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백서와 기니픽의 대뇌피질에서 Opioid Kappa 수용체의 특성에 관한 연구
김기원(Kee-Won Kim),노혜원(Hye-Won Rho),김형일(Hyoung-Il Kim),은재순(Jae-Soon Eun),소수미(Soo-Mi Soh),조규박(Kyu-Park Cho) 대한약리학회 1994 대한약리학잡지 Vol.30 No.2
In this study, we tested the influences of several κ opioid ligands on the [<sup>3</sup>H]diprenorphine binding in rat and guinea pig cortex membrane preparations. Using paradigm to block μ and δ opioid receptors with DAMGO(1μM) and DPDPE(1μM), [<sup>3</sup>H]diprenorphine labeled κ sites. Competition analysis in both rat and guinea pig cortex has shown a single population of [<sup>3</sup>H]diprenorphine binding site with different Kd values, respectively. There is a significant difference in Ki values of (-) WIN44441 and (+)WIN44441 in both rat and guinea pig cortex. Bremazocine, (-)ethylketocyclazocine, (-)cyclazocine, nor-binaltorphimine effectively inhibited the [<sup>3</sup>H]diprenorphine binding with different Ki values in rat and guinea pig cortex. U-69,593, U-50,488H and dynorphine-A (1-8) did not inhibit the [<sup>3</sup>H]diprenorphine binding in rat but in guinea pig cortex. Nor-binaltorphimine was a ligand discriminate the κ<sub>1</sub>, and κ<sub>2</sub> receptor most effectively. We, also, examined the influence of Na ion and GTPγS, a nonhydrolyzable guanine nucleotide analog, on the inhibition of [<sup>3</sup>H]diprenorphine binding by diprenorphine, (-)ethyl-ketocyclazocine, U-69,593 and bremazocine. By the replacement of NaCl with N-methy-D-glucamine or addition of GTPγS, Ki values of diprenorpnine were not changed and that of ethylketocyclazocine were changed significantly in both rat and guinea pig cortex. The Ki value of bremazocine was decreased by removal of Na ion, and increased by GTPγS, however, was not changed by any one of either. These results suggest that there are 2 kinds of subtypes of κ opioid receptor, κ<sub>1</sub>, and κ<sub>2</sub>, showing different Ki values for various κ opioid ligands, also, bremazocine possess the antagonistic property at κ<sub>2</sub> site which is dominant subtype of K receptor in rat cortex.
스마트 미디어 환경의 시각 인터페이스 디자인에 관한 연구
최진원(Jin Won Choi),박정기(Jeong Kee Park) 한국디자인문화학회 2013 한국디자인문화학회지 Vol.19 No.3
최근 웹뿐만 아니라 모바일 전반을 아우르며 디지털 디바이스의 사용자 환경(UI :User Interface) 디자인 패러다임이 새롭게 변화하고 있다. 이러한 변화 가운데 디바이스가 다양해지고 콘텐츠들이 많아지면서 사용자들은 타 기기에서도 웹 서비스를 일관성 있게 제공받기를 원하게 되었다. 이에 본 연구에서는 스마트 미디어 환경에 대해 이해하고, 웹사이트 UI디자인 동향을 수집하여 특징을 알아보고, 그에 따라 분류된 레이아웃, 스크롤, 해상도, 그래픽요소, 기술 요소를 기준으로 브랜드, 프로모션, 쇼핑몰, 3가지 유형의 사례 분석을 진행하였다. 그 결과 레이아웃은 콘텐츠가 단순하고 비주얼이 강화된 일반 그리드, 브로슈어 레이아웃과 스마트기기에 적합한 블록 레이아웃의 형태가 나타났다. 스크롤은 전반적으로 태블릿, 폰에 좀 더 적합한 싱글 페이지 구조의 세로 스크롤 사이트가 늘어나고 있음을 알수 있었다. 해상도 반응의 경우 다양한 해상도에 대응하는 반응형 웹사이트가 늘어나고 있고, 그래픽 요소의 경우 직관적이고 신뢰할 수 있는 사진 이미지의 사용이 많았다. 기술적 요소는 스마트 기기에 적합한 html5, jQuery의 적용이 많았고, 세로 스크롤 방식을 통해 마우스 휠이 아닌 넘김 방식으로 스토리에 맞는 모션이 혼합되어 차별화된 경험을 제공했다. 이러한 결과로 도출된 동향을 통해 추후 웹사이트 제작 시기초자료로 활용할 수 있으리라 기대한다. Recently, with the web as well as mobile digital devices, the user experience (UI: User Interface) is a new design paradigm is changing. Among these changes, the device As more users are diverse and content to other devices, in addition to the PC consistently provide Web services were to be won. In this research, a smart media environment for the understanding and design trends by collecting website UI features to learn, and accordingly classified layout, scroll, resolution, design elements, technical elements, based on brand, promotion, shopping malls, three type of case analysis was conducted. As a result, the content, the layout is simple and regular grid with enhanced visuals, brochure layout and is suitable for smart devices in the form of a block layout appeared. Scroll structure as a whole tablet, phones, a more suitable structure of a single-page vertical scroll was found that increasing the site. Resolution corresponding to different resolutions reaction responsive Web sites is growing, graphic elements, the intuitive and reliable use of photographic images respectively. Technology components suitable for the smart devices html5, jQuery application of the common vertical scrolling mouse wheel over the story in a way that meets a non-feed is a mixture of motion were differentiated experience. As a result, the derived trends as a basis for making future web site can use to expect that.
( Chihyeon Sohng ),( Jun Hong Park ),( Won Kee Lee ),( Jun Young Kim ),( Yong Hyun Jang ),( Weon Ju Lee ),( Seok-jong Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Infrared thermal imaging (ITI), aka thermography, has been used widely in medicine, but been studied rarely its clinical application in vascular malformations (VMs). Objectives: This study investigated validity and usefulness of ITI as a new screening test to differentiate between capillary malformation (CM) and arteriovenous malformation (AVM). Methods: This study included 50 patients with VMs who conducted ITI between 2011 and 2018. They were divided into two groups; CM and AVM, and those with Parkes-Weber syndrome (PWS) were also included in AVM group. Temperature difference (ΔT) between lesional and contralateral non-lesional area was compared using ITI to calculate the maximum ΔT (ΔTmax). The receiver operating characteristic (ROC) curve was then plotted to determine optimal cutoff value of ΔTmax. Results: Of the total 50 patients, 34 were finally diagnosed with CM, and 16 AVM (12 pure AVM, and 4 PWS). AVM group had significantly higher ΔTmax (2.57±1.23°C) than CM group (0.69±0.50°C).The area under the curve of ΔTmax for diagnosis of AVM versus CM was 0.938. The sensitivity and specificity were showed 87.5% and 94.1% (LR+, 14.87; LR-, 0.13) in cutoff value of ΔTmax 1.39°C, and 81.3% and 97.1% (LR+, 27.62; LR-, 0.19) in cutoff value of ΔTmax 1.42°C. Conclusion: The value of ΔTmax measured by ITI was useful to distinguish AVM from CM, so ITI can be employed as a new non-invasive differential screening test for uncertain VMs.
김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.1
Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.
NK Cell Activity and PAPG Alteration during N-Methylnitrosourea Induced Gastric Carcinogenesis
Kee-Teak Jang,Soo Young Park,Hye Won Shin,Kyoung Bun Lee,Ja-June Jang 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.4
To know the role of NK cells during gastric carcinogenesis, especially in late stage of tumorigenesis, the changes of NK activity was examined. Rats were given N-methylnitrosourea (MNU) at a concentration of 100 ppm in their drinking water for 15 weeks. Rats were sacrificed sequentially on week 15, 20, 30, and 40 of experimental period. Histological changes such as mild erosion, regenerative changes, focal or severe atypical lesions and invasive adenocarcinoma were observed sequentially in the pyloric region. Adenomatous hyperplasia was induced in majority of the rat stomach in MNU treated group and incidence of adenocarcinoma was 20% in 40 weeks of MNU-treated group. There was no difference in NK activity until week 20, however, it was decreased in MNU-treated rats at week 30 and week 40, when compared to that of untreated control group. From week 15, the ratio of pepsinogen 1-altered pyloric gland (PAPG) between untreated control and MNU treated rats was progressively increased. These results suggest that PAPG is a relatively good marker for the evaluation in progression of gastric carcinogenesis and decreased NK activity is shown, esepcialy in late stage of gastric carcinogenesis.
Pictorial Review of Mediastinal Masses with an Emphasis on Magnetic Resonance Imaging
Park Jin Wang,Jeong Won Gi,Lee Jong Eun,Lee Hyo-jae,Ki So Yeon,Lee Byung Chan,Kim Hyoung Ook,Kim Seul Kee,Heo Suk Hee,Lim Hyo Soon,Shin Sang Soo,Yoon Woong,Jeong Yong Yeon,Kim Yun-Hyeon 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.1
Magnetic resonance imaging (MRI) has become a crucial tool for evaluating mediastinal masses considering that several lesions that appear indeterminate on computed tomography and radiography can be differentiated on MRI. Using a three-compartment model to localize the mass and employing a basic knowledge of MRI, radiologists can easily diagnose mediastinal masses. Here, we review the use of MRI in evaluating mediastinal masses and present the images of various mediastinal masses categorized using the International Thymic Malignancy Interest Group’s three-compartment classification system. These masses include thymic hyperplasia, thymic cyst, pericardial cyst, thymoma, mediastinal hemangioma, lymphoma, mature teratoma, bronchogenic cyst, esophageal duplication cyst, mediastinal thyroid carcinoma originating from ectopic thyroid tissue, mediastinal liposarcoma, mediastinal pancreatic pseudocyst, neurogenic tumor, meningocele, and plasmacytoma.
Clinical Features of Early and Late Postoperative Hypothyroidism After Lobectomy
Park, Suyeon,Jeon, Min Ji,Song, Eyun,Oh, Hye-Seon,Kim, Mijin,Kwon, Hyemi,Kim, Tae Yong,Hong, Suck Joon,Shong, Young Kee,Kim, Won Bae,Sung, Tae-Yon,Kim, Won Gu The Endocrine Society 2017 The Journal of clinical endocrinology & metabolism Vol.102 No.4
Park, Jeong Mi,Chung, Chun Kee,Kim, June Sic,Lee, Kyung Myun,Seol, Jaeho,Yi, Suk Won Elsevier 2018 NEUROSCIENCE Vol.369 No.-
<P><B>Abstract</B></P> <P>The present study investigated the influence of musical expectations on auditory representations in musicians and non-musicians using magnetoencephalography (MEG). Neuroscientific studies have demonstrated that musical syntax is processed in the inferior frontal gyri, eliciting an early right anterior negativity (ERAN), and anatomical evidence has shown that interconnections occur between the frontal cortex and the belt and parabelt regions in the auditory cortex (AC). Therefore, we anticipated that musical expectations would mediate neural activities in the AC via an efferent pathway. To test this hypothesis, we measured the auditory-evoked fields (AEFs) of seven musicians and seven non-musicians while they were listening to a five-chord progression in which the expectancy of the third chord was manipulated (highly expected, less expected, and unexpected). The results revealed that highly expected chords elicited shorter N1m (negative AEF at approximately 100 ms) and P2m (positive AEF at approximately 200 ms) latencies and larger P2m amplitudes in the AC than less-expected and unexpected chords. The relations between P2m amplitudes/latencies and harmonic expectations were similar between the groups; however, musicians’ results were more remarkable than those of non-musicians. These findings suggest that auditory cortical processing is enhanced by musical knowledge and long-term training in a top-down manner, which is reflected in shortened N1m and P2m latencies and enhanced P2m amplitudes in the AC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Harmonically expected chords reduced P2m latencies in the auditory cortex. </LI> <LI> Harmonically expected chords enhanced P2m amplitudes in the auditory cortex. </LI> <LI> The results from musicians were more salient than non-musicians. </LI> </UL> </P>