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Domenico De Berardis,Luigi Olivieri,Gabriella Rapini,Serena Di Natale,Nicola Serroni,Michele Fornaro,Laura Orsolini,Alessandro Valchera,Alessandro Carano,Federica Vellante,Paola Annunziata Varasano,Ga 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.2
Objective: This study was performed to elucidate relationships between alexithymia, suicide ideation and homocysteine levels in drug-naïve outpatients with major depressive disorder (MDD). Methods: Sixty seven outpatients with MDD with melancholic features were evaluated by the means of the Hamilton Depression Rating Scale, the Toronto Alexithymia Scale (TAS–20), the Scale of Suicide Ideation, and homocysteine levels. Results: Alexithymic subjects showed higher scores on all scales and higher homocysteine levels. Regression analysis shown higher homocysteine levels and TAS-20’ “Difficulty in Describing Feelings” dimension, in turn being associated with higher suicide ideation. Conclusion: In conclusion, alexithymic MDD outpatients may characterize for homocysteine dysregulation that may be linked to suicide ideation, regardless depression’ severity. However, study limitations are discussed and must be considered.
Cariprazine Add-on in Inadequate Clozapine Response: A Report on Two Cases
Domenico De Berardis,Gabriella Rapini,Luigi Olivieri,Agostina Giardini,Ida De Lauretis,Nicola Serroni,Laura Orsolini,Michele Fornaro,Felice Iasevoli,Sabatino Trotta,Paolo Cottura,Federica Vellante,Mar 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.1
Cariprazine is a novel antipsychotic drug that exerts partial agonism of dopamine D2/D3 receptors with preferential binding to the D3 receptor, antagonism of 5HT2B receptors, and partial agonism of 5HT1A. Currently, cariprazine has shown clinical efficacy in patients with schizophrenia and with bipolar disorder, as well as adjunctive treatment in patients with Major Depressive Disorder (MDD) and drug-resistant MDD. In the present case series, we report on two patients with treatment-resistant schizophrenia and partial response to clozapine who benefit from combination with cariprazine. The effects of cariprazine combination were remarkable also concerning the adverse metabolic effects of clozapine.
Piersanti, Stefano,de Paulis, Francesco,Olivieri, Carlo,Jung, Daniel H.,Kim, Joungho,Orlandi, Antonio [Institute of Electrical and Electronics Engineers 2017 IEEE transactions on electromagnetic compatibility Vol.59 No.5
<P>Small form factors and high bandwidth are two imperatives nowadays for three-dimensional integrated circuits (3-D-ICs). These requirements can be achieved by the use of through silicon vias, by the reduction of their radius and, at the same time, of the pitch among them. Having a considerable number of devices in a limited space inevitably increases the probability of the creation of defects (short, open, void, etc.). The study of the nature, topology, and creation mechanism of defects is crucial for 3-D-IC design. This paper suggests a procedure able to determine the nature of a defect (open-or short-circuit) and to estimate its position, basing its approach on the study of the electrical parameters of the defected structure, avoiding the use of invasive method such as Lock-in Thermography. A daisy-chain structure is manufactured and open or short defects are intentionally placed along the channel. With and without defects, the equivalent capacitance and inductance are extracted from the S-Parameters, from measurement and three-dimensional electromagnetic simulations, and used to define and validate the proposed procedure.</P>
Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients
Ilenia Cirilli,Sonia Silvestri,Fabio Marcheggiani,Fabiola Olivieri,Roberta Galeazzi,Roberto Antonicelli,Rina Recchioni,Fiorella Marcheselli,Tiziana Bacchetti,Luca Tiano,Patrick Orlando 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.6
Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.
The In Vitro Activity of Angelica archangelica L. Essential Oil on Inflammation
Daniele Fraternale,Laura Teodori,Alexander Rudov,Francesco Prattichizzo,Fabiola Olivieri,Andrea Guidarelli,Maria Cristina Albertini 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.12
The use of herbs with medicinal value and biomedical effects has increased tremendously in the last years. However, inadequate basic knowledge of their mode of action is the main issue related to phytotherapy, although they have shown promising potential. To provide insights into these important issues, we tested here on appropriate in vitro models the efficacy of Angelica archangelica essential oil (Aa-EO) for anti-inflammatory properties. The results demonstrated that Aa-EO induced significant apoptosis and necrosis at high doses in U937 cells. We used nontoxic concentrations to treat for anti-inflammatory capacity. The results also demonstrated a decreased proinflammatory cytokine interleukin-6 level in human umbilical vein endothelial cells, as senescence in vitro model, when cells are challenged with lipopolysaccharide (LPS), one of the most powerful proinflammatory inducer in the presence of Aa-EO. In addition, down expression of miR-126 and miR-146a (inflammamirs) produced by LPS stimulation was reverted by Aa-EO simultaneous treatment. These results provide noteworthy basis for the development/formulation of new drugs for future clinical uses and new food products or dietary supplements for contrasting inflammation.
Domenico De Berardis,Michele Fornaro,Laura Orsolini,Luigi Olivieri,Francesco Nappi,Gabriella Rapini,Federica Vellante,Cosimo Napoletano,Nicola Serroni,Massimo Di Giannantonio 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.4
Clozapine may be associated with cardiovascular adverse effects including QTc prolongation and, more rarely, with myocarditis and pericarditis. Although rare, these latter cardiovascular adverse effects may be life-threatening and must be immediately recognized and treated. Several cases of clozapine related-pericarditis have been described and often it has a subtle and insidious onset with symptoms that may be often misdiagnosed with psychiatric manifestations (e.g. anxiety, panic or somatization) leading to a delayed correct diagnosis with potential fatal consequences. In the present report we describe the case of a 27-year-old girl with schizoaffective disorder taking long acting aripiprazole and valproate who developed a sudden onset clozapine-related pericarditis during titration phase that resolved with immediate clozapine discontinuation and indomethacin administration. We underline the importance of an early diagnosis of clozapine- related pericarditis and the need to have monitoring protocols to prevent this potentially fatal adverse effect especially when polypharmacy is administered to patients taking clozapine.
In vitro and in vivo experimental models for drug screening and development for Chagas disease.
Romanha, Alvaro José,Castro, Solange Lisboa de,Soeiro, Maria de Nazaré,Correia,Lannes-Vieira, Joseli,Ribeiro, Isabela,Talvani, André,Bourdin, Bernadette,Blum, Bethania,Olivieri, Bian O Instituto 2010 Memórias do Instituto Oswaldo Cruz Vol.105 No.2
<P>Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Although the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control vector transmission, there still remain serious challenges, including the maintenance of sustainable public policies for Chagas disease control and the urgent need for better drugs to treat chagasic patients. Since the introduction of benznidazole and nifurtimox approximately 40 years ago, many natural and synthetic compounds have been assayed against Trypanosoma cruzi, yet only a few compounds have advanced to clinical trials. This reflects, at least in part, the lack of consensus regarding appropriate in vitro and in vivo screening protocols as well as the lack of biomarkers for treating parasitaemia. The development of more effective drugs requires (i) the identification and validation of parasite targets, (ii) compounds to be screened against the targets or the whole parasite and (iii) a panel of minimum standardised procedures to advance leading compounds to clinical trials. This third aim was the topic of the workshop entitled Experimental Models in Drug Screening and Development for Chagas Disease, held in Rio de Janeiro, Brazil, on the 25th and 26th of November 2008 by the Fiocruz Program for Research and Technological Development on Chagas Disease and Drugs for Neglected Diseases Initiative. During the meeting, the minimum steps, requirements and decision gates for the determination of the efficacy of novel drugs for T. cruzi control were evaluated by interdisciplinary experts and an in vitro and in vivo flowchart was designed to serve as a general and standardised protocol for screening potential drugs for the treatment of Chagas disease.</P>