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- 저자 : Nevine (검색결과 39 건)
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Prognostic Significance of CD24 Expression in Gastric Carcinoma
Nevine S. Darwish,Min A Kim,Mee Soo Chang,Byung Lan Lee,Woo Ho Kim,이혜승,Yong Il Kim 대한암학회 2004 Cancer Research and Treatment Vol.36 No.5
Purpose: The human CD24 antigen is a small heavily glycosylated cell surface protein, which is expressed in hematological malignancies, as well as in a large variety of solid tumors. Its expression is now known to be related to the prognosis of several kinds of tumors. This study is designed to examine the prognostic significance of CD24 in Korean gastric cancer patients. Materials and Methods: In the present study, we examined CD24 expression in 300 consecutive cases of gastric carcinoma by immunohistochemical staining using the tissue-array method. We also investigated the clinicopathological profiles related to CD24 expression. Results: One hundred and three cases out of 300 (34.3%) showed the positive expression of CD24. The altered expression of CD24 was significantly associated with differentiated cancer (p=0.003), the intestinal subtype according to the Lauren classification (p〈0.001), the advanced stage cancer (p=0.027), with lymphatic invasion (p=0.038) and with vascular invasion (p=0.006). The survival analysis revealed that the patients with CD24 positive expression showed significantly poorer survival than those without CD24 expression. Moreover, a combined evaluation revealed that PTEN /CD24 cases showed the best survival compared to other groups (p=0.01). Conclusion: Positive CD24 expression occurs in a subset of gastric carcinomas and it correlates significantly with lymphatic invasion, blood vessel invasion and poor survival. (Cancer Res Treat. 2004;36:298-302)
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Prognostic Value of Prepro-Gastrin Releasing Peptide in Lung Cancer Patients; NCI-Prospective Study
Shafik, Nevine F,Rahoma, M,Elshimy, Reham AA,El kasem, Fatma M Abou Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Background: Prior series investigated the expression of prepro-gastrin releasing peptide (prepro-GRP) in the peripheral blood of lung cancer patients. Our aim was to assess any prepro-GRP role as a prognostic factor for small cell lung cancer (SCLC) and NSCLC and correlations with clinical presentation and treatment outcome. Methods: A prospective study was conducted during the time period from the beginning of January 2012 till the end of January 2014. Prepro-GRP expression was analysed using a nested RT-PCR assay in peripheral blood of 62 untreated lung cancer patients attending the National Cancer Institute (NCI), Cairo University, and 30 age and sex matched healthy volunteers. Results: Among the 62 lung cancer cases, there were 24 (38.7%) SCLC, and 38 (61.3%) NSCLC (10 squamous cell carcinomas, 12 adenocarcinomas, 11 large cell carcinomas, 4 undifferentiated carcinomas, and 1 adenosquamous carcinoma). Twenty six patients (41.9%) were prepro-GRP positive. Prepro-GRP expression was higher (58.3%) among SCLC patients compared to NSCLC (squamous cell carcinoma (15.4%), large cell carcinoma (36.4%), and adenocarcinoma (25%)). Mean OS among prepro-GRP negative cases was longer than that among preprogastrin positive cases (17.6 vs 14.9 months). The mean PFS durations among preprogastrin negative versus positive cases were 7.7 vs 4.6 months (p= 0.041). No difference in response to chemotherapy was identified between the groups (p=0.983). Conclusion: Prepro-GRP is suggested to be a useful prognostic marker for lung cancer patients, especially with the fast- growing, bad prognostic SCLC type. More studies should aim at detailed understanding of the mechanisms of prepro-GRP action and its use in monitoring the response to treatment in a larger cohort.
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Fayek, Ihab Samy,Kamel, Ahmed Ahmed,Sidhom, Nevine FH Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Purpose: To study the safety of prophylactic level VII nodal dissection regarding hypoparathyroidism (temporary and permanent) and vocal cord dysfunction (temporary and permanent) and its impact on disease free survival. Materials and Methods: This prospective study concerned 63 patients with papillary thyroid carcinoma with N0 neck node involvement (clinically and radiologically) in the period from December 2009 to May 2013. All patients underwent total thyroidectomy and prophylactic central neck dissection including levels VI and VII lymph nodes in group A (31 patients) and level VI only in group B (32 patients). The thyroid gland, level VI and level VII lymph nodes were each examined histopathologically separately for tumor size, multicentricity, bilaterality, extrathyroidal extension, number of dissected LNs and metastatic LNs. Follow-up of both groups, regarding hypoparathyroidism, vocal cord dysfunction and DFS, ranged from 6-61 months. Results: The mean age was 34.8 and 34.3, female predominance in both groups with F: M 24:7 and 27:5 in groups A and B, respectively. Mean tumor size was 12.6 and 14.7mm. No statistical differences were found between both groups regarding age, sex, bilaterality, multicentricity or extrathyroidal extension. The mean no. of dissected level VI LNs was 5.06 and 4.72 and mean no. of metastatic level VI was 1 and 0.84 in groups A and B, respectively. The mean no. of dissected level VII LNs was 2.16 and mean no. of metastatic LNs was 0.48. Postoperatively temporary hypoparathyroidism was detected in 10 and 7 patients and permanent hypoparathyroidism in 2 and 3 patients; temporary vocal cord dysfunction was detected in 4 patients and one patient, and permanent vocal cord dysfunction in one and 2 patients in groups A and B, respectively. No significant statistical differences were noted between the 2 groups regarding hypoparathyroidism (P=0.535) or vocal cord dysfunction (P=0.956). The number of dissected LNs at level VI only significantly affected the occurrence of hypoparathyroidism (<0.001) and vocal cord dysfunction (<0.001).The DFS was significantly affected by bilaterality, multicentricity and extrathyroidal extension. Conclusions: Level VII nodal dissection is a safe procedure complementary to level VI nodal dissection with prophylactic central neck dissection for papillary thyroid carcinoma.
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El-Gayar, Dina,El-Abd, Nevine,Hassan, Noha,Ali, Reem Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Background: Cell-free DNA circulating in blood is a candidate biomarker for malignant tumors. Unlike uniformly truncated DNA released from apoptotic non diseased cells, DNA released from necrotic cancer cells varies in size. Objectives: To measure the DNA integrity index in serum and the absolute DNA concentration to assess their clinical utility as potential serum biomarkers for colorectal carcinoma (CRC) compared to CEA and CA19-9. Materials and Methods: Fifty patients with CRC, 10 with benign colonic polyps and 20 healthy sex and age matched volunteers, were investigated by real time PCR of ALU repeats (ALU q-PCR) using two sets of primers (115 and 247 bp) amplifying different lengths of DNA fragments. The DNA integrity index was calculated as the ratio of q-PCR results of ALU 247/ALU 115bp. Results: Serum DNA integrity was statistically significantly higher in CRC patients compared to the benign and control groups (p<0.001). ROC curves for differentiating CRC patients from normal controls and benign groups had areas under curves of 0.90 and 0.85 respectively. Conclusions: The DNA integrity index is superior to the absolute DNA concentration as a potential serum biomarker for screening and diagnosis of CRC. It may also serve as an indicator for monitoring the progression of CRC patients. Combining CEA and CA19-9 with either of the genetic markers studied is better than either of them alone.
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( Hoda El Aggan ),( Sabah Mahmoud ),( Nevine El Deeb ),( Amany Elyamany ),( Manar Attia ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatitis C virus (HCV) is a major risk of hepatocellular carcinoma (HCC), however, the molecular mechanism of HCV-related hepatocarcinogenesis is still unclear. The polycistronic microRNA (miR)-17~92 cluster, designated also as “OncomiR-1”, plays a role in tumorigenesis and is transactivated by c-MYC oncogene. The cluster negatively regulates phosphatase and tensin homolog (PTEN) and activates nuclear factor-kappa B (NF-κB). The present study was designed to evaluate plasma levels of miR-17 host gene (MIR17HG) protein, encoded by miR-17~92 cluster host gene, in patients with HCV-related HCC in relation to tumor c-MYC, PTEN and NF-κB expression. Methods: Forty five patients with chronic HCV infection [18 patients with chronic hepatitis C (CHC), 12 patients with cirrhosis and 18 patients with HCC] and 15 healthy subjects were enrolled in the study. The HCC stage was determined according to the Barcelona Clinic Liver Cancer (BCLC) staging system and Cancer of the Liver Italian Program (CLIP). Quantitative measurement of plasma MIR17HG protein levels was performed using an enzyme-linked immunosorbant assay kit. The HCC histologic grade was assessed according to Edmonson and Steiner scoring system. Immunohistochemical staining of liver specimens was done using anti-human antibodies against c-MYC, PTEN and NF-kB and was scored semiquatitatively. Results: Plasma MIR17HG protein levels showed significant increases in CHC and cirrhotic patients with and without HCC compared with healthy subjects and in patients with HCC compared with those without HCC (P < 0.001). By plotting ROC curve, the sensitivity and specificity of plasma MIR17HG protein levels in detecting HCC were 100% and 93.3% respectively at a cut-off level of 257.25 pg/ml [AUC = 0.996]. The HCC tissues showed a significant increase in c-MYC, and NF-kB expression and a significant decrease in PTEN expression compared with CHC, cirrhotic and surrounding non-neoplastic liver tissues (P < 0.05). The plasma MIR17HG protein levels were positively correlated with tumor size (P = 0.001), stage (P = 0.001) and HCC histological grade (P = 0.002) and c-MYC (P = 0.001) and NF-kB expression (P = 0.015) and were inversely correlated with PTEN expression (P = 0.001). Conclusions: Activation of miR-17~92 cluster induced by c-MYC may play an important role in the development and progression of HCV-related HCC, possibly, through inhibition of PTEN and activation of NF-kB and could provide a potential therapeutic target for HCC. Circulating MIR17HG protein could be a useful non-invasive biomarker for the detection of HCC in chronic HCV infection.
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Nevin Gamze Karsli,Okan Gul,Taner Yilmaz 한국섬유공학회 2022 Fibers and polymers Vol.23 No.4
This study aims to investigate the effect of graphene nanoplatelet (GNP) and terpolymer addition on themechanical, adhesive wear and thermal properties of carbon fiber (CF) reinforced poly(phenylene sulphide) (PPS) matrixcomposites. In the composites the CF content was fixed at 10 wt.% and the terpolymer content at 2 wt.%, while the GNPcontent was changed to 0.1, 0.3 and 0.5 wt.%. Physical properties of composites were evaluated by using tensile test,adhesive wear test, differential scanning calorimeter analysis and scanning electron microscopy analysis. As a result, it wasconcluded that the simultaneously addition of both 0.5 wt.% GNP and 2 wt.% terpolymer to CF reinforced compositesimproved the mechanical and tribological properties of composites. Thus, a solution has been developed to increase theefficiency of use of high performance composite materials produced for use in areas requiring good mechanical andtribological performance such as the aerospace and automotive industries.
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