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Minsoo Son,Hyunsoo Kim,Injoon Yeo,Yoseop Kim,Areum Sohn,Youngsoo Kim 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.2
Quantifying multiple protein biomarkers in a blood sample at one time has many advantages for diagnosing human diseases. In this study, 34 multiplex assays by multiple reaction monitoring-mass spectrometry (MRM-MS) for serum biomarkers were characterized according to Clinical Proteomic Tumor Analysis Consortium (CPTAC) guidelines. The assays revealed that the median lower limit of quantitation (LLOQ) was 0.37 fmol/μL (16.0 ng/mL) and that the median total coefficient of variation (CV) was 18.2%, 12.2%, and 10.6% in the low-, medium-, and high-quality control (QC) samples. With regard to selectivity, the median mean differences in slope and concentration were 2.1% and 4.3%, respectively. The median values for all CVs and %difference from the nominal concentration for stability were 9.5% and 2.7% in low-QC and 3.8% and 3.1% in medium-QC. The median total CV was 9.8% in the reproducibility. Finally, 17 protein-based biomarker assays were reliable and transferrable for preclinical purposes per CPTAC guidelines.
손민수(Minsoo Son),박미소(Miso Park),정혜진(Hyejin Jung) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
We have studied on a nanoparticle precipitator using thermophoretic force by temperature gradient. The deposition time of nanoparticles onto a substrate was computed by theoretical analysis and CFD methods, respectively. We analyzed the deposition time by two methods, and we notice of a particle motion and tendency. Also, we carried out experiments using simple apparatus and got the SEM images collected particles. As a result, we predicted a particle motion in the precipitator using theoretical equation and CFD and we designed the precipitator using design variables by this study.
Son, Boram,Kim, Hwan D.,Kim, Minsoo,Kim, Jeong Ah,Lee, Jinkyu,Shin, Heungsoo,Hwang, Nathaniel S.,Park, Tai Hyun Wiley (John WileySons) 2015 Advanced Healthcare Materials Vol.4 No.9
<P>Chondrogenic commitments of mesenchymal stem cells (MSCs) require 3D cellular organization. Furthermore, recent progresses in bioreactor technology have contributed to the development of various biophysical stimulation platforms for efficient cartilage tissue formation. Here, an approach is reported to drive 3D cellular organization and enhance chondrogenic commitment of bone-marrow-derived human mesenchymal stem cells (BM-hMSCs) via magnetic nanoparticle (MNP)-mediated physical stimuli. MNPs isolated from Magnetospirillum sp. AMB-1 are endocytosed by the BM-hMSCs in a highly efficient manner. MNPs-incorporated BM-hMSCs are pelleted and then subjected to static magnetic field and/or magnet-derived shear stress. Magnetic-based stimuli enhance level of sulfated glycosaminoglycan (sGAG) and collagen synthesis, and facilitate the chondrogenic differentiation of BM-hMSCs. In addition, both static magnetic field and magnet-derived shear stress applied for the chondrogenic differentiation of BM-hMSCs do not show increament of hypertrophic differentiation. This MNP-mediated physical stimulation platform demonstrates a promising strategy for efficient cartilage tissue engineering.</P>
Robust Position Control of One DOF Mechanical Systems Using Dual PIOs Without Velocity Measurement
Minsoo Han,Cho Won Lee,Joo-Hyoung Yook,Young Ik Son 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.1
This paper presents a robust position controller for a one degree-of-freedom (DOF) mechanical system using only position measurement. In order to alleviate the performance degradation owing to various uncertainties, a two-stage design method is studied by employing a proportional integral observer (PIO). In the first stage, a baseline backstepping controller is designed for a nominal system without accounting for uncertainties. The PIO is developed for estimating both the velocity information for the backstepping controller and an equivalent input disturbance for a feedforward compensation using the estimated uncertainty. It is shown that the estimation errors with the proposed PIO can be made arbitrarily small in a finite time. If the system suffers from undesirable actuator nonlinearities, however, it might be necessary to estimate the velocity and the disturbance with different rates of convergence. The proposed method combines the predesigned backstepping controller and dual PIOs to reduce mechanical vibrations as well as steady-state errors. The performance of the proposed method is tested through comparative computer simulations and experiments using a laboratory prototype.