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Enrichment of Vitamins $D_3$, K and Iron in Eggs of Laying Hens
Park, S.W.,Namkung, H.,Ahn, H.J.,Paik, I.K. Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.2
An experiment was conducted to produce eggs enriched with vitamins $D_3$, K and iron in eggs. Six hundred 97-wk-old ISA Brown force molted hens were allocated to completely randomized block arrangement of six dietary treatments: T1; control (C), T2; C+4,000 IU vitamin $D_3$+2.5 mg vitamin K+100 ppm Fe, T3; C+8,000 IU vitamin $D_3$+5.0 mg vitamin K+100 ppm Fe, T4; C+12,000 IU vitamin $D_3$+7.5 mg vitamin K+100 ppm Fe, T5; C+16,000 IU vitamin $D_3$+10.0 mg vitamin K+100 ppm Fe, T6; C+20,000 IU vitamin $D_3$+12.5 mg vitamin K+100 ppm Fe. Fe was supplemented with Fe-methionine. Each treatment consisted of five replicates of ten cages with two birds per cage. Egg production and egg weight were highest in T2 and incidence of soft and broken egg was highest in T6. Haugh unit was not different among treatments although it tended to be increased as dietary vitamins $D_3$ and K increased. Eggshell strength was not different among treatment. Concentrations of vitamin $D_3$ and K in egg yolk increased and plateaued approximately 20 days after feeding supplemented diets. The level of these vitamins peaked at 12,000 IU/kg vitamin $D_3$ and 7.5 mg/kg vitamin K supplementation and then decreased at the higher than these supplementation levels. The peak concentrations of vitamin $D_3$ and vitamin K were 4.6 times and 4.8 times greater than the control, respectively. Supplementary Fe also increased Fe content in egg yolk. It is concluded that vitamin $D_3$ and K in eggs can be effectively enriched by proper supplementation time and level of these vitamins.
Lee, H. G,P. Y. Lee,Y. K. Lee,S. J. Kim,H. K. Chung,M. K. Seo,J. K. Park,K. S. Min,W. K. Chang 한국동물생명공학회(구 한국동물번식학회) 2003 Reproductive & developmental biology Vol.27 No.4
The effects of additions/deletions in glycosylated residues of recombinant human EPO (rhEPO) produced in CHO-K1 on their secretion were examined. hEPO cDNA was amplified from human liver mRNA and cloned into the pCR2.1 TOPO. Using overlapping-extension site-directed mutagenesis method, glycosylation sites at 24th, 38th, 83rd, and 126th were respectively or accumulatively removed by substituting its asparagine (or serine) with glutamine. To add novel glycosylation sites, 69 and 105th leucine was mutated to asparagine. Mutant and wild type rhEPO constructs were cloned into the pcDNA3 expression vector with CMV promoter and transfected into CHO cell line, CHO-K1, to produce mutant rhEPO mutant rhEPO proteins. Enzyme-linked immunosorbant assay (ELISA) and Western analysis with monoclonal anti-EPO antibody were performed using supernatants of the cultures showing transient and stable expressions respectively. Addition of novel glycosylation reduced rhEPO secretion dramatically while deletion mutants had little effect except some double deletion mutants (△24/83 and △38/83) and triple mutant (△24/38/83). This fact suggests that not single but combination of changes in glycosyl groups affect secretion of rhEPO in cell culture, possibly via changes in their conformations.
Park, N. W.,Ahn, J. Y.,Park, T. H.,Lee, J. H.,Lee, W. Y.,Cho, K.,Yoon, Y. G.,Choi, C. J.,Park, J. S.,Lee, S. K. Royal Society of Chemistry 2017 Nanoscale Vol.9 No.21
<P>Recently, significant progress has been made in increasing the figure-of-merit (ZT) of various nanostructured materials, including thin-film and quantum dot superlattice structures. Studies have focused on the size reduction and control of the surface or interface of nanostructured materials since these approaches enhance the thermopower and phonon scattering in quantum and superlattice structures. Currently, bismuth-tellurium-based semiconductor materials are widely employed for thermoelectric (TE) devices such as TE energy generators and coolers, in addition to other sensors, for use at temperatures under 400 K. However, new and promising TE materials with enhanced TE performance, including doped zinc oxide (ZnO) multilayer or superlattice thin films, are also required for designing solid-state TE power generating devices with the maximum output power density and for investigating the physics of in-plane TE generators. Herein, we report the growth of Al2O3/ZnO (AO/ZnO) superlattice thin films, which were prepared by atomic layer deposition (ALD), and the evaluation of their electrical and TE properties. All the in-plane TE properties, including the Seebeck coefficient (S), electrical conductivity (sigma), and thermal conductivity (kappa), of the AO/ZnO superlattice (with a 0.82 nm-thick AO layer) and AO/ZnO films (with a 0.13 nm-thick AO layer) were evaluated in the temperature range 40-300 K, and the measured S, s, and. were -62.4 and -17.5 mu V K-1, 113 and 847 (Omega cm)(-1), and 0.96 and 1.04 W m(-1) K-1, respectively, at 300 K. Consequently, the in-plane TE ZT factor of AO/ZnO superlattice films was found to be similar to 0.014, which is approximately two times more than that of AO/ZnO films (ZT of similar to 0.007) at 300 K. Furthermore, the electrical power generation efficiency of the TE energy generator consisting of four couples of n-AO/ZnO superlattice films and p-Bi0.5Sb1.5Te3 (p-BST) thin-film legs on the substrate was demonstrated. Surprisingly, the output power of the 100 nm-thick n-AO/ZnO superlattice film/p-BST TE energy generator was determined to be similar to 1.0 nW at a temperature difference of 80 K, corresponding to a significant improvement of similar to 130% and similar to 220% compared to the 100 nm-thick AO/ZnO film/p-BST and n-BT/p-BST film generators, respectively, owing to the enhancement of the TE properties, including the power factor of the superlattice film.</P>
K-means 및 헝가리안 알고리즘기반 중소형 유통사업장 배송지역 균등할당 알고리즘 개발
박건우(K. W. Park),전창범(C. B. Jeon),정의연(U. Y. Jung),최원화(W. H. Choi),정홍진(H. J. Jeong),김준(J. Kim),김보현(B. H. Kim) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월
최근 COVID-19 로 언택트 시대를 맞이하여 유통산업의 물류량은 급진적으로 증가하고 있는 추세이다. 따라서 유통산업은 효율적인 물류관리를 위해 배송 최적화에 노력하고 있다. 하지만 중소형 유통업체는 대형 유통업체에 비해 인력 및 비용의 한계로 배송 최적화에 어려움이 있다. 중소형 유통업체의 배송지 최적화의 이슈는 고객으로부터 접수한 주문의 배송지를 균등하게 할당하는 것이다. 따라서 본 연구는 중소형 유통업체의 배송 최적화를 위해 배송 인력과 배송 이동거리를 고려하여 배송 지역 균등할당 알고리즘을 개발한다. 배송 지역 균등할당 알고리즘은 배송지 밀집도의 특징을 고려하여 배송지를 가용 배송기사에게 균등 할당하는 것이다. 배송지 밀집도 특징을 도출하기 위해 밀도기반 클러스터링 기법인 DBSCAN 으로 배송지의 밀집도가 높은 권역과 낮은 권역으로 나누었다. 밀집도가 높은 권역은 배송 출발지에서 가까우며 배송지 수가 많은 특징을 가지고, 밀집도가 낮은 권역은 배송 출발지에서 멀리 떨어져 있으며 배송지 수가 적은 특징을 가진다. 밀집도가 낮은 권역은 이동거리의 편차가 더 커질 수 있기 때문에 K-means 알고리즘의 Elbow Method 를 사용하여 배송지를 할당한다. 밀집도가 높은 권역은 K-means 알고리즘으로 배송지 그룹을 나누고 그룹의 중심점과 그룹 간 배송지의 거리가 최소가 되게 헝가리안 알고리즘을 적용하여 배송지를 할당한다. 실 데이터를 사용하여 비교한 결과 본 연구에서 제안한 균등알고리즘은 이동거리의 편차와 배송지 수의 편차를 감소시킬 수 있는 것으로 나타났다.
신상구(S.G. Shin),임정규(J.K. Lim),박찬웅(C.W. Park),김명석(M.S. Kim) 대한약리학회 1976 대한약리학잡지 Vol.12 No.1
Aconiti tuber butanol fraction shows positive inotropic effect on the isolated atrium of rabbit heart. To investigate the mechanism, the effect on microsomal ATPase activity of rabbit heart is observed. The microsomal fraction which contains the Na<sup>+</sup>- and K<sup>+</sup>-activated ATPase in the presence of Mg<sup>++</sup> is isolated from the left ventricle of rabbit heart. The microsomal ATPase activity is maximally stimulated at Na<sup>+</sup> and K<sup>+</sup> concentration of 100 mM and 10 mM respectively. Microsomal Na<sup>+</sup>-K<sup>+</sup>-activated ATPase is inhibited by ouabain and Aconiti tuber butanol fraction. Ouabain and Aconiti tuber butanol fraction depress Na<sup>+</sup>-stimulation on microsomal ATPase activity, and the inhibitory effects are not completely reversed at Na<sup>+</sup> concentration of 300 mM. Also, K<sup>+</sup>-stimulation on microsomal ATPase activity is inhibited by ouabin and Aconiti tuber butanol fraction and the inhibitions are not compeletely reversed at K<sup>+</sup> concentration of 30 mM. It is, therefore, suggested that the inhibitory effect of Aconiti tuber butanol fraction on the microsomal ATPase activity may contribute to leading to the positive inotropic effect.
Novel K/Ka Bandpass Filters using LIGA Micromachined Process
Park, K. Y.,Park, J. Y.,Choi, H. K.,Lee, J.C.,Lee, B.,Kim, J. H.,Kim, N. Y.,Park, J. Y.,Kim, G. H.,Kim, D. W.,Bu, J. U.,Chung, K. W. The Korean Institute of Electromagnetic Engineerin 2000 한국전자파학회논문지 Vol.11 No.6
New class of three dimensional (3-D) micromachined microwave planar filters at K and Ka-band are presented using LIGA micro-machined process. The K-and Ka-band filters show wide bandpass characteristics of~36% and ~39% with the insertion loss 1.26dB at 19.11GHz and 1.7dB at GHz, respectively. These filters can be applicable in high power MMIC of MIMIC.
Park, E-Y,Kim, W-Y,Kim, Y-M,Lee, J-H,Han, K-H,Weiner, I D,Kim, J Gutenberg 2012 HISTOLOGY AND HISTOPATHOLOGY Vol.27 No.12
<P>Potassium depletion (K?-D) induces hypertrophy and hyperplasia of collecting duct cells, and potassium repletion (K?-R) induces regression of these changes. The purpose of this study was to examine the time courses of the changes in cellular composition, the origin of intercalated cells (ICs) and the mechanism responsible for these changes. SD rats received K?-depleted diets for 1, 7, or 14 days. After K?-D for 14 days some of the rats received normal diets for 1, 3, 5, or 7 days. In the inner stripe of the outer medulla, K?-D increased significantly the number and proportion of H?-ATPase-positive ICs, but decreased the proportion of H?-ATPase-negative principal cells (PCs). However, proliferation was limited to H?-ATPase-negative PCs. During K?-R, the cellular composition was recovered to control level. Apoptosis increased during K?-R and exclusively limited in H?-ATPase-negative PCs. Double immunolabeling with antibodies to PC and IC markers identified both cells negative or positive for all markers during both K?-D and K?-R. Electron microscopic observation showed that ultrastructure of AE1-positive some cells were similar to AE1-negative some cells during K?-R. LC3 protein expression increased significantly and autophagic vacuoles appeared particularly in PCs on days 14 of K?-D and in ICs on days 3 of K?-R. These results suggest that PCs and ICs may interconvert in response to changes in dietary K+ availability and that autophagic pathways may be involved in the interconversion.</P>