A New Approach to Objective Evaluation of the Success of Nasal Septum Perforation

Ozturk, Sinan,Zor, Fatih,Ozturk, Serdar,Kartal, Ozgur,Alhan, Dogan,Isik, Selcuk Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.4

Background Perforations in the nasal septum (NSP) give rise not only to disintegration of the septum anatomy but also impairment in normal nasal physiology. The successes of these surgical techniques are usually equated to anatomical closure of the perforation. The goal of this study is to evaluate the subjective and objective results of our surgical technique for septal perforation surgery. Methods All NSPs in the six patients were closed by inferior turbinate flap. The Nasal Obstruction Symptom Evaluation (NOSE) instrument was used to evaluate the preoperative and postoperative subjective sensation of nasal obstruction. Measurement of preoperative and postoperative nasal airway resistance was performed using active anterior rhinomanometry which is an objective test. Wilcoxson signed rank test and Spearman correlation test were used to analyze correlation between NOSE scores and rhinomanometric measurements. Results The full closure of the septal perforations was noted in 100% of patients. The total NOSE score was 14 preoperatively and one postoperatively. The improvement in NOSE scores was statistically significant ($P{\leq}0.002$). The mean preoperative total resistance (ResT150) value was $0.13Pa/cm^3s^{-1}$, which is below the normal range ($0.16-0.31Pa/cm^3s^{-1}$), while the mean postoperative ResT150 value was $0.27Pa/cm^3s^{-1}$. The correlation between the improvement in NOSE scores and improvements in ResT150 values was statistically significant. Conclusions Surgical approaches should aim to solve both the anatomical and physiological problems of NSP. The application of subjective and objective tests in the postoperative period will help surgeons assess the applied techniques.

A New Approach to Objective Evaluation of the Success of Nasal Septum Perforation

Sinan Ozturk,Fatih Zor,Serdar Ozturk,Ozgur Kartal,Dogan Alhan,Selcuk Isik 대한성형외과학회 2014 Archives of Plastic Surgery Vol.41 No.4

Background: Perforations in the nasal septum (NSP) give rise not only to disintegration ofthe septum anatomy but also impairment in normal nasal physiology. The successes of thesesurgical techniques are usually equated to anatomical closure of the perforation. The goal ofthis study is to evaluate the subjective and objective results of our surgical technique forseptal perforation surgery. Methods: All NSPs in the six patients were closed by inferior turbinate flap. The NasalObstruction Symptom Evaluation (NOSE) instrument was used to evaluate the preoperativeand postoperative subjective sensation of nasal obstruction. Measurement of preoperative andpostoperative nasal airway resistance was performed using active anterior rhinomanometrywhich is an objective test. Wilcoxson signed rank test and Spearman correlation test were usedto analyze correlation between NOSE scores and rhinomanometric measurements. Results: The full closure of the septal perforations was noted in 100% of patients. The totalNOSE score was 14 preoperatively and one postoperatively. The improvement in NOSE scoreswas statistically significant (P≤0.002). The mean preoperative total resistance (ResT150) valuewas 0.13 Pa/cm3s-1, which is below the normal range (0.16–0.31 Pa/cm3s-1), while the meanpostoperative ResT150 value was 0.27 Pa/cm3s-1. The correlation between the improvement inNOSE scores and improvements in ResT150 values was statistically significant . Conclusions: Surgical approaches should aim to solve both the anatomical and physiologicalproblems of NSP. The application of subjective and objective tests in the postoperative periodwill help surgeons assess the applied techniques.

Effects of Ensiling Alfalfa with Whole-crop Maize on the Chemical Composition and Nutritive Value of Silage Mixtures

Ozturk, Durmus,Kizilsimsek, Mustafa,Kamalak, Adem,Canbolat, Onder,Ozkan, Cagri Ozgur Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.4

The aim of this study was to evaluate the chemical composition, in vitro DM degradability, ME and OMD of alfalfa-maize silage mixtures in comparison to pure maize and alfalfa silages, and to test the existence of associative effects of ensiling alfalfa forage with whole-crop maize using the in vitro gas production technique. Ensiling alfalfa with whole-crop maize had a significant (p<0.001) effect on chemical composition, pH, in vitro DM degradability, OMD and estimated ME values of mixtures. DM content of the resultant silages significantly increased with increasing proportion of whole-crop maize in the mixtures, whereas the pH value, crude protein (CP), acid detergent fibre (ADF) and ash contents of mixtures decreased due to the dilution effect of whole-crop maize which was low in CP, ADF and ash. The pH values of all alfalfa-maize silage mixtures were at the desired level for quality silage. Gas production of alfalfa-maize silage mixtures at all incubation times except 12 h increased with increasing proportion of whole-crop maize. When alfalfa was mixed with whole-crop maize in the ratio 40:60, ME and OMD values were significantly (p<0.001) higher than other silages. Maximum gas production ($A_{gas}$) ranged from 65.7 to 78.1 with alfalfa silage showing the lowest maximum gas production. The results obtained in this study clearly showed that maximum gas production increased with increased percentage of whole-crop maize in the silage mixtures (r = 0.940, p<0.001). It was concluded that ensiling alfalfa with whole-crop maize improved the pH, OMD and ME values. However, trials with animals are required to see how these differences in silage mixtures affect animal performance.

Knowledge Level of Working and Student Nurses on Cervical Cancer and Human Papilloma Virus Vaccines

Topan, Aysel,Ozturk, Ozlem,Eroglu, Hulya,Bahadir, Ozgur,Harma, Muge,Harma, Mehmet Ibrahim Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Purpose: To determine knowledge levels of working and student nurses about cervical cancer and prophylactic cancer vaccines. Materials and Methods: This study was performed on 259 nursing students in the Department of Nursing and 137 nurses working in Health Research and Practice Center, approved to participate in the study between April-June 2012. The study was performed universally without selecting a sample. A questionnaire that was prepared for evaluating participants' knowledge and attitudes about human papilloma virus (HPV) vaccine was distributed to the nurses and data obtained from the forms were transferred to SPSS 15.00 program and statistically analyzed. Results: It was found that 54.8% of the student nurses were between 21-24 years old and 13.1% of working students were between 25-28 years old. When student nurses and working nurses were compared in terms of their knowledge about the causes of cervical cancer, their ideas about prevention from cervical cancer with HPV vaccine, their ideas about possible risks of HPV vaccine and conservation ratios of HPV vaccine, it was observed that there were no statistically significant differences (p>0.05). When student nurses and working nurses were compared in terms of the information-source about HPV, ways of HPV contamination, awareness about people who are susceptible to HPV contamination and age of HPV vaccination, it was determined that there was a statistically significant difference (p<0.05). Conclusions: It was found that all nurses had some knowledge about cervical cancer and HPV vaccine, but this was not sufficient. Therefore; it is recommended to use verbal, written and visual communication tools intensively in order to have topics on cervical cancer, early diagnosis and prevention in bachelor and master programs for nurses, to inform society about cervical cancer and HPV vaccine for public health and to teach precautions for its prevention.

The effect of alumina and aluminium nitride coating by reactive magnetron sputtering on the resin bond strength to zirconia core

sengul Danisman,Soner Savas,Ozgur Ozturk,Seniha Baba,safak Kulunk,Tolga Kulunk 대한치과보철학회 2013 The Journal of Advanced Prosthodontics Vol.5 No.4

PURPOSE Although several surface treatments have been recently investigated both under in vitro and in vivo conditions, controversy still exists regarding the selection of the most appropriate zirconia surface pre-treatment. The purpose of this study was to evaluate the effect of alumina (Al) and aluminium nitride (AlN) coating on the shear bond strength of adhesive resin cement to zirconia core. MATERIALS AND METHODS Fifty zirconia core discs were divided into 5 groups; air particle abrasion with 50 µm aluminum oxide particles (Al2O3), polishing + Al coating, polishing + AlN coating, air particle abrasion with 50 µm Al2O3 + Al coating and air particle abrasion with 50 µm Al2O3 + AlN coating. Composite resin discs were cemented to each of specimens. Shear bond strength (MPa) was measured using a universal testing machine. The effects of the surface preparations on each specimen were examined with scanning electron microscope (SEM). Data were statistically analyzed by one-way ANOVA (α=.05). RESULTS The highest bond strengths were obtained by air abrasion with 50 µm Al2O3, the lowest bond strengths were obtained in polishing + Al coating group (P<.05). CONCLUSION Al and AlN coatings using the reactive magnetron sputtering technique were found to be ineffective to increase the bond strength of adhesive resin cement to zirconia core.

HPV-Associated p16^INK4A Expression and Response to Therapy and Survival in Selected Head and Neck Cancers

Kanyilmaz, Gul,Ekinci, Ozgur,Muge, Akmansu,Celik, Sevinc,Ozturk, Furkan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

Background: Development of squamous cell cancer of head and neck (SCCHN) is associated with human papillomavirus (HPV) infection, which in turn is closely related with expression of $p16^{INK4A}$. Loss of $p16^{INK4A}$ expression by deletion, mutation, or hypermethylation is common in SCCHN. We here evaluated $p16^{INK4A}$ as a prognostic marker of treatment response and survival in our SCCHN patients with laryngeal, hypopharyngeal or nasopharyngeal cancers. Materials and Methods: 131 patients diagnosed with SCCHN between January 2,2006 and July 17, 2010 were examined for $p16^{INK4A}$. The median age was 60 years (15-82 years). Fifty one patients were stage I-II and 80 were stage III-IV. Immunohistochemical expression of $p16^{INK4A}$ was analyzed in pretreatment paraffin-embedded tumor blocks. The influence of $p16^{INK4A}$ status on disease-free survival, and overall survival after treatment was evaluated. Results: $p16^{INK4A}$ positivity was found in 58 patients (44%). Tumor-positivity for$ p16^{INK4A}$ was correlated with improved disease free survival (70.1 months vs 59 months) and improved overall survival (2, 3 and 5-year values; 77% vs 72%, 70% vs 63% and, 63% vs 55%; respectively). On multivariate analysis, stage was determined as independent prognostic factor for disease-free survival. Conclusions: Stage was the major prognostic factor on treatment response and survival in our patients. $p16^{INK4A}$ status predicts better outcome in laryngeal, hypopharyngeal or nasopharyngeal cancer cases treated with surgery plus adjuvant radiochemotherapy as well as with definitive radiation therapy and/or chemotherapy.

The effect of alumina and aluminium nitride coating by reactive magnetron sputtering on the resin bond strength to zirconia core

Kulunk, Tolga,Kulunk, Safak,Baba, Seniha,Ozturk, Ozgur,Danisman, Sengul,Savas, Soner The Korean Academy of Prosthodonitics 2013 The Journal of Advanced Prosthodontics Vol.5 No.4

PURPOSE. Although several surface treatments have been recently investigated both under in vitro and in vivo conditions, controversy still exists regarding the selection of the most appropriate zirconia surface pre-treatment. The purpose of this study was to evaluate the effect of alumina (Al) and aluminium nitride (AlN) coating on the shear bond strength of adhesive resin cement to zirconia core. MATERIALS AND METHODS. Fifty zirconia core discs were divided into 5 groups; air particle abrasion with 50 ${\mu}m$ aluminum oxide particles ($Al_2O_3$), polishing + Al coating, polishing + AlN coating, air particle abrasion with 50 ${\mu}m$ $Al_2O_3$ + Al coating and air particle abrasion with 50 ${\mu}m$ $Al_2O_3$ + AlN coating. Composite resin discs were cemented to each of specimens. Shear bond strength (MPa) was measured using a universal testing machine. The effects of the surface preparations on each specimen were examined with scanning electron microscope (SEM). Data were statistically analyzed by one-way ANOVA (${\alpha}$=.05). RESULTS. The highest bond strengths were obtained by air abrasion with 50 ${\mu}m$ $Al_2O_3$, the lowest bond strengths were obtained in polishing + Al coating group (P<.05). CONCLUSION. Al and AlN coatings using the reactive magnetron sputtering technique were found to be ineffective to increase the bond strength of adhesive resin cement to zirconia core.

Can continuous positive airway pressure improve lower urinary tract symptoms and erectile dysfunction in male patients with severe obstructive sleep apnea syndrome?

Soner Coban,Aygul Gunes,Abdullah Gul,Ali Riza Turkoglu,Muhammet Guzelsoy,Murat Ozturk,Osman Akyuz,Ozgur Ekici 대한비뇨의학회 2020 Investigative and Clinical Urology Vol.61 No.6

Purpose: We aimed to investigate the effect of continuous positive airway pressure (CPAP) administered for the treatment of obstructive upper airway on lower urinary tract symptoms and erectile dysfunction in male patients. Materials and Methods: A total of 626 male with suspected obstructive sleep apnea syndrome (OSAS) were evaluated prospectively. Nocturnal polysomnography tests were administered to the male. After application of the exclusion criteria, 54 patients with severe OSAS (Apnea-Hypopnea Index ≥30) were included in the study. International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF-15), and nocturia were assessed in all patients before and after CPAP therapy, and prostate volume, total prostate-specific antigen (tPSA), and uroflowmetric measurements were assessed in patients aged >40 years. Results: The mean age of the 54 patients was 47.06±11.15 years. Post-treatment IIEF scores were better than pre-treatment scores (24.27±7.58 vs. 22.68±8.65, p=0.014). IPSS values, nocturia, and uroflowmetric outcomes significantly improved after CPAP therapy (p<0.05). On the other hand, mean values of body mass index, tPSA, prostate volume, and postvoid residual urine volume did not differ significantly after treatment. Conclusions: CPAP therapy improves lower urinary tract symptoms, nocturia, and erectile dysfunction in male with severe OSAS.