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Factors affecting cognitive function according to gender in community-dwelling elderly individuals
Miwon Kim,Jeong-Mo Park 한국역학회 2017 Epidemiology and Health Vol.39 No.-
OBJECTIVES: This study aimed to identify the factors affecting the cognitive function of elderly people in a community by gender. METHODS: We obtained 4,878 secondary data of people aged ≥65 years in 2016 at a dementia prevention center in Gyeyang-gu, Incheon. Data were obtained through Mini-Mental Status Examination optimized for screening dementia and a questionnaire. The data were statistically analyzed using analysis of variance, analysis of covariance, and hierarchical regression. RESULTS: There were significant differences in cognitive function according to gender, and the differences were significant even when age was controlled, but gender differences disappeared when education was controlled. Age, education, social activities, number of comorbid diseases, and alcohol drinking affected cognitive function through interaction with gender, but interaction with gender disappeared when education was controlled. Regression analysis showed that depression, cohabitant, social activities etc., had a significant impact on both men and women under controlled education and age. In men, the effect of social activities was greater than that of women, and hyperlipidemia had the effect only in women. CONCLUSIONS: The differences in gender-related cognitive functions were due to differences in gender education period. The period of education is considered to have a great influence on cognitive function in relation to the economic level, occupation, and social activity.
Protective Effect of Taurine on Indomethacin-induced Gastric Mucosal Injury
Son, Miwon,Kim, Hee-Kee,Kim, Won-Bae,Yang, Junnick,Kim, Byong-Kak The Pharmaceutical Society of Korea 1996 Archives of Pharmacal Research Vol.19 No.2
It has been suggested that oxygen-derived free radicals play an important role in the pathophysiology of acute gastric ulceration induced by NSAIDs and ischemia-reperfusion. Taurine is hypothetized to exert its protective effect on NSAIDs-induced gastric injury by its antioxidant properties. Protective effect of taurine on indomethacin-induced gastric mucosal lesion and its protection mechanism were investigated. Intragastric administration of 25 mg/kg of indomethacin induced hemorrhagic lesions on the glandular stomach in rats. Pretreatment with 0.25 or 0.5 g/kg of taurine one day before or for 3 days significantly reduced the gastric lesion formation and inhibited the elevation of lipid peroxide level in gastric mucosa. The luminol-dependent chemiluminescence of rat peritoneal neutrophils increased immediately after treatment of FMLP or indomethacin. Taurine (5-20 mM) inhibited chemiluminescence of neutrophils activated by FMLP. Human neutrophils (polymorphonuclear leukocytes) significantly adhered to the confluent monolayer of human umbilical vein endothelial cells (HUVEC) after coincubation with indomethacin. This neutrophil adhesion induced by indomethacin to HUVEC was prevented by taurine in a dose-dependent manner. These results indicate that the protective effect of taurine against NSAIDs-induced gastric mucosal injury is due to its antioxidant effect, which inhibits lipid peroxidation and neutrophil activation.
밀리타리스 동충하초(Cordyceps militaris) 에탄올 추출물의 면역억제 마우스 면역활성에 미치는 영향
김혜주(Hyeju Kim),이태호(Tae Ho Lee),권용삼(Yong Sam Kwon),손미원(Miwon Son),김채균(Chaekyun Kim) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.4
본 연구에서는 면역억제 동물모델에서 밀리타리스 동충하초 50% 에탄올 추출물의 면역력 증강 기능을 평가하였다. 이를 위하여 C57BL/6 마우스에 cyclophosphamide를 2회 복강주사 하여 면역력을 억제한 후, 밀리타리스 동충하초 추출물을 30, 100, 300 mg/kg 용량으로 12일간 경구투여 하였다. 마우스를 희생하여 몸무게 및 면역장기 무게, 비장세포의 증식, 비장세포의 cytokine 분비능, NK 세포 활성을 측정하였다. 그 결과, cyclophosphamide 투여에 의한 면역억제는 마우스의 몸무게와 간의 무게에 영향을 주지 않았으나 흉선의 무게는 감소시켰고 비장의 무게는 증가시켰다. 밀리타리스 동충하초 추출물 투여는 마우스의 몸무게 및 면역장기 무게에 영향을 주지 않았다. Cyclophosphamide 투여는 비장세포의 증식능을 감소시켰으며 밀리타리스 동충하초 추출물은 용량 의존적으로 비장세포 증식을 증가시켜 실험에 사용한 전 용량에서 비장세포의 유의적인 증식효과를 보였다. 비장세포의 cytokine 분비능을 측정한 결과, 밀리타리스 동충하초 추출물 투여는 IL-2, IL-12, IFN-γ, TNF-α 같은 Th1 cytokine의 분비를 대조군에 비해 유의적으로 증가시켰으나, IL-4와 IL-10 같은 Th2 cytokine의 분비에는 영향을 미치지 않았다. 또한 cyclophosphamide는 NK 세포의 활성을 정상군에 비하여 유의적으로 감소시켰으며, 밀리타리스 동충하초 추출물 투여는 cyclophosphamide에 의해 저하된 NK 세포 활성을 현저하게 증가시켰다. 이상의 결과를 종합해 볼 때, 밀리타리스 동충하초는 면역력이 억제된 상황에서 면역력을 증강시키며, 이러한 면역력 증강 효과는 체액성 면역보다 세포성 면역력 증강에 기인하는 것으로 보인다. In order to determine the functional benefits of Cordyceps militaris in the immune system, we examined the immunomodulatory activities of Cordyceps militaris in an immunocompromised C57BL/6 mice model. Mice were injected intraperitoneally with an immunosuppressive drug, cyclophosphamide, and then administered orally with 3% hydroxypropylmethylcellulose or 30, 100, and 300 mg/kg of 50% ethanol extract of Cordyceps militaris (CM 30, CM 100, and CM 300, respectively) for 12 days. Mice treated with CM displayed significantly increased splenocyte proliferation and natural killer cell activity compared to immunosuppressed control mice (p<0.05). The spleen cells isolated from mice treated with CM also displayed increased production of Th1 cytokines, including IL-2, IL-12, IFN-γ and TNF-α, suggesting enhanced cellular immunity in response to CM. However, CM had no significant effect on the production of IL-4 and IL-10. These results indicate that Cordyceps militaris enhances immune function by promoting immune cell proliferation and Th1 cytokine production.
사고 환아에 대한 임상적 고찰 - 일 도시 종합병원을 중심으로 -
김기숙(Kisook Kim),김미원(Miwon Kim) 전남대학교 간호과학연구소 1996 Nursing and Health Issues(NHI) Vol.1 No.-
While increased living standards and development of medical sciences have markedly reduced the death rate of children by infectious disease, the number of pediatric patients with various accidents is being steadily increased. The present study was aimed to examine the cause of the accidents and to help take a measure to meet the situation. As many as 1,161 patients aged less than 15 years, who visited the emergency room of Chonnam National University Hospital from January 1,1989 to December 31,1991,have been surveyed. The patients were examined according to their sex, age, time of the day and place to occur, injury site, etc. The resuIts obtained were as follow s: 1. Annual accidental pediatric patients were 571 in number in 1989, 463 in 1990,and 627 in 1991. 2. Traffic accident w as the most frequnt of all (3 4 .1% ). Male patients outnumbered female by the ratio of 1.8 to 1. The ages between 7 and 12 years (school children) made up 36.5% of the whole numbers. 3. Accidents mainly took place between 5PM to 8PM (37.1% ). The frequent places to occur were home (4 0 .6% ) and streets and highway (35 .0% ). 4. Injury sites were mainly on heads and faces (59 .7% ). 5. Most patients discharged from the hospital in good condition (83.1%) and the rest of them had sequelae (9.3%) or died(7.6%). 6. The patients were with their family at the time of the accident(67.3%). 7. In terms of order in their siblins, 43.1% were the eldest. 8. Most parents graduated from senior high school or above. Mothers in 78.5% of the patents did not have occuapation.
김선미(Sun Mi Kim),김혜주(Hye Ju Kim),손미원(Miwon Son),정세영(Se Young Choung) 대한약학회 2012 약학회지 Vol.56 No.5
Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness among the elderly. In this study, extract of Vaccinium uliginosum L. that has potent antioxidant activity was evaluated as effective preventive supplement for AMD using AMD animal model induced by high fat diet and UV A irradiation. Treatment with VU extract protected photoreceptor cells of retina and blocked the accumulation of lipofuscin pigment-granules induced by high fat diet and UV A light irradiation. This study suggests that VU extract may be a useful agent for prevention of progress of AMD.
Park, Eun-Jin,Kim, Bongcheol,Eo, Haekwan,Park, Kyungcheol,Kim, Yeonran,Lee, Hwa Jun,Son, Miwon,Chang, Yoon-Seok,Cho, Sang-Heon,Kim, Sunyoung,Jin, Mirim Elsevier 2005 The journal of allergy and clinical immunology Vol.116 No.5
<P><B>Background</B></P><P>Various allergic responses are thought to result from the unbalanced development of T<SUB>H</SUB>1 and T<SUB>H</SUB>2 pathways and, subsequently, the overproduction of IgE. Therefore the modulation of T<SUB>H</SUB>1 and T<SUB>H</SUB>2 responses is a rational strategy for the treatment of allergic diseases.</P><P><B>Objective</B></P><P>The present study was performed to investigate the immune-modulating activities of PG102 preparations from <I>Actinidia arguta</I> in ovalbumin-sensitized murine models.</P><P><B>Methods</B></P><P>Two preparations from <I>A arguta</I>, PG102T and PG102E, were chosen for animal experimentation on the basis of their ability to regulate the production of IgE in U266B1 cells. The changes in splenic levels of cytokines and plasma levels of immunoglobulin isotypes were examined. The effects of PG102 on subcellular composition (CD4<SUP>+</SUP>IL-4<SUP>+</SUP> or CD19<SUP>+</SUP>IgE<SUP>+</SUP> cells), IgE production in B cells, and selective transcription factors were analyzed.</P><P><B>Results</B></P><P>Oral administration of PG102T and PG102E significantly decreased the level of selective T<SUB>H</SUB>2 cytokines, whereas it increased the level of T<SUB>H</SUB>1 cytokines. The differential effects of PG102T and PG102E on T<SUB>H</SUB>1 and T<SUB>H</SUB>2 cytokines were accompanied by a decrease in the plasma levels of IgE and IgG1 and by an increase in the plasma level of IgG2a. The percentages of both IL-4–producing T cells and IgE-producing B cells were decreased. The concentration of IgE produced within B cells also appeared to be reduced. Finally, PG102T and PG102E downregulated the level of GATA-binding protein 3, while inducing that of T-box transcription factor and nuclear factor of activated T cells c2.</P><P><B>Conclusion</B></P><P>PG102T and PG102E have great potential as orally active immune modulators for the therapy of various allergic diseases.</P>