Multi-point optimization on meridional shape of a centrifugal pump impeller for performance improvement

Ji Pei,Wenjie Wang,Shouqi Yuan 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.11

A wide operating band is important for a pump to safely perform at maximum efficiency while saving energy. To widen the operating range, a multi-point optimization process based on numerical simulations in order to improve impeller performance of a centrifugal pump used in nuclear plant applications is proposed by this research. The Reynolds average Navier Stokes equations are utilized to perform the calculations. The meridional shape of the impeller was optimized based on the following four parameters; shroud arc radius, hub arc radius, shroud angle, and hub angle as the design variables. Efficiencies calculated under 0.6Q d , 1.0Q d and 1.62Q d were selected as the three optimized objectives. The Design of experiment method was applied to generate various impellers while 35 impellers were generated by the Latin hypercube sampling method. A Response surface function based on a second order function was applied to construct a mathematical relationship between the objectives and design variables. A multi-objective genetic algorithm was utilized to solve the response surface function to obtain the best optimized objectives as well as the best combination of design parameters. The results indicated that the pump performance predicted by numerical simulation was in agreement with the experimental performance. The optimized efficiencies based on the three operating conditions were increased by 3.9 %, 6.1 % and 2.6 %, respectively. In addition, the velocity distribution, pressure distribution,streamline and turbulence kinetic energy distribution of the optimized and reference impeller were compared and analyzed to illustrate the performance improvement.

Multiparameter optimization for the nonlinear performance improvement of centrifugal pumps using a multilayer neural network

Ji Pei,Wenjie Wang,Majeed Koranteng Osman,Xingcheng Gan 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.6

To increase efficiency at the design point of a centrifugal pump, this study adopted an artificial neural network in the construction of an accurate nonlinear function between the optimization objective and the design variables of impellers. Modified particle swarm optimization was further applied to refine the mathematical model globally. The database, which consisted of 200 sets of impellers, were generated from the Latin hypercube sampling method, and their corresponding efficiencies were obtained automatically from numerical simulation. Design variables were the distributions of blade angles, and results established that the difference between the numerical performance curve and the experimental results was acceptable. Optimization with a two-layer feedforward network improved the pump efficiency at the design point by 0.454 %. Flow complexity improved as the blade curvature increased. The application of the multilayer neural network could provide a meaningful reference to single- and multi-objective optimization of complex and nonlinear pump performance.

Involvement of Yellow-y in the cuticle pigmentation of the larvae, pupae and adults in Henosepilachna vigintioctopunctata

Wang Pei,Ze Long-Ji,Jin Lin,Li Guo-Qing 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.1

Yellow-y (Y-y) contributes to the accumulation of melanins in insect cuticle. However, the underlining mecha nism requires further investigation. Two classical hypotheses have been proposed: Y-y acts as a dopachrome conversion enzyme (DCE) to accelerate biosynthesis of melanins; alternatively, Y-y serves as a cuticular anchor for pigments. Henosepilachna vigintioctopunctata is a serious defoliator attacking Solanaceae and Cucurbitaceae plants. The beetle shows a species-specific pigmentation pattern: stage-dependent dark patches are distributed on pale-yellow background. Here we noted that RNA interference (RNAi)-aided knockdown of Hvyellow-y at the newly-ecdysed second- and third-instar larval, and 1-day-old prepupal stages changed coloration in both dark patches and pale-yellow background. Black pigmentation was lightened in the Hvy-y hypomorphs, including various body portions such as larval heads, antennae, mouthparts, scoli, strumae, legs and exuviae, pupal and adult thoraces and abdomens, and adult elytra and hindwings. Moreover, the coloration background was yel lowed in the RNAi beetles. Specifically, more yellow pigments were observed to deposit around the black dorsal markings in the hypomorphic pupal metathorax. Furthermore, the boundaries between black patches and yellow background were distinct in the resultant ladybirds. Similarly, the margins around bristle follicles and droplet spots were not fuzzy within the RNAi pupal black patches. In summary, even though Y-y facilitates the pigmentation in H. vigintioctopunctata exocuticle, our data did not support the pigment anchor hypothesis.

Application of different surrogate models on the optimization of centrifugal pump

Wenjie Wang,Ji Pei,Shouqi Yuan,Jinfeng Zhang,Jian-Ping Yuan,Changzheng Xu 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.2

An optimization process for impellers was carried out based on numerical simulation, Latin hypercube sampling (LHS), surrogate model and Genetic algorithm (GA) to improve the efficiency of residual heat removal pump. The commercial software ANSYS CFX 14.5 was utilized to solve the Reynolds-averaged Navier-Stokes equations by using the Shear stress transport turbulence model. The impeller blade parameters, which contain the blade inlet incidence angle ∆β, blade wrap angle φ, and blade outlet angle β 2 , were designed by random sample points according to the LHS method. The efficiency predicted under the design flow rate was selected as the objective function. The best combination of parameters was obtained by calculating the surrogate model with the GA. Meanwhile, the prediction accuracies of three surrogate models, namely, Response surface model (RSM), Kriging model, and Radial basis neural network (RBNN), were compared. Results showed that the calculated findings agree with the experimental performance results of the original pump. The RSF model predicted the highest efficiency, while the RBNN had the highest prediction accuracy. Compared with the simulated efficiency of the original pump, the optimization increased efficiency by 8.34% under the design point. Finally, the internal flow fields were analyzed to understand the mechanism of efficiency improvement. The optimization process, including the comparison of the surrogate models, can provide reference for the optimization design of other pumps.

The Effects of ALA-PDT on Leukemia Cells and Hepatoma Cells

Chen, Ji-Yao,Ren, Qing-Guang,Wu, Su-Min,Wang, Pei-Nan Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2

S-aminolevulinic acid (ALA) is a new kind drug used in photodynamic therapy. ALA-PDT have successfully used in superficial malignancies and some skin diseases. Here the effects of ALA-PDT were studied on leukemia cells and hepatoma cells to explore the application on different kind cancers. It was found from the fluorescence emission spectra, that after ALA incubation the sensitizer - protoporphyrin IX (PpIX) was endogenously produced in both leukemia and hepatoma cells. The fluorescence images showed that the PpIX distribute in cytoplasm. However the efficiency of ALA photodynamic inactivation to two cell lines was different. The leukemia cells were more sensitive for ALA-PDT than hepatoma cells, revealing that the ALA-PDT effect is cell line dependent. However by using ALA-Hexyl ester (He-ALA) instead of ALA, the cell photo-inactivation was improved. The PDT efficiency of He-ALA was 10 times high than that of ALA, showing He-ALA is a very promising drug in ALA-PDT.

Multi-component optimization of a vertical inline pump based on multiobjective pso and artificial neural network

Xingcheng Gan,Ji Pei,Wenjie Wang,Shouqi Yuan,Yajing Tang 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.12

The vertical inline pump is a single-stage single-suction centrifugal pump with a curved inlet pipe before the impeller, which is widely used in where the constraint is installation space. In this paper, with the objective functions of efficiencies at 0.5 , d Q 1.0 , d Q and 1.5 , d Q a multi-objective optimization on inlet pipe and impeller was proposed to broaden the efficient operating period of a vertical inline pump. Two 5th order Bézier curves were adopted to fit the shape of the mid curve of the inlet pipe and the trend of the blade angle of the impeller. Fourteen design variables were selected after the data-mining process. 300 sample cases were generated using Latin hypercube sampling (LHS), and they were solved by 3D RANS code to obtain the objective functions. The feed-forward artificial neural network with a hidden layer and an output layer was adopted to fit the two objective functions and the 14 design variables. The Pareto frontiers were generated for the three objectives using multi-objective particle swarm optimization (MOPSO), and three different configurations on the Pareto front are selected for detailed study by computational fluid dynamics (CFD). The results showed that the profile of the inlet pipe and the blade have a dramatic impact on the performance of the vertical inline pump. The Pareto frontiers reported that the performance under the overload condition usually keeps stable when the nominal efficiency is lower than 82 %, or the part-load efficiency is lower than 62 %, and it will decrease rapidly after that. After optimization, the improvement of efficiencies at the part-load condition and nominal condition of the picked case were 9.65 % and 7.95 %, respectively.

Fluid-structure interaction analysis of an impeller for a high-pressure booster pump for seawater desalination

Tingyun Yin,Ji Pei,Shouqi Yuan,Majeed Koranteng Osman,Jiabin Wang,Wenjie Wang 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.11

A High-pressure booster pump (HPBP) is an essential piece of equipment in a Seawater reverse osmosis (SWRO) system. As the corerotating component in the HPBP, the impeller operates extensively in a high-pressure and corrosive environment and its work status directly affects the reliability of the pump device. The vibration characteristics of the rotor were analyzed using fluid-structure interaction theory to determine the characteristics that would ensure the long-term safe operation of the HPBP. The stress and deformation analysis was performed on a partitioned solution for an impeller in a moving fluid, and the modal analysis of the impeller was conducted in still fluid based on a monolithic solution. The influence of the impeller shroud thickness on the resulting vibration characteristics was investigated by using three modifications of the impeller. A comparison of the results with the initial impeller geometry was then carried out under partial load operations. Three commonly used materials for an impeller were also evaluated. The three-dimensional turbulent flow was modeled utilizing the SST k-ω turbulence model, and the numerical results were verified by the experimental data. The results show that natural frequency of the 20CrMnTi is the highest among the three materials for each order mode, followed by 00Cr17Ni14Mo2Ti (316L) and HT250Ni2Cr. Increasing the rear shroud thickness would result in a notable reduction in its deformation. Evidently, the thicker the front and rear shrouds, the lower the shroud deformations. Among the three operating points, the displacement fields of the impeller were quite akin. An outward displacement growth was observed within the impeller hub to the outer diameter, thereby leaving both shrouds with a local maximum on the blade passage. Additionally, higher equivalent stress values were observed at the junction between the blade and the shroud. These results reveal the deformation and stress affecting the impeller, which then enables identification of and provides specific theoretical guidance for the optimization of the structural design of the pump.

Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy

Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.

Anisotropic NdFeCoZrBGa Magnet Powder with High properties Produced by Modified HDDR Process

FU Meng,LIAN Fa-zeng,WANG Ji-jie,PEI Wen-li,ZHOU Gui-qin,YANG Hong-cai 한국자기학회 2003 한국자기학회 학술연구발표회 논문개요집 Vol.13 No.2

De novo transcriptome analysis of an albino mutant Pasphiopedilum pacific shamrock reveals reduced expression of genes related to chloroplast biosynthesis and division

Han Li,Hua Cao,Rong‑pei Yu,Zhen Miao,Ji‑hua Wang,Su‑Ping Qu,Qiang Yuan,Shenchong Li 한국원예학회 2018 Horticulture, Environment, and Biotechnology Vol.59 No.3

Paphiopedilum pacific shamrock is an orchid with high ornamental value. Understanding the mechanisms responsible for leaf color in albino mutants is important for ornamental development and breeding. In this study, we compared the leaf photosynthetic pigment content and transcriptome of albino mutants ppa01 and wild-type P. pacific shamrock. Photosynthetic pigment in mutants was less than 2% of the wild type and chl a/b was 60% less than the wild type. Transcriptome sequencing yielded 6.27 Gb and 5.67 Gb clean data from the mutant and wild-type leaves, respectively. De novo assembly yielded 104,763 unigenes with 15,400 greater than 1 kb in length. In unigene expression analysis, 3170 differentially expressed genes (DEGs) were identified with 2231 (70.38% of total DEGs) down-regulated. Results from GO and KEGG enrichment analysis, KEGG pathway analysis and qPCR suggest that the reduction of chloroplast biosynthesis and division in the mutant was due to low expression levels of ppGLK1 and ppFtsz. Mutants were associated with fewer chloroplasts in leaf cells, abnormal chloroplast structures, impaired chlorophyll biosynthesis, and thus reduced total chlorophyll and carotenoid contents. Furthermore, down-regulated expression of ppNYC1 reduced transformation of chlorophyll b into chlorophyll a, leading to a chl a/b decline. The research will guide future studies of leaf pigment mutations and the breeding of P. pacific shamrock.