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Lipid Metabolism in Rats Fed Acetaminophen with Coadministration of Adzuki Bean Extract
Kyu-Ho Han,Kiyoshi Ohba,Chi-Ho Lee,Ken-ichiro Shimada,Mitsuo Sekikawa,Michihiro Fukushima 한국식품과학회 2007 Food Science and Biotechnology Vol.16 No.4
The effect of water extract of adzuki beans on acetaminophen-altered lipid metabolism was examined in rats. Control group of rats was fed a basal diet, another group of rats was fed 0.5% acetaminophen (APAP group), and a third group of rats was fed 0.5% acetaminophen plus 5% adzuki bean extract (ABE group) for 4 weeks. Serum total and HDL cholesterol levels in the APAP group were significantly lower than those in the control and ABE groups. Hepatic cholesterol 7α- hydroxylase and fatty acid synthase mRNA levels in the APAP and ABE groups were significantly higher and lower than in the control group, respectively. Hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA level in the APAP group was significantly lower than in the control group, whereas that in the ABE group was significantly higher than in the APAP group. These results indicate that adzuki bean extract may improve the acetaminophen-altered serum lipid metabolism in rats.
Effect of Colored Potato Flakes Against Acetaminophen-induced Liver Damage in Rats
Kiyoshi Ohba,Shoko Watanabe,Kyu-Ho Han,Naoto Hashimoto,Takahiro Noda,Ken-ichiro Shimada,Hisashi Tanaka,Mitsuo Sekikawa,Michihiro Fukushima 한국식품과학회 2007 Food Science and Biotechnology Vol.16 No.3
We examined the hepatoprotective effects of colored potato flakes on acetaminophen(AAP)-induced liver damage in rats. F344/DuCrj (8 week-old) rats were fed a cholesterol-free diet with 54,9486 g of α-corn starch/100 g diet and were orally treated with 25% colored flakes of Kitamurasaki (KM: light purple), Northern Ruby (NR: red), and Queen (SQ: medium purple) potatoes co-administered with AAP (0.5 g/100 g diet)for 4 weeks. The hepatic thiobarbituric acid-reactive substances (TBARS) values in the KM, NR, and SQ group were significantly lower (p<0.05) than those in the control groups with and wothout AAP. Furthermore, the hepatic catalase, Mn-superoxide dismutase (SOD), and Cu/Zn-SOD mRNA levels in the KM, NR, and SQ groups were higher than those in the control groups with and without AAP. The present findings suggest that colored potato flakes are useful as a prophylactic agent against oxidative liver damage.
Hepatoprotective Effects of Potato Peptide against D-Galactosamineinduced Liver Injury in Rats
Kiyoshi Ohba,Kyu-Ho Han,Ruvini Liyanage,Megumi Nirei,Naoto Hashimoto,Ken-ichiro Shimada,Mitsuo Sekikawa,Keiko Sasaki,Chi-Ho Lee,Michihiro Fukushima 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.6
The effect of some peptides on hepatoprotection and cecal fermentation against D-galactosamine (GalN)-treated rats was studied. In acute hepatic injury tests, serum alanine aminotransferase (ALT), aspartate aminotranferase (AST), and lactic dehydrogenase (LDH) activities were remarkably increased after injection of GalN. However, potato and soybean peptides significantly decreased GalN-induced alterations of serum ALT and AST activities. Hepatic thiobarbituric acidreactive substance (TBARS) concentration in GalN-treated groups fed potato and soybean peptides was significantly lower than that in GalN-treated control group. Hepatic glutathione level in the GalN-treated group fed potato peptide was significantly higher than that in GalN-treated control group. Furthermore, cecal Lactobacillus level in GalN-treated groups fed potato and soybean peptides was significantly higher than that in GalN-treated control group, and cecal short-chain fatty acid concentrations in GalN-treated group fed potato peptide were significantly higher than in GalN-treated control group. These results indicate that potato peptide may improve the cecal fermentation and prevent the GalN-induced liver damage in rats.
Chi-Ho Lee,Kyu-Ho Han,You-Jin Jeon,Yasantha Athukorala,Kang-Duk Choi,Cheon-Jei Kim,Jin-Kook Cho,Mitsuo Sekikawa,Michiro Fukushima 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
A water extract of Artemisia capillarisThunberg (Compositae) was investigated for protective effects againstoxidative stress induced by 2,2.-azobis(2-amidinopropane) dihydrochloride (AAPH) in Sprague-Dawley male rats. Rats wereorally administered A. capillariswater extract (ACWE; 7.5 g/kg) for 7 days before AAPH treatment (60 mg/kg). AAPH in-toxication significantly elevated enzyme markers of liver injury (glutamic oxaloacetic transaminase and glutamic pyruvictransaminase). The pre-administration of ACWE significantly reduced the liver-damaging effects of AAPH as indicated bythe low levels of these enzymes. Moreover, the ACWE administration significantly attenuated the accumulation of thiobar-bituric acid-reactive substances in both plasma and liver tissues compared with those of rats administered AAPH alone. Fur-thermore, ACWE administration slightly improved the liver reduced glutathione levels and enhanced the production of an-tioxidant enzymes like catalase. A. capillariscontained 10.1 mg of catechin in 100 g of dried sample; the high-performanceliquid chromatography results showed catechin composition in the ACWE to be 28% (. )-epigallocatechin gallate, 49% (. )-epigallocatechin, and 23% other catechins. These observations clearly indicate that ACWE contains antioxidant catechins ca-pable of ameliorating the AAPH-induced hepatic injury by virtue of its antioxidant activity.