http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Raj Kumar Mongre,정동기,심린더 싱 소디,Mrinmoy Ghosh,김정현,김남은,니레시사르마 한국발생생물학회 2014 발생과 생식 Vol.18 No.4
Osteosarcoma (OS) is one of the most common malignant primary bone tumors and NF-κB appears to play acausative role, but the mechanisms are poorly understood. OS is one of the pleomorphic, highly metastasized and invasiveneoplasm which is capable to generate osteoid, osteoclast and osteoblast matrix. Its high incidence has been reported inadolescent and children. Cell signal cascade is the pivotal functional mechanism acquired during the differentiation,proliferation, growth and survival of the cells in neoplasm including OS. The major limitation to the success of chemotherapyin OS is the development of multidrug resistance (MDR). Answers to all such queries might come from the knock-inexperiments in which the combined approach of miRNAs with NF-κB pathway is put into use. Abnormal miRNAs canmodulate several epigenetical switching as a hallmark of number of diseases via different cell signaling. Studies on miRNAshave opened up the new avenues for both the diagnosis and treatment of cancers including OS. Collectively, through thepresent study an attempt has been made to establish a new systematic approach for the investigation of microRNAs, biophysiologicalfactors and their target pairs with NF-κB to ameliorate oncogenesis with the “bridge between miRNAs and NF-κB”. The application of NF-κB inhibitors in combination with miRNAs is expected to result in a more efficient killing of thecancer stem cells and a slower or less likely recurrence of cancer.