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Parthasarathy Thirumala,Daniel Lai,Jonathan Engh,Miguel Habeych,Donald Crammond,Jeffrey Balzer 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.4
Background and Purpose Intraoperative neurophysiological monitoring (IONM) using upper and lower somatosensory evoked potentials (SSEPs) is an established technique used to predict and prevent neurologic injury during intracranial tumor resections. Endoscopic port surgery (EPS) is a minimally-invasive approach to deep intraparenchymal and intraventricular brain tumors. The authors intended to evaluate the predictive value of SSEP monitoring during resection of intracranial brain tumors using a parallel endoscopic technique. Methods A retrospective review was conducted of patients operated on from 2007-2010 utilizing IONM in whom endoscopic ports were used to remove either intraparenchymal or intraventricular tumors. Cases were eligible for review if an endoscopic port was used to resect an intracranial tumor and the electronic chart included all intraoperative monitoring data as well as pre- and post-operative neurologic exams. Results 139 EPS cases met criteria for inclusion. Eighty five patients (61%) had intraparenchymal and fifty four (39%) had intraventricular tumors or colloid cysts. SSEP changes were seen in eleven cases (7.9%), being irreversible in three (2.2%) and reversible in eight cases (5.8%). Seven patients (5.0%) with intraparenchymal tumors had SSEP changes which met our criterea for significant changes while there were four (2.9%) with intraventricular (p-value=0.25). Five patients suffered post operative deficits, two reversible and two irreversible SSEP changes. Only one case exhibited post operative hemiparesis with no SSEP changes. The positive predictive value of SSEP was 45.4% and the negative predictive value was 99.2%. Conclusions Based on the high negative and low positive predictive values, the utility of SSEP monitoring for cylindrical port resections may be limited. However, the use of SSEP monitoring can be helpful in reducing the impact of endoscopic port manipulation when the tumor is closer to the somatosensory pathway.
Parthasarathy Thirumala,Felix D. Nguyen,Amol Mehta,John Schindler,Suresh Mulukutla,Vinodh Jeevanantham,Lawrence Wechsler,Thomas Gleason 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.4
Background and Purpose Perioperative stroke is a significant complication of transcatheter aortic valve implantation (TAVI). This study aimed to quantify perioperative stroke as an independent risk factor for in-hospital mortality and postoperative morbidity in patients receiving TAVI. Methods A retrospective cohort study was conducted using the National Inpatient Sample. Patients undergoing TAVI during 2012 and 2013 were identified using diagnostic codes of International Classification of Diseases, ninth revision. Univariate and multivariate analyses were performed using patient demographics and comorbidities to identify predictors of mortality and morbidity, defined by a length of stay of >14 days and/or discharge to a place other than home. Results Data were obtained from 7,556 patients undergoing TAVI during 2012 and 2013. The incidence rates of mortality and morbidity were 4.57 and 71.12%, respectively. Perioperative stroke was an independent risk factor for mortality [odds ratio (OR)=3.182, 95% confidence interval (CI)=1.530–6.618, p=0.002], as were infection (OR=17.899, 95% CI=9.876–32.440, p< 0.001) and pericardial tamponade (OR=7.272, 95% CI=2.874–18.402, p<0.001). Stroke also predicted morbidity (OR=5.223, 95% CI=2.005–13.608, p=0.001), which was also associated with age, being female, being Asian, moderate and high Van Walraven scores (VWR), and infection. Conclusions In conclusion, perioperative stroke was found to be independently associated with in-hospital mortality and postoperative morbidity, as are age and high VWR. Our findings support the use of further preoperative, intraoperative, and postoperative management strategies during TAVI.
The Review of Upgrading Coal Techniques in South Korea
Prakash Parthasarathy,Hang Seok Choi,Hoon Chae Park,Jae Gyu Hwang,Ho Seong Yoo,Byeong-Kyu Lee 한국폐기물자원순환학회 2016 한국폐기물자원순환학회지 Vol.33 No.5
High-rank coals are limited, while low-rank coals are abundant. However, the low-rank coals needs upgradation so as to improve their quality. If not, the utilization of low-rank coals will lead to many operational difficulties. As this study was made in South Korea, this article discusses the energy and coal scenario of South Korea. The critique discusses the concerns of utilizing low-grade coal and the need for upgrading low-grade coal. The article also briefly discusses the currently practiced low-rank coal upgradation techniques. Also, the review paper suggests some best upgradation techniques.
Structure-property relationship of melt intercalated maleated polyethylene nanocomposites
R.Parthasarathy,M.M.Reddy,Rahul k.Gupta,S.N.Bhattacharya 한국유변학회 2007 Korea-Australia rheology journal Vol.19 No.3
Low density polyethylene nanocomposites were prepared by melt intercalating maleic anhydride grafted polyethylene and montmorillonite clay. It has been found that maleic anhydride has promoted strong interactions between polyethylene and montmorillonite, leading to the homogeneous dispersion of clay layers. Rheological experiments revealed that prepared nanocomposites exhibited shear thinning behaviour. Polyethylene nanocomposites exhibited an increase in steady shear viscosities compared to virgin polyethylene owing to strong polymer clay interactions. The tensile strength of nanocomposites was improved but elongation at break decreased considerably. Also, barrier properties improved significantly with montmorillonite content.
Gayathri, Parthasarathy,Hariharan, Palamarneri Sivaraman,Moon, Dohyun,Anthony, Savarimuthu Philip Elsevier 2019 Journal of luminescence Vol.211 No.-
<P><B>Abstract</B></P> <P>Aggregation enhanced emissive (AEE) triphenylamine-phenylacetonitrile based donor-accepter compounds showed alkoxy chain length dependent solid state fluorescence efficiency and stimuli induced off-on fluorescence switching. Molecular conformational and packing differences lead to fluorescence tuning between 480 and 530 nm. The compounds exhibited off-on mechanofluorochromism upon crushing and heating. Interestingly, all compounds produced stable non-fluorescent melt that was converted to strongly fluorescent solids upon crystallization. The high-contrast off-on crystallization induced fluorescence switching has been used to demonstrate rewritable fluorescence platform. Single crystal structural analysis, powder X-ray diffraction and differential scanning calorimetry have been performed to understand the mechanism of fluorescence switching.</P> <P><B>Graphical abstract</B></P> <P>Crystallization induced fluorescence switching of alkoxy chain substituted triphenylamine smart fluorophores have been used to demonstrate rewritable fluorescent platform.</P> <P>[DISPLAY OMISSION]</P>
Effect of combined slow pyrolysis and steam gasification of sugarcane bagasse on hydrogen generation
Prakash Parthasarathy,Sheeba Narayanan 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.11
The present work aims at improving the generation of H2 from sugarcane bagasse in steam gasification process by incorporating slow pyrolysis technique. As a bench scale study, slow pyrolysis of sugarcane bagasse is performed at various pyrolysis temperature (350, 400, 450, 500 and 550 oC) and feed particle size (90<DP<212, 212< Dp<355, 355<Dp<500, 500<Dp<850 μm) to determine effective conditions of char generation. In the combined process (slow pyrolysis of biomass followed by steam gasification of char), first slow pyrolysis is carried out at the effective conditions (pyrolysis temperature and particle size) of char generation (determined from bench scale study) and steam gasification is at varying gasification temperature (600, 650, 700, 750 and 800 oC) and steam to biomass (S/B) ratio (1, 2, 3, 4, 5 and 6) to determine the effective conditions of H2 generation. The effect of temperature and S/B on gas product composition and overall product gas volume was also investigated. At effective conditions (gasification temperature and S/B) of H2 generation, individual slow pyrolysis and steam gasification were also experimented to evaluate the performance of combined process. The effective condition of H2 generation in combined process was found to be 800 oC (gasification temperature) and 5 (S/B), respectively. The combined process produced 35.90% and 23.60% more gas volume (overall) than slow pyrolysis and steam gasification process, respectively. With respect to H2 composition, the combined process generated 72.37% more than slow pyrolysis and 17.91% more than steam gasification process.
Inhibition of Atherosclerosis in Low-Density Lipoprotein Receptor-Negative Mice by Sesame Oil
Sampath Parthasarathy,Shylesh Bhaskaran,Nalini Santanam,Meera Penumetcha 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4
Diet has profound effects on the development of atherosclerosis. Fatty acid composition, antioxidants, andother components such as lignans have major effects on the atherosclerotic process. Sesame oil has both mono- and polyun-saturated fatty acid constituents in equal proportions. In addition, it also has high levels of numerous antioxidants and induc-ers of peroxisome proliferator-activated receptor. The objective of this study was to determine the anti-atherosclerotic effectsof sesame oil. In this study, male low-density lipoprotein (LDL) receptor (LDLR) . /. mice were fed atherogenic diet oratherogenic diet reformulated with the same level of sesame oil (sesame oil diet). Plasma lipids and atherosclerotic lesionswere quantified after 3 months of feeding. Sesame oil-containing diet significantly reduced the atherosclerotic lesion forma-tion and plasma cholesterol, triglyceride, and LDL cholesterol levels in LDLR . /. mice. These findings suggest that sesameoil could inhibit atherosclerosis lesion formation effectively, perhaps because of the synergistic actions of fatty acid and non-saponifiable components.