http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Insights into phytase-containing transgenic Lemna minor (L.) as a novel feed additive
Ghosh, Mrinmoy,Sharma, Neelesh,Gera, Meeta,Kim, Nameun,Huynh, Do,Zhang, Jiaojiao,Min, Taesun,Sodhi, Simrinder Singh,Kim, Min Bae,Rekha, V. P. B.,Ko, Sukmin,Jeong, Dong Kee Springer-Verlag 2018 Transgenic research Vol.27 No.2
Rekha, V. P. B.,Ghosh, Mrinmoy,Adapa, Vijayanand,Oh, Sung-Jong,Pulicherla, K. K.,Sambasiva Rao, K. R. S. Hindawi Publishing Corporation 2013 BioMed research international Vol.2013 No.-
<P>The present study deals with the production of cold active polygalacturonase (PGase) by submerged fermentation using <I>Thalassospira frigidphilosprofundus</I>, a novel species isolated from deep waters of Bay of Bengal. Nonlinear models were applied to optimize the medium components for enhanced production of PGase. Taguchi orthogonal array design was adopted to evaluate the factors influencing the yield of PGase, followed by the central composite design (CCD) of response surface methodology (RSM) to identify the optimum concentrations of the key factors responsible for PGase production. Data obtained from the above mentioned statistical experimental design was used for final optimization study by linking the artificial neural network and genetic algorithm (ANN-GA). Using ANN-GA hybrid model, the maximum PGase activity (32.54 U/mL) was achieved at the optimized concentrations of medium components. In a comparison between the optimal output of RSM and ANN-GA hybrid, the latter favored the production of PGase. In addition, the study also focused on the determination of factors responsible for pectin hydrolysis by crude pectinase extracted from <I>T. frigidphilosprofundus</I> through the central composite design. Results indicated 80% degradation of pectin in banana fiber at 20°C in 120 min, suggesting the scope of cold active PGase usage in the treatment of raw banana fibers.</P>
Mongre, Raj Kumar,Sodhi, Simrinder Singh,Ghosh, Mrinmoy,Kim, Jeong Hyun,Kim, Nameun,Sharma, Neelesh,Jeong, Dong Kee The Korean Society of Developmental Biology 2014 발생과 생식 Vol.18 No.4
Osteosarcoma (OS) is one of the most common malignant primary bone tumors and NF-${\kappa}B$ appears to play a causative role, but the mechanisms are poorly understood. OS is one of the pleomorphic, highly metastasized and invasive neoplasm which is capable to generate osteoid, osteoclast and osteoblast matrix. Its high incidence has been reported in adolescent and children. Cell signal cascade is the pivotal functional mechanism acquired during the differentiation, proliferation, growth and survival of the cells in neoplasm including OS. The major limitation to the success of chemotherapy in OS is the development of multidrug resistance (MDR). Answers to all such queries might come from the knock-in experiments in which the combined approach of miRNAs with NF-${\kappa}B$ pathway is put into use. Abnormal miRNAs can modulate several epigenetical switching as a hallmark of number of diseases via different cell signaling. Studies on miRNAs have opened up the new avenues for both the diagnosis and treatment of cancers including OS. Collectively, through the present study an attempt has been made to establish a new systematic approach for the investigation of microRNAs, bio-physiological factors and their target pairs with NF-${\kappa}B$ to ameliorate oncogenesis with the "bridge between miRNAs and NF-${\kappa}B$". The application of NF-${\kappa}B$ inhibitors in combination with miRNAs is expected to result in a more efficient killing of the cancer stem cells and a slower or less likely recurrence of cancer.
Raj Kumar Mongre,정동기,심린더 싱 소디,Mrinmoy Ghosh,김정현,김남은,니레시사르마 한국발생생물학회 2014 발생과 생식 Vol.18 No.4
Osteosarcoma (OS) is one of the most common malignant primary bone tumors and NF-κB appears to play acausative role, but the mechanisms are poorly understood. OS is one of the pleomorphic, highly metastasized and invasiveneoplasm which is capable to generate osteoid, osteoclast and osteoblast matrix. Its high incidence has been reported inadolescent and children. Cell signal cascade is the pivotal functional mechanism acquired during the differentiation,proliferation, growth and survival of the cells in neoplasm including OS. The major limitation to the success of chemotherapyin OS is the development of multidrug resistance (MDR). Answers to all such queries might come from the knock-inexperiments in which the combined approach of miRNAs with NF-κB pathway is put into use. Abnormal miRNAs canmodulate several epigenetical switching as a hallmark of number of diseases via different cell signaling. Studies on miRNAshave opened up the new avenues for both the diagnosis and treatment of cancers including OS. Collectively, through thepresent study an attempt has been made to establish a new systematic approach for the investigation of microRNAs, biophysiologicalfactors and their target pairs with NF-κB to ameliorate oncogenesis with the “bridge between miRNAs and NF-κB”. The application of NF-κB inhibitors in combination with miRNAs is expected to result in a more efficient killing of thecancer stem cells and a slower or less likely recurrence of cancer.
Raj Kumar Mongre,Simrinder Singh Sodhi,Mrinmoy Ghosh,Jeong Hyun Kim,Nameun Kim,Neelesh Sharma,Dong Kee Jeong 한국발생생물학회 2014 발생과 생식 Vol.18 No.4
Osteosarcoma (OS) is one of the most common malignant primary bone tumors and NF-κB appears to play a causative role, but the mechanisms are poorly understood. OS is one of the pleomorphic, highly metastasized and invasive neoplasm which is capable to generate osteoid, osteoclast and osteoblast matrix. Its high incidence has been reported in adolescent and children. Cell signal cascade is the pivotal functional mechanism acquired during the differentiation, proliferation, growth and survival of the cells in neoplasm including OS. The major limitation to the success of chemotherapy in OS is the development of multidrug resistance (MDR). Answers to all such queries might come from the knock-in experiments in which the combined approach of miRNAs with NF-κB pathway is put into use. Abnormal miRNAs can modulate several epigenetical switching as a hallmark of number of diseases via different cell signaling. Studies on miRNAs have opened up the new avenues for both the diagnosis and treatment of cancers including OS. Collectively, through the present study an attempt has been made to establish a new systematic approach for the investigation of microRNAs, biophysiological factors and their target pairs with NF-κB to ameliorate oncogenesis with the “bridge between miRNAs and NF- κB”. The application of NF-κB inhibitors in combination with miRNAs is expected to result in a more efficient killing of the cancer stem cells and a slower or less likely recurrence of cancer.
Huynh, Do Luong,Zhang, Jiao Jiao,Chandimali, Nisansala,Ghosh, Mrinmoy,Gera, Meeta,Kim, Nameun,Park, Yang Ho,Kwon, Taeho,Jeong, Dong Kee Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.4
<P><B>Abstract</B></P> <P>Pancreatic ductal adenocarcinoma (PDAC) is a major malignant phenotype in pancreatic cancer, which is one of the most death causes by cancer in the world. PDAC developed from pancreatic intra-epithelial neoplasms (PanINs) and poorly diagnosed at early stages. Beside of high drug resistance, metastasis is the great concern during pancreatic cancer treatment. SALL4 expression is inherent in the upregulations of endothelial mesenchymal transition (EMT) genes and therefore promoting cancer metastasis. Furthermore, some of evidences indicated reactive oxygen species (ROS) is also influent to metastasis and self-antioxidant capacity seems a gold standard for successful metastasis rate. In this study, we have found the role Spalt like protein 4 (SALL4) to PDAC proliferation, mobility and its regulation to mitochondrial ROS via FoxM1/Prx III axis. It is possible that SALL4 mainly induces endothelial-mesenchymal transition (EMT) phenotype and favors ROS loss to facilitate metastasis efficiency in PDAC cells. Therefore, SALL4 might be a promising marker for PDAC treatment and targeting SALL4 would benefit anti-proliferative and anti-metastasis therapies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SALL4 promotes stemness traits and metastatic phenotype <I>in vitro</I>. </LI> <LI> SALL4 expression positively impacts PDAC-derived tumor growth. </LI> <LI> SALL4 regulates intracellular ROS via FoxM1/Prx III by activation of ERK1/2. </LI> </UL> </P>