만성 두부외상 환자에서 99mTc - HMPAO Brain SPECT의 임상적 유용성

서정호(Jung Ho Suh),김동익(Dong Ik Kim),정태섭(Tae Sub Chung),이종두(Jong Doo Lee),박창윤(Chang Yoon Park),정진일(Jin Ill Chung),김영수(Young Soo Kim) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1

N/A Minima1 deterioration of cerebral perfusion or microanatomical changes were undetectable on conventional Brain CT or MRI. So evaluation of focal functional changes of the brain parenchyme is essential in chronic head injury patients, who did not show focal anatomical changes on these radiological studies. However, the patients who had longstanding neurologic sequelae following head injury, there had been no available imaging modalities for evaluating these patients precisely. Therefore we tried to detect the focal functional changes on the brain parenchyme using Tc-99m-HMPAO Brain SPECT on the patients of chronic head injuries. Twenty three patients who had suffered from headache, memory dysfunction, personality change and insomnia lasting more than six months following head injury were included in our cases, which showed no anatomical abnormalities on Brain CT or MRI. At first they underwent psychological test whether the symptoms were organic or not. Also we were able to evaluate the cerebral perfusion changes with Tc-99m-HMPAO Brain SPECT in 22 patients among the 23, which five patients were focal and 17 patients were nonfocally diffuse perfusion changes. Thus we can predict the perfusion changes such as local vascular deterioration or functional defects using Tc-99m-HMPAO Brain SPECT in the patients who had suffered from post-traumatic sequelae, which changes were undetectable on Brain CT or MRI.

Cytochalasin B와 Colchicine이 생쥐 간장의 담세관과 간세포의 미세구조에 미치는 영향

박창현,장병준,엄창섭,엄창섭 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.2

흰쥐에서 분리 배양한 척수앞뿔신경세포의 형태 분화 및 축삭 형성

엄창섭,엄창섭,박창현,권계숙,유임주,박선화,전용혁 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.2

장기간 숙성에 따른 죽초 및 목초액의 이화학적 변화

구창섭,문성필,박상범,권수덕 한국목재공학회 2002 목재공학 Vol.30 No.4

졸참나무, 맹종죽 및 소나무로부터 제조한 미정제 죽초 및 목초액을 약 1년 간 저장하고, 이들의 이화학적 변화를 주기적으로 분석하였다. pH, 유기산·용해타르 함량 및 비중은 전 숙성기간 중 큰 변화가 관찰되지 않았다. 그러나 색차의 경우 7∼10개월 사이에서 현저한 변화를 나타내었다. 또한 이 기간동안에 이들 죽초 및 목초액의 색깔은 연한 노랑 띤 오렌지색에서 자주색과 오렌지색으로 크게 변화하였다. 죽초 및 목초액 중 유기산 및 중성 성분(dihydro-2(3H)-furanone, furfural, furfuryl alcohol, 2-hydroxy-1-methyl-1-cyclopenten-3-one, 1-hydroxy-2-propanone, methanol)들의 함량은 3개월 간격으로 주기적인 증감을 나타내었다. 특히 유기산류와 중성 성분들의 관계는 0.92 정도의 높은 상관관계를 나타내었다. 페놀류의 함량은 비록 유사한 주기적인 증감이 관찰되었으나, 그 함량의 경우 숙성 전 기간에 걸쳐 감소하였다. Three different kinds of the crude vinegars obtained from oak(Quercus serrata), bamboo(Phyllostachys pubescens) and pine(Pinus densiflora) species were stored for approximately one year and periodically analyzed to monitor their physicochemical changes. Small changes in physical properties, such as the pH, specific gravity and amount of organic acids as well as water-soluble tar were observed in the entire course of aging period. However, the color difference of the vinegars showed a remarkable change between 7 and 10 months. In addition, these vinegars' colors changed from light yellowish orange to much deeper purple and orange during this period. The amount of organic acids and neutral compounds(dihydro-2(3H)-furanone, furfural, furfuryl alcohol, 2-hydroxy-1-methyl-1-cyclopenten-3-one, 1-hydroxy-2-propanone and methanol) in the vinegars increased or decreased periodically every three months. A good linear relationship (correlation coefficient of ca. 0.92) was obtained between the amount of organic acids and the amount of neutral compounds in such changes. However, although the amount of phenols increased or decreased periodically, its amount was decreased over the entire aging period.

소비자생활협동조합의 사회적 성과 창출과정에 대한 질적 연구

신창섭 ( Chang Sub Shin ),박창길 ( Chang Ki Park ) 한국협동조합학회 2013 韓國協同組合硏究 Vol.31 No.2

The purpose of this study was to investigate the structure and process of creating social performance by the consumer cooperative. For the investigation, 11 month fieldwork was conducted at the iCOOP consumer cooperative. The data were collected through direct observations, documents, formal/informal interviews with 19 people. The collected data were analyzed using the grounded theory by Strauss & Corbin. The outcomes of social performance in the consumer cooperative were positive changes in the emotions and attitude toward life, positive feelings for efficacy of the cooperative policies by the cooperative members, improved economic lives of producer members, increased reputation of the cooperative and collaboration among different local cooperatives in the area. The social performances were created through diverse internal devices and business strategies of the organization to strengthen the representation of members and realize the expectations of members. The uniqueness of these devices and strategies of the cooperative can be characterized by the core concept of “control by members”. Accordingly general consumer cooperatives can be classified into four different types by the sub-dimensions of “control by members” in the study.

냉기치료후 슬관절강내의 온도변화

백승석,최기섭,박시복,이상건,김영호,양길태,장윤희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

사관생도의 체육활동을 통한 사회성발달요인이 신체적 자기효능감에 미치는 영향

민창기(Min, Chang-Gi),이종민(Lee, Jong-Min),박상섭(Park, Sang-Sub),박순희(Park, Sun-Hee),김인기(Kim, In-Ki) 한국체육과학회 2014 한국체육과학회지 Vol.23 No.2

The purpose of this study of cadets social development through physical activity factor out the impact of physical self-efficacy are seeing. To this end, on the basis of previous research and theory, cadets according to the individual characteristics of participants in physical activity factors, social development, and physical effects on self-efficacy was determined empirically. The subjects of this study are based in KAFA cadets to participate in physical activity among the 200 selected patients, 169 were used in the final part were used. By the way, more studies were summarized as follows. First, the social development of the sub-factors of the social factors, governance, stability, no statistically significant differences between men and women in the show, and overall social development factors in men than in women was higher. Physical self-efficacy subscale of physical competence and physical attractiveness in the sense of gender showed statistically significant differences, and about the physical self-efficacy was higher in women than men. Second, the social development of the factors involved in the stability of the sub-factors, depending on stocks showed a statistically significant difference, and the overall social development factors were the highest in the group event. Self-efficacy of physical competence subscale of the body involved in the events showed significant differences according to the tatistical and physical competence, the individual events and the most underestimated, interpersonal and organization in order. In other words, the overall physical self-efficacy and the lowest individual events, personal events, corporate events in order, respectively. Third, social development, physical factors impact on self-efficacy to evaluate the results with social dominance physical competence, physical self-expression, sense of physical attractiveness showed a positive correlation, and perceived physical ability and a negative correlation with has shown. Stability in the perceived physical ability, has shown a positive correlation.

홍화(Carthamus tinctorius L.)씨 분말의 랫드 골절에 대한 치유 효과

박창현,엄창섭,배춘식,Park, Chang-Hyun,Uhm, Chang-Sub,Bae, Chun-Sik 한국현미경학회 2001 Applied microscopy Vol.31 No.4

12주령 랫드의 비골의 골절을 유발한 후 골절치유에 미치는 홍화씨 분말의 영향을 알아보고자 실험을 실시한 결과 다음과 같은 결과를 얻었다. 비골의 골절은 골절유발 후 5주에 성숙된 신생골 조직으로 충만되어 조직형태학적으로 완전한 유합이 이루어지는데, 홍화씨 분말을 투여한 결과 골절유발 후 4주에 성숙된 신생골 조직으로 골절단이 충만되어 완전한 유합을 이룬 후 5주에서는 골수강도 개통되는 등 대조군과 비교하여 유합시기를 기준으로 1.5주 정도의 빠른 골절의 치유가 이루어졌다. 이상의 결과는 홍화씨 분말에 골절의 치유를 촉진시키는 성분이 포함되어 있을 가능성을 시사한다고 사료된다. Safflower (Carthamus tinctorius L.) is a thistle-like annual plant mainly grown in dry hot climates as an oilseed or birdseed. Traditionally, the oil has mainly been sold in the health food market because it is unsaturated having high linoleic and oleic acid levels. With increased health consciousness in recent years, the oil quality has become a more general health issue. This study was designed to understand whether safflower seed powder has positive effects on the fracture healing in rats. Simple transverse fracture of rat fibula was made with a rotating diamond disc saw. The histologic changes of rats were observed with a scanning electron microscope. The fractured fibulae showed a complete fusion at the fracture site in the 4th to 5th week after a simple transverse fracture. Administration of safflower seed powder facilitated the speed of histologic changes without affecting qualitative changes. These results suggest that safflower seed powder nay have substances that help the fracture healing process.

우취(牛膵) Ribonuclease가 자궁암 세포의 염색체수에 미치는 영향에 관한 연구

이석우,박혜숙,장남섭 최신의학사 1970 最新醫學 Vol.13 No.7

Chroniosome numbers have been studied in a Hela cell population sensitive to the inhibitory influences of RNase(strain S3) and in its sub-lines-,r resistant to RNase according to the length of time and the density of concentration, respectively. It has been found that strain S3 has a stem-line of 59 chromosomes, while the RNase-resistant sub lines of exhibit stem-lines of 56,53 and 50. The data suggest that RNase "resistancy" in the cell strain and sub-lines is due to subler varj4tion than a net decrease of 3,6 and I9 chromosomes, respectively.

Gene profile of fibroblasts identify relation of CCL8 with idiopathic pulmonary fibrosis

Lee, Jong-Uk,Cheong, Hyun Sub,Shim, Eun-Young,Bae, Da-Jeong,Chang, Hun Soo,Uh, Soo-Taek,Kim, Young Hoon,Park, Jong-Sook,Lee, Bora,Shin, Hyoung Doo,Park, Choon-Sik BioMed Central 2017 Respiratory research Vol.18 No.-

<P><B>Background</B></P><P>Idiopathic pulmonary fibrosis (IPF) is characterized by the complex interaction of cells involved in chronic inflammation and fibrosis. Global gene expression of a homogenous cell population will identify novel candidate genes.</P><P><B>Methods</B></P><P>Gene expression of fibroblasts derived from lung tissues (8 IPF and 4 controls) was profiled, and ontology and functional pathway were analyzed in the genes exhibiting >2 absolute fold changes with <I>p</I>-values < 0.05. <I>CCL8</I> mRNA and protein levels were quantified using real-time PCR and ELISA. <I>CCL8</I> localization was evaluated by immunofluorescence staining.</P><P><B>Results</B></P><P>One hundred seventy eight genes differentially expressed and 15 genes exhibited >10-fold change. Among them, 13 were novel in relation with IPF. <I>CCL8</I> expression was 22.8-fold higher in IPF fibroblasts. The levels of <I>CCL8</I> mRNA and protein were 3 and 9-fold higher in 14 IPF fibroblasts than those in 10 control fibroblasts by real-time PCR and ELISA (<I>p</I> = 0.022 and <I>p</I> = 0.026, respectively). The <I>CCL8</I> concentrations in BAL fluid was significantly higher in 86 patients with IPF than those in 41 controls, and other interstitial lung diseases including non-specific interstitial pneumonia (<I>n</I> = 22), hypersensitivity pneumonitis (<I>n</I> = 20) and sarcoidosis (<I>n</I> = 19) (<I>p</I> < 0.005, respectively). Cut-off values of 2.29 pg/mL and 0.43 pg/mL possessed 80.2 and 70.7% accuracy for the discrimination of IPF from NC and the other lung diseases, respectively. IPF subjects with <I>CCL8</I> levels >28.61 pg/mL showed shorter survival compared to those with lower levels (<I>p</I> = 0.012). <I>CCL8</I> was expressed by α-SMA-positive cells in the interstitium of IPF.</P><P><B>Conclusions</B></P><P>Transcriptome analysis identified several novel IPF-related genes. Among them, <I>CCL8</I> is a candidate molecule for the differential diagnosis and prediction of survival.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s12931-016-0493-6) contains supplementary material, which is available to authorized users.</P>