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Vitamin A Supplementation for Different Periods Alters Oxidative Parameters in Lungs of Rats
Matheus Augusto de Bittencourt Pasquali,Daniel Pens Gelain,Marcos Roberto de Oliveira,Guilherme Antônio Behr,Leonardo Lisbôa da Motta,Ricardo Fagundes da Rocha,Fábio Klamt,José Cláudio Fonseca Moreira 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6
Lungs require an adequate supply of vitamin A (retinol) for normal embryonic development, postnatal maturation, and maintenance and repair during adult life. However, recent intervention studies revealed that supplementation with retinoids resulted in higher incidence of lung cancer, although the mechanisms underlying this effect are still unknown. Here, we studied the effect of vitamin A supplementation on oxidative stress parameters in lungs of Wistar rats. Vitamin A supplementation at either therapeutic (1,000 and 2,500IU/kg) or excessive (4,500 and 9,000IU/kg) doses for 3, 7, or 28 days induced lipid peroxidation, protein carbonylation, and oxidation of protein thiol groups, as well as change in catalase and superoxide dismutase activity. Together, these results suggest that vitamin A supplementation causes significant changes in redox balance, which are frequently associated with severe lung dysfunction.
Mairim Russo Serafini,Rodrigo Correia Santos,Adriana Gibara Guimarães,João Paulo Almeida dos Santos,Alan Diego da Conceicão Santos,Izabel Almeida Alves,Daniel Pens Gelain,Paulo Cesar de Lima Nogueira 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10
Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as “Noni”) has been used in folk medicine by Polynesians for over 2,000 years. It is reported to have a broad range of therapeutic effects, including effects against headache, fever, arthritis, gingivitis, respiratory disorders, infections, tuberculosis, and diabetes. The aim of this study was to investigate the antioxidant, anti-inflammatory, antinociceptive, and antibacterial properties of the aqueous extract from M. citrifolia leaves (AEMC). Antioxidant activity was observed against lipid peroxidation, nitric oxide, and hydroxyl radicals. The antinociceptive effect of AEMC was observed in the acetic acid–induced writhing test at the higher dose. Moreover, AEMC significantly reduced the leukocyte migration in doses of 200 and 400 mg/kg and showed mild antibacterial activity. Together, the results suggest that properties of M. citrifolia leaf extract should be explored further in order to achieve newer tools for managing painful and inflammation conditions, including those related to oxidant states.
Pen, B.,Oyabu, T.,Hidaka, S.,Hidari, H. Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.4
Ten 18.5-month old Holstein steers were allocated into two diet groups of five and fed either concentrates as control group or potato by-products based silage (PBS) as experimental group for six months to investigate the effect of PBS on growth performance, carcass characteristics and fatty acid composition of carcass fats. The PBS diet consisted, in a DM basis, of 74.5% PBS, 16% hay, and 9.5% soybean milk residue (SMR). The control diet consisted, in a DM basis, of 82.5% concentrates and 17.5% hay. There were no significant differences in the overall average daily gain (ADG), dry matter intake (DMI), feed efficiency, yield score and meat quality score of dressed carcass between the two diet groups. There were no statistical differences in DM, crude protein (CP), and ether extract (EE) of beef and melting point of all adipose tissues from steers fed both diets. The PBS-fed steers tended to have lower Warner Bratzler shear (WBS) values than in the concentrate-fed steers (13.0 vs. 17.7 lb, p<0.1). At both sampling times 3 and 6 months of feeding period, PBS-fed steers had higher proportions of polyunsaturated fatty acids (PUFA), especially linoleic (C18:2) acids in subcutaneous fat than in control group (p<0.05). PBS-fed steers had significantly higher proportions of PUFA, especially C18:2 fatty acids than in concentrate-fed steers in carcass fats (p<0.05). In conclusion, feeding PBS to fattening steers has shown to have the same potential as concentrate feeding in terms of effect on the growth performance, feed efficiency, and carcass characteristics. Interestingly, PBS also seems preferable to concentrates because it increased the proportion of C18:2 fatty acid composition of carcass fats which is valuable for beef consumers.
Pen Hua Su,Jia Yuh Chen,Suh Jen Chen 한국유전학회 2008 Genes & Genomics Vol.30 No.1
We report on a 10-year-old boy with severe psychomotor retardation and craniofacial anomalies. Using high resolution GTG banding, SKY FISH, and CGH analysis, he was found to be carrying a del(7)(q34) inherited from a paternal balanced translocation t(6;7)(qter;q34). Reported deletions of the terminal part of the 7q chromosome have not been associated with a clearly distinctive and recognizable phenotype. Frequent findings included: pre/postnatal growth and developmental retardation, microcephaly, eye anomalies, flat/broad nasal bridge with bulbous nasal tip, genital abnormalities and brain defects. In addition to the typical abnormalities, this case further provides evidence for a pituitary dwarfism. The patient was beneficially treated with human growth hormone.
De Novo Partial Trisomy 14 and Extra Marker Chromosome in a Newborn Male with The CHARGE Syndrome
Pen-Hua Su,Ming Chen,Jia-Yuh Chen,Suh-Jen Chen,Ju-Shan Yu,Yu-Jie Kai 한국유전학회 2007 Genes & Genomics Vol.29 No.1
The characteristic phenotype of partial trisomy 14 includes growth and developmental retardation, microcephaly, distinctive facies and anomalies of the hands and feet. In many cases, the presence of marker chromosomes complicates the phenotypic picture. We describe a ompatible with CHARGE syndrome. The patient presented with intrauterine growth retardation, coloboma, heart disease, choanae stenosis, cleft palate, corpus calosum genital anomalies, azygos anterior cerebral artery (ACA), single internal carotid artery (ICA) and ear anomalies. Cytogenetic analysis revealed trisomy 14pter→characterized by spectral karyotyping (SKY) and found to have been derived from chromosome 1. No pathogenic mutation was detected in the CHD7 gene. This case apears to be the first report of a patient having both trisomy 14 with marker chromosome 1 and the CHARGE syndrome, and it presents a unique opportunity to observe the overlaping
RESIDUALS IN MINIMAL RESOLUTION IV DESIGNS
Pen-Hwang Liau 한국통계학회 2003 Journal of the Korean Statistical Society Vol.32 No.3
In unreplicated factorial or fractional factorial experiments, the presencethe normal plot oft residuals to identify outliers in factorial or fractionalfactorial is an easy method to nd these dubious points. In some cases, thet residuals form the identical pairs. One can not ell from the plot whichIV, which ts the model containing all main eects and some two-factorinteractions, whether it is orthogonal or not. In these kinds of models, whenwe drop one point or two points (not foldover pair) from the fraction, thephenomenon of identical pairs oftthe theoretical background of the phenomenon and its sequences will beinvestigated in detail.AMS 2000 subject classications.Primary 62B15; Secondary 62K15.Keywords.Residual, resolution, minimal design, foldover, normal plot.1. Introductionone can hardly be certain whether the model is appropriate or not before checkingsome basic assumptions. Residuals act an important role in the linear model. Oneusually uses residuals for detecting normal asumption, homogeneous variance,etc. For the linear model, the random errorsεi are generally assumed to be independent normal variables with mean 0 andconstant varianceσ2. Unfortunately, the residualsei not have common variance. In performing the data nalysis, the residuals andthe scaled versions of the residuals have ben used extensively to study validityof the linear model and its assumptions.Received December 2002; accepted April 2003.
A Note on Constructing and Designs When Linear Terms are Essential
Pen-Hwang Liau 한국통계학회 2005 Journal of the Korean Statistical Society Vol.34 No.2
Under the assumption that the three-level factors are quantitative, the linear effects are taken more attention than the quadratic effects of the interaction terms. Webb (1971) presented some small incomplete factorial designs that are mixed two- and three-level designs with 20 or fewer runs. The designs provided the estimating linear-by-linear components of interactions between the three-level factors; moreover, they could also offer estimation of interactions that interest the experiments. Webb used ad hoc methods to find these plans; hence, there was still no unified structure to those experiments. In this paper, we develop the methods to construct the 2n31 and 2133 designs. The designs constructed by these methods not only supply orthogonal estimates of all the main effects but also permit estimation of all the two-factor interactions not involving the quadratic effects. Furthermore, the designs we find are nearly orthogonal.