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Hemophagocytic Lymphohistiocytosis can Mimic the Superior Vena Cava Syndrome
Park, Meerim,Choi, Jae-Wook,Park, Hyeon Jin,Kim, Hee Jin,Hi Son, Meong,Yoon, Jong-Hyung,Kim, Su-Jin,Park, Won Seo,Park, Byung-Kiu Lippincott Williams Wilkins, Inc. 2012 Journal of pediatric hematology/oncology Vol.34 No.4
We report a case of a 3-year-old boy with hemophagocytic lymphohistiocytosis (HLH), with enlarged cervical lymph nodes causing internal jugular vein compression, who initially presented a condition similar to the superior vena cava syndrome. Laboratory data along with neck node and bone marrow biopsies confirmed the HLH. Genetic analysis revealed the patient to be compound heterozygous for 2 variations of the perforin gene, c.1620 A>G and c.562C>G. This case featuring a rare initial manifestation of HLH that has not been previously reported, points to the necessity of considering this disease when symptoms similar to superior vena cava syndrome are encountered.
Yoon, Jong Hyung,Kim, Hyery,Lee, Ji Won,Kang, Hyoung Jin,Park, Hyeon Jin,Park, Kyung Duk,Park, Byung-Kiu,Shin, Hee Young,Park, June Dong,Park, Sung-Hye,Ahn, Hyo Seop by Lippincott Williams Wilkins. 2014 Journal of pediatric hematology/oncology Vol.36 No.7
Ewing sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNETs) typically occur in the long or flat bones, the chest wall, extraskeletal soft tissue, or less frequently, in solid organs. They can arise from anywhere in the body; however, ES/pPNETs arising from the adrenal gland are very rare, especially in children and adolescents. Herein, the authors report a case of an ES/pPNET in the adrenal gland of a 17-year-old girl, who was successfully treated with a multimodal treatment, with a brief review of the pertinent literature.
[논문]거리변환알고리즘을 이용한 이동로봇의 경로 계획 및 추적
박기형,최영규 釜山大學校生産技術硏究所 2004 生産技術硏究所論文集 Vol.63 No.-
본 논문에서 자율이동로봇의 효율적이고 안전한 주행을 위해서 경로계획과 추적 및 장애물 회피의 문제들이 다루어진다. 경로계획을 위해서 기존의 거리변환알고리즘의 검색순서를 단순화하고 경로재생성부분을 추가하여 개선시키고, 개선 된 거리변환알고리즘을 이용하여 기존의 방법에 의한 것보다 짧은 거리의 경로를 얻는다. 경로추적 단계에서는 퍼지 논리 제어기를 사용하여 경로추적 행위와 장애물회피 행위를 실행한다. 컴퓨터 시율레이션을 통하여 자율이동로봇의 주행에 적용된 본 연구방법의 효율성을 입증한다.
성장호르몬 결핍증 환아에서 성장호르몬 분비안자에 대한 성장호르몬 분비 양상
문형로,양세원,박병규 대한내분비학회 1990 Endocrinology and metabolism Vol.5 No.1
The authors observed the growth hormone (GH) response to pharmacologic agents (arginine-insulin, L-dopa) and growth hormone releasing hormone (GHRH) at Seoul National University Children's Hospital from September 1988 to August 1989. 42 patients included in the study were divided into 3 groups according to the peak plasma GH levels after pharmacologic stimulation test: complete GH deficiency group (25 patients), GH$lt;5 ng/ml; imcomplete GH deficiency group (6 patients), 5≤GH$lt;10 ng/ml; normal GH group (11 patients), GH≥10 ng/ml (GH levels of more than 10 ng/ml were measured from 8 patients). The peak plasma GH levels were measured from each group after GHRH stimulation test. The results were as follows: 1) The mean peak plasma levels of GH measured from complete and incomplete GH deficiency groups after GHRH stimulation test were higher than those after pharmacologic stimulation test, but were not different significantly in normal GH group. Following GHRH administration, peak plasma GH levels of more than 10 ng/mwere measured from 8 patients with idiopathic GH deficiency. Thus hypothalamic defect was suggested as the origin of their GH deficiency. 2) The serial mean plasma GH levels measured from normal GH group were persistently higher than those from complete and incomplete GH deficiency groups. But considerable overlapping of peak GH levels was observed among three groups. 3) The peak plasma GH levels after GHRH stimulation test were negatively correlated with age in complete GH deficiency and normal GH group. 4) The peak value of sequential mean plasma GH levels measured from incomplete GH deficiency group after GHRH stimulation test was reached earlier than that from complete GH deficiency group. In conclusion, GHRH stimulation test might be useful in the evaluation of readily releasable GH reservoir and speculation of putative mechanism of GH deficiency. But the discriminination of GH deficiency from normal GH status couldn't be made solely on the basis of the peak plasma GH levels after single GHRH stimulation test. Further study using different doses of GHRH is recommended for the evaluation of GH status (J. Kor Soc Endocrinol 5:14~22, 1990).
Gonadal and Sexual Dysfunction in Childhood Cancer Survivors
Yoon, Ju Young,Park, Hyeon Jin,Ju, Hee Young,Yoon, Jong Hyung,Chung, Jin Soo,Hwang, Sang Hyun,Lee, Dong Ock,Shim, Hye Young,Park, Byung-Kiu 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4
<P><B>Purpose</B></P><P>Few studies have addressed gonadal and sexual dysfunctions in childhood cancer survivors. We evaluated the prevalence rates and risk factors for gonadal failure among adolescent/young adult childhood cancer survivors and their sexual function.</P><P><B>Materials and Methods</B></P><P>Subjects were childhood cancer survivors aged 15-29 years who had completed therapy more than 2 years ago. Demographic and medical characteristics were obtained from the patients’ medical records. In addition, hormonal evaluation and semen analysis were performed and sexual function was evaluated via questionnaire.</P><P><B>Results</B></P><P>The study included 105 survivors (57 males, 48 females), of which 61 were adults (age > 19 years) and 44 were adolescents. In both males and females, the proportion of survivors with low sex hormone levels did not differ among age groups or follow-up period. Thirteen female subjects (27.1%) needed sex hormone replacement, while five males subjects (8.8%) were suspected of having hypogonadism, but none were receiving sex hormone replacement. Of 27 semen samples, 14 showed azospermia or oligospermia. The proportion of normospermia was lower in the high cyclophosphamide equivalent dose (CED) group (CED ≥ 8,000 mg/m<SUP>2</SUP>) than the low CED group (27.3% vs. 62.5%, p=0.047). Among adults, none were married and only 10 men (35.7%) and eight women (34.3%) were in a romantic relationship. Though a significant proportion (12.0% of males and 5.3% of females) of adolescent survivors had experienced sexual activity, 13.6% had not experienced sex education.</P><P><B>Conclusion</B></P><P>The childhood cancer survivors in this study showed a high prevalence of gonadal/sexual dysfunction; accordingly, proper strategies are needed to manage these complications.</P>