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한국산 생약으로부터 해독물질의 개발(제5보) 배양 백서 신경아교세포에서 Caffeic acid와 카드뮴의 결합에 의한 해독효과
백승화,이홍,배현옥,김영옥,곽정숙,유현경,한두석,Baek, Seung-Hwa,Lee, Hong,Pae, Hyun-Ock,Kim, Young-Ok,Kwak, Jung-Suk,Yoo, Hyeon-Gyeong,Han, Du-Seok 한국독성학회 1995 Toxicological Research Vol.11 No.2
This study was carried out to develop the antitoxic compound about cytotoxicity of cadmium on cultured rat neuroglial cells. These cells divided into 3 groups; control group (medium only) or $MTT_{50}$ group (neuroglial cell, $61{\mu}M$ cadmium) and experimental group ($61{\mu}M$ caffeic acid). Neutral red (NR) and tetrazolium MTT of the colorimetric assay were performed to evaluate the cytotoxicity of cell organelles. The light microscopic study was carried out to morphological changes of cultured rat neuroglical cells. The results indicated that caffeic acid showed detoxification effect on cytotoxicity of cadmium in $61{\mu}M$ concentration. According to the spectroscopic study of 1:1 complex of cadmium and caffeic acid, it showed that this formation of complex eliminated cadmium from cultured rat neurogllal cells.
활성화된 설치류 RAW 264.7 대식세포에서 당귀 에탄올 추출물의 항염증 효과
장선일,김형진,황기명,배현옥,윤용갑,정헌택,김윤철,Jang Seon-Il,Kim Hyeong-Jin,Hwang Ki-Myeong,Pae Hyeon-Ok,Yun Yong-Gap,Chung Heon-Taek,Kim Yun-Cheol 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
The inhibitory effects of ethanol extract of Radex Angelica uchiyamana, on LPS- or IFN- plus LPS-induced production of NO, and $TNF-{\alpha}$, and expression of iNOS and COX-2 were investigated in the activated RAW 264.7 cells. This extract significantly inhibited the production of NO and $TNF-{\alpha}$, and suppressed the expression of iNOS and COX-2 in a dose-dependent manner. These results show that ethanol extract of Radex Angelica uchiyamana may explain some known biological activities including anti-inflammatory effect, and is of considerable benefit in the treatment for NO and pro-inflammatory cytokine overproduction related immunological diseases.