말초신경자극이 동통반응에 미치는 영향

백광세(Paik, Kwang-Se),정진모(Chung, Jin-Mo),남택상(Nam, Taick-Sang),강두희(Kang, Doo-Hee) 대한생리학회 1981 대한생리학회지 Vol.15 No.2

Experiments were conducted in ischemic decerebrate cats to study the effects of electroacupuncture and electrical stimulation of peripheral nerve on pain reaction. Flexion reflex was used as an index of pain. The reflex was elicited by stimulating the sural nerve(20 V, 0.5 msec duration) and recorded as a compound action potential from the nerve innervated to the semitendinosus muscle. Electroacupuncture was performed, using a 23-gauge hyperdermic needle, on the tsusanli point in the lateral upper tibia of the ipsilateral hindlimb. The common peroneal nerve was selected as a peripheral nerve which may be associated with electroacupuncture action, as it runs through the tissue portion under the tsusanli point. Both for electroacupuncture and the stimulation of common peroneal nerve a stimulus of 20 V-intensity, 2 msec-duration and 2 Hz-frequency was applied for 60 min. The results are summerized as follows: 1) The electroacupuncture markedly depressed the flexion reflex; this effect was eliminated by systemic application of naloxone (0.02~0.12 mg/kg), a specific narcotic antagonist. 2) Similarly, the electrical stimulation of the common peroneal nerve significantly depressed the flexion reflex, the effect being reversed by naloxone. 3) When most of the afferent nerves excluding sural nerve in the ipsilateral hindlimb were cut, the effect of electroacupuncture on the flexion reflex was not observed. Whereas direct stimulation of the common peroneal nerve at the proximal end from the cut resulted in a significant reduction of the flexion reflex, again the effect was reversible by naloxone application. 4) Transection of the spinal cord at the thoracic 12 did not eliminate the effect of peripheral nerve stimulation on the flexion reflex and its reversal by naloxone, although the effect was significantly less than that in the animal with spinal cord intact. These results suggest that: 1) the analgesic effect of an electroacupuncture is directly mediated by the nervous system and involves morphine-like substances in CNS, 2) the site of analgesic action of electroacupuncture resides mainly in the brainstem and in part in the spinal cord.

우리나라 마라톤選手의 體力現況 및 體力管理

白光世 대한의학협회 1969 대한의학협회지 Vol.12 No.1

Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid

Paik, Yong-Han,Lee, Kwan Sik,Lee, Hyun Jin,Yang, Kyung Min,Lee, Se Jun,Lee, Dong Ki,Han, Kwang-Hyub,Chon, Chae Yoon,Lee, Sang In,Moon, Young Myoung,Brenner, David A Springer Science and Business Media LLC 2006 Laboratory investigation Vol.86 No.7

흰 생쥐의 태아기 저단백식이가 생장후의 운동능력 및 젓산형성에 미치는 영향

백광세,홍성일,이중우,김인교,강두희 최신의학사 1975 最新醫學 Vol.18 No.10

The effect of maternal protein deficiency during gestation and lactation on the physical performance and lactate formation of the child mice was studied. Thirthy female mice were devided into two groups consisting of 15 each, one group was maintained with balanced and the other with low protein diet. The former, the control group, was fed balanced diet containing 20% casein and the latter, experimental group was fed low protein diet containing 5% casein during the periods of gestation, delivery and lactation. 30 male mice weaned from each group (Total 60 mice) were fed with balanced diet until the experiment. 15 mice from each group (total 30 mice) was used for single acute experiment and the other half were trained under severe training program. 8 weeks after weaning, the maximal running time was recorded on a small animal treadmill with a speed of 34.3m/min and 19° slope. 3 minutes after the maximal running, the mouse was sacrificed immediately by decaptitation and the blood was collected. The lactic and pyruvic acid in the blood were determined by the method of Barker and Summerson (1941), and Friedman and Haugen (1942) respectively. The results were summarized as follows; 1. Newly born young mice from low protein group during gestation and lactation gained less weight than balanced diet group until 8 weeks after weaning. 2. The maximal running time of the low protein diet group was longer than control group significantly (P<0.05). The control group ran for an average of 7.23±1.46 min compared to 11.53±1.28 min of experimental group and the maximal work done of experimental group was also higher than control, 4238±470 gm-m and 2698±544 gm-m respectively. 3. The lactate concentration and lactate/pyruvate ratio in blood of the control group was higher then the experimental group. 4. The maximal running time and the maximal work of both groups after severe training program became insignificant, although the experimental group showed a longer maximal time.

군사훈련이 신체적성에 미치는 영향

백광세,김광수,김형철 공군본부 의무감실 1972 항공의학 Vol.20 No.1-2

Alcohol, NAFLD, Other : The Incidence and Risk Factors for Hepatotoxicity in Patients Undergoing Adjuvant Folfox Chemotherapy after Curative Resection for Colorectal Cancer

( Se Ok Lee ),( Dong Hyun Sinn ),( Geum Youn Gwak ),( Yong Han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ),( Byung Chul Yoo ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: FOLFOX chemotherapy (folinic acid + fluorouracil + oxaliplatin) is a standard adjuvant regimen following curative resection of colorectal cancer (CRC). Some patients undergoing FOLFOX chemotherapy are reported to experience chemotherapy-related hepatotoxicity; however, the incidence and risk factors for the development of hepatotoxicity in these patients are not well described. Patients and methods: A total of 849 patients aged between 17 and 79 years who were treated with adjuvant FOLFOX chemotherapy after curative resection for CRC were recruited from Samsung Medical Center in October 2005 to June 2012. Their medical records were retrospectively collected and analyzed. Hepatotoxicity was graded according to Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. Results: Six hundreds and eighty six of 849 patients (80.8%) experienced hepatotoxicity during or shortly after FOLFOX chemotherapy, in which 586 were in grade 1, 84 in grade 2 and 16 patients in grade 3. However, most of these episodes were transient and spontaneously recovered. Risk factors associated with the development of any grade of hepatotoxicity were age < 60 years (HR 2.390, CI 1.667-3.425), female (HR 1.51, CI 1.038-2.234), baseline ALT>20 IU/mL (HR 1.717, CI 1.065- 2.768). Risk factors associated with the development of ≥ grade 2 of hepatotoxicity were age<60 years (HR 5.393, CI 2.951- 9.858), HCV carrier (HR 5.373, CI 1.181-24.442). There was no relation between the development of hepatotoxicity and obesity, baseline level of AST, PT (INR), cholesterol and platelet, and HBsAg status. Three of 22 HBsAg positive patients who were not given prophylactic antiviral treatment during FOLFOX chemotherapy did experience ≥ grade 2 of hepatotoxicity during or shortly after chemotherapy. However, the incidence was not different from those of HBsAg positive patients who were given antiviral therapy or HBsAg negative patients. All these three patients recovered without any specific treatment for HBV. Conclusion: Hepatotoxicity induced by adjuvant FOLFOX chemotherapy after curative resection for CRC is not uncommon; however, most episodes were mild and self-limited. Age<60 years and HCV carrier were risk factors for ≥ grade 2 of hepatotoxicity. Moreover, it is unlikely that a short course of FOLFOX chemotherapy influences HBV reactivation.

서울시 대기중의 연 농도에 관한 조사

백남원,이광묵,오세민 가톨릭대학 산업의학 쎈타 산업의학연구소 1975 韓國의 産業醫學 Vol.14 No.2

The principal source of lead in urban atmospheres is believed to be combustion of gasoline containing antiknock additives in the form of lead alkyls. This survey was carried out to find the amount of atmospheric lead in Seoul by location and time. The results obtained are as follows: 1. The highest value of 12.33㎍/㎥ was indicated at Eulchiro rotary and the lowest value of 1.24㎍/㎥ was indicated at Kyungundong. The traffic volume of 8,307 vehicles/hr at Eulchiro rotary was the heaviest value in Seoul. Therefore, it was found that the level of lead concentration in air was deeply associated with the traffic volume. 2. The higher values of atmospheric lead concentration was determined during the rush hours of 9:00 ~ 10:00 and 17:00 ~ 18:00. 3. Climatic factors did not show any significant correlation with the atmospheric lead concentration in Seoul during this short period of survey.

공군 조종사를 위한 신체적성 운동

백광세,이원규,이종관,최용국 공군본부 의무감실 1970 항공의학 Vol.18 No.1-2

Physical Pain in Oral Health Impact Profile among Korean Adults (55+) : Distribution and Associated Factors

Bae, Kwang-HaK,Kim, Hyun-Duck,Jung, Se-Hwan,Park, Deok-Young,Paik, Dai-Il,Chung, Sung-Chang 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

본 연구의 목적은 첫째, 55세이상성인을 대상으로 구강보건영향지수 중 물리적동통의 유병률을 파악하고, 둘째, 55세이상성인의 구강건강충격지수 중 물리적동통의 연관요인을 파악함에 있다. 조사대상자는 2000년 국민구강건강조사시 층화무작위추출법으로 표본추출된 4,250명의 55세이상성인집단 중에서 본 연구의 목적에 동의한 1,098명의 55세이상성인이었고, 조사방법은 전화면접조사법이었다. 면접문항은 구강건강충격지수 중 물리적동통에 관련된 9개의 문항와 성, 연령, 거주지역 및 의치장착여부등에 관한 4문항을 합하여 총 13문항이었고, 동통정도의 웅답은 5점리커트척도(0-4)룰 이용하여 기록되었다. 동통유병를은 동통정도 0-1을 동통무경험자로, 동통정도 2-4를 동통유경험자로 하였고, 총물리적동통정도(PPS)는 9개의 개별물리적동통정도의 합으로 최저 0점에서 최고 36점에 분포하도록 하였다. 동통유병률에 관한 연관요인을 파악하기 위하여 다변량 로지스틱회귀분석을 실시하였고, 총물리적동통정도에 관한 연관요인을 파악하기 위하여, 다변량 선형회귀분석을 실시하였다. 두통, 치은동통, 과민성치아 둥에 관한 유병률은 각각 6.8%, 17.2% 및 26.0% 이었다. 여자는 남자에서 보다 두통유병률의 가능성이 2.3배(95% 신뢰구간=1.33,3.99) 높았고, 치은동통유병률의 가능성은 1.4배(95% 신뢰구간=1.01, 1.97) 높았다. 국부의치장착자는 의치비장착자보다 치은동통유병률의 가능성이 1.8배(95% 신뢰구간=1.20, 2.58) 높았으며, 의치장착은 총물리적동통정도를 1.58 증가시겼다(확률값=0.001). 총괄적으로, 두통유병률과 과민성치아유병률의 연관요인은 성이었고, 치은동통유병률의 연관요인은 성과 의치장착이었다.

사례보고 : 급성 신부전을 동반한 전격성 간염으로 발현하여 간이식을 시행한 A형간염 4예

오세훈 ( Se Hoon Oh ),이준혁 ( Joon Hyoek Lee ),황지원 ( Ji Won Hwang ),김혜영 ( Hye Young Kim ),이창훈 ( Chang Hoon Lee ),곽금연 ( Geum Youn Gwak ),최문석 ( Moon Seok Choi ),고광철 ( Kwang Chul Koh ),백승운 ( Seung Woon Paik ) 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.3

A형간염은 대부분의 경우 가벼운 임상경과를 거치게 되나 드물게 전격성 간염으로 발전하여 사망에 이르거나 간이식을 시행하게 된다. 저자들은 비교적 높은 연령의 환자에서 급성 신부전을 동반한 전격성 간염으로 발현되어 간이식까지 시행했던 A형간염 4예를 경험하였기에 보고하고자 한다. 본 증례들은 공통적으로 1) 30대 후반 이상의 상대적 고령에 발생, 2) 급성 신부전을 동반, 3) 간종대를 동반, 4) 조직 소견에서 아광범성 간괴사 소견의 특징을 보였다. Hepatitis A is generally known as a mild, self-limiting disease of the liver, but in rare instances it can progress to fulminant hepatitis, which may require liver transplantation for recovery. Such cases are known to be related to old age and underlying liver disease. We report four cases of hepatitis A in which patients presented with fulminant hepatitis and acute renal failure and underwent liver transplantation. The following common features were observed in our cases: (1) occurrence in relatively old age (≥39 years old), (2) association with acute renal failure, (3) presence of hepatomegaly, and (4) microscopic features of sub-massive hepatic necrosis. (Korean J Hepatol 2009;15:362-369)