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Nagatsuka, H,Murata, M,Shin, H.I,Choi, K.S,Nagai, N 경북대학교 의학연구소 1999 경북대학교병원의학연구소논문집 Vol.3 No.1
Verruciform xanthoma is an uncommon beniㅎn lesion of unknown aetiology and pathogenesis. Two cases of verruciform xanthoma are presented together with an immunohistochemical and ultra-structural study. One case co-occurred with an odontogenic keratocyst which, to our knowledge, has not been previously reported and another case occurred on masticatory mucosa with an asympto-matic, granular exophytic lesion causing a cleft-like gingival recession. In an immunohistochemical study using antibodies to macrophage (CD 68[KP1]), alpha-1-antitrypsin, vimentin, desmin, keratin, neuron-specific enolase (NSE) and S-100 protein, the characteristic foam cells of verruciform xanthoma showed strong positive staining far CD 68[KPl] and vimentin and weak positive staining for a1pha-1-antitrypsin, while the other antibodies were negative. As in previous studies, S-100 protein positive dendritic cells were detected in lesional connective tissue. In addition, the ultrastructural findings revealed characteristics of macrophages containing varying sized lipid vacuoles and degen-erating epithelial cells. These findings suppotr the concepts that the foam cells in verruciform xan-thoma are of monocyte-macrophage lineage and that the epithelial degeneration from uncertain causes may be related to the pathogenesis of the lesion. ⓒ1997 Elsevier Science Ltd
Hayashi Nanako,Nagatsuka Haruna,Sato Mikako,Kazushige Goto 한국운동영양학회 2023 Physical Activity and Nutrition (Phys Act Nutr) Vol.27 No.2
[Purpose] Exercise-induced hemolysis, which is caused by metabolic and/or mechanical stress during exercise, is considered a potential factor for upregulating hepcidin. Intramuscular carnosine has multiple effects including antioxidant activity. Therefore, this study aimed to determine whether long-term carnosine/ anserine supplementation modulates exercise-induced hemolysis and subsequent hepcidin elevation. [Methods] Seventeen healthy male participants were allocated to two different groups: participants consuming 1,500 mg/day of carnosine/anserine supplements (n = 9, C+A group) and participants consuming placebo powder supplements (n = 8, PLA group). The participants consumed carnosine/anserine or placebo supplements daily for 30.7 ± 0.4 days. They performed an 80-running session at 70% V4 O pre-and 2peak post-supplementation. Iron regulation and inflammation in response to exercise were evaluated. [Results] Serum iron concentrations significantly increased after exercise (p < 0.01) and serum haptoglobin concentrations decreased after exercise in both groups (p < 0.01). No significant differences in these variables were observed between pre-and post-supplementation. Serum hepcidin concentration significantly increased 180 min after exercise in both groups (p < 0.01). The integrated area under the curve of hepcidin significantly decreased after supplementation (p = 0.011) but did not vary between the C+A and PLA groups. [Conclusion] Long-term carnosine/anserine supplementation does not affect iron metabolism after a single endurance exercise session.
Factors Associated with Early Hospital Arrival in Patients with Acute Ischemic Stroke
Song, Dongbeom,Tanaka, Eijirou,Lee, Kijeong,Sato, Shoichiro,Koga, Masatoshi,Kim, Young Dae,Nagatsuka, Kazuyuki,Toyoda, Kazunori,Heo, Ji Hoe Korean Stroke Society 2015 Journal of stroke Vol.17 No.2
<P><B>Background and Purpose</B></P><P>Factors associated with early arrival may vary according to the characteristics of the hospital. We investigated the factors associated with early hospital arrival in two different stroke centers located in Korea and Japan.</P><P><B>Methods</B></P><P>Consecutive patients with ischemic stroke arrived hospital within 48 hours of onset between January 2011 and December 2012 were identified and the clinical and time variables were retrieved from the prospective stroke registries of Severance Hospital of Yonsei University Health System (YUHS; Seoul, Korea) and National Cerebral and Cardiovascular Center (NCVC; Osaka, Japan). Subjects were dichotomized into early (time from onset to arrival ≤4.5 hours) and late (>4.5 hours) arrival groups. Univariate and multivariate analyses were performed to evaluate factors associated with early hospital arrival.</P><P><B>Results</B></P><P>A total of 1,966 subjects (992 from YUHS; 974 from NCVC) were included in this study. The median time from onset to arrival was 6.1 hours [interquartile range, 1.7-17.8 hours]. In multivariate analysis, the factors associated with early arrival were atrial fibrillation (Odds ratio [OR], 1.505; 95% confidence interval [CI], [1.168-1.939]), higher initial National Institute of Health Stroke Scale scores (OR, 1.037; 95% CI [1.023-1.051]), onset during daytime (OR, 2.799; 95% CI [2.173-3.605]), and transport by an emergency medical service (OR, 2.127; 95% CI [1.700-2.661]). These factors were consistently associated with early arrival in both hospitals.</P><P><B>Conclusions</B></P><P>Despite differences between the hospitals, there were common factors related to early arrival. Efforts to identify and modify these factors may promote early hospital arrival and improve stroke outcome.</P>
Yi, SoJeong,An, Hyungmi,Lee, Howard,Lee, Sangin,Ieiri, Ichiro,Lee, Youngjo,Cho, Joo-Youn,Hirota, Takeshi,Fukae, Masato,Yoshida, Kenji,Nagatsuka, Shinichiro,Kimura, Miyuki,Irie, Shin,Sugiyama, Yuichi,S Wolters Kluwer Health | Lippincott Williams Wilkin 2014 PHARMACOGENETICS AND GENOMICS Vol.24 No.10
BACKGROUND: Interethnic differences in genetic polymorphism in genes encoding drug-metabolizing enzymes and transporters are one of the major factors that cause ethnic differences in drug response. This study aimed to investigate genetic polymorphisms in genes involved in drug metabolism, transport, and excretion among Korean, Japanese, and Chinese populations, the three major East Asian ethnic groups. METHODS: The frequencies of 1936 variants representing 225 genes encoding drug-metabolizing enzymes and transporters were determined from 786 healthy participants (448 Korean, 208 Japanese, and 130 Chinese) using the Affymetrix Drug-Metabolizing Enzymes and Transporters Plus microarray. To compare allele or genotype frequencies in the high-dimensional data among the three East Asian ethnic groups, multiple testing, principal component analysis (PCA), and regularized multinomial logit model through least absolute shrinkage and selection operator were used. RESULTS: On microarray analysis, 1071 of 1936 variants (>50% of markers) were found to be monomorphic. In a large number of genetic variants, the fixation index and Pearson’s correlation coefficient of minor allele frequencies were less than 0.034 and greater than 0.95, respectively, among the three ethnic groups. PCA identified 47 genetic variants with multiple testing, but was unable to discriminate ethnic groups by the first three components. Multinomial least absolute shrinkage and selection operator analysis identified 269 genetic variants that showed different frequencies among the three ethnic groups. However, none of those variants distinguished between the three ethnic groups during subsequent PCA. CONCLUSION: Korean, Japanese, and Chinese populations are not pharmacogenetically distant from one another, at least with regard to drug disposition, metabolism, and elimination.