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J. Beaulieu,E. Millette,E. Trottier,L.-P. Pre´court,C. Dupont,P. Lemieux 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3
Previously, we reported that a malleable protein matrix (MPM), composed of whey fermented by a proprietary Lactobacillus kefiranofaciens strain, has immunomodulatory and anti-inflammatory properties. MPM consumption leads to a considerable reduction in the cytokine and chemokine production (tumor necrosis factor-α, interleukin-1β, and interleukin-6), thus lowering chronic inflammation or metaflammation. Inhibition of metaflammation should provide positive impact, particularly in the context of dyslipidemia, insulin resistance, and hypertension. In this study, we investigated whether short-term MPM supplementation ameliorates those features of metabolic syndrome (MetS). The ability of MPM to potentially regulate triglyceride level, cholesterol level, blood glucose level, and hypertension was evaluated in different animal models. MPM lowers triglyceride level by 37% (P<.05) in a poloxamer 407 dyslipidemia-induced rat model. It also reduces total cholesterol by 18% (P<.05) and low-density lipoprotein-cholesterol level by 32% (P<.05) and raises high-density lipoprotein-cholesterol level by 17% (P<.01) in Syrian Golden hamsters fed a high fat/high cholesterol diet for 2 weeks. MPM reestablishes the fasting glucose insulin ratio index to normal levels (P=.07) in this latter model and lowers the plasma glucose level area under the curve (−10%, P=.09) in fructose-fed rats after 2 weeks of treatment. In spontaneously hypertensive rats, MPM-treated animals showed a reduction of SBP by at least 13% (P<.05) for 4 weeks. Results from this study suggest that MPM is a functional ingredient with beneficial effects on lipid metabolism, blood glucose control, and hypertension that might contribute to the management of MetS and thus reducing the risk of cardiovascular diseases.
U. Fischer,P. Batistoni,E. Dupont,R. A. Forrest,H. Hendrikson,J. Izquierdo,J. -C. Sublet 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
An overview is presented of the European Fusion File (EFF) and the European Activation File (EAF) efforts which aim at developing qualified nuclear data bases and validated computational tools for nuclear calculations of fusion systems tailored to the specific needs of the European fusion programme. The related tasks are conducted in the frame of the Fusion for Energy (F4E) work programme and are devoted to the evaluation, processing, testing and benchmarking of required nuclear cross section and uncertainty data, the development of computational tools for sensitivity/uncertainty calculations, and to conduct integral benchmark experiments exploiting also new measurement techniques. The data evaluations are integrated into the Joint Evaluated Fission and Fusion File (JEFF) after having passed a series of qualification tests including their validation through computational analyses of integral benchmark experiments.
Status of the JEFF Nuclear Data Library
A. J. Koning,E. Bauge,C. J. Dean,E. Dupont,U. Fischer,R. A. Forrest,R. Jacqmin,H. Leeb,M. A. Kellett,R. W. Mills,C. Nordborg,M. Pescarini,Y. Rugama,P. Rullhusen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The status of the Joint Evaluated Fission and Fusion file (JEFF) is described. Recently, the JEFF-3.1.1 nuclear data library was released and shortly after adopted by the French nuclear power industry for inclusion in their production and analysis codes. Recent updates include actinide evaluations, materials evaluations that have emerged from various European nuclear data projects, the activation library, the decay data and fission yield sub-libraries, and fusion-related data files from the European F4E project. The revisions were motivated by the availability of new measurements, modelling capabilities and trends from integral experiments. Validations have been performed, mainly for criticality, reactivity temperature coefficients, fuel inventory, decay heat and shielding of thermal and fast systems. The next release of the library, JEFF-3.2, will be discussed. This will contain among others a significant increase of covariance data evaluations, modern evaluations for various structural materials, a larger emphasis on minor actinides and addition of high-quality gamma production data for many fission products.