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Highly Sweet Compounds of Plant Origin
Nam-CheolKim,A.DouglasKinghorn 대한약학회 2002 Archives of Pharmacal Research Vol.25 No.6
The demand for new alternative “low calorie” sweeteners for dietetic and diabetic purposes has increased worldwide. Although the currently developed and commercially used highly sweet sucrose substitutes are mostly synthetic compounds, the search for such compounds from natural sources is continuing. As of mid-2002, over 100 plant-derived sweet compounds of 20 major structural types had been reported, and were isolated from more than 25 different families of green plants. Several of these highly sweet natural products are marketed as sweeteners or flavoring agents in some countries as pure compounds, compound mixtures, or refined extracts. These highly sweet natural substances are reviewed herein.
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Nam Ah Kim,Jing Hui Jin,Kyung-Hee Kim,Dae Gon Lim,Heesun Cheong,Yun Hwan Kim,Woong Ju,SEUNG-CHEOLKIM,Seong Hoon Jeong 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.5
Ovarian cancer is recognized with high mortalitydue to asymptomatic nature of the disease and difficultiesin diagnosing early stage of the cancer. The presentstudy evaluates the use of differential scanning calorimetry(DSC) in differentiating the severity of ovarian cancer fromhealthy women. 47 diseased women were subdivided intofour stages with respect to clinical relevance and severity. Stages I–II were regarded as early stages and stages III–IVwere regarded as advanced stages. The two average transitiontemperatures (Tm) increased with disease severityfrom 64.84 and 70.32 C (healthy) to 68.46 and 75.24 C(stage IV), respectively. Tm were increased depending onclinical groups. In addition, the change in heat capacity wasalso dependent on the disease severity. To further supportand investigate the nature of the proposed interactions,matrix assisted laser desorption/ionization time-of-flightmass spectrometry (MALDI-TOF MS) analysis isemployed. The results suggest the differences in peptideexpression between early and advanced stage of ovariancancer, affected abundant proteins in plasma. The combinedDSC and MS approach was supportive in identifyinga unique signature of ovarian cancer stages, anddemonstrates the potential of DSC as a complementarydiagnostic tool in the evaluation of early stage ovariancancer.
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Chae-Wong Lim,Seajin Han,Bumseok Kim,Umanets Alexander,Young-Ran Lee,박태건,박겸준,Doo Nam Kim,손호선,Du- Hae An,Hyeon-CheolKIM,Cheolho Sim,SI-Yun Ryu,Bae-Keun PARK 한국임상수의학회 2016 한국임상수의학회지 Vol.33 No.3
The trematodes of Genus Nasitrema are the most common infection in the heads of small odontocetes. Five species of Nasitrema have been described in Asia. But those parasites has been not surveyed in the East Sea of Korean peninsula. There are no evidence of pathology associated with Nasitrema attenuate. To determine the infection ratio of N. attenuata in the dolphin, it was surveyed 9 long-beaked common dolphin, Delphinus capensis, caught incidentally from Samcheok to Pohang, East Sea, Korea. Five males and four females, estimated to be between 1 to 10 years old, were examined. The quantity of N. attenuata harvested by aspiration from pterygoid sinuses ranged from 10 to 100 with a 100% (9/9) infection with older dolphins exhibiting higher parasite counts. The body of trematoda was elongated with tegumental patches resembling the leaves of lilies and oral sucker located ventrally at the anterior terminal. Esophagus was absent and intestinal bifurcation arose immediately from the posterior of pharynx. The undulated intestinal caeca transversed the entire body and terminated at the posterior extremity of the worm. The genital pore opened anterior to the ventral sucker. This report confirms the prevalence and morphology of N. attenuata in the dolphins from the East Sea, Korea.
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