Dendritic Cell Dysfunction in Patients with End-stage Renal Disease

Kim, Ji Ung,Kim, Miyeon,Kim, Sinae,Nguyen, Tam Thanh,Kim, Eunhye,Lee, Siyoung,Kim, Soohyun,Kim, Hyunwoo 한국조명·전기설비학회 2017 한국조명·전기설비학회 학술대회논문집 Vol. No.

<P>End-stage renal disease (ESRD) with immune disorder involves complex interactions between the innate and adaptive immune responses. ESRD is associated with various alterations in immune function such as a reduction in polymorphonuclear leukocyte bactericidal activity, a suppression of lymphocyte proliferative response to stimuli, and a malfunction of cell-mediated immunity at the molecular level. ESRD also increases patients' propensity for infections and malignancies as well as causing a diminished response to vaccination. Several factors influence the immunodeficiency in patients with ESRD, including uremic toxins, malnutrition, chronic inflammation, and the therapeutic dialysis modality. The alteration of T-cell function in ESRD has been considered to be a major factor underlying the impaired adaptive cellular immunity in these patients. However, cumulative evidence has suggested that the immune defect in ESRD can be caused by an Ag-presenting dendritic cell (DC) dysfunction in addition to a T-cell defect. It has been reported that ESRD has a deleterious effect on DCs both in terms of their number and function, although the precise mechanism by which DC function becomes altered in these patients is unclear. In this review, we discuss the effects of ESRD on the number and function of DCs and propose a possible molecular mechanism for DC dysfunction. We also address therapeutic approaches to improve immune function by optimally activating DCs in patients with ESRD.</P>

증례 : 신장 ; 판코니 증후군을 동반한 간질성 신염 포도막염 증후군 1예

김미연 ( Miyeon Kim ),김현우 ( Hyun Woo Kim ),김지영 ( Ji Young Kim ),정진호 ( Jinho Jeong ),박은정 ( Eun Jung Park ),김진석 ( Jinseok Kim ),김소미 ( So Mi Kim ) 대한내과학회 2015 대한내과학회지 Vol.88 No.6

본 증례에서는 간질성 신염으로 진단되어 스테로이드 치료 후 호전된 중년여성에서 판코니 증후군 양상의 세뇨관장애 및 포도막염이 발생하여 간질성 신염 포도막염 증후군으로 재진단하고, 스테로이드로 치료한 1예를 경험하여 문헌고찰과 함께 보고하는 바이다. Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease that comprises 4.7% of acute interstitial nephritis. With reno-ocular manifestations, TINU syndrome is accompanied by symptoms such as fever, fatigue, malaise, anorexia, vomiting, and arthralgia. TINU syndrome is reported mainly in children or adolescent girls, and it is rare in adults. Although TINU syndrome can present with multiple renal tubular defects, Fanconi syndrome characterized by generalized impairment of proximal tubular function, leading to renal glucosuria, hyperuricosuria, hyperphosphaturia, proximal renal tubular acidosis, and kaliuresis leading to hypokalemia, has rarely been described. We report a case of TINU syndrome with Fanconi syndrome in a 46-year-old HLA B27-positive Korean woman. (Korean J Med 2015;88:711-714)

Ionizing irradiation to Helicoverpa armigera (Lepidoptera: Noctuidae) as a quarantine treatment

Miyeon Jang,Junheon Kim,Sin Ae Jang,Jeongmin Kim,Yeon Jeong Lee,Eunsik Shin,Chung Gyoo Park 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10

Rapid growth in trade of agricultural products has increased the risk of introduction of exotic pests into new area. In order to fulfill quarantine obligations, several treatments are in practice: fumigation with methyl bromide (MB), application of extreme temperatures, controlled atmospheres, and combinations of them. Although MB was most effective and widely applied for quarantine treatment, its use was banned by the Montreal Protocol. Ionizing irradiation phytosanitary treatments – gamma radiation, electron beam, and X-ray are being used as an alternative to MB currently. For applying ionizing irradiation as a quarantine treatment, there is a research protocol which should be followed, International Standards for Phytosanitary Measure 18 [ISPM #18] and Phytosanitary Treatment Regulation of Korea (Notice 2014-35). We have evaluated the effect of gamma radiation, electron beam, and X-ray on H. armigera as quarantine treatments. In this presentation, ISPM #18 and Notice 2014-35 will be talked with the example of H. armigera.

C-shaped root canal system in mandibular 2nd molars in Korean people evaluated by cone beam computed tomography

Miyeon Kim(김미연),Jeonghee Kim(김정희),Sunho Kim(김선호),Byungchul Song(송병철),Wook Nam(남욱) 대한턱관절교합학회 2016 구강회복응용과학지 Vol.32 No.1

Attraction of Athetis dissimilis to the pheromone components of Euzophera batangensis

Jeongmin Kim,Junheon Kim,Sin Ae Jang,Miyeon Jang,Yeon Jeong Lee,Young Sik Cho,Bong Kyu Byun,Chung Gyoo Park 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10

Athetis dissimilis (Hampson) (Lepidoptera: Noctuidae) [뒷흰날개담색밤나방] was attracted to pheromone traps for Euzophera batangesis (Lepidoprera Pyrimidae) [밤알락명나방], when occurrence of E. batangesis was monitored in sweet persimmon orchard with its pheromone, (Z)-9-tetradecenol (Z9-14OH), (Z9,E12)-9,12-teradecadienol (Z9,E12-14OH) and their mixture. With the components, we monitored the seasonal occurrence of A. dissimilis, tested response of the moth to single or mixed components, and compared efficacy of three different types of traps. A. dissimilis was trapped on May 14 for the first time. First occurrence peak was observed during June 4-24 and second peak during August 20 – September 10. A. dissimilis was attracted to single component of Z9-14OH and Z9,E12-14OH and to their mixture at Jinju, Sancheong, and Sacheon. In trap efficacy tests, delta traps with white color caught most number of the moths significantly at Sacheon. However, at Sancheong, there was no statistical difference among the traps, although funnel trap caught most number of A. dissimilis. Pest status of A. dissimilis is not known eg. whether it is a pest of persimmon or other fruits. However, with Z9-14OH, E9,E12-14OH and their mixture, it is expected to be monitored and controlled.

Genome wide analysis of rice blast pathogen, Magnaporthe oryzae, in Korea

Yoonhee KIM,Hyejeong KIM,Jinsoo KIM,Miyeon JEONG,Soyoung PARK,Suyoung KIM,Jongsun Park,Soonok KIM,Yong-Hwan LEE,Seong Sook HAN,Jae Hwan ROH,Woobong CHOI 한국작물학회 2007 한국작물학회 학술발표대회 논문집 Vol.2007 No.11

Magnaporthe oryzae is a causal pathogen of the rice blast, the most destructive disease of rice worldwide. This ascomycete fungus has been intensively studied as a model organism in plant-pathogen interactions. Recently, the genome sequence of M. oryzae 70-15 was published by International Rice Blast Consortium. This led us to investigate comparative and functional analysis of this pathogen at genome-wide level. As a first step, sequencing project of M. oryzae Korean strain KJ201 was launched to face practical interests on diversity of plant pathogens. We constructed a fosmid library with a copy number controllable pCC1 vector. Over 13,000 end reads from 6637 fosmid clones were generated and anchored on genome sequence of the strain 70-15. Currently, 9,793 end reads, in which 2.684, clones with both ends and 1,757 clones with on end matched, are aligned to the sequence of strain 70-15. In the next step, shotgun sequencing of fosmid clones was conducted for fine scale comparative analysis of chromosome 7 that is well defined in genome sequencing of 70-15. Totally 119 fosmid clones were pooled in region and analyzed. For reasonable intra-species comparison in genome of M. oryzae, two strains, KJ201 and Guy11, were chosen for whole genome shotgun sequencing analysis with GS454 FLX system. About 8X genome coverage sequences were obtained for each strain and being merged for comparative analysis. Genome information of other strains is being also available from China and Japanese research groups and could be joined together for extended comparative analysis and the results give more detail in genome diversity in species level.

Proinsulin Shares a Motif with Interleukin-1α (IL-1α) and Induces Inflammatory Cytokine via Interleukin-1 Receptor 1

Lee, Siyoung,Kim, Eunsom,Jhun, Hyunjhung,Hong, Jaewoo,Kwak, Areum,Jo, Seunghyun,Bae, Suyoung,Lee, Jongho,Kim, Busun,Lee, Jungmin,Youn, Sulah,Kim, Somi,Kim, Miyeon,Kim, Hyunwoo,Lee, Youngmin,Choi, Dong American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.28

<P>Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but mature INS was unable to induce an immune response. An affinity-purified rabbit polyclonal antibody raised against mature IL-1α recognized IL-1α and pINS but failed to detect mature INS and IL-1β. Analysis of the pINS sequence revealed the existence of an INS/IL-1α motif in the C-peptide of pINS. Surprisingly, the INS/IL-1α motif was recognized by monoclonal antibody raised against IL-1α. Deleting the INS/IL-1α motif in pINSd and IL-1α changed their activities. To investigate the pINSd receptor, the reconstitution of IL-1 receptor 1 (IL-1R1) in Wish cells restored pINSd activity that was reversed by an IL-1R antagonist. These data suggested that pINSd needs IL-1R1 for inflammatory cytokine induction. Mouse embryo fibroblast cells of IL-1R1-deficient mice further confirmed that pINSd promotes immune responses through IL-1R1.</P>

아동의 창의성 개발을 위한 발상방법에 대한 연구 : 디자인 교육을 중심으로

김윤정,김미연,김수정 디자인 여성학회 2006 디자인여성학연구 Vol.2 No.2

성공적 삶을 주도해나가기 위해서 창의성은 이제 누구에게나 필수적으로 갖추어야 할 기본 능력이 되었다. 창의적 인간 양성은 오늘날 어느 국가에서나 교육의 가장 큰 목적 중의 하나로 부상하고 있다. 인간의 성격이나 탐구 태도가 어린 시절에 형성되어지므로 이 시기의 창의성 교육은 막연하고 애매한 지도가 아니라 구체적이고 확실하게 이루어져야 할 것이다. 디자인은 문제 해결에 있어 합리적인 사고를 하게 하는 창조적인 학문이다. 디자인 교육은 주어진 문제를 파악하고 방향을 설정하며 감성적 사고를 시각적으로 표현해 가는 전 과정을 중요시 하므로 아동의 창의성 개발을 위해 중요한 의미를 지닌다. 또한 이동에게 있어서 디자인 교육은 인지, 정서, 사회성, 지각, 창의성 동의 발달과 자아 개념의 자신감 강화 등 아주 다양한 분야에 효과가 크게 나타나고 있으며 이러한 점에서 아동의 창의성 중진에 대한 디자인 교육의 가치를 찾을 수 있다. 이러한 디자인 교육에 있어서 기본이 되는 아이디어 창출을 위한 '발상'의 단계는 창의적인 생각을 다양하게 산출해내는 창의적 사고의 기본인 동시에 핵심적 특성이며, 발상 방법의 지도가 창의성 교육의 성패를 좌우한 다고 불 수 있다. 아동들의 발상능력 증진은 곧 창의성 증진의 결과를 가져오는 것이다. 창의성은 단기간에 기를 수 있는 것이 아니므로, 아동기에 적절한 교육 방법을 통해 체득해 놓으면 언젠가 창의성을 발휘할 수 있게 된다. Today's education should help children get ready for the world and create new things instead of making them accept what is given, Children's originality and flexibility can be developed when they are educated intentionally in everyday life. Based on such education, children will develop creative and cognitive thinking. The brainstorming method presented in this study will help children to have original, flexible, and creative thinking always. Creation of ideas, conception of creative ideas is a first step not only toward design education but also toward creative process. In the process of increasing children's creativity, design education is necessary as basic education to increase creativity and not to make them into artists. When we think of design as creative conception, educating children to conceive new ideas will help them have more creative thinking and the children receiving such education will become creative human resources. More specific and methodological research on creative education and the development appropriate programs are needed to provide a better design education environment for children. The education to increase creativity is in the hands of adults who teach these children- If the adults can't help them conceive creative ideas, we can't expect them to develop creativity, Creative thinking appears when the limit of cognition and thinking is broken. The true purpose of creativity education lies in making the life of individuals and society 'new and meaningful' by nurturing creative thinking abilities.

Insecticidal and acetylcholinesterase inhibitory activities of Lamiaceae plant essential oils and their major components against Drosophila suzukii (Diptera: Drosophilidae)

Miyeon Jang,Junheon Kim,Eunsik Shin,Kyungjae Andrew Yoon,Chung Gyoo Park 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04

Twelve Lamiaceae plant essential oils (EOs) and their components were evaluated for their fumigant and contact toxicities. Inhibition of AChE by the major components of active EOs was also assessed. Strong fumigant toxicity was observed from EOs of Mentha piperita and Perilla frutescens. Menthone and menthol, and perilla aldehyde were identified as major components of the above two EOs, respectively. The LC50 (mg/L) values of M. piperita, P. frutescens, menthone, menthol and perilla aldehyde were 3.87, 2.44, 5.76, 1.88, and 0.99 against male, and 4.10, 3.31, 5.13, 1.94, and 1.15 against female, respectively. Strong contact toxicity was observed from the EOs of Satureja montana and Thymus zygis. Thymol and carvacrol were major components of these two EOs. The LD50 (μg/fly) values for contact toxicity of S. montana, T. zygis, thymol and carvacrol were 2.95, 2.93, 1.63, and 1.30 for male, and 4.59, 5.09, 2.68, and 2.60 for female, respectively. Among the five major components, perilla aldehyde showed most active inhibition activity against AChE of both sexes of SWD.

A Study on the Evaluation of Energy Performance for Application of Solar Energy System in Apartments

Miyeon Kim(김미연),Hyunggeun Kim(김형근) 한국신재생에너지학회 2013 한국신재생에너지학회 학술대회논문집 Vol.2013 No.05