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- 저자 : Prok, Y. (검색결과 5 건)
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Moments of the spin structure functions g1p and g1d for 0.05<<sup>Q2</sup><3.0<sup> GeV2</sup>
Prok, Y.,Bosted, P.,Burkert, V.D.,Deur, A.,Dharmawardane, K.V.,Dodge, G.E.,Griffioen, K.A.,Kuhn, S.E.,Minehart, R.,Adams, G.,Amaryan, M.J.,Anghinolfi, M.,Asryan, G.,Audit, G.,Avakian, H.,Bagdasaryan, Elsevier 2009 Physics letters: B Vol.672 No.1
<P><B>Abstract</B></P><P>The spin structure functions <SUB>g1</SUB> for the proton and the deuteron have been measured over a wide kinematic range in <I>x</I> and <SUP>Q2</SUP> using 1.6 and 5.7 GeV longitudinally polarized electrons incident upon polarized NH<SUB>3</SUB> and ND<SUB>3</SUB> targets at Jefferson Lab. Scattered electrons were detected in the CEBAF Large Acceptance Spectrometer, for 0.05<<SUP>Q2</SUP><5<SUP> GeV2</SUP> and W<3 GeV. The first moments of <SUB>g1</SUB> for the proton and deuteron are presented – both have a negative slope at low <SUP>Q2</SUP>, as predicted by the extended Gerasimov–Drell–Hearn sum rule. The first extraction of the generalized forward spin polarizability of the proton γ0p is also reported. This quantity shows strong <SUP>Q2</SUP> dependence at low <SUP>Q2</SUP>. Our analysis of the <SUP>Q2</SUP> evolution of the first moment of <SUB>g1</SUB> shows agreement in leading order with Heavy Baryon Chiral Perturbation Theory. However, a significant discrepancy is observed between the γ0p data and Chiral Perturbation calculations for γ0p, even at the lowest <SUP>Q2</SUP>.</P>
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Neonatal Diabetes Caused by Activating Mutations in the Sulphonylurea Receptor
Peter Proks 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.3
Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels in pancreatic β-cells play a crucial role in insulin secretion and glucose homeostasis. These channels are composed of two subunits: a pore-forming subunit (Kir6.2) and a regulatory subunit (sulphonylurea receptor-1). Recent studies identified large number of gain of function mutations in the regulatory subunit of the channel which cause neonatal diabetes. Majority of mutations cause neonatal diabetes alone, however some lead to a severe form of neonatal diabetes with associated neurological complications. This review focuses on the functional effects of these mutations as well as the implications for treatment.
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Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid)
Sviatoslav Hladysh,Jana Dvořáková,Vladimír Proks 한국고분자학회 2023 Macromolecular Research Vol.31 No.6
Zwitterionic polymers are frequently used as non-fouling materials for surface modification with following application in medical devices, implants or areas of our lives such as food, water, and energy. Here, authors report the synthesis of zwitterionic poly(L-glutamic acid) copolymer bearing sulfobetaine via combining the ring-opening polymerization of N-carboxyanhydride of γ-benzyl-L-glutamate and grafting reaction of propargylamine, tyramine, and 3-(dimethylamino)-1-propylamine to the polymer backbone with subsequent reaction of 1,3-propanesultone leading to the formation of zwitterionic poly(L-glutamic acid) containing sulfobetaine groups. Zwitterionic properties of the copolymer are represented by positively charged quaternary ammonium groups and negatively charged sulfobetaine moieties. The chemical structure of the synthesized zwitterionic poly(L-glutamic acid) was characterized by 1H NMR, FTIR, and UV/Vis spectroscopy. The zwitterionic abilities of copolymer were confirmed by zeta potential measurements. The zeta potential of zwitterionic polymer decreased from + 15 mV to − 19 mV upon stepwise pH increases from 2 to 11. The surface properties such as hydrophilicity and non-fouling abilities were tested by contact angle analysis and surface plasmon resonance technique, respectively. The prepared material indicates the formation of highly hydrophilic surfaces with relatively low contact angle (26°) and remarkable anti-protein adsorption functions reflected in lower resonance wavelength shifts from SPR sensogram. Results of this work show the importance of the developed biodegradable zwitterionic poly(L-glutamic acid)-based coatings for applications in various biomedical fields.
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Dharmawardane, K.V.,Kuhn, S.E.,Bosted, P.,Prok, Y.,Adams, G.,Ambrozewicz, P.,Anghinolfi, M.,Asryan, G.,Avakian, H.,Bagdasaryan, H.,Baillie, N.,Ball, J.P.,Baltzell, N.A.,Barrow, S.,Batourine, V.,Battag Elsevier 2006 Physics letters: B Vol.641 No.1
<P><B>Abstract</B></P><P>We report results for the virtual photon asymmetry <SUB>A1</SUB> on the nucleon from new Jefferson Lab measurements. The experiment, which used the CEBAF Large Acceptance Spectrometer and longitudinally polarized proton (NH315) and deuteron (ND315) targets, collected data with a longitudinally polarized electron beam at energies between 1.6 GeV and 5.7 GeV. In the present Letter, we concentrate on our results for <SUB>A1</SUB>(x,<SUP>Q2</SUP>) and the related ratio <SUB>g1</SUB>/<SUB>F1</SUB>(x,<SUP>Q2</SUP>) in the resonance and the deep inelastic regions for our lowest and highest beam energies, covering a range in momentum transfer <SUP>Q2</SUP> from 0.05 to 5.0<SUP>(GeV/c)2</SUP> and in final-state invariant mass <I>W</I> up to about 3 GeV. Our data show detailed structure in the resonance region, which leads to a strong <SUP>Q2</SUP>-dependence of <SUB>A1</SUB>(x,<SUP>Q2</SUP>) for <I>W</I> below 2 GeV. At higher <I>W</I>, a smooth approach to the scaling limit, established by earlier experiments, can be seen, but <SUB>A1</SUB>(x,<SUP>Q2</SUP>) is not strictly <SUP>Q2</SUP>-independent. We add significantly to the world data set at high <I>x</I>, up to x=0.6. Our data exceed the SU(6)-symmetric quark model expectation for both the proton and the deuteron while being consistent with a negative <I>d</I>-quark polarization up to our highest <I>x</I>. This data set should improve next-to-leading order (NLO) pQCD fits of the parton polarization distributions.</P>
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Bosted, P. E.,Biselli, A. S.,Careccia, S.,Dodge, G.,Fersch, R.,Guler, N.,Kuhn, S. E.,Pierce, J.,Prok, Y.,Zheng, X.,Adhikari, K. P.,Adikaram, D.,Akbar, Z.,Amaryan, M. J.,Anefalos Pereira, S.,Asryan, G. American Physical Society 2016 Physical Review C Vol.94 No.5
<P>Beam-target double-spin asymmetries and target single-spin asymmetries in exclusive pi(+) and quasiexclusive pi(-) electroproduction were obtained from scattering of 1.6- to 5.7-GeV longitudinally polarized electrons from longitudinally polarized protons (for pi(+)) and deuterons (for pi(-)) using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. The kinematic range covered is 1.1 < W < 2.6 GeV and 0.05 < Q(2) < 5 GeV2, with good angular coverage in the forward hemisphere. The asymmetry results were divided into approximately 40 000 kinematic bins for pi(+) from free protons and 15 000 bins for pi(-) production from bound nucleons in the deuteron. The present results are found to be in reasonable agreement with fits to previous world data for W < 1.7 GeV and Q(2) < 0.5 GeV2, with discrepancies increasing at higher values of Q(2), especially for W > 1.5 GeV. Very large target-spin asymmetries are observed for W > 1.6 GeV. When combined with cross-section measurements, the present results can provide powerful constraints on nucleon resonance amplitudes at moderate and large values of Q(2), for resonances with masses as high as 2.3 GeV.</P>
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