attracted much attention for tissue regeneration because of their biocompatibility and tissue-adhesive property. In this study, we introduce a new type of chitosan-based hydrogel as a tissue sealant, which was prepared by enzymatic mediation from periodate-oxidized chitosan–polyethylene glycol–tyramine. The oxidized chitosan backbone was expected to enhance the interconnection between the hydrogel layer and collagen in the tissues via the Schiff-base reaction. Proton nuclear magnetic resonance spectra indicated that tyramine-functionalized polyethylene glycol-nitrophenyl carbonate ester was conjugated to the oxidized chitosan. The degree of oxidation of the chitosan backbone was around 14% of the glucosamine units by proton nuclear magnetic resonance. The hydrogel was rapidly formed in situ (within a few seconds) in the presence of horseradish peroxidase and hydrogen peroxide. In vitro experiments with live/dead cell assays showed that the oxidized chitosan-based hydrogel was cytobiocompatible. The hydrogel exhibited high tissue adhesion strength on porcine skin models as well as good tissue-adhesive ability and wound healing properties on rabbit skin. These positive results could be promising for the application of oxidized chitosan-based hydrogels as a wound sealant.</P>

Factors Affecting Financial Independence of Young Adults: An Empirical Study in Vietnam

Lan NGUYEN,Quyen Thi TRINH,Thao Ngoc Minh TRAN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.10

Nowadays, with the constant enhancement in the health of the economy, the average income and living standard have accordingly increased, making the need for financial independence a favorable choice. This research aims to identify the factors affecting the financial independence of young people. The authors implement quantitative analysis, with a set of primary data collected from a survey of 2664 Vietnamese people aged from 18 to 28. The research results demonstrate the considerable impact of monetary, psychological, group-related, and family-related factors on the financial independence of young people. The results of the sample analysis provide adequate evidence to reject the correlative relationship between family and group factors and the financial independence of young people. In addition, there are 3 factors, including demographic factors, monetary factors, and psychological factors, all have varying degrees and directions of influence on young people’s financial independence. Most of the mentioned variables reflect a positive effect on financial independence. The only exception is the education variable, illustrated by its negative standardized beta value. A significant difference in financial independence between genders also is reported, suggesting that males seem to have a higher level of financial independence than females.

Applying Stochastic Fractal Search Algorithm (SFSA) in Ranking the Determinants of Undergraduates Employability: Evidence from Vietnam

DINH, Hien Thi Thu,CHU, Ngoc Nguyen Mong,TRAN, Van Hong,NGUYEN, Du Van,NGUYEN, Quyen Le Hoang Thuy To Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.12

Employability has recently become the first target of the national higher education. Its model has been updated to catch the new trend of Industry 4.0. This paper aims at analyzing and ranking the determinants of undergraduate employability, focusing on business and economics majors in Ho Chi Minh City, Vietnam. In-depth interviews with content analysis have been primarily conducted to reach an agreement on a key group of factors: human capital, social capital, and identity. The Stochastic Fractal Search Algorithm (SFSA) is then applied to rank the sub-factors. Human capital is composed of three major elements: attitude, skill, and knowledge. Social capital is approached at both structural and cognitive aspects with three typical types: bonding, bridging, and linking. The analysis has confirmed the change of priority in employability determinants. Human capital is still a driver but the priority of attitude has been confirmed in the contemporary context. Then, social capital with the important order of linking, bridging, and bonding is emphasized. Skill, knowledge, and identity share the least weight in the model. It is noted that identity is newly proposed in the model but a certain role has been found. The findings are crucial for education strategies to enhance university graduate employability.

Barriers to Derivative Accounting Disclosure: The Case of Vietnamese Firms

NGUYEN, Hanh Thi Hong,TRAN, Ngoc Minh,NGUYEN, Quyen Le Hoang Thuy To Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.10

This paper explores the barriers to derivative accounting disclosures in Vietnamese companies and ranks their relative importance for effective and efficient remedies. The Delphi technique was applied to get agreement of panel of experts on the measurement of factors hindering disclosure. Unstructured questionnaires were first sent to twelve experts who had both practical experience and academic knowledge in the field to get ideas on the obstructions to derivatives disclosure. The structured questionnaire was designed to get their agreement on barriers to derivative accounting disclosures. The data analysis with mean, median, mode, standard deviation, and quartile has been implemented to ensure the unanimity. Market-related factors, legislation, accountants' attributes, managers' attributes, information technology and communication, and on-site training were the six major obstacles agreed upon by the experts during their in-depth interviews. Then, these factors were ranked by applying the analytical hierarchy process (AHP). The findings confirmed the priority of information technology and communication, which held the greatest weight. Legislation ranked second, followed by market-related factors and on-site training, which explained the impediments to derivatives disclosure. Managers' and accountants' attributes had the least contribution to the barriers to derivative disclosures. The results have important implications for actions to enhance corporate derivative disclosures in Vietnam.

<i>In situ</i> growth of flower-like V₂O₅ arrays on graphene@nickel foam as high-performance electrode for supercapacitors

Van Hoa, Nguyen,Quyen, Tran Thi Hoang,Nghia, Nguyen Huu,Van Hieu, Nguyen,Shim, Jae-Jin Elsevier 2017 Journal of alloys and compounds Vol.702 No.-

<P><B>Abstract</B></P> <P>Hierarchical flower-like V<SUB>2</SUB>O<SUB>5</SUB> growth on graphene and nickel foam electrodes was fabricated by using chemical vapor deposition and hydrothermal methods for electrochemical capacitors. Taking advantages of the high conductivity of graphene, high capacitance of well-defined V<SUB>2</SUB>O<SUB>5</SUB> flower-like structure and open framework of three-dimensional nickel foam, the resulting electrodes exhibited rapid electron and ion transport, large electroactive surface area, and excellent structural stability. The specific capacitance was as high as 1235 F g<SUP>−1</SUP> at a current density of 2 A g<SUP>-1</SUP>, suggesting its potential as a high performance electrode for supercapacitors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hierarchical flower-like V2O5/graphene/nickel foam electrodes was fabricated. </LI> <LI> The electrodes exhibited rapid electron and ion transport, large electroactive surface area. </LI> <LI> The specific capacitance was as high as 1235 A g−1 at a current density of 2 A g−1. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>