A New Approach to Objective Evaluation of the Success of Nasal Septum Perforation

Ozturk, Sinan,Zor, Fatih,Ozturk, Serdar,Kartal, Ozgur,Alhan, Dogan,Isik, Selcuk Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.4

Background Perforations in the nasal septum (NSP) give rise not only to disintegration of the septum anatomy but also impairment in normal nasal physiology. The successes of these surgical techniques are usually equated to anatomical closure of the perforation. The goal of this study is to evaluate the subjective and objective results of our surgical technique for septal perforation surgery. Methods All NSPs in the six patients were closed by inferior turbinate flap. The Nasal Obstruction Symptom Evaluation (NOSE) instrument was used to evaluate the preoperative and postoperative subjective sensation of nasal obstruction. Measurement of preoperative and postoperative nasal airway resistance was performed using active anterior rhinomanometry which is an objective test. Wilcoxson signed rank test and Spearman correlation test were used to analyze correlation between NOSE scores and rhinomanometric measurements. Results The full closure of the septal perforations was noted in 100% of patients. The total NOSE score was 14 preoperatively and one postoperatively. The improvement in NOSE scores was statistically significant ($P{\leq}0.002$). The mean preoperative total resistance (ResT150) value was $0.13Pa/cm^3s^{-1}$, which is below the normal range ($0.16-0.31Pa/cm^3s^{-1}$), while the mean postoperative ResT150 value was $0.27Pa/cm^3s^{-1}$. The correlation between the improvement in NOSE scores and improvements in ResT150 values was statistically significant. Conclusions Surgical approaches should aim to solve both the anatomical and physiological problems of NSP. The application of subjective and objective tests in the postoperative period will help surgeons assess the applied techniques.

A New Approach to Objective Evaluation of the Success of Nasal Septum Perforation

Sinan Ozturk,Fatih Zor,Serdar Ozturk,Ozgur Kartal,Dogan Alhan,Selcuk Isik 대한성형외과학회 2014 Archives of Plastic Surgery Vol.41 No.4

Background: Perforations in the nasal septum (NSP) give rise not only to disintegration ofthe septum anatomy but also impairment in normal nasal physiology. The successes of thesesurgical techniques are usually equated to anatomical closure of the perforation. The goal ofthis study is to evaluate the subjective and objective results of our surgical technique forseptal perforation surgery. Methods: All NSPs in the six patients were closed by inferior turbinate flap. The NasalObstruction Symptom Evaluation (NOSE) instrument was used to evaluate the preoperativeand postoperative subjective sensation of nasal obstruction. Measurement of preoperative andpostoperative nasal airway resistance was performed using active anterior rhinomanometrywhich is an objective test. Wilcoxson signed rank test and Spearman correlation test were usedto analyze correlation between NOSE scores and rhinomanometric measurements. Results: The full closure of the septal perforations was noted in 100% of patients. The totalNOSE score was 14 preoperatively and one postoperatively. The improvement in NOSE scoreswas statistically significant (P≤0.002). The mean preoperative total resistance (ResT150) valuewas 0.13 Pa/cm3s-1, which is below the normal range (0.16–0.31 Pa/cm3s-1), while the meanpostoperative ResT150 value was 0.27 Pa/cm3s-1. The correlation between the improvement inNOSE scores and improvements in ResT150 values was statistically significant . Conclusions: Surgical approaches should aim to solve both the anatomical and physiologicalproblems of NSP. The application of subjective and objective tests in the postoperative periodwill help surgeons assess the applied techniques.

Comparison of the Practical and Theoretical Knowledge of the Hepatitis B Virus among Dental Hygiene Students

( Sinan Yasin Ertem ),( Sertac Ozdogan ),( Ayla Ozturk ),( Ozge Akcam ) 한국치위생과학회 2020 치위생과학회지 Vol.20 No.3

Background: Hepatitis B is an important public health problem as one of the leading causes of morbidity and mortality. The aim of this study was to compare the theoretical and practical knowledge levels of dental assistant students about Hepatitis B Virus. Methods: The 1st and 2nd grade students of the Oral and Dental Health program were invited to participate in the survey. Out of the 68 invited students, 61 completed the questionnaire. The average ages of the male and female students surveyed were 20.27±1.45 and 19.56±1.16, respectively. A total of 34 questions were asked, of which 15 measured basic theoretical knowledge and 19 assessed basic practical knowledge. Results: There was no statistically significant difference between the students’ knowledge for each question according to their sex and grade. When the questionnaire was grouped into basic theoretical and basic practical knowledge levels, both were observed to be high. While the lowest correct answer rate was 35.00% for the questions about practical applications, it was 31.14% for the questions measuring the level of theoretical knowledge. There was no statistically significant difference when the levels of knowledge of 1st and 2nd grade students were compared. Students answered the majority of the questions correctly, and ranged between 71% and 100%. Conclusion: Students’ high level of basic theoretical knowledge can be a result of their in-class education on the fundamentals. However, their knowledge about the correct approaches in practical applications indicates the beneficial role of having well-defined criteria and prevention protocols that are required in hospitals and the effectiveness of their environmental orientations.

Comparison of the Effects of Magnetically Controlled Growing Rod and Tradiotinal Growing Rod Techniques on the Sagittal Plane in the Treatment of Early-Onset Scoliosis

Erdogan, Sinan,Polat, Baris,Atici, Yunus,Ozyalvac, Osman Nuri,Ozturk, Cagatay The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.5

Objective : Comparing the effects of magnetically controlled growing rod (MCGR) and traditional growing rod (TGR) techniques on the sagittal plane in the treatment of early-onset scoliosis (EOS). Methods : Twelve patients were operated using dual MCGR technique in one center, while 15 patients were operated using dual TGR technique for EOS in another center. Patients' demographic characteristics, complications and radiological measurements such as cobb angle, thoracic kyphosis, lumbar lordosis, T1-S1 range (mm), proximal junctional angle, distal junctional angle, sagittal balance, coronal balance, pelvic incidence, sacral slope and pelvic tilt were assessed and compared in preoperative, postoperative and last follow-up period. Results : Age and sex distributions were similar in both groups. The mean number of lengthening in the MCGR group was 12 (8-15) and 4.8 (3-7) in the TGR group. Two techniques were shown to be effective in controlling the curvature and in the increase of T1-S1 distance. In TGR group, four patients had rod fractures, six patients had screw pull-out and four patients had an infection, whereas three patients had screw pull-out and one patient had infection complications in the MCGR group. Conclusion : There was no significant difference between the two groups in terms of cobb angle, coronal and sagittal balance and sagittal pelvic parameters. MCGR can cause hypokyphosis and proximal junctional kyphosis in a minimum 2-year follow-up period. The implant-related complications were less in the MCGR group. However, larger case groups and longer follow-up periods are required for the better understanding of the superiority of one method on other in terms of complications.

Cholesterol removal onto the different hydrophobic nanospheres: A comparison study

Tulden Kalburcu,Nevra Ozturk,Nalan Tuzmen,Adil Denizli,Sinan Akgo¨ l 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.1

The aim of this study is to prepare two different hydrophobic polymeric nanospheres for cholesterolremoval. Poly(HEMA–MAT) nanospheres with an average size of 100 nm and poly(HEMA–MAP)nanospheres with an average size of 158 nm were produced by surfactant free emulsion polymerizationof HEMA and MAT and MAP monomers. These hydrophobic nanospheres were characterized by FTIR,SEM, elemental analysis, particle size and surface area measurements. Cholesterol removal experimentswere performed in a batch experimental set-up and removal medium was methanol. Cholesteroladsorption capacity of poly(HEMA–MAP) nanospheres was approximately three times higher than thatof poly(HEMA–MAT) nanospheres.

Dynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with urolithiasis

Mehmet Giray Sonmez,Betul Kozanhan,Çigdem Damla Deniz,Mehmet Sinan Iyisoy,Muzaffer Tansel Kilinc,Gokhan Ecer,Ahmet Ozturk,Salim Neselioglu,Ozcan Erel 대한비뇨의학회 2019 Investigative and Clinical Urology Vol.60 No.4

Purpose: A dynamic thiol/disulfide balance is pivotal in organizing anti-oxidant defense, detoxification, apoptosis, and enzyme activities, as well as transcription and cellular signal-transfer mechanisms. The connection between urolithiasis and oxidant/antioxidant status, which can be assessed through thiol-disulfide homeostasis (TDH), has not yet been examined. In this study, we evaluated the effects of TDH on the formation, size, and location of stones by examining the associations between TDH parameters and urolithiasis. Materials and Methods: Patients with urolithiasis and healthy controls were recruited. The patients were divided into subgroups in terms of stone size (>15 mm or ≤15 mm) and stone location (nephrolithiasis or ureterolithiasis). TDH parameters were measured using a novel automatic and spectrophotometric method and compared statistically. Results: TDH parameters were different between the urolithiasis and control groups. TDH tended towards the disulfide side in the urolithiasis group. Stone size increased an average 0.14 mm with a 1 µmol/L increase in disulfide level and decreased an average 0.058 mm with a 1 µmol/L increase in native thiol level. Disulfide and native thiol levels were found to be different across patients with stone size >15 mm, ≤15 mm, and controls (p<0.001 and p<0.001, respectively). However, the nephrolithiasis and ureterolithiasis groups were similar in respect of TDH parameters. Conclusions: In this study, it was found that patients with urolithiasis displayed oxidative stress characterized by a TDH tendency towards the disulfide side, and an inadequate antioxidant response identified by a lower level of native thiol as compared with healthy controls.