An Image Encryption Scheme Based on Concatenated Torus Automorphisms

( Qian Mao ),( Chin-chen Chang ),( Hsiao-ling Wu ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.6

A novel, chaotic map that is based on concatenated torus automorphisms is proposed in this paper. As we know, cat map, which is based on torus automorphism, is highly chaotic and is often used to encrypt information. But cat map is periodic, which decreases the security of the cryptosystem. In this paper, we propose a novel chaotic map that concatenates several torus automorphisms. The concatenated mechanism provides stronger chaos and larger key space for the cryptosystem. It is proven that the period of the concatenated torus automorphisms is the total sum of each one`s period. By this means, the period of the novel automorphism is increased extremely. Based on the novel, concatenated torus automorphisms, two application schemes in image encryption are proposed, i.e., 2D and 3D concatenated chaotic maps. In these schemes, both the scrambling matrices and the iteration numbers act as secret keys. Security analysis shows that the proposed, concatenated, chaotic maps have strong chaos and they are very sensitive to the secret keys. By means of concatenating several torus automorphisms, the key space of the proposed cryptosystem can be expanded to 2135. The diffusion function in the proposed scheme changes the gray values of the transferred pixels, which makes the periodicity of the concatenated torus automorphisms disappeared. Therefore, the proposed cryptosystem has high security and they can resist the brute-force attacks and the differential attacks efficiently. The diffusing speed of the proposed scheme is higher, and the computational complexity is lower, compared with the existing methods.

Soil and ribbed concrete slab interface modeling using large shear box and 3D FEM

Qian, Jian-Gu,Gao, Qian,Xue, Jian-feng,Chen, Hong-Wei,Huang, Mao-Song Techno-Press 2017 Geomechanics & engineering Vol.12 No.2

Cast in situ and grouted concrete helical piles with 150-200 mm diameter half cylindrical ribs have become an economical and effective choice in Shanghai, China for uplift piles in deep soft soils. Though this type of pile has been successful used in practice, the reinforcing mechanism and the contribution of the ribs to the total resistance is not clear, and there is no clear guideline for the design of such piles. To study the inclusion of ribs to the contribution of shear resistance, the shear behaviour between silty sand and concrete slabs with parallel ribs at different spacing and angles were tested in a large direct shear box ($600mm{\times}400mm{\times}200mm$). The front panels of the shear box are detachable to observe the soil deformation after the test. The tests were modelled with three-dimensional finite element method in ABAQUS. It was found that, passive zones can be developed ahead of the ribs to form undulated failure surfaces. The shear resistance and failure mode are affected by the ratio of rib spacing to rib diameter. Based on the shape and continuity of the failure zones at the interface, the failure modes at the interface can be classified as "punching", "local" or "general" shear failure respectively. With the inclusion of the ribs, the pull out resistance can increase up to 17%. The optimum rib spacing to rib diameter ratio was found to be around 7 based on the observed experimental results and the numerical modelling.

Novel Scientific Simulations (Finite Element Method) for Peristaltic Blood Flow in an Asymmetric Channel: Applications of Magnetic and Inertial Forces

Wei-Mao Qian,Bilal Ahmed,Sami Ullah Khan,M. Ijaz Khan,Abdul Haleem Hamid 한국자기학회 2021 Journal of Magnetics Vol.26 No.1

Radix ranunculus temate saponins induces apoptosis via the death receptor and mitochondrial pathways in SGC-7901 cells

Mao-lin Li,Han-min Gu,Hong-ya Hang,Yao-li Jiang,Jiao Jiang,Qian-na Gu,Wen-yan Wu,M.-L. Li 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.4

Radix ranunculus temate saponins (RRTS), one of the main constituents extracted from the popular traditional Chinese medicine Radix Ranunculi ternati, has been reported to have various biological activities including anti-cancer effect. The aim of this study is to investigate the effect of RRTS on the cell proliferation and apoptosis in human gastric adenocarcinoma SGC-7901 cells. The data showed that exposure to RRTS for 24 h produced cytotoxic effects on SGC- 7901 cells in a dose-dependent manner (with an IC50 value of 21.22±2.76 μg/mL), which was accompanied by apoptosis induction (from 2.18±0.89% (control) to 63.72±13.16% (100 μg/mL)). Both the extrinsic or death receptor pathway and the intrinsic or mitochondrial pathway were involved in RRTS-induced apoptosis in SGC-7901 cells. Furthermore, apoptotic signaling induced by RRTS was amplified by cross-link between the two pathways via the signal-integrating protein Bid. In conclusion, our findings contribute to better understanding the molecular mechanism of RRTS’ effect on gastric cancer cells and form the basis of the therapeutic development of RRTS in treating gastric cancer in the future.

Association between the XRCC3 Thr241Met Polymorphism and Breast Cancer Risk: an Updated Meta-analysis of 36 Case-control Studies

Mao, Chang-Fei,Qian, Wen-Yi,Wu, Jian-Zhong,Sun, Da-Wei,Tang, Jin-Hai Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Background: The X-ray repair cross-complementing group 3 (XRCC3) is a highly suspected candidate gene for cancer susceptibility. Attention has been drawn upon associations of the XRCC3 Thr241Met polymorphism with breast cancer risk. However, the previous published findings remain controversial. Hence, we performed a meta-analysis to accurately evaluate any association between breast cancer and XRCC3 T241M (23, 812 cases and 25, 349 controls) in different inheritance models. Materials and Methods: PubMed and Web of Science databases were searched systematically until December 31, 2013 to obtain all the records evaluating the association between the XRCC3 Thr241Met polymorphism and breast cancer risk. Crude odds ratios (ORs) together with 95% confidence intervals (CIs) were used to assess the strength of associations. Results: When all eligible studies were pooled into the meta analysis of XRCC3 T241M polymorphism, a significantly increased breast cancer risk was observed in heterozygote comparison (OR=1.06, 95%CI=1.01-1.12). No significant associations were found in other models. In subgroup analysis, this polymorphism seemed to be associated with elevated breast risk in Asians. No publication bias was detected. Conclusions: This meta-analysis suggests that the T241M polymorphism confers a weakly increased breast cancer risk. A study with the larger sample size is needed to further evaluate gene-gene and gene-environment interactions of the XRCC3 T241M polymorphism with breast cancer risk.

pH/Temperature Responsive Curcumin-Loaded Micelle Nanoparticles Promote Functional Repair after Spinal Cord Injury in Rats via Modulation of Inflammation

Qian Taibao,Li Zhixiang,Shang Lijun,Huang Sutao,Li Guanglin,Zheng Weiwei,Mao Yingji 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.6

BACKGROUND: The formation of an inhibitory inflammatory microenvironment after spinal cord injury (SCI) remains a great challenge for nerve regeneration. The poor local microenvironment exacerbates nerve cell death; therefore, the reconstruction of a favorable microenvironment through small-molecule drugs is a promising strategy for promoting nerve regeneration. METHODS: In the present study, we synthesized curcumin-loaded micelle nanoparticles (Cur-NPs) to increase curcumin bioavailability and analyzed the physical and chemical properties of Cur-NPs by characterization experiments. We established an in vivo SCI model in rats and examined the ability of hind limb motor recovery using Basso–Beattie– Bresnahan scoring and hind limb trajectory assays. We also analyzed neural regeneration after SCI using immunofluorescence staining. RESULTS: The nanoparticles achieved the intelligent responsive release of curcumin while improving curcumin bioavailability. Most importantly, the released curcumin attenuated local inflammation by modulating the polarization of macrophages from an M1 pro-inflammatory phenotype to an M2 anti-inflammatory phenotype. M2-type macrophages can promote cell differentiation, proliferation, matrix secretion, and reorganization by secreting or expressing pro-repair cytokines to reduce the inflammatory response. The enhanced inflammatory microenvironment supported neuronal regeneration, nerve remyelination, and reduced scar formation. These effects facilitated functional repair in rats, mainly in the form of improved hindlimb movements. CONCLUSION: Here, we synthesized pH/temperature dual-sensitive Cur-NPs. While improving the bioavailability of the drug, they were also able to achieve a smart responsive release in the inflammatory microenvironment that develops after SCI. The Cur-NPs promoted the regeneration and functional recovery of nerves after SCI through anti-inflammatory effects, providing a promising strategy for the repair of SCIs.

A Wireless Sensor Network Clustering Algorithm based on Hypergraph

Xu Qian,Hu Ji-cheng,Lin Hai,Kong Ruo-shan,Luo Yong-en,Zhu Li,Mao Hua-qing 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.6

The paper proposes a clustering algorithm for wireless sensor network based on hypergraph. Under the hypergraph model, a wireless sensor network is mapped to a hypergraph. Then a hierarchical iterative clustering algorithm is applied to the hypergraph, thus dividing the hypergraph into multiple parts. A cluster head is selected from each part. In order to improve the partitioning process, a new modularity function is proposed. Compared with the classic clustering algorithm LEACH, simulation shows that our algorithm performs better in energy consuming and network lifetime.

TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury

Xia Qian,Zhan Gaofeng,Mao Meng,Zhao Yin,Li Xing 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Excessive and unresolved neuroinflammation is a key component of the pathological cascade in brain injuries such as ischemic stroke. Tripartite motif-containing 45 (TRIM45) is a ubiquitin E3 ligase involved in various critical biological processes. However, the role of TRIM45 in cerebral ischemia remains unknown. Here, we found that the TRIM45 protein was highly expressed in the peri-infarct areas of mice subjected to cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion. This study systemically evaluated the putative role of TRIM45 in the regulation of neuroinflammation during ischemic injury and the potential underlying mechanisms. We found that TRIM45 knockdown significantly decreased proinflammatory cytokine and chemokine production in primary cultured microglia challenged with oxygen-glucose deprivation and reoxygenation (OGD/R) treatment. Mechanistically, we demonstrated that TRIM45 constitutively interacted with TAB2 and consequently facilitated the Lys-63-linked polyubiquitination of TAB2, leading to the formation of the TAB1–TAK1–TAB2 complex and activation of TAK1, which was ultimately followed by activation of the nuclear factor-kappa B (NF-κB) signaling pathway. In an in vitro coculture Transwell system, downregulation of TRIM45 expression also inhibited the OGD/R-induced activation of microglia and alleviated neuronal apoptosis. More importantly, microglia-specific knockdown of TRIM45 in mice significantly reduced the infarct size, mitigated neurological deficit scores, and improved cognitive function after ischemic stroke. Taken together, our study reveals that the TRIM45–TAB2 axis is a crucial checkpoint that controls NF-κB signaling in microglia during cerebral ischemia and reperfusion injury. Therefore, targeting TRIM45 may be an attractive therapeutic strategy.

Concrete properties prediction based on database

Bin Chen,Qian Mao,Jingquan Gao,Zhaoyuan Hu 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.3

1078 sets of mixtures in total that include fly ash, slag, and/or silica fume have been collected for prediction on concrete properties. A new database platform (Compos) has been developed, by which the stepwise multiple linear regression (SMLR) and BP artificial neural networks (BP ANNs) programs have been applied respectively to identify correlations between the concrete properties (strength, workability, and durability) and the dosage and/or quality of raw materials’. The results showed obvious nonlinear relations so that forecasting by using nonlinear method has clearly higher accuracy than using linear method. The forecasting accuracy rises along with the increasing of age and the prediction on cubic compressive strength have the best results, because the minimum average relative error (MARE) for 60-day cubic compressive strength was less than 8%. The precision for forecasting of concrete workability takes the second place in which the MARE is less than 15%. Forecasting on concrete durability has the lowest accuracy as its MARE has even reached 30%. These conclusions have been certified in a ready-mixed concrete plant that the synthesized MARE of 7-day/28-day strength and initial slump is less than 8%. The parameters of BP ANNs and its conformation have been discussed as well in this study.

The relevance of breast motions and gaits in running exercises

Jie Zhou,Qian Mao,Jun Zhang,Newman M. L. Lau,Jianming Chen 한국의류학회 2022 Fashion and Textiles Vol.9 No.1

The control of breast motions is a critical indicator to evaluate the comfort and function of sports bras. If the breast motions can be predicted based on the gait parameters detected by wearable sensors, it will more economical and convenient to evaluate the bras. Thirteen unmarried Chinese females with a breast cup of 75B were recruited in this study to investigate the regularity of breast motions and the relevance between breast motions and gaits during running exercises. The breast motion indicator is the distance alteration of breast regions. The gaits were described by the rotation angles of the hip, knee, ankle joints, and the foot height of the ground. Firstly, the Mann-Whitney U test and the Kruskal-Wallis H test were utilized to analyze the motion diversity among the eight breast regions. Then, the gray correlation analysis was applied to explore the relevance between breast motions and gaits. Finally, the back-propagation neural network, the genetic algorithm, and the particle swarm optimization algorithm were utilized to construct the prediction models for breast motions based on gait parameters. The results demonstrate that the same breast regions on the bilateral breasts and the diferent breast regions on the ipsilateral breasts present a signifcant motion diversity. There is a moderate correlation between breast motions and gait parameters, and the back-propagation neural network optimized by the particle swarm optimization algorithm performs better in breast motion prediction, which has a coeffcient of determination of 84.58% and a mean absolute error of 0.2108.