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- 저자 : Mulan Qin (검색결과 3 건)
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Studies on Residue Stress and Deformation Behavior of GCr15 Subjected to Whirlwind Milling
Qin Guo,Youfeng Xu,Mulan Wang,Wenliang Yang,Yuliln Wang 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.8
Whirlwind milling is gaining extensive application for processing a large screw. Due to its specific forming principle, the profile of residual stresses and the deformation behavior would been given significant emphasis. Under conditions of large cutting depth (0.06–0.12 mm), the effect of cutting parameters on three characteristic parameters of the residual stress, such as surface residual stress, maximum residual stress and residual stress extreme value, was always different from that under small cutting depth (6–10 μm). Comparing to the right arc of the screw, the plastic deformation in the left arc is more obvious and far-reaching. The most extensive deformation region caused by WM cutting force was found for the topmost surface. As cutting speed increased, the nanohardness variation reflected the decreasing plastic deformation. Therefore, the research on physical change by WM is instructive for extending the fatigue life of the screw.
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( Mulan Wei ),( Xujie Liu ),( Chunyu Cao ),( Jianlin Yang ),( Yafeng Lv ),( Jiaojiao Huang ),( Yanlin Wang ),( Ye Qin ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.11
Recent studies showed that the PD-1/PD-L1 checkpoint blockade is a dramatic therapy for melanoma by enhancing antitumor immune activity. Currently, major strategies for the PD-1/PD-L1 blockade have mainly focused on the use of antibodies and compounds. Seeking an alternative approach, others employ endogenous proteins as blocking agents. The extracellular domain of PD-1 (ePD1) includes the binding site with PD-L1. Accordingly, we constructed a PD-1-based recombinantly tailored fusion protein (dFv-ePD1) that consists of bivalent variable fragments (dFv) of an MMP-2/9-targeted antibody and ePD1. The melanoma-binding intensity and antitumor activity were also investigated. We found the intense and selective binding capability of the protein dFv-ePD1 to human melanoma specimens was confirmed by a tissue microarray. In addition, dFv-ePD1 significantly suppressed the migration and invasion of mouse melanoma B16-F1 cells, and displayed cytotoxicity to cancer cells in vitro. Notably, dFv-ePD1 significantly inhibited the growth of mouse melanoma B16-F1 tumor cells in mice and in vivo fluorescence imaging showed that dFv-ePD was gradually accumulated into the B16-F1 tumor. Also the B16-F1 tumor fluorescence intensity at the tumor site was stronger than that of dFv. This study indicates that the recombinant protein dFv-ePD1 has an intensive melanoma-binding capability and exerts potent therapeutic efficacy against melanoma. The novel format of the PD-L1-blocked agent may play an active role in antitumor immunotherapy. [BMB Reports 2018; 51(11): 572-577]
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Shuquan Liang,Mulan Qin,Yan Tang,Qing Zhang,Xilin Li,Anqiang Pan 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.5
Nanosheet-structured vanadium pentoxide (V2O5) has been fabricated by a sol-gel method. As revealed bythe TEM, the as-synthesized V2O5 crystallites are composed of layer-by-layer stacked nanosheets. As acathode material for lithium batteries, it exhibits much better electrochemical performance than the startingcommercial V2O5 powders. A high specific discharge capacity of 264 mA h g-1 can be obtained for thenanosheet-structured electrodes, which retains the capacity of 90% after 50 cycles. However, the commercialV2O5 only delivers a specific discharge capacity of 206 mA h g-1 with a capacity retention of 64%after 50 cycles. Moreover, the nanosheet-structured V2O5 electrodes show much-improved C-rate capability. The superior cycling performance demonstrates that the nanosheet-structured V2O5 is a promising cathodematerial in lithium-ion battery applications.
ScienceON
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