일부 부인과 양성 질환자의 지방조직 및 혈청의 PCBs와 DDE 농도

박성균,이강숙,노영만,구정완,민선영,한진구,고원경,김미란,정재근,이종승,김진홍 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 연구는 지방조직과 혈청의 PCBs와 DDE 농도를 측정하고, 이에 영향을 미치는 것으로 알려진 요인들과의 관련성을 평가하고자 하였다. 방법 : 유방암, 자궁내막증 등 유기염소계 화합물의 영향이 있는 것으로 알려진 호르몬 관련 질병을 제외한 부인과 환자 52명을 대상으로 지방조직과 혈청을 분석하였으며, 설문조사를 통하여 연령, 교육수준, 직업, 비만도, 흡연과 음주, 출산력, 수유력등을 조사하였다. 지방조직과 혈청의 PCBs와 DDE 농도는 가스크로마토그래피를 사용하여 측정하였다. 결과 : 지방조직의 경우, 13개 PCBs congeners 농도의 합은 중앙값이 48.29 ng/g, 기하평균값이 56.78 ng/g이었고, DDE 농도는 중앙값이 142.89ng/g, 기하평균값이 117.06 ng/g이었으며, 혈청의 경우는 PCBs congeners 농도의 합은 중앙값이 4.67 ㎍/L, 기하평균값이 4.85 ㎍/L이었고, DDE 농도는 중앙값이 1.75 ㎍/L, 기하평균값이 2.09 ㎍/L로 나타났다. 지방조직과 혈청의 DDE 농도 사이는 높은 상관성을 보였으나(r²=0.310, p=0,0002), PCBs는 상관성이 약한 것으로 나타났다(r²=0.029, p=0.2582). 영향요인을 범주화한 후 로그변환 시킨 지방조직과 혈청의 PCBs, DDE 평균의 차이를 분석한 결과, 지방조직의 DDE만이 출산자녀수(p=0.015), 초산연령 (p=0.014), 비만지수(p=0.035)와 연관성이 발견되었다 다중회귀분석의 결과 지방조직의 DDE는 출산자녀수가 적을수록, 초산연령이 늦을수록 증가하는 경향을 보였다. 결론 : 출산자녀수와 초산연령, 비만도가 지방조직의 DDE와 관련성을 보였으며, 또한 유기염소계 화합물의 장기간의 노출에 의한 영향을 평가하는데 있어서 혈청보다 지방조직이 더 유용한 생물지표임을 알 수 있었다. Objectives : This study was purposed to determine the levels of PCBs and DDE in adipose tissue and serum and to evaluate the relations with factors affecting these levels. Methods : We analyzed adipose tissues and sera from 52 gynecologic benign disease patients aged 27-78 years, except hormonal diseases such as breast cancer and endometriosis. We also surveyed age, education, occupation, body mass index (BMI), smoking, drinking, number of children, and duration of breastfeeding by questionnaires. Tissue and serum levels of PCBs and DDE were measured using gas chromatography. Results : The median and geometric mean levels of PCBs were 48.29 ng/g, 56.78 ng/g for adipose tissue and 4.67 ㎍/L, 4.85 ㎍/L for serum, and those of DDE were 142.89 ng/g, 117.06 ng/g for adipose tissue and 1.75 ㎍/L, 2.09 ㎍/L for serum, respectively. Adipose tissue and serum levels for DDE showed high correlation (r²=0.310, p=0.0002), but those of PCBs didn't (r²=0.029, p=0.2582). In analyses of the differences of the means of log transformed adipose tissue and serum PCBs and DDE levels for groups of potential covariates, only adipose tissue DDE levels were significantly associated with number of children (p=0.015), age at first birth (p=0.074) and BMI (p=0.035). In multiple regression analysis, adipose tissue DDE levels were significantly increased with decreasing number of children and increasing age at first birth. Conclusions : This study suggested that parity and adiposity were associated with levels of DDE in adipose tissue, and adipose tissue is a better biomarker than serum for evaluating the long-term exposure of organochlorines.

일개 지역 전공의들의 주사침 상해

박신구,이종영,송정흡,유재영,최태성 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.1

목 적 : 병원 종사자들 중에서 전공의들의 주사침 상해의 실태를 파악하고, 주사침 상해 발생의 관련 요인을 알아보고자 하였다. 방 법 : 2000년 7얼에 대구지역에 소재한 전공의 수련병원 중 대학병원 2개소와 종합병원 1개소의 전공의 695명 전원을 대상으로 실시한 자가 기입식 설문지를 통하여 자료를 얻었단. 정확하게 응답한 443명(63.7 %)을 최종분석대상으로 하였다. 결 과 : 새로운 연차가 시작된 4개월 동안 경험한 주사침 상해는 응답자 443명중 200명으로 45.1 %이었고, 평균상해횟수 1.8회, 1000명당 1년 상해율은 5,377건 이었다. 업무특성에 따라 인턴이 96.5 %, 외과계 레지던트가 40.6 %, 내과계 레지던트가 34.4 %의 주사침 상해를 경험하였다. 주사침상해 발생의 관련요인을 분석하기 위해 다중 로지스틱 회귀분석(multiple logistic regression analysis)을 시행하였고, 분석결과는 내과계 레지던트에 비해 인턴이, 12시간이하 근무시간에 비해 16시간이상의 근무시간이 유의한 관련요인으로 나타났다. 결 론 : 병원종사자들 중에서 전공의들은 높은 주사침 상해율을 나타내고 있다. Objectives : This study was conducted in order to assess the experience of needle stick injury among interns and residents working in hospitals during the previous 4 nonths. Methods : We conducted a questionnaire survey of 695 interns and residents working in two university hospitals and one general hospital in Tague city. Four hundred and forty three of those questioned(63.7 %) fully responded. Results : Two hundred of the respondents(45.1 %) suffered at least one injury. Respondents suffered an average of 1.8 injuries. 96.5 % of interns, 40.6 % of surgical residents and 34.4 % of non-surgical residents suffered at leat one injury. According to multiple logistic regression, Intern status and an increased amount of working time is associated with high risk of needle stick injury. Conclusions : This study demonstrates that interns and residents suffer a high rate of needle stick injury.

응급진료시 여성환자의 소변검체 채취방법

박원녕,정상원,이종호,구홍두,심호식,김승호 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Urinalysis is a useful laboratory test in the diagnosis of various diseases. In sampling for the urinalysis, there is much concern about contamination that can lead to misdiagnosis in the mid-stream urine sampling method. We conducted this study to determine, in terms of concordance of results and contamination in culture, whether there was any superiority in nod-stream sampling methods with or without disinfection measures compared to the catheterization method. Materials and Methods: We used three kinds of urine sampling methods sequentially, mid-stream non-clean catch, mid-stream clean catch, and catheterization, for ambulatory, non-pregnant, non-men-struating female patients who visited NHIC Ilsan Hospital emergency department during a one-week period in September 2001. Each sample was electrophotometrically analyzed for leukocyte esterase, nitrite, and blood by using a reagent strip and was cultured immediately or after overnight refrigeration. Results: Of the 41 patients, 9 had culture-proven urinary tract infections. The concordance rates(kappa) for nitrite, blood, and leukocyte esterase were 0.875, 0.403, and 0.406 between non-clean catch and catheterized samples and 0.875, 0.481, and 0.560 between clean catch and catheterized samples, respectively. The contamination rate of the non-clean catch, the clean catch, and the catheterized samples were statistically different: 51.2%, 29.3% and 0%, respectively. Conclusion: We found that cleaning with disinfectant was effective for reducing the contamination rate, even though the best urine sampling method for zero contamination was catheterization. We recommend considering cost, patients' comfort, an acceptable threshold for contamination, and the necessity for a culture before choosing a urine sampling method for women who visit the emergency department.

천연두 백신 접종 후 발생된 급성 심근염 1예

박옥성,김종환,이광욱,윤성훈,강동구,이승욱,조상기 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Acute myocarditis complicating coronary vasospasm after smallpox vaccination is very rare complication that can be generally developed within less than 30 days after vaccination. Clinically and biochemically, this disorder is often mimic and highly suggestive of acute myocardial infarction. We report 21 years old man that had a history of a smallpox vaccination 3 weeks ago and prodromal symptoms(fever, malaise etc) a few days ago. hIe visited to our hospital because of abrupt onset of severe substernal chest pain, dyspnea and diaphoresis. At admission, electrocardiography was ST elevation in lead Ⅰ, aVL, V4, V5, and V6. The CK-MB level was 68 U/L, LDH level was 760 U/L, Troponin-Ⅰ was 24.64 ng/㎖, and Troponin-T was positive. 2D-echocardiograpy was normal left ventricular function, Clinically we presumed this disorder as acute myocardial infarction and we promptly performed the coronary angiography and revealed focal spasm in distal left coronary artery territory without critical stenosis in both coronary arteries. We diagnosed this disorder as coronary vasospam complicating acute myocarditis that is different with acute myocardial infarction, and we prescribed nitroglycerin and nifedipine. After discharge, he is now well without any symptoms and has been following up monthly at our outward department for 6 months.

한 자동차 제조 사업장의 산업재해 분석

이경종,박재범,정호근,김종구 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목 적 : 우리나라 자동차 산업업체의 산업재해 발생 현황을 파악하고 산재예방에 필요한 기초자료를 마련하기 위하여 한 완성 자동차 제조공장에서 1997년도에 발생한 산업재해를 분석하여 다음과 같은 결과를 얻었다. 방 법 : 1년간 산업재해보상보험에 요양 급여를 신청한 근로자들의 재해일지, 건강진단 결과등을 가지고 단면적 연구를 시행하였다. 결 과 : 연령별 재해율은 45-49세 군이 1.6 %로 가장 높았고 35-3971 군이 1.3 %, 40-44세 군, 30-34세 군이 각각 0.9 %, 25-29세 군이 0.6 %, 20-24세 군이 0.4 % 순이며, 근무경력별로는 25년 이상 근로자가 2.7 %으로 가장 높아 연령이 증가할수록, 근무경력이 길수록 재해율이 증가하였다. 작업형태별로는 숙련 작업이 2.3 %로 재해률이 가장 높았고 고정작업이 1.2 % 순 이었다. 작업시간별 발생율은 10-11시(21.4 %)와 오후 2-3시(17.9 %)에 높았다. 요일별로는 금요일(20.5 %), 수요일(17.9 %), 월요일(16.2%), 화요일(15.4 %), 토요일(12.0 %), 목요일(11.1%), 일요일(6.8 %) 순이었다. 월별 발생률은 5월(17.9 %), 3월(11.1 %), 4월(11.1 %) 순으로 봄철이 높았고 8월(10.3 %), 1월(9.4 %) 순이었다. 재해발생 부위는 허리가 41.0 %로 가장 많이 많았고, 다음으로 손가락이 17건(14.5 %), 다리(9.4 %), 손(7.7 %), 머리(6.0 %) 순이었다. 손상 종류별로는 염좌가 38.5 %로 가장 많았고 골절(22.2 %), 요추간판 탈출증(11.1 %), 타박상(9.4 %) 순이었다. 재해의 원인으로는 중량물 취급(34.2 %), 전도(17.1 %), 협착(16.2 %), 낙하비래(6.8 %) 순이었다. 결 론 : 자동차 제조업에서는 중량물 취급과 점심식사 전후나 금요일 등 피로한 시간대에 발생이 많은 근골격계 손상에 대한 주의가 필요해 보인다. Objeetives : To know the present conditions of industrial accidents in automobile facto-ries in Korea and make the basic materials essential to prevention of industrial accidents Methods : We reviewed and analyzed the records of industrial accidents occurred in an automobile factory in 1997 by time of occurrence, job categories (fixed production, skilled trades, mechanical material handling, and clerical & technical), type of injury, kind of accident, and location of injury. Results 1. By age groups, the accident rate was the highest in age 45-49(1.6 %) followed by age 35-39(1.3 %), 40-44(0.9 %), 30-34(0.9 %), 25-29(0.6 %), and 20-24(0.4 %) and by working duration, it was highest in group of experience over 25 years, and so we could see that the more age or working duration increases the more accident rate increases. 2. By work time, the accident rate was the highest in 10-11 a. m. (21.4 %) followed by 2-3 p.m. (17.9%). By the day of the week, it was as follows, Friday(20.5 %), Wednesday(17.9%), Monday(16.2 %), Thesday(15.4 %), Saturday(12.0 %), Thursday(11, 1 %), Sunday(6.8 %) in order. By the month, it was high in May(17.9%), March(11.1 %), and April(71.1 %) followed by August(10.3 %) and January(9.4%) , so we could see it was high in spring. 3. The most frequent injury was in the back by 41.0 % followed by 17 cases in fingers(14.5 %), legs(9.4 %), hands(7.7 %), head(6.0 %) In order. And by the type of Injuries, the sprain was most frequent by 38.5% followed by fracture(22.2 %), lumbar HNP(11.1 %), and contusion(9.4 %) in order. The causes of accident were handling heavy materials(34.2 %), upset(17.1 %), stenosis(16.2 %), and falling(6.8 %) in order. Conclusions : By the above results, to prevent the industrial accidents in automobile factories in Korea, preventive activities for handling heavy materials and back and continuous industrial education are necessary.

桂枝茯笭丸 및 그 構成藥物의 血小板凝集抑制에 關한 硏究

金宗求,朴宣東,朴元煥 동국대학교 한의학연구소 2000 東國韓醫學硏究所論文集 Vol.8 No.2

動物性 脂肪攝取量의 增加, 運動不足, 肥滿, 스트레스의 加重, 高齡化의 增加 等의 原因으로 循環器系疾患의 發病率이 增加하고 있으며, 이러한 循環器系疾患의 危險因子로서 血栓症이 重要하게 대두되고 있다. 특히 최근 문제시되고 있는 狹心症이나 心筋梗塞등의 虛血性 心疾患은 血小板凝集에 의해 일어나는 血栓形成에 起因하고 있다. 韓醫學에서 血栓症은 瘀血의 範疇에 屬하며, 瘀血은 각종 病理的 原因에 의해 발생한 全身性 또는 局所性의 血液循環 障碍 또는 血流停滯와 그에 수반되는 일련의 病症을 나타내며, 驚悸정충, 鼓脹, 積聚, 미하, 癲狂, 中風等의 發病原因이 된다. 또한 瘀血에 의한 각종 症候에는 活血祛瘀劑 또는 驅瘀血劑등이 사용되고 있다. 本 硏究에서는 韓醫學에서 瘀血症으로 惹起되는 여러 가지 症狀의 개선에 사용되는 驅瘀血劑들의 血小板凝集에 미치는 영향을 검색하기 위하여 桂枝茯笭丸(Geijibokryunghwan; GBH) 및 그 構成藥物을 使用하였다. 桂枝茯笭丸은 『금궤요략』에 있는 方으로써 祛邪不傷正하고 調氣寒熱하여 예로부터 驅瘀血劑로 사용되어 왔다. 이에 桂枝茯笭丸 및 그 構成藥劑의 ADP, AA 또는 collagen으로 유도되는 血小板凝集에 대하여 抑制效果를 探索한 結果, 桂枝茯笭丸 및 個別 構成藥物의 血小板凝集抑制作用을 확인하였고, 血小板凝集으로 惹起되는 血栓症등에 桂枝茯笭丸 및 個別 構成藥物은 매우 臨床實驗的 應用價値가 있는 것으로 생각되었다. The cause that the increase of animality fat intakes, under exercise, fatness, adding the stress, advanced age etc., the occurrence rate of the circulation system &sea= has been increased. And the thrombosis importantly came to the front as the risk factor of these circulation system's disease. Nowadays, the ischemic disease has especially discussed, for example the angina or myocardial infarction, originated in thrombosis that came from the platelet aggregation. In the western medicine, as the cure and prevention, using the aspirin or ticlopidine for platelet aggregation suppressant. But in the <Synopsis of the golden chamber : On Pulse, Syndrome Complex and Treatment of Chest Obstruction, Heart Pain and Shortness of Breath>, the curing method must be used properly according to the pectoralgia or heartache's lund, state, grade. The platelet do not attache to the normal hemangioendothelial cell. But when It stimulated by endothelium peronia and so on, it attache to the injury endothelium or rise aggregation between the platelet. On this time, it secrete the platelet aggregation inducer as like ADP, thromboxane A2 from the inside of platelet. So it has first defensive function through the aggregation augment that prevent the celerity consumption of blood. But the activation of abnormal platelet occur the platelet grume and thrombogenesis. So it bring up the occlusive angiosis. so to speak, cardiovascular disease, cerebrovascular disease, arterial sclerosis. In oriental medicine, the thrombosis in the category of blood stasis and this blood stasis present the generalise or local blood circulation disturbance that generated by all kinds of pathological fact or blood stream retention accompanying with a series of syndrome. As the syndrome, stabbing pain fixed at certain region, squamous and dry skin, fullness and pain of the chest and hypochondrium, firmness and fullness of the lower abdomen, black stool, dark purple tongue or with ecchymoses and petechiae etc.. has been created. And it becomes the pathopoiesis cause that the convulsion and palpitation, severe palpitation. tympanites, the symtom complex with a mass or swelling in the abdomen, insanity, stricken by wind etc.. Moreover, it used the drugs for invigorating blood circulation and eliminating blood stasis or drugs for removing blood stasis for all kinds of syndrome through the blood stasis. And the drugs for activating the blood circulation, such as Salviae Radix, Angelicae Sinensis Radix, Persicae Semen, Achyranthis Radx, Cnidii Rhizoma, Carthami Flos are used for that. And it is used to the herbs of insects that has strong effect about the disintergrating blood stasis such as Hirudo, Scolopendrae Corpus, Buthus, Lumbricus etc.. On this study, It used Geijibokryunghwan(GBH) and the consisting herbs to investigate the influence of platelet aggregation about drugs that used to improvement various symptoms created by the thrombosis in oriental medicine. GBH formula has as formula recorded in the <Synopsis of the golden chamber>, action of 'eleminating the evil and not impairment of healthy energy' and 'promoting the flow of QI and cold and heat, so used for the expel blood stasis herbs from the ancient. Therefore we investigated the restraint effect of GBH and the consisting herbs about the platelet agregation induced to the ADP, AA or collagen. The conclusion is following. 1. When it added the aggregation inducer after that it added GBH and individual consisting herbs in the PRP, GBH showed the (+) inhibition effect on the platelet aggregation and it showed the (+) inhibition effect in the individual consisting herbs as like Paeoniae Radix and Moutan Cortex Radicis. 2. It showed the (+), (+,++) inhibition effect on the platelet aggregation in Paeoniae Radix·Hoelen, Paeoniae Radix· Moutan Cortex Radicis, Hoelen· Moutan Cortex Radicis etc. 3. In the aggregation inhibition activating on the difference of density, GBH showed strong ihbition effect to the aggregation state induced to collagen, and it showed the inhibition effect in the individual consisting herbs as like Paeoniae Radix and Moutan Cortex Radicis about the aggregation induced by the collagen. 4. It showed the strong inhibition effect about the aggregation induced by the collagen in Paeoniae Radix·Hoelen, Paeoniae Radix· Moutan Cortex Radicis, Hoelen·Moutan Cortex Radicis etc Like this, as confirm GBH and the individual consisting herb's inhibition effect of platelet aggregation, We considerated that GBH and the individual consisting herbs have practical applicational value of clinical trial in the thrombosis caused by platelet aggregation.

압력센서의 디지털 인터페이스와 신호처리에 관한 연구

강형구,이종호,안광희,이충호,박찬원 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-

A smart pressure measurement system is described, which provides a precise A/D conversion and is highly suitable for communication with microprocessors. In order to avoid unstable problems of remote pressure sensing we have developed a new interface board which performs the A/D conversion and smart signal processing of the measured pressure data Serial communication software which is based on ASCII code commands is also developed to process initial setup an calibration functions as well as multi-drop communication with PC. The test and evaluation of the proposed system has been shown as having the better performance compared to the other types of existing pressure measuring systems and will give good applications to the industrial use where a highly precision remote sensing is needed.

선인장 양심실 보조장치의 설계 및 임상적용을 위한 평가

민병구,박찬영,최재순,이혁수,황창모,김삼성,윤걸중,김종원,선경,이경갑,정종태,김원곤 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.1

현재 개발되고 있는 맥동형 이식형 인공심장은 완전이식형 인공심장과 좌심실보조장치 뿐이다. 좌심실보조장치를 장착한 환자의 10~15%가 우심실의 보조를 필요로하고 완전이식형 인공심장의 장착을 위해서는 자연심장을 제거해야하는 상황에서 이식형 양심실보조장치에 대한 필요성이 대두되고 있다. 본 연구진은 완전이식형 인공심장으로 개발된 한국형 인공심장을 개선하여 양심 실 보조장치를 개발하였다. 양심실보조장치는 이동형 작동기식 미케니즘을 이용하고 있으며 에너지 변환장치와 감속기로 구성된 작동기와 혈액주머니, 그리고 내장형 제어기로 구성되어 있다. 선인장 펌프로 명명된 KAH350은 캐뉼라의 연결을 위한 커넥터를 포함하여 길이 177mm, 폭 164mm, 높이 67 이고 무게 780g이며 최대 심박출량은 5L/min 이다. 양심실보조장치로 개발된 선인장펌프는 좌심실보조장치로도 응용이 가능하다. 이식적합성과 생체적합성을 평가하기 위하여 좌심실보조장치로 5회, 양싱실보조장치로 6회의 동물실험을 수행하였다. 각각 최장 28일간 생존하였으며 11회의 동물실험중 장치의 결함에 의한 것이 3회 있었는데 이들은 모두 전자장치의 결함과 방수처리문제였다. 현재 이식적합성과 일박출량을 향상시킨 KAH400모델이 개발중이다. The types of pulsatile implantable artificial hearts that are on the way of development and have been developed are totally implantable artificial heart and implantable left ventricular assist device (LVAD). Approximately 10% to 15% of all patients Implanted with wearable VADs have required right heart support with another device. And it is reluctant to patient who should remove his or her own heart to be implanted with total artificial heart. These situations drive the development of implantable bi-ventricular assist device (BVAD). The Korean BVAD was develophed by modifying the moving actuator type Korean artificial heart. This electro-mechanical BVAD comprises actuator including energy converter and reduction gear train, blood sacs, and internal motor and energy controllers. The KAH350 which is named as 'Cactus Pump' is 177mm in length, 164mm in width, and 67mm in thickness including connectors and nuts. The weight and maximum cardiac output of Cactus Pump is 780g and 5L/min, respectively. The Cactus Pump that was developed as BVAD could be used as LVAD by attaching compliance caps on the 2 ports of one ventricle. The animal experiments were undergone 5 times for LVAD, and 6 times for BVAD. The best records were 28 days survival in both applications. There were 3 times of device failure and they were all associated with electrical connection and hermetic sealing. The KAH400 that has improved anatomical fitting characterisitcs and stroke volume is on development.

토양에서 분리한 Toluene 분해 세균의 동정 및 일부 특성

김종구,박근태,이건,이상준,손홍주 부산대학교 환경문제연구소 1998 環境硏究報 Vol.16 No.-

경상남도 양산천 일대의 토양시료로 부터 toluene을 유일한 탄소원 및 에너지원으로 생육하는 미생물들을 분리하였고, 그 중 toluene의 분해능이 가장 우수한 균주를 선별하여 공시균으로 선택하였다. 공시균의 형태학적, 배양적, 생화학적 및 화학분류학적 제반 특성들을 토대로 분류학적 위치를 검토한 결과 Rhodococcus 속으로 동정되어 편의상 Rhodococcus sp. EL-43P로 명명하였다. Rhodococcus sp. EL-43P는 phenol 및 다양한 phenol 유도체, benzene 등의 방향족화합물 기질에서 생육할 수 있었다. 특히 phenol 분해에 관련된 각종 환경조건을 최적화시키면 실제의 phenol 함유 폐수처리공정에서 충분히 적용가능성이 있음을 알 수 있었다. Rhodococcus sp. EL-43P는 catechol 1,2-dioxygenase의 활성을 가지고 있어 ortho pathway에 의하여 phenol을 분해함을 알 수 있었다. 또한 본 공시균은 toluene dioxygenase의 활성도 가지고 있었다. The microorganisms which degrade toluene as the sole and energy source were isolated from soil around Yangsan river. Among them, the strain EL-43P had the highest toluene degradability and identified as a Rhodococcus sp. according to morphological, cultural, biochemical and chemotaxonomical properties. Rhodococcus sp. EL-43P was able to grow at the various chlorinated phenols such as o-, p-chlorophenol, 2,3-,2,5-, 2,6- and 3,4-dichlorophenol, and benzene, respectively. If detailed phenol degradation conditions are established, the treatment of phenol wastewater using Rhodococcus sp. EL-43P would be possible. Rhodococcus sp. EL-43P had the catechol 1,2-dioxygenase which degrades Phenol derivatives by ortho pathway. This strain also had toluene dioxygenase.

황화수소 중독증 2례

김종구,이경종,이세휘,박재범 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

평택시에 위치한 펄프 회사에서 탱크 내부를 청소하고자 근로자가 탱크 속으로 들어가는 도중 의식을 잃었다. 펄프제지 과정에서 유기물질의 발효로 인하여 유해한 가스가 발생한다. 발생할 수 있는 가스의 종류에는 이산화탄소(CO₂), 일산화탄소(CO), 암모니아(NH₃), 황화수소(H₂S) 그리고 메틸 머캅탄(methyl mercaptans, CH₃SH) 등이 있다. 작업환경 측정전 이러한 가스들이 존재할 것으로 추정하였으나 실제적으로 황화수소와 일산화탄소만 검출되었을 뿐 암모니아와 메틸 머캅탄은 측정되지 않았다. 그런데 상기 환자들에 있어서 HbCO이 정상 범주이므로 일산화탄소의 중독은 배제할 수 있었다. 따라서 황화수소 중독에 의한 의식소실임을 알 수 있었다. Hydrogen sulfide poisoning is frequently encountered in the workplace. Two workers lost their consciousness In an underground tank at a factory producing paper. The tank contained liquid mixture of used paper, sodium oxygenate chloride (NaOCl), and sodium thiosulfate pentahydrate(Na₂S₂O₃.□H₂O). A worker(worker A; 36-year-old man) entered tank to remove sludge. When worker A lost his consciousness, worker B entered the tank to rescue worker A, however he lost consciousness inside the tank. We discuss in detail the clinical features of this condition. Hydrogen sulfide poisonings have occurred in industries involving petroleum refining, the manufacture of heavy water, tanning of hides, vulcanization of rubber, and the manufacture of rayon. And it is necessary to stress the health education for workers and managers in these industries.