Application of Bonelike® as synthetic bone graft in orthopaedic and oral surgery in veterinary clinical cases.

José Miguel Campos,Ana Catarina Sousa,Pedro Olivério Pinto,Jorge Ribeiro,Miguel Lacueva França,Ana Rita Caseiro,Mariana Vieira Branquinho,Sílvia Santos Pedrosa,Carla Mendonça,Ana Brandão,José Domingos 한국생체재료학회 2019 생체재료학회지 Vol.23 No.1

Autologous bone remains the gold standard grafting substrate for bone fusions used for small gaps and critical defects. However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed. In the present case series, a glass-reinforced hydroxyapatite synthetic bone substitute, with osteoinductive and osteoconductive proprieties, was applied. This synthetic bone substitute comprises the incorporation of P2O5-CaO glass-based system within a hydroxyapatite matrix, moulded into spherical pellets with 250-500 μm of diameter. A total of 14 veterinary clinical cases of appendicular bone defects and maxillary / mandibular bone defects are described. In all clinical cases, the synthetic bone substitute was used to fill bone defects, enhancing bone regeneration and complementing the recommended surgical techniques. Results demonstrated that it is an appropriate synthetic bone graft available to be used in veterinary patients. It functioned as a space filler in association with standard orthopaedic and odontological procedures of stabilization, promoting a faster bone fusion without any local or systemic adverse reactions. This procedure improves the animals’ quality of life, decreasing pain and post-operative recovery period, as well as increasing bone stability improving positive clinical outcomes.

Treatment of Odontoid Type II Fractures in Octogenarians: Balancing Two Different Treatment Strategies

Oliver Gembruch,Elias Lemonas,Yahya Ahmadipour,Ulrich Sure,Nicolai El Hindy,Richard Dodel,Oliver Müller 대한척추신경외과학회 2019 Neurospine Vol.16 No.2

Objective: Demographic changes have led to a higher incidence of C-2 fractures, especially in elderly patients. For patients with type II fractures, treatment remains controversial, as discussed by Anderson and D’Alonzo, due to the rising morbidity and mortality rates for any treatment. The aim of this study was to compare conservative and surgical management in patients with type II C-2 fractures regarding outcomes, complications, and the mortality rate. Methods: A retrospective analysis was performed of the medical records, X-rays, and/or computed tomography scans of patients ≥80 years of age with type II fractures who were admitted to our Department of Neurosurgery between January 1990 and December 2017. The success of treatment was evaluated 3 months after surgery. Results: In total, 125 patients were included, of whom 98 were treated surgically and 27 were treated conservatively. Surgical treatment was successful in 90.8% of cases, while conservative treatment was successful in 70.0%. The in-hospital mortality was 14.29% and the 3-month mortality was 27.8% in the surgical group, compared to 3.7% and 20% in the conservatively treated group. The in-hospital complication rate was 22.4% in the surgically treated patients and 7.4% in the conservatively treated patients. Conclusion: Surgical treatment of type II fractures seemed to be associated with higher success and complication rates than conservative treatment. Nevertheless, 3-month mortality was comparable in both groups. Therefore, we conclude that surgical treatment for type II fractures in elderly patients is superior to conservative management, although conservative treatment remains a valuable option in elderly patients with severe comorbidities.

Adaptive Local Model Networks with Higher Degree Polynomials

Oliver Banfer,Marlon Franke,Oliver Nelles 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10

A new adaptation method for local model networks with higher degree polynomials which are trained by the polynomial model tree (POLYMOT) algorithm is presented in this paper. Usually the local models are linearly parameterized and those parameters are typically adapted by a recursive least squares approach. For the utilization of higher degree polynomials a subset selection method, which is a part of the POLYMOT algorithm, selects and estimates the most significant parameters from a huge parameter matrix. This matrix contains one parameter wi,nx for each input u<SUP>l</SUP>p up to the maximal polynomial degree and for all the combinations of the inputs. It is created during the training procedure of the local model network. For the online adaptation of the trained local model network only the selected parameters should be used. Otherwise the local model network would be too flexible and the idea of subset selection would be lost. Therefore the presented adaptation method generates at first a new parameter matrix with the selected and most significant parameters which are unequal to zero. Afterwards the local model parameters can be adapted with the aid of a standard recursive least squares method.

Looping Seoul (video still)

Oliver GRIEM 한국색채학회 2016 International Invitation Exhibition of Color Works Vol.2016 No.-

Why institutions matter

Oliver E. Williamson 한국제도경제학회 2018 제도와 경제 Vol.12 No.1

Metabolomics Insights Into Pathophysiological Mechanisms of Interstitial Cystitis

Oliver Fiehn,김자영 대한배뇨장애요실금학회 2014 International Neurourology Journal Vol.18 No.3

Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient’s quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.

Endogenous and radiation-induced expression of @?H2AX in biopsies from patients treated for carcinoma of the uterine cervix

Olive, P.L.,Banuelos, C.A.,Durand, R.E.,Kim, J.Y.,Aquino-Parsons, C. Elsevier Science Publishers 2010 Radiotherapy and oncology Vol.94 No.1

<P>Background and purpose: The possibility of using gamma H2AX foci as a marker of DNA damage and as a potential predictor of turnout, response to treatment was examined using biopsies from 3 sets of patients with advanced carcinoma of the cervix. The relation between endogenous gamma H2AX expression and hypoxia was also examined. Materials and methods: Set I consisted of 26 biopsies that included pre-treatment and 24 h post-radiation treatment samples. Pre-treatment biopsies from 12 patients in Set 2 were used to develop image analysis Software while pre-treatment biopsies from 33 patients in Set 3 were examined for the relation between staining for the hypoxia marker pimonidazole and endogenous gamma H2AX expression. Formalin-fixed paraffin-embedded sections were analyzed after antigen retrieval and fluorescence antibody labeling for the hypoxia markers CAIX or pimonidazole in combination with gamma H2AX staining. Results: Before treatment, 24 +/- 19% of cells contained gamma H2AX foci, with most positive cells containing fewer than 5 foci per nucleus. Twenty-four hours after exposure to the first fraction of 1.8-2.5 Gy. 38 +/- 19% contained foci. CAIX positive cells were 1.4 times more likely to exhibit endogenous gamma H2AX foci, and pimonidazole-positive cells were 2.8 times more likely to contain gamma H2AX foci. For 18 patients for whom both pre-treatment and 24 h post-irradiation biopsies were available, local control was unrelated to the fraction of cells that retained gamma H2AX foci. However, 24 h after irradiation, tumours that had received 2.5 Gy showed a significantly higher fraction of cells with residual gamma H2AX foci than tumours given 1.8 Gy. Conclusions: Endogenous gamma H2AX foci are enriched in hypoxic tumour regions. Small differences in delivered dose can produce quantifiable differences in residual DNA damage that can overshadow inter-tumour differences in response. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 94 (2010) 82-89</P>

Synthesis of Pegylated Immunonanoparticles

Oliver, Jean-Christophe,Huertas, Ramon,Lee, Hwa Jeong,Calon, Frederic,Pardridge, William M. 梨花女子大學校 藥學硏究所 2002 藥學硏究論文集 Vol.- No.11

Purpose. This work describes the syrthesis of pesylated immu-nonanoparticies by conjugation of an anti-transferrin receptor mono-clonal antibody (MAb) to maleimide-grafted pegylated nanoparticlesprepared from poly(lactic acid) (PLA) and a hi-functional polyeth-yleneglycol (PEG).Methods. Maleimide-PEG_3500-PLA_4000 and methoxy PEG_2600-PLA_4000 copolymers were synthesized by ring opening polymeriza-tion of L-lactide using stannous octoate as catalyst. Pegylated nano-particles were prepared from these copolymers by a multiple emul-sion/solvent evaporation method and thiolated OX26 MAb wasconjugated through the maleimide function located at the distal endof the PEG spacer. The pegylated immunonanoparticles were char-actenzed by quasi-elastic light scattering, gel permeation chromatog-raphy, turbidimetry assays, and transmission electron microscopy.Results. NMR spectroscopy confirmed the synthesis of both copoly-mers and the preservation of the maleimide function. The pegylatedimmunonanoparticles had an auerage diameter of 121 ± 5 nm andappeared spherical by transmission electron microscopy. The numberof OX26 MAb molecules conjugated per individual pegylated nano-particle was 67 ± 4. The MAb conjugated to the surface of the pe-gylated immunonanoparticle was visualized directly by electron mi-croscopy using a conjugate of 10 nm gold and an anti-mouse immu-noglobulin secondary antibody.Conclusion. Pegylated immunonanopartirles can be synthesized withbifunctional PEG derivatives that bridge the nanoparticle and thetargeting MAb. This novel formulation may enable the targeted de-livery of small molecules, protein drugs, and gene medicines.

Divine Mercy

Oliver GRIEM 한국색채학회 2017 International Invitation Exhibition of Color Works Vol.- No.-

Patterns of Precarity: Historical Trajectories of Vietnamese Labour Mobility

Oliver Tappe 서강대학교 동아연구소 2019 TRaNS(Trans –Regional and –National Studies of Sou Vol.7 No.1

In past and present Vietnam, the dialectic of precarity and resilience shapes the everyday lives of mobile labourers. Vietnamese labour mobility is characterised by an interplay between precariousness ‘at home’ and the uncertainties of migration. The paper aims to highlight continuities and contingencies in the longue durée of Vietnamese work migration through a historical contextualisation of precarious labour relations. Both colonial ‘coolie’ workers and present-day labour migrants share similar experiences, for example socioeconomic marginalisation in the regions of origin, opportunity and risk, and emerging translocal identities.