식용식물자원으로부터 활성물질의 탐색-IX. 흰씀바귀(Ixeris dentata forma albiflora)뿌리에서 Sesquiterpene Lactone 화합물의 분리 및 구조 동정; ACAT, DGAT 및 FPTase 효소 활성의 저해

방면호,장태오,송명종,김동현,권병목,김영국,이현선,정인식,김대근,김성훈,박미현,백남인,Bang, Myun-Ho,Jang, Tae-O,Song, Myoung-Chong,Kim, Dong-Hyun,Kwon, Byoung-Mog,Kim, Young-Kuk,Lee, Hyun-Sun,Chung, In-Sik,Kim, Dae-Keun,Kim, Sung-Hoon,Par 한국응용생명화학회 2004 Applied Biological Chemistry (Appl Biol Chem) Vol.47 No.2

식용식물자원으로부터 활성소재를 찾기 위하여 흰씀바귀 뿌리를 80% MeOH로 추출하고, 얻어진 추출물을 EtOAc, n-BuOH및 $H_2O$로 용매 분획하였다. EtOAc와 n-BuOH 분획에 대하여 column chromatography를 반복하여 4종의 화합물을 분리하였다. 각각에 대하여 2D-NMR을 포함한 스펙트럼 데이터의 해석과 문헌 자료를 조사하여 zaluzanin C (1), $9{\alpha}-hydroxyguaian-4(l5),10(14),11(13)-triene-6,12-olide$ (2), $3{\beta}-O-{\beta}-D-glucopyranosyl-8{\beta}-hydroxyguaian-4(15),\;10(14 )-diene-6,12-olide$ (3), $3-O-{\beta}- D-glucopyranosyl-8{\beta}hydroxyguaian-10(14)-ene-6,12-olide$ (4)로 구조를 결정하였다. 이들 화합물에 대하여 ACAT(Acyl-CoA: cholesterol acyltransferase), DGAT (diacylglycerol acyltransferase) 및 FPTase(farnesyl-protein transferase)의 활성에 미치는 억제효과를 측정하였다. Compound 1과 Compound 2는 DGAT에 대한 활성억제효과에 있어서 $IC_{50}$ 값이 각각 0.13 mM, 0.10 mM로 나타났고, FPTase에 대하여는 각각 0.15 mM, 0.18 mM로 나타났으며, ACAT에 대하여는 약한 억제 활성을 나타냈다. 따라서 흰씀바귀는 항암 및 항고혈압의 소재 개발에 있어서 유용한 자원으로 활용될 수 있을 것이다. The root of lxeris dentata forma albiflora was extracted with 80% aqueous MeOH and solvent fractionated with EtOAc, n-BuOH and water, successively. From the EtOAc and n-BuOH fractions, four sesquiterpene compounds were isolated through the repeated silica gel and ODS column chromatographies. The chemical structures were determined as zaluzanin C (1), $9{\alpha}-hydroxyguaian-4(l5),10(14),11(13)-triene-6,12-olide$ (2), $3{\beta}-O-{\beta}-D-glucopyranosyl-8{\alpha}-hydroxyguaian-4(15),10(14 )-diene-6,12-olide$ (3), and $3{\beta}-O-{\beta}- D-glucopyranosyl-8{\beta}hydroxyguaian-10(14)-ene-6,12-olide$ (4) through the interpretation of several spectral data including 2D-NMR. Some showed the inhibitory effects on DGAT (Diacylglycerol acyltransferase), ($IC_{50}$ values of 1, 2: 0.13, 0.10 mM), the catalyzing enzymes of the intracellular esterification of diacylglycerol and FPTase (Famesyl-protein transferase), ($IC_{50}$ values of 1, 2: 0.15, 0.18 mM), the farnesylation enzyme for Ras protein charge of cancer promotion.

구개편도 아밀로이드증 1예

권오성,김기식,최진수,최병권,이종빈,박가현,이광호 동국대학교 의학연구소 2006 東國醫學 Vol.13 No.2

아밀로이드증은 원섬유 형태의 부정형 단백 물질의 세포외 침착을 특징으로 한다. 구개편도 아밀로이드증은 Mutschler가 1933년 보고한 이후 전세계적으로 9예가 보고된 바 있으며, 이중 1예만이 국내에서 보고되었을 뿐이다. 본 증례는 구개편도에 국한된 원발성 아밀로이드증으로 구개편도에 국한된 종물을 안전변연을 두고 절제하였으며, H & E 염색 및 Congo-red 염색 후 편광현미경하에서 확진하였다. 타부위와의 연관성을 검사하기 위해 추가적인 검사를 시행하였으나 특이소견 발견되지 않았으며, 현재까지 재발징후 없는 상태이다. 이 증례를 통해 구개편도 아밀로이드증의 임상양상, 진단방법, 병리소견 및 치료방법에 관해 문헌고찰과 함께 보고하고자 한다. Amyloidosis is characterized by extracellular deposition of amorphous protein materials in the forms of fibrils. Amyloidosis of palatine tonsil is a rare disease that was first documented in 1933 by Mutschler, then followed by nine more cases reported worldwide. Among all cases, only one case have been reported from Korean literature. Our case of tonsillar amyloidosis with primary localized form, in which was excised with safety margin and confirmed with H & E stain and Congo-red stain under the polarized filter. In order to assess systemic involvement, extensive work-ups were performed and in which turned out to be a local involvement. Until recently, no evidence of recurrence has been demonstrated. Thus, we present a case of tonsillar amyoloidosis along with the review of its clinical patterns, diagnostic tools, pathologic findings and treatments.

Anisotropy-Driven High Thermal Conductivity in Stretchable Poly(vinyl alcohol)/Hexagonal Boron Nitride Nanohybrid Films

Kwon, O. Hwan,Ha, Taeyong,Kim, Dong-Gyun,Kim, Byoung Gak,Kim, Yong Seok,Shin, Tae Joo,Koh, Won-Gun,Lim, Ho Sun,Yoo, Youngjae American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.40

<P>Controlling the anisotropy of two-dimensional materials with orientation-dependent heat transfer characteristics is a possible solution to resolve severe thermal issues in future electronic devices. We demonstrate a dramatic enhancement in the in-plane thermal conductivity of stretchable poly(vinyl alcohol) (PVA) nanohybrid films containing small amounts (below 10 wt %) of hexagonal boron nitride (<I>h</I>-BN) nanoplatelets. The <I>h</I>-BN nanoplatelets were homogeneously dispersed in the PVA polymer solution by ultrasonication without additional surface modification. The mixture was used to prepare thermally conductive nanocomposite films. The in-plane thermal conductivity of the resulting PVA/<I>h</I>-BN nanocomposite films increased to 6.4 W/mK when the strain was increased from 0 to 100% in the horizontal direction. More specifically, the thermal conductivity of a PVA/<I>h</I>-BN composite film with 10 wt % filler loading can be improved by up to 32 times as compared to pristine PVA. This outstanding thermal conductivity value is significantly larger than that of materials currently used in in-plane thermal management systems. This result is attributed to the anisotropic alignment of <I>h</I>-BN particles in the PVA chain matrix during stretching, enhancing phonon conductive paths and hence improving the thermal conductivity and thermal properties of PVA/<I>h</I>-BN nanocomposite films. These polymer nanocomposites have low cost as the amount of expensive conductive fillers is reduced and can be potentially used as high-performance materials for thermal management systems such as heat sink and thermal interface materials, for future electronic and electrical devices.</P> [FIG OMISSION]</BR>

Inactive Hepatitis B Surface Antigen Carrier State and Hepatotoxicity During Antituberculosis Chemotherapy

Lee, Byoung Hoon,Koh, Won-Jung,Choi, Moon Seok,Suh, Gee Young,Chung, Man Pyo,Kim, Hojoong,Kwon, O. Jung Elsevier 2005 Chest Vol.127 No.4

<P>STUDY OBJECTIVES: To determine whether inactive hepatitis B surface antigen (HBsAg) carriers are at a higher risk of drug-induced hepatotoxicity than control subjects during antituberculosis treatment with standard short-course regimens of isoniazid, rifampin, ethambutol, and/or pyrazinamide. DESIGN: Retrospective case-control study. SETTING: Tertiary university medical center. PATIENTS: One hundred ten inactive HBsAg carriers with newly diagnosed active tuberculosis who had been treated with isoniazid, rifampin, ethambutol, and/or pyrazinamide were included in the study population. Inactive HBsAg carriers were defined as follows: (1) positive for HbsAg; (2) negative for hepatitis B e antigen (HBeAg), positive for antibody to HBeAg; (3) < 10(5) copies per mL of serum hepatitis B virus DNA; and (4) normal pretreatment aspartate aminotransferase (AST)/alanine aminotransferase (ALT) levels. Ninety-seven HBsAg-negative patients who received standard antituberculosis medication were selected as control subjects. RESULTS: The baseline characteristics of the 110 inactive HBsAg carriers were similar to those of the 97 noncarriers. A total of 85% of persons in both groups had received an initial treatment regimen that included pyrazinamide. Thirty-eight inactive HBsAg carriers (35%) and 19 control subjects (20%) exhibited elevated liver enzyme levels during antituberculosis treatment (p = 0.016). Drug-induced hepatotoxicity, which was defined as a liver transaminase level of >/= 120 IU/L, occurred more frequently in HBsAg carriers (9 of 110 carriers; 8%) than in control subjects (4 of 97 control subjects; 4%), although this was not a statistically significant discrepancy (p = 0.230). More importantly, HBsAg carriers (n = 9; 8%) who received antituberculosis therapy evidenced a higher proportion of moderate-to-severe drug-induced hepatotoxicity when compared with the control subjects (n = 2; 2%; p = 0.05). Isoniazid and rifampin were reintroduced as therapy after AST/ALT levels returned to baseline values in 10 patients (6 HBsAg carriers and 4 control subjects) among the 13 patients exhibiting drug-induced hepatotoxicity, and these retrials proved to be successful in 7 patients (5 HBsAg carriers and 2 control subjects). CONCLUSIONS: Tuberculosis treatment in HBsAg-positive and HBeAg-negative inactive carriers could be pursued in the usual manner, using standard short-course regimens of isoniazid, rifampin, ethambutol, and/or pyrazinamide, with the condition that monthly liver function tests are performed.</P>

정상(正常) 성인(成人) 남녀(男女) 상지부위(上肢部位)의 실측(實測)을 통한 수혈부위(穴部位) 도량형(度量衡)의 기준정립(基準定立)

성병식 ( Byoung Sik Sung ),권오상 ( O Sang Kwon ),전인숙 ( In Suk Jeon ),김재효 ( Jae Hyo Kim ),안성훈 ( Sung Hun An ),손인철 ( In Chul Sohn ) 대한경락경혈학회 2008 Korean Journal of Acupuncture Vol.25 No.3

Objectives: Weights and measures (度量衡) in Korean traditional medicine have been changed in many dynasties and countries. Thus, measurements of chon (寸) and cheok (尺) have been considered as symbolical meaning in recent studies on meridians and acupoints. The present study was made to settle up standard measurement by surveying Length of each parts of upper Limb as follows. Methods: To calculate Length of 1 chon (寸), the Length of each part was divided into the numbers of chon (寸) as shwon in 《Goldo · Hwangjenaegyeong-yeongchu (靈樞· 骨度篇)》; the chon (寸) Length in 《Goldo · Hwangjenaegyeong-yeongchu (靈樞· 骨度篇)》was compared with the chon (寸) Length which is calculated by dividing human average hight into 75 chon. Results: Increment of Length of 1 chon (寸) did not change as increment of height in subjects. Length of 1 chon (寸) in height is representative of Length of 1 chon (寸) in each parts of upper Limb. Conclusions: We suggest that most suitable Length of 1 chon (寸)for the standard measurement of acupoint Location is 2.20 ± 0.17 cm based on Length of elbow joint to wrist joint.

아말감 충전시 이장재로 사용되는 수종의 접착성 레진의 미세변연누출에 관한 연구

권오택(O-Taek, Kwon),금기연(Kee-Yean, Kum),노병덕(Byoung-Duck, Noh),윤태철(Tai-Cheol, Yoon),이찬영(Chan-Young, Lee) 대한치과의사협회 1997 대한치과의사협회지 Vol.35 No.9

Stocker 서보모터 토크 부하율을 이용한 사전고장예측 방법연구

권오준(O-Jun Kwon),주병윤(Byoung-Yun Joo) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11

Stocker is the main cassette transfer equipment of TFT-LCD industry. Breakdown of stocker causes a serious production problem by stopping cassette transfer. Therefore, Prevention of breakdown of stocker is crucial factor of yield. The main problem is failure of servo motor which driving stocker. Acceleration vibrograph sensor, which uses piezoelectric effect, is commonly used to analysis problem of servo motor. However, high cost is the wall to adapt acceleration vibrograph sensor. Therefore, this paper proposes a load factor based preliminary failure detection method. We adapt two algorithm, set point and SPC-mixture, to check problem of servo motor. Our novel method effectively detects servo motor problem of stocker.

인두후농양을 동반한 경부 결핵성 림프절 농양의 수술적 치료 1예

최병권,최진수,권오성,김기식,이광호,이종빈,박가현 동국대학교 의학연구소 2006 東國醫學 Vol.13 No.2

결핵성 경부 림프절염(tuberculous cervical lymphadenitis)은 폐외결핵중에서 가장 빈도가 높은 질환이다(1,2). 결핵 진단법의 발달과 항결핵제에 대한 개발로 결핵감염이 급격히 줄어들고 있어 결핵의 유병율은 점차 낮아지는데 비하여 폐외결핵은 줄지 않고 있다(3). 35세 여자환자가 4개월간 지속된 경부 종괴를 주소로 내원하였다. 이학적 검사상 좌측 구인두 후벽이 전방으로 팽윤되는 소견 보였고, 양측 경부에 흉쇄유돌근의 후방 변연을 따라 발적된 유동적이고 무통성의 종물이 촉지 되었고 파동성을 관찰할 수 있었다. 저자들은 양측 경부의 농양에 대해 절개 배농 및 소파술을 시행하였고 인두후 농양에 대해서는 Rose 체위에서 경구적으로 구강인두 후벽에 종절개를 하여 농성 분비물을 제거하였다. 이러한 단순 절개 및 배농을 통하여 결핵성 경부 림프절염 환자를 효과적으로 치료하여 문헌고찰과 함께 보고하는 바이다. Tuberculous cervical lymphadenitis is one of the most common extrapulmonary manifestations of tuberculosis. Recently, We experienced a 35 year-old female patient who had been admitted with neck masses lasted for past 4 months. The physical examination revealed protrusion of the left posterior pharyngeal wall and neck masses (movable, erythematous, non tender) on the both sides of neck. She was diagnosed tuberculous cervical lymphadenitis with retropharyngeal abscess. We effectively treated her with trial simple neck abscess drainage and intraoral drainage and frequent dressing with betadine. Here we report it with a review of the literature.

정상성인상지부위실측(正常成人上肢部位實測)에 근거한 도량형기준정립(度量衡基準定立)

성병식 ( Byoung Sik Sung ),권오상 ( O Sang Kwon ),전인숙 ( In Suk Jeon ),김재효 ( Jae Hyo Kim ),안성훈 ( Sung Hun Ahn ),손인철 ( In Chul Sohn ) 원광대학교 인체과학연구소 2008 원광인체과학회지 Vol.9 No.1

Objectives: Weights and measures (度量衡) in Korean traditional medicine has been changed in many dynasty and country. Thus, measurements of chon (寸) and cheok (尺) have been estimated as symbolical meaning in a study of meridian and acupoint in today. The present study was made to settle up standard measurement by surveying length of each parts of upper limb as the follows. Methods: To calculate length of 1 chon (寸), it was divided length of each parts into number of chon (寸) in 《Goldo · Hwangjenaegyeong-yeongchu (靈樞· 骨度篇)》; it was compared chon (寸) length in 《Goldo · Hwangjenaegyeong-yeongchu (靈樞·骨度篇)》with chon (寸) length in length of 1 chon (寸) which is calculated by dividing hight into 75 chon. Results: Increment of length of 1 chon (寸) did not changed as increment of height in subjects. Length of 1 chon (寸) in height is representative of length of 1 chon (寸) in each parts of upper limb. Conclusions: We suggest that most suitable length of 1 chon (寸)for the standard measurement of acupoint location is 2.20 ± 0.17 cm based on length of elbow joint to wrist joint.

가상자산의 법적 성질 - 미국과 한국의 증권규제를 중심으로 -

김병연 ( Kim¸ Byoung-youn ),권오훈 ( Kwon¸ O-hoon ) 한국상사판례학회 2021 상사판례연구 Vol.34 No.3

어떠한 계약이 미국 증권거래법상 투자계약에 해당하는지는 전통적으로 미국 연방증권법상 증권의 개념과 관련하여 Howey 판결에 따라 이루어졌다. 그러나 최근 SEC는 가상자산에 대한 Howey 기준과 관하여, 원래는 투자계약이어서 증권으로 분류되어야 하는 토큰이 프로젝트의 성질에 따라 이후에는 증권이 아닌 것으로 취급될 수 있다는 견해를 피력하기도 하였다. SEC의 이러한 관점을 토대로 국내 규제와 비교 고찰한다면, 아직 성숙하지 않은 가상자산의 법적 성질에 대한 논의가 더욱 풍부해질 것으로 생각된다. 가상자산이 전자화폐인지와 관련하여, 전자금융거래법에 따르면 전자화폐는 이전 가능한 금전적 가치가 전자적 방법으로 저장되어 발행된 증표 또는 그 증표에 관한 정보로 정의된다. 전자화폐의 정의상 ‘이전 가능한 금전적 가치’란, 현금 또는 예금과 같은 가치로 교환되어 발행된 것을 의미한다. 따라서 전자화폐는 원화 등 법정통화와의 교환이 담보되어야 성립한다. 그러나 대부분 가상자산은 각 국가의 통화 발행과는 무관하게 발행되고 활용되며, 많은 경우 재산적 가치가 담보되지 않는다. 이러한 가상자산의 특징으로 보건대, 가상자산은 전자금융거래법상 전자화폐의 정의에 들어맞지는 않는다고 볼 수 있다. 미국의 경우, SEC는 가상자산을 원칙적으로 투자계약증권으로 전제하고, 탈중앙화가 진행된 블록체인 상의 가상자산을 예외적으로 증권이 아닌 것으로 확인하고 있다. 그러나 가상자산은 매우 다양한 변종이 존재하고, 계속하여 새로운 방식으로 소개되고 있기 때문에, 하나의 분류로 일률적으로 규정하여서는 개별 가상자산의 법적인 성격을 명확히 포섭하기 어렵다. 국내에서도 해외의 검토 방안을 참고하여 가상자산이 기반을 두고 있는 블록체인 네트워크의 성질을 분석하고, 그 이후에 가상자산의 실질을 종합적으로 판단하여야 한다. 이러한 분석을 토대로, 이른바 지급형 및 유틸리티 코인은 전자금융거래법 상 전자지급수단으로, 증권형 코인은 자본시장법 상 투자계약증권으로 포섭함이 타당함을 논증한다. Whether or not an investment contract is applicable under the U.S. Securities and Exchange Act traditionally relates to the concept of securities under the U.S. Federal Securities Act as in the Howey case. However, the SEC recently expressed a position that, with respect to the Howey verification of virtual assets, tokens that were originally an investment contract and therefore classified as securities may later be treated as non-security over time, depending on the nature of the project. Based on this perspective of the SEC, if we compare such interpretation with that of Korean local regulations, the discussion on the legal nature of virtual assets that are not yet mature shall be enriched. With regards to the concept of Electronic Payment Methods, a system of transferable monetary value mainly means legal tenders. It can be seen that such value of legal tender is stored electronically, and that such storage is done on the digital token. However, in general, virtual assets do not have a process of storing existing monetary values. The market value of virtual assets is often evaluated ex post by being traded on virtual asset exchanges. Therefore, Electronic Payment Methods are different from virtual assets in that they are basically prepaid, while virtual assets are not. Furthermore, there is an issuance limit for electronic payment methods, and it be operated by a separate centralized management system. The difference between virtual assets and Electronic Payment Methods is clearer in that most virtual assets are managed by a decentralized system using a public blockchain network. In the United States, the SEC assumes that virtual assets are in principle investment contract securities, and conveyed its opinion that virtual assets on the blockchain that have been decentralized will not be regarded as securities. However, because virtual assets have a wide variety of variants and are continuously introduced in a new way, it is difficult to clearly incorporate the legal nature of individual virtual assets in a single classification. In Korea, the properties of the virtual assets should be comprehensively determined by reviewing the blockchain network under which virtual assets are based, and should be analyzed by referring to other regulations such as that of the US. Under the above premise, this article provides that payment and utility type tokens should be regarded as Electronic Payment Methods, while security type tokens should be regulated as Investment Contract Securities.