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HCC : Single center experience of Liver transplnatation in patients with portal vein thrombosis (초)
( Sang Hyun Song ),( Choon Hyuck David Kwon ),( Jong Man Kim ),( Mill Jae Shin ),( Hyung Hwan Moon ),( Sang Hoon Lee ),( Tae Suk Kim ),( Jae Won Joh ),( Sung Joo Kim ),( Suk Koo Lee ),( Hye Ran Yi ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)
Inexplicable but real phenomenon: rapidly regressed
( Sung Min Park ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Gun Wook Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Kaposi’s sarcoma (KS) is a type of spindle cell malignancy that arises from the vascular endothelium, usually presenting as violaceous papules and plaques. KS development is invariably linked with human herpesvirus (HHV)-8 infection. Almost spontaneous regressions of KS have been previously described in the iatrogenic type. Herein, we present a classic KS in immunocompetent patient showing rapid regression after biopsy. A 78-year-old male presented with relatively well-defined erythematous patches on forehead, Rt. upper eyelid and chin, and violaceous papule on nose. His medical and family histories were noncontributory. The patient denied history of recent overseas travel, homosexual or unnatural sexual practices, and serum anti-HIV antibody was negative. A histopathologic examination from the nose revealed typical findings of KS and tumor cells showed positive staining for CD31, CD34, and factor VIII-related antigen. Polymerase chain reaction in a biopsy specimen was positive for HHV-8. Without specific treatment, the lesion rapidly regressed within 2 weeks. It is generally accepted that immune status plays an important role for KS. As viral wart disappear after biopsy occasionally, it is possible that the biopsy may have then exposed antigens and induced an immunologic reaction, which led to the rapid regression of KS.
Fabrication of Indium Tin Oxide (ITO) Thin Film with Pre-treated Sol Coating
Sung-Jei Hong,Chan-Jae Lee,Dae-Gyu Moon,한정인,Seung-Suk Choi,Yong-Hoon Kim 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.3
A new pre-treated sol-coating method to fabricate an indium tin oxide (ITO) thin lm is introduced in this paper. The pre-treatment sol-coating method is to form a seed layer on the substrate before spin coating of ITO sol. The pre-treatment was carried out at room temperature in order not to damage the substrate during the pre-treatment. It is eective to enhance the formation of the ITO sol lm on the substrate, owing to the seed layer. The seed layer consists of ultrane grains, which are observed at the pre-treated substrate. For the optimal pre-treatment condition, we used pre-treatment times of 24, 48, 72, and 96 hours to observe the eect on the characteristics of ITO sol lm. As a result, the lowest resistance could be achieved with a pre-treatment time of 72 hours. The optical transmittance of the ITO sol lm with the pre-treatment time of 72 hours exceeded 80 % at a wavelength of 400 nm. So, an ITO sol lm with good electrical and optical properties could be fabricated by using the pretreatment sol coating. A new pre-treated sol-coating method to fabricate an indium tin oxide (ITO) thin lm is introduced in this paper. The pre-treatment sol-coating method is to form a seed layer on the substrate before spin coating of ITO sol. The pre-treatment was carried out at room temperature in order not to damage the substrate during the pre-treatment. It is eective to enhance the formation of the ITO sol lm on the substrate, owing to the seed layer. The seed layer consists of ultrane grains, which are observed at the pre-treated substrate. For the optimal pre-treatment condition, we used pre-treatment times of 24, 48, 72, and 96 hours to observe the eect on the characteristics of ITO sol lm. As a result, the lowest resistance could be achieved with a pre-treatment time of 72 hours. The optical transmittance of the ITO sol lm with the pre-treatment time of 72 hours exceeded 80 % at a wavelength of 400 nm. So, an ITO sol lm with good electrical and optical properties could be fabricated by using the pretreatment sol coating.
The use of ingenol mebutate gel as adjuvant therapy for large or multiple Bowen disease
( Sang Jin Cheon ),( Hyun Ju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Hoon Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Bowen disease (BD) is squamous cell carcinoma in situ, which may progress to invasive carcinoma if not adequately managed. In single and small BD, many therapeutic options are available including excision, curettage, cryotherapy, and topical agents such as 5-fluorouracil and imiquimod. But in the case with large or multiple lesions, therapeutic choice is restrictive. Herein, we experienced two cases of large or multiple BD successfully managed with ingenol mebutate gel. A 81-year-old woman was diagnosed as BD for large lesion on the right calf measuring 7 x 10 cm. We applied ingenol mebutate gel 0.05% on the affected area once daily for 2 consecutive days. 1 month after treatment, crust fell out and only focal small lesion was remained. After additional cryotherapy was done twice and clinically resolved large BD during follow-up 6 months.. A 54-years-old woman was diagnosed as BD for multiple hyperkeratotic plaques on the both palms. We applied ingenol mebutate gel 0.05% once daily for 2 consecutive days. After 3 months, only a few lesions were remained. Following three times additional cryotherapy, the lesions were improved enough to be controlled cryotherapy. Through our experience, we suggest ingenol mebutate gel could be effective adjuvant therapy option for large or multiple BD.
Sang-Rok Moon,Hoon-Keun Lee,Chang-Hee Lee IEEE 2013 Journal of optical communications and networking Vol.5 No.3
<P>We propose an automatic wavelength control method using Rayleigh backscattering in a feeder fiber for tunable lasers employed in a wavelength-division multiplexing passive optical network. We demonstrate two realization methods, maximizing backscattered power and maximizing the second harmonic component with wavelength modulation. We analyze their limiting factors and impacts on the system performance. We use a VCSEL as a low-cost tunable light source.</P>
Flexible metal-insulator-metal (MIM) devices for plastic film AM-LCD
Sung-Jei Hong,Chan-Jae Lee,Jeong-In Han,Won-Keun Kim,Dae-Gyu Moon,Min-Gi Kwak,Sung-Kyu Park,Yong-Hoon Kim 한국물리학회 2002 Current Applied Physics Vol.2 No.3
We developed new flexible metal–insulator–metal (MIM) devices subject to plastic film substrate. The structure of the MIM device is that a Ta2O5 insulator is covered with two flexible Al electrodes on both sides. The flexible structure of the MIM device was successfully fabricated applyingour own etch-free process. 2002 Elsevier Science B.V. All rights reserved.
Mycoplasma pneumoniae -induced rash and mucositis
( Sung Min Park ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Mycoplasma pneumoniae (M. pneumoniae)is one of the most common causes of respiratory tract infections in pediatric and adult populations worldwide. In dermatologic disorder, M. pneumoniae infection is known to be associated with erythema multiforme (EM) and Stevens-Johnson syndrome (SJS) in children and young adults. Recently, several cases with M. pneumoniae-associated mucositis with lacks typical target lesions have been reported. The term of Mycoplasma-induced rash and mucositis (MIRM) was suggested to revise from M. pneumoniae-associated mucocutaneous disease including EM and SJS because of distinct morphology, mild disease course, and potentially important clinical implications regarding treatment.Herein, we report a patient with MIRM. A 5-year-old boywas referred to the department of dermatology forerythematous maculopapuleson the face, trunk, and extremities. Physical examination revealed swollen eyelids with conjunctival injection, swollen lips, and erythematous erosive patch on the penile tip and perianal area.Histopathologic finding showed subepidermal blister with epidermal necrosis, and perivascular lymphohistiocytic infiltrations.Chest radiograph demonstrated localized infiltration in the right upper lobe, and M. pneumoniaeIgM antibodies was positive. Hewas treated with antibiotics, intravenous immunoglobulins, and showed rapid recovery within 2 weeks without any sequelae. Keyword: Mycoplasma pneumoniae, Mucositis, Rash, Stevens-Johnsons syndrome, Erythema multiforme
Sang-Hoon Kim,Shin Hwang,Gi-Won Song,Dong-Hwan Jung,Deok-Bog Moon,Jae Do Yang,Hee Chul Yu 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.1
Backgrounds/Aims: Mechanisms for the development of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected patients remain unclear. The aim of the present study was to identify genes and pathways involved in the development of HBV-associated HCC. Methods: The GSE121248 gene dataset, which included 70 HCCs and 37 adjacent liver tissues, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) in HCCs and adjacent liver tissues were identified. Gene ontology and Kyoto Encyclopedia of Genes and Genome pathway enrichment analyses were then performed. Results: Of 134 DEGs identified, 34 were up-regulated and 100 were down-regulated in HCCs. The 34 up-regulated DEGs were mainly involved in nuclear division, organelle fission, spindle and midbody formation, histone kinase activity, and p53 signaling pathway, whereas the 100 down-regulated DEGs were involved in steroid and hormone metabolism, collagen-coated extracellular matrix, oxidoreductase activity, and activity on paired donors, including incorporation or reduction of molecular oxygen, monooxygenase activity, and retinol metabolism. Analyses of protein-protein interaction networks with a high degree of connectivity identified significant modules containing 14 hub genes, including ANLN, ASPM, BUB1B, CCNB1, CDK1, CDKN3, ECT2, HMMR, NEK2, PBK, PRC1, RACGAP1, RRM2, and TOP2A, which were mainly associated with nuclear division, organelle fission, spindle formation, protein serine/threonine kinase activity, p53 signaling pathway, and cell cycle. Conclusions: This study identified key genes and carcinogenic pathways that play essential roles in the development of HBV-associated HCC. This may provide important information for the development of diagnostic and therapeutic targets for HCC.
( Sung Min Park ),( Gun Wook Kim ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Dermatologic diseases are generally managed on outpatient clinic and most of them show very low mortality. However, some severe dermatologic diseases are life- threatening. Objectives: To investigate the dermatological diseases leading to death and related factors. Methods: A retrospective study was conducted by reviewing medical records of patients who died in the dermatology ward, Pusan National University Hospital from 1998 to 2014. Patients`` demographics, their dermatologic diseases, immediate causes of death, comorbidities, and factors related death were investigated. Results: The total number of inpatients on dermatology during the study period was 3,142. Fourteen patients (6 males, and 8 females) expired while in hospital. The median age was 63.8 years (ranged 18 to 86), and the maximum number of death occurred in the age group more than 70 years old. Drug reaction was the most common underlying dermatologic disease, followed by bullous disease, generalized pustular psoriasis, dermatomyositis. Sepsis due to infection was the most common immediate cause of death. All patients had at least one comorbidities including hypertension, diabetes mellitus, kidney disease, and angina. Conclusion: Old age, comorbidities and septicemia were important factors which contributed to the mortality. Theintensive care is required during hospitalization in patients with severe dermatologic disease accompanying above risk factors.