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RISS 인기검색어
- 검색키워드
- 저자 : Qu Jiachen (검색결과 2 건)
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Jiachen Shi,Qiuling Ma,Wenting Su,Congyan Liu,Huangqin Zhang,Yuping Liu,Xiaoqi Li,Xi Jiang,Chang Ge,Fei Kong,Yan Chen,Ding Qu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Conventional dissolving microneedles (DMNs) face significant challenges in anti-melanoma therapy due to the lack of active thrust to achieve efficient transdermal drug delivery and intra-tumoral penetration. Methods In this study, the effervescent cannabidiol solid dispersion-doped dissolving microneedles (Ef/CBD-SD@ DMNs) composed of the combined effervescent components (CaCO3 & NaHCO3) and CBD-based solid dispersion (CBD-SD) were facilely fabricated by the “one-step micro-molding” method for boosted transdermal and tumoral delivery of cannabidiol (CBD). Results Upon pressing into the skin, Ef/CBD-SD@DMNs rapidly produce CO2 bubbles through proton elimination, significantly enhancing the skin permeation and tumoral penetration of CBD. Once reaching the tumors, Ef/CBD-SD@ DMNs can activate transient receptor potential vanilloid 1 (TRPV1) to increase Ca2+ influx and inhibit the downstream NFATc1-ATF3 signal to induce cell apoptosis. Additionally, Ef/CBD-SD@DMNs raise intra-tumoral pH environment to trigger the engineering of the tumor microenvironment (TME), including the M1 polarization of tumor-associated macrophages (TAMs) and increase of T cells infiltration. The introduction of Ca2+ can not only amplify the effervescent effect but also provide sufficient Ca2+ with CBD to potentiate the anti-melanoma efficacy. Such a “one stone, two birds” strategy combines the advantages of effervescent effects on transdermal delivery and TME regulation, creating favorable therapeutic conditions for CBD to obtain stronger inhibition of melanoma growth in vitro and in vivo. Conclusions This study holds promising potential in the transdermal delivery of CBD for melanoma therapy and offers a facile tool for transdermal therapies of skin tumors.
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Li Lingyan,Qu Jiachen,Zhu Huan,Liu Yuqin,Wu Jianhao,Shao Guang,Guan Xianchao,Qu Yongli 아세아·태평양축산학회 2024 Animal Bioscience Vol.37 No.2
Objective: The objective of this study was to evaluate the growth performance, rumen fermentation parameters and bacterial community of post-weaning dairy calves in response to five diets varying in corn silage (CS) inclusion.Methods: A total of forty Holstein weaned bull calves (80±3 days of age;128.2±5.03 kg at study initiation) were randomized into five groups (8 calves/group) with each receiving one of five dietary treatments offered as total mixed ration in a 123-d feeding study. Dietary treatments were control diet (CON; 0% CS dry matter [DM]); Treatment 1 (T1; 27.2% CS DM); Treatment 2 (T2; 46.5% CS DM); Treatment 3 (T3; 54.8% CS DM); and Treatment 4 (T4; 67.2% CS DM) with all diets balanced for similar protein and energy concentration.Results: Results showed that calves offered CS had greater average daily gain, body length and chest depth growth, meanwhile altered rumen fermentation indicated by decreased rumen acetate concentrations. Principal coordinate analysis showed the rumen bacterial community structure was affected by varying CS inclusion diets. <i>Bacteroidetes</i> and <i>Firmicutes</i> were the predominant bacterial phyla in the calf rumens across all treatments. At the genus level, the abundance of <i>Bacteroidales_RF16_group</i> was increased, whereas <i>Unclassified_ Lachnospiraceae</i> was decreased for calves fed CS. Furthermore, Spearman’s correlation test between the rumen bacteria and rumen fermentation parameters indicated that <i>Bacteroidales_RF16_group</i> and <i>Unclassified Lachnospiraceae</i> were positively correlated with propionate and acetate, respectively.Conclusion: The results of the current study suggested that diet CS inclusion was beneficial for post-weaning dairy calf growth, with 27.2% to 46.5% CS of diet DM recommended to achieve improved growth performance. <i>Bacteroidales_RF16_group</i> and <i>Unclassified Lachnospiraceae</i> play an important role in the rumen fermentation pattern for post-weaning calves fed CS.
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