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Development and prognosis of hepatocellular carcinoma in patients with diabetes
Takuma Nakatsuka,Ryosuke Tateishi 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.1
The incidence of diabetes mellitus and hepatocellular carcinoma (HCC) has been increasing worldwide during the last few decades, in the context of an increasing prevalence of obesity and non-alcoholic fatty liver disease (NAFLD). Epidemiologic studies have revealed that patients with diabetes have a 2- to 3-fold increased risk of developing HCC, independent of the severity and cause of the underlying liver disease. A bidirectional relationship exists between diabetes and liver disease: advanced liver disease promotes the onset of diabetes, and HCC is an important cause of death in patients with diabetes; conversely, diabetes is a risk factor for liver fibrosis progression and HCC development, and may worsen the long-term prognosis of patients with HCC. The existence of close interconnections among diabetes, obesity, and NAFLD causes insulin resistance-related hyperinsulinemia, increased oxidative stress, and chronic inflammation, which are assumed to be the underlying causes of hepatocarcinogenesis in patients with diabetes. No appropriate surveillance methods for HCC development in patients with diabetes have been established, and liver diseases, including HCC, are often overlooked as complications of diabetes. Although some antidiabetic drugs are expected to prevent HCC development, further research on the optimal use of antidiabetic drugs aimed at hepatoprotection is warranted. Given the increasing medical and socioeconomic impact of diabetes on HCC development, diabetologists and hepatologists need to work together to develop strategies to address this emerging health issue. This article reviews the current knowledge on the impact of diabetes on the development and progression of HCC.
Keiko Nakatsuka(中塚圭子) 동북아시아문화학회 2013 동북아 문화연구 Vol.1 No.35
In Yuzawa in Akita, there is a festival called the Innuko Matsuri where 16,000 people and 500 pet dogs gather together.As far as I know, there is no other example of a traditional event where a large group of dogs gather together like at the Innuko Matsuri. At this festival, there are a many people and dogs in one place. Despite this the festival continues to this day without any major incidents. The aim of this research is to explain why the Innuko Matsuri became a place of coexistance between man and dog by researching the culture of coexistence between people and their pet dogs in Yuzawa, Akita. In conclusion, firstly, it has become clear that following points are reasons behind why the Inukko Matsuri became a place of coexistence between man and dog. There were wolves living in Yuzawa in Akita. There is a culture of a hunting represented by the Matagi. Yuzawa, Akita is where Akita dogs come from. Also, as the people of Yuzawa, Akita, have this kind of background, their natural existence is to have a sense of fear, religion, partnership and family. At the Inukko Matsuri that is held there, while respecting the nature of dogs or participants, both people and dogs work to find the place where they feel comfortable. At this time, at the Innuko Matsuri, divided times and divided spaces become a divided coexistence at the festival grounds. It is clear that a comfortable space of coexistence is made by dogs, their owners and festival participants.
The study of essential factors that affect mandibular dental arch forms by cluster analysis
Michiko Nakatsuka,Chizuko Inui-Yamamoto,주성숙,김지연,박영석,Shunji Kumabe,Katsura Ueda,Chun-Ying An,Aiko Morishita,신제원,Yasutomo Iwai 대한구강해부학회 2013 대한구강해부학회지 Vol.34 No.1
To elucidate dent al arch morphological characters in young Japanese adolescents. we studied morphological and dimensional characteristics of the dental arch forms in 396 sets of dental stone study models (age: 18-26: ma le: 257. female: 139) . 53 mandibular arches (male: 29. female: 24) in the diagnostic casts of normal dentition and occ1usion were selected and evaluated. We determined midpoints of the incisal ridge of the incisors (Ih. Ih. 12R & 12d. cusp tips of the canines (CR & Cd. summits of buccal cusps of the premolars (Ph. Ph. P2R & P2d. summits of mesiobuccal cusps of the molars (Mh. Mh. M2R & M2d and the midpoint A of line (Ih-Ih) . Point B was defined as the intersection of the vertical line from point A with the line (M2R-M2L). Point E was the intersection of (A-B) with (CR-Cd. The midpoint of line (M2R-M2L : original line) is defined as point O. We examined the mandibular arch forms by estimation of length. angles and the transition of anterior and buccal segments which were represented by items developed from the reference points and lines . The obtained data were studied using a hierarchical c1uster analytic approach: the factor loading of principal components in the c1usters O.e.. pt’ 2nd and 3rd c1usters) were further evaluated By the analyses. we observed significant differences in each c1uster.especially of the arch length. protrusion of canines. degree of curvature of anterior teeth segment and the degree of roundness of the mandibular dental arches. Arch length of the 3rd cluster was longer than that of the other clusters . In addition. we noticed that width differences of the dental arch and anterior segment were useful to distingui sh between the 1st and 2nd clusters . The study concludes that the mandibular dental arch form consisted of essential components of arch length. arch width and the curvature of anterior teeth. Besides. we can effectively divide the mandibular arch form into clusters by dental arch length and width.
Recent topics on the engineering for solid-state peak-power lasers in repetitive operation
Masahiro Nakatsuka,Hidetsugu Yoshida,Hisanori Fujita,Kana Fujioka,Yasushi Fujimoto,Yasushi Fujimoto 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.43 No.42
Solid-state lasers have been developed for peak-power operation in the terawatt to petawatt regions by using chirped pulse amplication (CPA) and optical parametric (OPCPA) technology. Also thermal distortion-free, 10-nsec repetitive peak-power lasers have been developed. Broadband amplication of a solid-state laser is a key issue for the pre-amplication stage of CPA system, and the OPA scheme gives a high gain with a very low pre-pulse level while keeping a 5-nm bandwidth. On the other hand, nonlinear optical technology using stimulated Brillouin scattering (SBS) is promising as a way to compensate for thermal diculties caused in strongly pumped laser materials. SBS is well known for the phase conjugation mirror (PCM) used for an average power output with a high re ectivity of over 95 %. A liquid uorocarbon with a special treatment can be used to achieve a 10-ns duration, 50-Hz repetition laser delivering 0.4-GW peak power, with a 200-W average power. A liquid ow system in an SBS cell can be used to realize PCM behavior up to the kW range. The last theme in this paper is a short review of new ceramic materials for a scalable solid-state laser. In past ten years, Japanese researchers have investigated new transparent ceramic YAG materials for industrial application. The ceramics have many advantages for an average power laser, such as high doping rate, co-doping potential, large-size fabrication, and composite structure.