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- 저자 : Nisha, A. (검색결과 85 건)
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Nisha Adhikari,Won-Sik Shim 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.9
Mast cells play essential role in allergic reactionsthrough the process called mast cell degranulation. Recent studies have found that a basic secretagogue compound48/80 (C48/80) induces non-IgE-mediated mastcell degranulation via activation of human Mas-related Gprotein-coupled receptor X2 (MRGPRX2) and mouse MrgprB2. Although previous studies have revealed that caff eicacid (CA) and its derivatives possess anti-allergic eff ects viaIgE-dependent manner, it is largely elusive whether thesecompounds have impact on MRGPRX2/MrgprB2 to exertinhibitory eff ects. Therefore, the present study investigatedwhether CA as well as its derivatives – rosmarinic acid (RA)and caff eic acid phenethyl ester (CAPE) – has the abilityto inhibit the activity of MRGPRX2/MrgprB2 to evokepseudo-allergic eff ects. As a result, it was found that CAPEinhibits C48/80-induced activation of MRGPRX2/MrgprB2,but neither CA nor RA showed discernible inhibition. Furthermore,the β-hexosaminidase release assay showed thatCAPE inhibits mouse peritoneal mast cell degranulationin both IgE-dependent and MrgprB2-dependent manners. Additionally, mouse paw edema induced by C48/80 was dramaticallysuppressed by co-treatment of CAPE, suggestingthat CAPE possesses a protective eff ect on C48/80-evokedpseudo-allergic reactions. The pretreatment of CAPE also signifi cantly decreased scratching bouts of mice evokedby C48/80, demonstrating that CAPE also has an anti-pruriticeff ect. Therefore, these data implicate that CAPE cansuppress pseudo-allergic reactions evoked by C48/80 viaMrgprB2-dependent manner. Finally, molecular dockinganalysis showed that CAPE is predicted to bind to humanMRGPRX2 in the region where C48/80 also binds, implyingthat CAPE can be a competitive inhibitor of MRGPRX2. Inconclusion, it is found that CAPE has the ability to inhibitMRGPRX2/MrgprB2, leading to the prevention of mast celldegranulation and further to the alleviation of mast cell reactions. These results indicate that CAPE as a CA derivativecould be developed as a new protective agent that exerts dualinhibition of mast cell degranulation mediated by IgE andMRGPRX2/MrgprB2.
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Unwanted Daughters: Exploring the practice of sex determination and its ramification in Haryana
Nisha SINGH 이화여자대학교 아시아여성학센터 2018 이화여자대학교 아시아여성학센터 학술대회자료집 Vol.2018 No.1
Women in Indian society have been in a subordinate position and hardly given space to access their choices. Patriarchal socio-cultural norms have created the compulsion to prefer sons over daughters in a family composition, hence women have been portrayed as a sex commodity and son producer. The Sex Determination Technologies (ultrasound and amniocentesis) are widely misused to accommodate the widespread preference for sons. A million of female fetuses are aborted annually in India as daughters are considered unwanted. Consequentially, the Country is struggling with an adverse sex ratio for last 40 years. It has further affected the status of women in terms of their sexuality, health, and mobility. Women are being sold and purchased in the name of marriage across the regional boundaries. Such marriages, surely do not give a picture of intimate relations between two people, rather merely a transaction of women for the sex, reproduction of sons and cheap labor. In this paper, I have attempted to explore the misuse of the Sex Determination Technologies for practicing female foeticide in the Haryana State of India and how the practice has affected the identity of women’s agency and society as a whole. Further, I have highlighted, the status of ‘purchased wives’ in the society.
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Nisha Marwah,Manali Satiza,Niti Dalal,Sudhir Atri,Monika Gupta,Sunita Singh,Rajeev Sen 대한혈액학회 2021 Blood Research Vol.56 No.1
Background Morphological diagnosis of non-Hodgkin lymphoma (NHL) is usually based on lymph node biopsy. Bone marrow biopsy (BMB) is important for staging, and morphology alone can be challenging for subtyping. Immunohistochemistry (IHC) allows a more precise diagnosis and characterization of NHL using monoclonal antibodies. However, there is a need for a minimal panel that can provide maximum information at an affordable cost. Methods All newly diagnosed cases of B-cell NHL with bone marrow infiltration between 2017 and 2019 were included. BMB was the primary procedure for diagnosing B-cell NHL. Subtyping of lymphomas was performed by immunophenotyping using a panel of monoclonal antibodies on IHC. The primary diagnostic panel of antibodies for B-cell NHL included CD19, CD20, CD79, CD5, CD23, CD10, Kappa, and Lambda. The extended panel of antibodies for further subtyping included CD30, CD45, CD56, Cyclin D1, BCL2, and BCL6. Results All cases of B-cell NHL were classified into the chronic lymphocytic leukemia (CLL) and non-CLL groups based on morphology and primary IHC panel. In the CLL group, the most significant findings were CD5 expression, CD23 expression, dim CD79 expression, and weak surface immunoglobulin (Ig) positivity. In the non-CLL group, they were CD5 expression, positive or negative CD23 expression, strong CD79 expression, and strong surface Ig expression. An extended panel was used for further subtyping of non-CLL cases, which comprised CD10, Cyclin D1, BCL2, and BCL6. Conclusion We propose a two-tier approach for immunophenotypic analysis of newly diagnosed B-cell NHL cases with a minimum primary panel including CD5, CD23, CD79, Kappa, and Lambda for differentiation into CLL/non-CLL group and Kappa and Lambda for clonality assessment. An extended panel may be used wherever required for further subtyping of non-CLL.
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Design and Implement a Quasi-resonant Cuk Converter for Photovoltaic Applications
Nisha C. Rani,Amuthan Nallathambi 대한전자공학회 2023 IEIE Transactions on Smart Processing & Computing Vol.12 No.5
Solar energy has emerged as a growing source of alternative electrical energy in the new century because of the reliability, improvements, and efficiency in photovoltaic (PV) systems. In a PV system, maximum power point tracking (MPPT) is a significant feature because a set of conditions in PV system power is maximized, and thereby, array efficiency increases. In this article, a quasi-resonant Cuk-converter (QRCC)-based voltage source inverter (VSI) is proposed for application to large-scale photovoltaic generators. The quasi-resonant Cuk converter is built on zero voltage transition (ZVT) and zero current transition (ZCT) strategies, designing an optimization technique based on a VSI that eliminates harmonics. Through simulation related to MPPT controllers, the QRCC is achieved, feeding the load through the VSI to minimize harmonics. The results show that the proposed VSI, based on Harris hawks optimization, reduces network harmonics, and those results are compared to the quasi-resonant single-ended primary inductance converter (QRSEPIC).
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Nisha G. Pillai,Archana K,이경엽,박수진,Asif A 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.79 No.-
Curcumin is a bioactive molecule having potential applications in medicalfield. Present study focuses tosynthesise the hybrid biomaterials of curcumin loaded nano zeolitic imidazolate frameworks of zinc andcobalt metals by solvothermal method. Influence of curcumin on surface morphology and thermalproperties of the hybrid biomaterials have been investigated. The framework hybrids are characterised byFTIR, XRD, SEM, TEM, BET surface area and TGA. The studies reveal that the hybrid biomaterials show highthermal stability with well identified morphology, decrease in particle size and large pore volume. Invitro antiproliferative studies corroborate that hybrid biomaterial displays greater cell growth inhibitoryperformance than that of pure metal organic framework and pure curcumin towards HeLa cells. In vitrocytotoxicity studies reveal that CCM–ZIF-67 hybrid biomaterial exhibits more specificity towardscancerous cells.
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Tunable Release of Combined Contraceptive Steroids from Coreshell Gelatin/PCL Fibers
Nisha U,Merline C,Lakshminarayanan Ragupathy,Diksha Painuly 한국섬유공학회 2020 Fibers and polymers Vol.21 No.9
The present study investigates simultaneous release of two hydrophobic contraceptive steroids from core-shellfibers made by coaxial electrospinning. The contraceptive steroids levonorgestrel (LNG) and ethinylestradiol (EE) wereincorporated in gelatin/poly(ε-caprolactone) (PCL) core-shell fibers. The influence of shell concentration and core feed/flow rate (ml/h) on the physical, chemical, mechanical and release properties of drug incorporated coaxial fibers wereevaluated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), differential scanningcalorimetry (DSC), Fourier transform infrared (FT-IR) spectroscopy, universal testing machine (UTM) and highperformanceliquid chromatography (HPLC). SEM results revealed the influence of feed/flow rate on pore size (in the range586-1036 nm) and fiber diameter (i.e. 621-1650 nm) of the coaxial fibers. TEM analysis confirmed the presence of coreshellmorphology. DSC results conferred that drugs were in an amorphous form within core-shell fibers. The FT-IR spectraestablished the drug encapsulation by the electrospinning process. Swelling studies demonstrate that increasing the shell(PCL) concentration i.e. 4-10 % w/v decreases the swelling ratio (295-140 %). The drugs release kinetics satisfactorilydescribed by first-order (R2>0.95) model and Korsmeyer-Peppas model (R2≥0.95) for all the prepared core-shellformulations. These formulations were found to follow anomalous non-Fickian transport, which suggests that the drugrelease is controlled by both diffusion and erosion of polymer matrix. These results clearly demonstrate that it is possible tocontrol the release rate for the two hydrophobic (contraceptive) drugs through coaxial electrospinning process for the firsttime to the best of our knowledge.
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Synergistic Multi Enzyme Platform for Isopropanol Detection Using Electrochemical Biosensing Assay
Nisha BHARDWAJ,Myeong-Eun LEE,Young Jin KO,Sung Ok HAN 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
The electrochemical biosensors with enzymes have always been an attractive research topic in various sectors of biology due to their high specificity and reproducibility. In this study, we suggest a novel cellulosome scaffolding based multi-enzyme platform for the detection of isopropyl alcohol (IPA) using electrochemical biosensing assay. Three enzymes namely alcohol dehydrogenase (ADH), NADH oxidase (NOX), and peroxidase were isolated and successfully overexpressed in E.coli BL21 Rosetta respectively. The ability of enzymes to catalyze NAD+/NADH was confirmed using the absorption spectrum at 340㎚ wavelength. From the results, it was confirmed that the rate of oxidization of NADH by NOX and the rate of reduction of NAD+ by ADH were approximately 3 folds compared to control. In the synergistic reaction, comparative to the individual curves i.e. logistic for ADH and decaying for NOX, a straight line parallel to the baseline was obtained which confirmed that NAD+ was reduced to NADH and can be used by NOX for further oxidation simultaneously. Taken together, this study can be a progression in the area of electrochemical biosensors for the detection of IPA.
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