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Le, Thi Thao Nguyen,Ly, Nguyen Hoang,Nguyen, Thanh Danh,Nguyen, Thi Ha,Kim, Moon-Kyung,Zoh, Kyung-Duk,Joo, Sang-Woo Elsevier 2018 Colloids and surfaces. A, Physicochemical and engi Vol.551 No.-
<P><B>Abstract</B></P> <P>For this report, we compared interfacial spectroscopic tools to monitor in situ Fenton reactions of organic dyes on ascorbic acid-reduced gold nanostars (AuNSs). Ultraviolet-visible (UV–vis) absorption and Raman spectroscopic tools were introduced to check the hydroxyl radical destruction of ethyl violet (EV), which contains a triarylmethane group. AuNSs with sharp edges, tips, and corners were used as efficient surface-enhanced resonance Raman scattering (SERRS) substrates for in situ Fenton reaction monitoring. The SERRS intensity of the EV showed a first-order decay curve with a reaction rate constant value of 0.0263 min<SUP>−1</SUP>, while the decolorization yielded second-order kinetic behavior with a constant value of 0.00430 L/mol min. In addition to the destruction of the organic dyes, the increased number of ferric (III) ions, as a result of the Fenton reactions, was detected via 4-aminobenzo-15-crown-5 (4AB15C5) conjugated with 4-mercaptobenzoic acid (4MBA). We found that the SERRS bands at ∼1500 cm<SUP>−1</SUP> of 4AB15C5 on AuNSs increased after treatment with H<SUB>2</SUB>O<SUB>2</SUB> and FeSO<SUB>4</SUB>. Real industrial textile wastewater samples were then tested to determine whether this Raman method could be applied to detect increases in ferric ions. Our spectroscopic data used SERRS peaks via Fenton reaction results to calculate an estimated ∼65% destruction of the organic dyes.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Nguyen Phuong Thao,Bui Thi Thuy Luyen,Nguyen Thi Thanh Ngan,Le Duc Dat,Nguyen Xuan Cuong,Nguyen Hoai Nam,Phan Van Kiem,Seok Bean Song,Chau Van Minh,김영호 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
Peroxisome proliferator-activated receptors(PPARs) are ligand-activated transcription factors thatregulate the expression of multiple genes involved inmetabolic, anti-inflammatory, and developmental processes. This study evaluated the PPARs transactivationaleffects of thirteen cembranoid diterpenoids 1–13 from thesoft coral Lobophytum crassum, using PPAR-responsiveelements–luciferase reporter and GAL4–PPAR chimeraassays. All isolated compounds activated the transcriptionof PPARs in a dose-dependent manner, with EC50 valuesranging from 2.07 ± 1.73 to 130.20 ± 1.85 lM. Moreover,compounds 6–9 affected the transactivation of allthree PPAR types, PPARa, c, b(d), in a dose-dependentmanner, with EC50 values in a ranging from 11.92 ± 1.23to 122.50 ± 2.12 lM. These results provide a scientificrationale for further studies on the soft coral L. crassum andits diterpenoid constituents to develop medicinal productsagainst inflammatory and metabolic diseases.
Thao Tram Le Nguyen,Xuan Loc Vu Doan,Vy Thuc Nguyen 아시아심장혈관영상의학회 2020 Cardiovascular Imaging Asia Vol.4 No.4
Anomalous left coronary artery from the pulmonary artery (ALCAPA) syndrome is a rare congenital coronary artery anomaly. Clinical presentation can range from asymptomatic conditions to sudden death with exertion. The majority of cases is diagnosed in childhood and dies within the first year, however medical literature has confirmed several cases in adults. We report a case of a 49-year-old woman hospitalized for vague chest pain. Echocardiography found collateral circulation on the anterior wall, and ALCAPA syndrome was diagnosed on multislice CT.
Thao Nguyen Vu,Jung-Hyun Byun,Roshan D’Souza,Naina Adren Pinto,Le Phuong Nguyen,DongeunYong,Yunsop Chong 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.1
Background: The existing modified carbapenem inactivation methods (mCIMs) recommended by the CLSI for detecting carbapenemase production have not been applicable for Acinetobacter baumannii. We evaluated the influence of matrices used in mCIMs and CIMTris on the stability of the disks for detecting carbapenemase producers and suggested optimal mCIM conditions for detecting carbapenemase-producing A. baumannii. Methods: Seventy-three A. baumannii isolates characterized for antimicrobial susceptibility and carbapenemase encoding genes were tested for carbapenemase production using mCIM and CIMTris. The influence of the matrices (Tryptic soy broth [TSB] and Tris-HCl) used in these methods on the stability of the meropenem (MEM) disk was also evaluated. The mCIM conditions were adjusted to enhance screening sensitivity and specificity for detecting carbapenemase-producing A. baumannii. Results: The matrices had an impact on the stability of the MEM disk after the incubation period (two or four hrs). TSB nutrient broth is an appropriate matrix for mCIM compared with Tris-HCl pH 7.6, which leads to the loss of MEM activity in CIMTris. The sensitivity and the specificity of the optimal mCIM were both 100%. Conclusions: We established optimal mCIM conditions for simple, accurate, and reproducible detection of carbapenemase-producing A. baumannii.
Anti-inflammatory Triterpenes and Glyceryl Glycosides from Kandelia candel (L.) Druce
Le Duc Dat,NGUYEN PHUONG THAO,BUIHUU TAI,Bui Thi Thuy Luyen,양서영,김소현,구정은,고영상,Nguyen The Cuong,Nguyen Hoai Nam,Nguyen Van Thanh,Phan Van Kiem,Chau Van Minh,김영호 한국생약학회 2015 Natural Product Sciences Vol.21 No.3
Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the spectroscopic data with those of reported values. In present study, we described the inhibitory effects of fractions and isolated compounds from K. candel on pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-a) production in lipopolysaccharide (LPS) stimulated bone marrow-derived dendritic cells (BMDCs). Results indicated that compounds 3, 6, and 7 showed potent inhibition on IL-6 production (IC50 values at less than 0.5 mM, respectively). Meanwhile, compounds 6 and 7 exhibited strong inhibitory effects on the production of TNF-a (IC50 values of 1.7 ? 0.1 and 5.5 ? 0.2 mM). Compounds 1 and 3 were also showed the inhibitory effects on IL-12 p40 production (IC50 values of 8.9 ? 0.4 and 3.3 ? 0.1 mM, respectively).
The effective model of the human Acetyl-CoA Carboxylase inhibition by aromatic-structure inhibitors
Nguyen Truong Cong Minh,Bui Tho Thanh,Le Xuan Truong,Nguyen Thi Bang Suong,Le Thi Xuan Thao 한국전기전자학회 2017 전기전자학회논문지 Vol.21 No.3
The research investigates the inhibition of fatty acid biosynthesis of the human Acetyl-CoA Carboxylase enzyme by the aromatic-structure inhibitors (also known as ligands) containing variables of substituents, contributing an important role in the treatment of fatty-acid metabolic syndrome expressed by the group of cardiovascular risk factors increasing the incidence of coronary heart disease and type-2 diabetes. The effective interoperability between ligand and enzyme is characterized by a 50% concentration of enzyme inhibitor (IC50) which was determined by experiment, and the factor of geometry structure of the ligands which are modeled by quantum mechanical methods using HyperChem 8.0.10 and Gaussian 09W softwares, combining with the calculation of quantum chemical and chemico-physical structural parameters using HyperChem 8.0.10 and Padel Descriptor 2.21 softwares. The result data are processed with the combination of classical statistical methods and modern bioinformatics methods using the statistical softwares of Department of Pharmaceutical Technology – Jadavpur University – India and R v3.3.1 software in order to accomplish a model of the quantitative structure - activity relationship between aromatic-structure ligands inhibiting fatty acid biosynthesis of the human Acetyl-CoA Carboxylase.
Rapid Determination of Ethyl Alcohol in Alcoholic Beverages Using a Fluorescent Nanofiber Film
Nguyen Le Thao Nguyen,백승훈,Zico Alaia Akbar,장성연,하시영,박종필,박태정 한국바이오칩학회 2018 BioChip Journal Vol.12 No.3
Electrospinning has been recognized as a simple, versatile, and viable technique to fabricate ultrathin nanofibers from various materials, e.g., polymers and composites, in aqueous solutions. In this study, we used polyvinyl alcohol (PVA) as a substrate to synthesize nanofibers by using an electric field between the syringe needle and PVA. The nanofibers demonstrate an immense potential for developing fluorescent detection system of ethyl alcohol from several types of beverages due to their special characteristics of a simple, albeit useful, and effective top-down fabrication process. The development of nanofibers, a fundamental understanding of electrospinning, and properties of the nanofibers, as well as their applications to determine the alcohol content in beverages by direct injection into the fiber surface, were described. This method was accomplished using a PVA nanofiber scaffold as the immobilized sensing film in samples of wine, beer, or some alcohol beverages. Various beverages were tested, which were found to contain low alcohol concentrations. The optical properties of nanofibers in an aqueous PVA solution were observed by fluorescence spectra. The PVA nanofiber films could be useful for detecting the alcohol upto 1.0vol% in a real sample within several seconds. Details of the type of electrospun fibers, and their characteristics were also explained. This study should serve as a guiding tool for nanoscience researchers in fibers, textiles, food validations, and polymer fields.
Thao Nguyen, Nguyen Le,Park, Chan Yeong,Park, Jong Pil,Kailasa, Suresh Kumar,Park, Tae Jung The Royal Society of Chemistry 2018 New journal of chemistry Vol.42 No.14
<P>The use of the synergistic molecular assembly of an aptamer and cetyltrimethylammonium bromide (CTAB) on gold nanoparticles (AuNPs) is described for the selective and sensitive colorimetric recognition of As<SUP>3+</SUP> ions in water samples. The As<SUP>3+</SUP> ions coordinate with Ars-3 aptamer-AuNPs, causing aggregation in the presence of CTAB, which induces a red-shift in the surface plasmon resonance (SPR) band and a visual change in the color. The aptamer has shown a strong tendency to bind with As<SUP>3+</SUP> ions using CTAB as a binder, exhibiting good linearity between the absorption ratio (<I>A</I>650/<I>A</I>520) and the concentration of As<SUP>3+</SUP> ions (1.0-100 ppb) with a detection limit of 16.9 ppb. In contrast, other chemical species (metal ions and anions) did not induce these changes at all, and thus the aptasensor is highly specific for As<SUP>3+</SUP> ion sensing. The spectroscopic and TEM results show high selectivity for As<SUP>3+</SUP> ion sensing and the assay is completed within 30 min. The aptamer-AuNP-based colorimetric method illustrates the potential utility for screening As<SUP>3+</SUP> ion levels in real samples. The developed aptasensor was successfully applied for the detection of As<SUP>3+</SUP> ions in water and cosmetic samples, signifying its remarkable application for As<SUP>3+</SUP> ion sensing in real samples.</P>
Thao Tram Le Nguyen,Xuan Loc Vu Doan,Vy Thuc Nguyen 아시아심장혈관영상의학회 2021 Cardiovascular Imaging Asia Vol.5 No.3
In the published article, “Anomalous Left Coronary Artery from the Pulmonary Artery Syndrome: A Case Report in a 49-Year-Old Woman”, the affiliation was published incorrectly. 1Diagnostic Imaging Department, Vinmec Nha Trang International Hospital, Nha Trang, Vietnam The affiliation should be corrected as follows. Changes are marked by underlines: 1Diagnostic Imaging Department, Vinmec Nha Trang International Hospital, Vinmec Healthcare System, Nha Trang, Vietnam