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RISS 인기검색어
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- 저자 : Nu Yan (검색결과 3 건)
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Fatigue Behavior of Plasma Radical Nitrided SCM435 Steel in Super-Long Life Regime
Nu Yan,Ri-ichi Murakami,Insup Lee 대한금속·재료학회 2011 METALS AND MATERIALS International Vol.17 No.4
Fatigue behavior in a super-long life regime was investigated for plasma radical nitrided JIS SCM435 steels at room temperature in air. Specimens were nitrided at the 723 K and 823 K for 3 h and at 773 K for 1 h, 3 h, and 5 h. The fatigue strengths of the nitrided specimens were greater than that of the un-nitrided specimen. However, the fatigue strength and fracture mechanism of the nitrided specimens were markedly influenced by nitriding temperature and time. Both surface cracking and subsurface cracking, e.g. fish-eye fractures, were observed in the specimens subjected to the nitriding conditions. Hardened layers and compressive residual stress were formed on the specimen surfaces by nitriding, which led to an improvement of the fatigue strength and determined the initiation type of the fatigue cracking. Stress intensity factor at crack initiation was evaluated in fish-eye type fractures. As a result, the stress intensity factor range in the facet area indicated a constant value, approximately 3.5 MPa·m^(1/2), regardless of the fatigue life.
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Yi-Jing Wang,Pan Zhao,Bing-Dong Sui,Nu Liu,Cheng-Hu Hu,Ji Chen,Chen-Xi Zheng,An-Qi Liu,Kun Xuan,Ya-Ping Pan,Yan Jin 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Mesenchymal stem cell (MSC)-based regeneration, specifically cell aggregate or cell sheet engineering, is a promising approach for tissue reconstruction. Considering the advantages of ease of harvest and lack of immune rejection, the application of autologous MSCs (i.e., patients’ own MSCs) in regenerative medicine has developed considerable interest. However, the impaired cell viability and regenerative potential following MSCs impacted by disease remain a major challenge. Resveratrol (RSV) exhibits reliable and extensive rejuvenative activities that have received increasing clinical attention. Here, we uncovered that resveratrol enhances the functionality and improves the regeneration of mesenchymal stem cell aggregates. Periodontal ligament MSCs (PDLSCs) from normal control subjects (N-PDLSCs) and periodontitis patients (P-PDLSCs) were investigated. Compared to N-PDLSCs, P-PDLSCs were less capable of forming cell aggregates, and P-PDLSC aggregates showed impaired osteogenesis and regeneration. These functional declines could be mimicked in N-PDLSCs by tumor necrosis factor alpha (TNF-α) treatment. Notably, a TNF-α-induced functional decline in N-PDLSC aggregates was rescued by RSV application. More importantly, in both N-PDLSCs and P-PDLSCs, RSV promoted cell aggregate formation and improved their osteogenic potential. Furthermore, as proven ectopically in vivo, the tissue regenerative capability of P-PDLSC aggregates was also enhanced after RSV treatment during aggregate formation in vitro. Finally, in a rat in situ regeneration model, we successfully applied both N-PDLSC aggregates and P-PDLSC aggregates to repair periodontal defects upon long-term functional improvements by RSV preconditioning. Together, our data unravel a novel methodology for using pharmacology (i.e., RSV)-based cell aggregate engineering to improve the functionality and facilitate the regeneration of MSCs from both healthy and inflammatory microenvironments, shedding light on improving the application of autologous MSC-mediated regenerative medicine.
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자오정린,왕옌,린훵,후우후이,저우후우??,장수찬,한누리,정대화,양재하,김상찬,자오르옹지에,Zhao, ZhengLin,Wang, Yan,Lin, Feng,Fu, Hui,Zhou, FuBo,Chang, Suchan,Han, Nu Ri,Jung, Dae Hwa,Yang, Chae Ha,Kim, Sang Chan,Zhao, RongJie The Korean Medicine Society for the Herbal Formula 2014 大韓韓醫學方劑學會誌 Vol.22 No.1
Background and objective: Methamphetamine (Meth) is a widely abused psychostimulant that produces hyperlocomotion in rodents. Radix of Glycyrrhizae uralensis comprises a variety of bioactive components that have neuroprotective effects. In a previous study, we have demonstrated methanol extracts from radix of Glycyrrhizae uralensis (MEGR) suppress acute cocaine-induced extracellular dopamine release in the nucleus accumbens. In the present study, we investigated the effect of MEGR on acute Meth-induced hyperlocomotion. Methods: Male Sprague-Dawley rats were orally administered with MEGR (60 mg/kg and 180 mg/kg) 60 min prior to an intraperitoneal injection of Meth (1.0 mg/kg). Results: Behavioral analysis showed acute Meth greatly increased locomotor activities, while pretreatment with MEGR dose dependently inhibited the hyperlocomotion. In parallel, there were markedly increased levels of dopamine and its metabolite 3, 4-dihydroxyphenylacetic acid in the nucleus accumbens tissues in Meth-treated rats, which were also almost completely reversed by 180 mg/kg MEGR. Conclusions: These results showed that radix of Glycyrrhizae uralensis attenuates Meth-induced hyperlocomotion by inhibiting dopamine synthesis and utilization, suggesting that radix of Glycyrrhizae uralensis might be effective in blocking the rewarding effect of Meth.
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