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( Fahmy T Ali ),( Mohamed A M Ali ),( Mayada M A Elgizawy ),( Ahmed M Elsawy ) 대한소화기학회 2015 Gut and Liver Vol.9 No.4
Background/Aims: The T-helper 1 (TH1) immune reaction is essential for the eradication of hepatitis C virus (HCV) during pegylated interferon α (PEG-IFN-α)- and ribavirin (RBV)-based therapy in chronic HCV patients. Secreted phosphoprotein 1 (SPP1) was shown to be a crucial cytokine for the initiation of a TH1 immune response. We aimed to investigate whether SPP1 single nucleotide polymorphisms (SNPs) may influence sustained virological response (SVR) rates. Methods: Two SNPs in the promoter region of SPP1 at the .443 C>T and .1748 G>A loci were genotyped in 100 patients with chronic HCV genotype 4 infection using a TaqMan SNP genotyping assay. Results: Sixty-seven patients achieved a SVR, and 33 patients showed no SVR. Patients carrying the T/T genotype at the .443 locus showed a significantly higher SVR rate than those carrying the C/T or C/C genotype (83.67% vs 50.98%, p<0.001). At the .1748 locus, the SVR rate was significantly higher in patients with the G/G genotype than in those with the A/A genotype (88.89% vs 52.63%, p=0.028) and in patients with the G/A genotype than in those with the A/A genotype (85.29% vs 52.63%, p=0.001). Conclusions: SPP1 SNPs at .443 C>T and .1748 G>A loci may be useful markers for predicting the response to PEG-IFN-α-2b plus RBV therapy in Egyptian patients with chronic HCV genotype 4 infection. (Gut Liver 2015;9:516-524)
Recent Advances in Filter Topologies and Realizations for Satellite Communications
Mohamed M. Fahmi,Jorge A. Ruiz-Cruz,Rafaat R. Mansour,Kawthar A. Zaki 한국통신학회 2011 Journal of communications and networks Vol.13 No.6
This paper presents an overview of recent advances in radio frequency and microwave filter topologies for satellite communication systems. Many types of filters have been developed during the last years in order to satisfy the demands of modern applications in both terrestrial systems and onboard spacecrafts, leading to a great variety of aspects such as transfer functions, resonator implementations or coupling structures. This paper revisits some of the last advances in this area, including the modeling and full-wave simulation. Some recent designs using dual-mode cavities along with other novel implementations in ridge waveguide will be shown.
Recent Advances in Filter Topologies and Realizations for Satellite Communications
Fahmi, Mohamed M.,Ruiz-Cruz, Jorge A.,Mansour, Rafaat R.,Zaki, Kawthar A. The Korea Institute of Information and Commucation 2011 Journal of communications and networks Vol.13 No.6
This paper presents an overview of recent advances in radio frequency and microwave filter topologies for satellite communication systems. Many types of filters have been developed during the last years in order to satisfy the demands of modern applications in both terrestrial systems and onboard spacecrafts, leading to a great variety of aspects such as transfer functions, resonator implementations or coupling structures. This paper revisits some of the last advances in this area, including the modeling and full-wave simulation. Some recent designs using dual-mode cavities along with other novel implementations in ridge waveguide will be shown.
Flow Downstream Sluice Gate with Orifice
Ibrahim M. Mohamed,Fahmy S. Abdelhaleem 대한토목학회 2020 KSCE Journal of Civil Engineering Vol.24 No.12
Gates and orifices were significant common structures used in controlling and adjusting the flow in water system channels. Installing of an orifice with sluice gates, increase the flow discharge with minimizing the horizontal jets under gate that was attributed with higher bed flow velocity and larger scour geometry downstream these gates. An experimental study was conducted to examine the flow pattern and the bed configurations downstream sluice gates with an orifice. In this research, a circular orifice employed with sluice gates as a means of energy dissipation downstream the gates, was explored. Forty-five runs were completed under 3 discharges, 3 upstream water heads, and 7 tail gate water depths. Five models for sluice gate with orifice were utilized. A series of regime plots were created to help designing the sluice gate with orifice as heading up and flow distributions structures. The outcomes illustrated that combining of an orifice with sluice gates productively scattered the jump energy and diminished the downstream local scour compared to the conventional sluice gate. Additionally,existed equations used to predict the jump length downstream sluice gate were applicable in case of sluice gate with orifice provided similar flow conditions were achieved. The optimum ratio of orifice and under gate areas was also introduced.
Synthesis and Antimicrobial Activity of New Substituted Anili-nobenzimidazoles
Nofal, Z.M.,Fahmy, H.H.,Mohamed, H.S. The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.3
A series of benzimidazole derivatives carrying different heterocycles such as 1,2,3-thiadiazole, 1,3,4-thiadiazole, thiazolidine, 2,3-dihydro-thiazole, 1,3,4-oxadiazole, semicarbazone and substituted thiosemi-carbazones were synthesized. Also a series of 1-methylbenzimidazole carrying hydroxy ethyl-amide, substituted sulfonyl hydrazide and benzoyl hydrazide from aminobenzoyl group at position 2 of 1-methylbenzimidazole were synthesized. The antimicrobial evaluation of some of the new compounds was carried out.
Outer membrane proteins of Salmonella Typhimurium as an adjuvant in rabies vaccine
Iman Ibrahim Negm,Yasser M. Ragab,Aly Fahmy Mohamed 대한백신학회 2021 Clinical and Experimental Vaccine Research Vol.10 No.2
Purpose: The objective of the present study was to evaluate the immune-enhancing potential of Salmonella Typhimurium outer membrane protein (OMP) and alum as adjuvants towards inactivated Vero cells rabies vaccine (FRV/K2). Materials and Methods: Six groups of female Sprague Dawley albino rats (10/group) were used in the evaluation of immunogenicity and safety of vaccines and adjuvants. Total immunoglobulin G secreted interferon-gamma (IFN-γ), and the percentage of proliferated CD4+ and CD8+ T cells were measured. Biochemical analysis and histopathological examination were used to test safety profiles. Results: OMP adjuvanted rabies vaccine (FRV/K2+OMP) (OMP combined locally prepared vaccine) induced significantly higher neutralizing antibodies on day 21 post-vaccination relative to free (FRV/K2) vaccine and alum adsorbed vaccine (FRV/K2+alum) (alum adsorbed locally prepared vaccine). (FRV/K2+OMP) induced a significantly higher level of IFN-γ on day 14 post-vaccination. CD8+ T cells were significantly higher post-vaccination with reference (RV), free (FRV/K2), and (FRV/K2+OMP) than (FRV/K2+alum). On the contrary, CD4+ T cells were significantly elevated post-vaccination with (FRV/K2+alum) at p<0.05. Biochemical analysis and histopathological examination revealed that OMP could be used safely as an adjuvant for the development of more effective rabies vaccines. Conclusion: Outer membrane proteins adjuvanted rabies vaccines would be beneficial to induce rapid neutralizing antibodies and essential cytokines.
Rania Ibrahim Shebl,Mohamed E. Amer,Tamer M. M. Abuamara,Emadeldin R. Matar,Hassan Fathy Ahmed,Tamer Albasyoni Gomah,Laila E. El Moselhy,Mohammed Abu-Elghait,Aly Fahmy Mohamed 대한백신학회 2021 Clinical and Experimental Vaccine Research Vol.10 No.3
Purpose: One of the essential goals regarding the successful control of rabies infection is the development of a safe, effective, and inexpensive vaccine. the current study aimed to evaluate the inactivation potential of β-propiolactone (βPL), binary ethyleneimine (BEI), and hydrogen peroxide (H2O2). Materials and Methods: Estimating the inactivation kinetics of βPL, BEI, and H2O2 revealed that the tested inactivants could completely and irreversibly inactivate rabies virus within 2, 12, and 4 hours, respectively while maintaining its viral immunogenicity. The potency of βPL, BEI, and H2O2 inactivated vaccines was higher than the World Health Organization acceptance limit and were in the order of 3.75, 4.21, and 3.64 IU/mL, respectively. Monitoring the humoral and cellular immunity elicited post-immunization using Staphylococcus aureus derived hyaluronic acid (HA) and bacillus Calmette-Guérin purified protein derivative (PPD) adjuvanted rabies vaccine candidates were carried out using enzyme-linked immunosorbent assay. Results: Results demonstrated that both adjuvants could progressively enhance the release of anti-rabies total immunoglobulin G as well as the pro-inflammatory mediators (interferon-gamma and interleukin-5) relative to time. However, a higher immune response was developed in the case of HA adjuvanted rabies vaccine compared to PPD adjuvanted one. The harmful consequences of the tested adjuvants were considered via investigating the histopathological changes in the tissues of the immunized rats using hematoxylin and eosin stain. Lower adverse effects were observed post-vaccination with HA and PPD adjuvanted vaccines compared to that detected following administration of the currently used alum as standard adjuvant. Conclusion: Our findings suggested that HA and PPD could serve as a promising platform for the development of newly adjuvanted rabies vaccines with elevated immune enhancing potentials and lower risk of health hazards.
Lead Sorption by Carbon Nanofibers Grown on Powdered Activated Carbon - Kinetics and Equilibrium
Abdullah Al Mamun,Yehya M. Ahmed,Ma'an Fahmi R. AlKhatib,Ahmad Tariq Jameel,Mohammed Abdul Hakeem Abdul Rahman AlSaadi 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.2
Carbon nanofibers (CNFs) were synthesized by using a safe and less hazardous method, compared to using floating catalysts in chemical vapor deposition (CVD) process. This process used C2H2 as carbon source and oil palm kernel shell-based powdered activated carbon (PAC) as cheap solid substrate. Use of nickel (Ni2+) impregnated PAC as fixed substrate for the synthesis of CNF is one of the novelties of the research work accomplished by the authors. The PAC–CNFs porous nanocomposite product was used for the sorption of lead ions (Pb2+) from synthetic aqueous solution. Kinetics of Pb2+ adsorption and isotherms were investigated by varying initial concentration of lead and contact time. PAC–CNFs were found to remove Pb2+ better at acidic pH of about 5.5. Langmuir and Freundlich isotherms were applied to the sorption equilibrium data to find the best fitted model. Langmuir isotherm model with R2=0.965 fitted the adsorption data better than the Freundlich isotherm. The kinetic processes of Pb2+ adsorption on CNFs were investigated by applying different kinetic models, namely zero-order, pseudo-first-order and pseudo-second-order. The pseudo-second-order rate equation exhibited the best results with R=0.999, qe=74.79 (mg/g) and K2=0.029 (min·g/mg). The novel nanocomposite product seemed to have the potential to remove Pb2+ ions from aqueous solution.