Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice

Hsiao, Wen-Ting,Su, Hui-Min,Su, Kuan-Pin,Chen, Szu-Han,Wu, Hai-Ping,You, Yi-Ling,Fu, Ru-Huei,Chao, Pei-Min The Korean Nutrition Society 2019 Nutrition Research and Practice Vol.13 No.4

BACKGROUND/OBJECTIVES: Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LCPUFA), is acquired by dietary intake or the in vivo conversion of ${\alpha}$-linolenic acid. Many enzymes participating in LCPUFA synthesis are regulated by peroxisome proliferator-activated receptor alpha ($PPAR{\alpha}$). Therefore, it was hypothesized that the tissue accretion of endogenously synthesized DHA could be modified by $PPAR{\alpha}$. MATERIALS/METHODS: The tissue DHA concentrations and mRNA levels of genes participating in DHA biosynthesis were compared among $PPAR{\alpha}$ homozygous (KO), heterozygous (HZ), and wild type (WT) mice (Exp I), and between WT mice treated with clofibrate ($PPAR{\alpha}$ agonist) or those not treated (Exp II). In ExpII, the expression levels of the proteins associated with DHA function in the brain cortex and retina were also measured. An n3-PUFA depleted/replenished regimen was applied to mitigate the confounding effects of maternal DHA. RESULTS: $PPAR{\alpha}$ ablation reduced the hepatic Acox, Fads1, and Fads2 mRNA levels, as well as the DHA concentration in the liver, but not in the brain cortex. In contrast, $PPAR{\alpha}$ activation increased hepatic Acox, Fads1, Fads2, and Elovl5 mRNA levels, but reduced the DHA concentrations in the liver, retina, and phospholipid of brain cortex, and decreased mRNA and protein levels of the brain-derived neurotrophic factor in brain cortex. CONCLUSIONS: LCPUFA enzyme expression was altered by $PPAR{\alpha}$. Either $PPAR{\alpha}$ deficiency or activation-decreased tissue DHA concentration is a stimulus for further studies to determine the functional significance.

A Fast and Secure Scheme for Data Outsourcing in the Cloud

( Yanjun Liu ),( Hsiao-ling Wu ),( Chin-chen Chang ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.8

Data outsourcing in the cloud (DOC) is a promising solution for data management at the present time, but it could result in the disclosure of outsourced data to unauthorized users. Therefore, protecting the confidentiality of such data has become a very challenging issue. The conventional way to achieve data confidentiality is to encrypt the data via asymmetric or symmetric encryptions before outsourcing. However, this is computationally inefficient because encryption/decryption operations are time-consuming. In recent years, a few DOC schemes based on secret sharing have emerged due to their low computational complexity. However, Dautrich and Ravishankar pointed out that most of them are insecure against certain kinds of collusion attacks. In this paper, we proposed a novel DOC scheme based on Shamir`s secret sharing to overcome the security issues of these schemes. Our scheme can allow an authorized data user to recover all data files in a specified subset at once rather than one file at a time as required by other schemes that are based on secret sharing. Our thorough analyses showed that our proposed scheme is secure and that its performance is satisfactory.

Deficiency or activation of peroxisome proliferator-activated receptor ⍺ reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice

Wen-Ting Hsiao,Hui-Min Su,Kuan-Pin Su,Szu-Han Chen,Hai-Ping Wu,Yi-Ling You,Ru-Huei Fu,Pei-Min Chao 한국영양학회 2019 Nutrition Research and Practice Vol.13 No.4

BACKGROUND/OBJECTIVES: Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LCPUFA), is acquired by dietary intake or the in vivo conversion of α-linolenic acid. Many enzymes participating in LCPUFA synthesis are regulated by peroxisome proliferator-activated receptor alpha (PPARα). Therefore, it was hypothesized that the tissue accretion of endogenously synthesized DHA could be modified by PPARα. MATERIALS/METHODS: The tissue DHA concentrations and mRNA levels of genes participating in DHA biosynthesis were compared among PPARα homozygous (KO), heterozygous (HZ), and wild type (WT) mice (Exp I), and between WT mice treated with clofibrate (PPARα agonist) or those not treated (Exp II). In ExpII, the expression levels of the proteins associated with DHA function in the brain cortex and retina were also measured. An n3-PUFA depleted/replenished regimen was applied to mitigate the confounding effects of maternal DHA. RESULTS: PPARα ablation reduced the hepatic Acox, Fads1, and Fads2 mRNA levels, as well as the DHA concentration in the liver, but not in the brain cortex. In contrast, PPARα activation increased hepatic Acox, Fads1, Fads2, and Elovl5 mRNA levels, but reduced the DHA concentrations in the liver, retina, and phospholipid of brain cortex, and decreased mRNA and protein levels of the brain-derived neurotrophic factor in brain cortex. CONCLUSIONS: LCPUFA enzyme expression was altered by PPARα. Either PPARα deficiency or activation-decreased tissue DHA concentration is a stimulus for further studies to determine the functional significance.

Relativistic Quantum Collision Theory for Many-particle Systems

Keh-Ning Huang,Hsiao-Ling Sun,Sheng-Fang Lin,Hao-Tse Shiao,Xin-Zeng Wu 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.41

Starting from the relativistic equation of motion governing quantum collision processes, we shall formulate the relativistic quantum collision theory in an ab-initio manner. Quantum electrodynamic effects are, however, incorporated perturbatively. Because heavy projectiles or ultra-high incident energies are considered, the recoil of the target is also treated. Electron-impact ionization of the uranium ion U^(91+) and proton-impact ionization of hydrogen will be given as examples.

An Image Encryption Scheme Based on Concatenated Torus Automorphisms

( Qian Mao ),( Chin-chen Chang ),( Hsiao-ling Wu ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.6

A novel, chaotic map that is based on concatenated torus automorphisms is proposed in this paper. As we know, cat map, which is based on torus automorphism, is highly chaotic and is often used to encrypt information. But cat map is periodic, which decreases the security of the cryptosystem. In this paper, we propose a novel chaotic map that concatenates several torus automorphisms. The concatenated mechanism provides stronger chaos and larger key space for the cryptosystem. It is proven that the period of the concatenated torus automorphisms is the total sum of each one`s period. By this means, the period of the novel automorphism is increased extremely. Based on the novel, concatenated torus automorphisms, two application schemes in image encryption are proposed, i.e., 2D and 3D concatenated chaotic maps. In these schemes, both the scrambling matrices and the iteration numbers act as secret keys. Security analysis shows that the proposed, concatenated, chaotic maps have strong chaos and they are very sensitive to the secret keys. By means of concatenating several torus automorphisms, the key space of the proposed cryptosystem can be expanded to 2135. The diffusion function in the proposed scheme changes the gray values of the transferred pixels, which makes the periodicity of the concatenated torus automorphisms disappeared. Therefore, the proposed cryptosystem has high security and they can resist the brute-force attacks and the differential attacks efficiently. The diffusing speed of the proposed scheme is higher, and the computational complexity is lower, compared with the existing methods.

Biometric-based key management for satisfying patient’s control over health information in the HIPAA regulations

( Quy-anh Bui ),( Wei-bin Lee ),( Jung-san Lee ),( Hsiao-ling Wu ),( Jo-yun Liu ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.1

According to the privacy regulations of the health insurance portability and accountability act (HIPAA), patients’ control over electronic health data is one of the major concern issues. Currently, remote access authorization is considered as the best solution to guarantee the patients’ control over their health data. In this paper, a new biometric-based key management scheme is proposed to facilitate remote access authorization anytime and anywhere. First, patients and doctors can use their biometric information to verify the authenticity of communication partners through real-time video communication technology. Second, a safety channel is provided in delivering their access authorization and secret data between patient and doctor. In the designed scheme, the user’s public key is authenticated by the corresponding biometric information without the help of public key infrastructure (PKI). Therefore, our proposed scheme does not have the costs of certificate storage, certificate delivery, and certificate revocation. In addition, the implementation time of our proposed system can be significantly reduced.