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Cranberry Product Decreases Fat Accumulation in Caenorhabditis elegans
Quancai Sun,Yiren Yue,Peiyi Shen,Jeremy J. Yang,Yeonhwa Park 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.4
Cranberry phenolic compounds have been linked to many health benefits. A recent report suggested that cranberry bioactives inhibit adipogenesis in 3T3-L1 adipocytes. Thus, we investigated the effects and mechanisms of the cranberry product (CP) on lipid metabolism using the Caenorhabditis elegans (C. elegans) model. CP (0.016% and 0.08%) dose-dependently reduced overall fat accumulation in C. elegans (N2, wild type) by 43% and 74%, respectively, without affecting its pumping rates or locomotive activities. CP decreased fat accumulation in aak-2 (an ortholog of AMP-activated kinase α) and tub-1 (an ortholog of TUBBY) mutants significantly, but only minimal effects were observed in sbp-1 (an ortholog of sterol response element-binding protein-1) and nhr-49 (an ortholog of peroxisome proliferator-activated receptor-α) mutant strains. We further confirmed that CP downregulated sbp-1, cebp, and hosl-1 (an ortholog of hormone-sensitive lipase homolog) expression, while increasing the expression of nhr-49 in wild-type C. elegans. These results suggest that CP could effectively reduce fat accumulation in C. elegans dependent on sbp-1, cebp, and nhr-49, but not aak-2 and tub-1.
Short-term Reactive Power Reserve Optimization Based on Trajectory Sensitivity
Quancai Sun,Haozhong Cheng,Jian Zhang,Baiqing Li,Yue Song 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2
An increasing concern is paid to short-term voltage stability with the growth of penetration of induction motor loads. Reactive power reserve(RPR) of power system is critical to improve voltage stability. A definition of short-term voltage stability-related RPR SVRPR) is proposed. Generators vary their contributions to voltage stability with their location and system condition, etc. Voltage support coefficient based on the second-order trace sensitivity method is proposed to evaluate SVRPR’s contribution to short-term voltage stability. The evaluation method can account for the generator’s reactive support in transient process and the contingency severity. Then an optimization model to improve short-term voltage stability is built. To deal with multiple contingencies, contingency weight taking into account both its probability and severity is proposed. The optimization problem is solved by primal dual interior point method. Testing on IEEE_39 bus system, it is indicated that the method proposed is effective. Short-term voltage stability is improved significantly by the way of SVRPR optimization. Hence, the approach can be used to prevent the happening of voltage collapse during system’s contingency.
Short-term Reactive Power Reserve Optimization Based on Trajectory Sensitivity
Sun, Quancai,Cheng, Haozhong,Zhang, Jian,Li, Baiqing,Song, Yue The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.2
An increasing concern is paid to short-term voltage stability with the growth of penetration of induction motor loads. Reactive power reserve(RPR) of power system is critical to improve voltage stability. A definition of short-term voltage stability-related RPR(SVRPR) is proposed. Generators vary their contributions to voltage stability with their location and system condition, etc. Voltage support coefficient based on the second-order trace sensitivity method is proposed to evaluate SVRPR's contribution to short-term voltage stability. The evaluation method can account for the generator's reactive support in transient process and the contingency severity. Then an optimization model to improve short-term voltage stability is built. To deal with multiple contingencies, contingency weight taking into account both its probability and severity is proposed. The optimization problem is solved by primal dual interior point method. Testing on IEEE_39 bus system, it is indicated that the method proposed is effective. Short-term voltage stability is improved significantly by the way of SVRPR optimization. Hence, the approach can be used to prevent the happening of voltage collapse during system's contingency.
The Bioactive Effects of Chicoric Acid As a Functional Food Ingredient
Ye Peng,Quancai Sun,박연화 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.7
Chicoric acid, a hydroxycinnamic acid, has been reported to possess a variety of health benefits, including antivirus, antioxidant, anti-inflammation, obesity prevention, and neuroprotection effects. The purpose of this article is to summarize current knowledge of pharmacological and biological effects of chicoric acid. Since most studies to date on chicoric acid have limited their focus to cell cultures and animals, more human and mechanistic studies are therefore needed to further determine the beneficial effects of chicoric acid as a potential functional food ingredient.