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서민준(Minjun Seo),박진한(Jinhan Park),이제현(Jehyun Lee),정지욱(Jiwook Jung) 한국한의학연구원 2011 한국한의학연구원논문집 Vol.17 No.1
Objective : In the present study, we assessed the enhancing effect of the fermented Angelicae Gigantis Radix on memory and cognitive function in scopolamine induced amnesia mice. Method : The memory and cognitive enhancing effect of the fermented Angelicae Gigantis Radix was investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine. Result : The fermented Angelicae Gigantis Radix significantily reversed the scopolamine-induced cognitive impairments in the passive avoidance test. Moreover, the fermented Angelicae Gigantis Radix also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze. On the Y-maze test, fermented Angelicae Gigantis Radix also significantily reversed the scopolamine-induced cognitive impairments in mice. Conclusion : The fermented Angelicae Gigantis Radix possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent on the learning models.
서민준(Minjun Seo),이규봉(Kyubong Lee),박진한(Jinhan Park),홍승헌(Seungheon Hong) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.2
Objective : The purpose of this study was to provide the information about Bojungikki-tang by domestic papers and theses. Method : Domestic papers related to Bojungikki-tang were reviewed and analyzed. These papers were classified by year, research method, experimental method, and subject. Result : The following results were obtained in this study. 1. The study of Bojungikki-tang started from 1984 and continued steadily. 2. The domestic papers about Bojungikki-tang were 47 volumes. Among them, there were 26 volumes since 2000. 3. Classified by research method from the year 2000, 20 experimental studies, 4 clinical experiments, and 2 documentary researches. 4. Classified by experimental method from the year 2000, 10 studies used mouse in vivo experiment and 4 studies used rat in vivo experiment and 6 studies used each cell in vitro experiment. 5. Classified by subject from the year 2000, papers related to immune enhancing effect, nerve and mental system, radiation protection effect, anti-allergy, anti-inflammatory, anti-cancer, remedy of diabetes, skin protection and so on. Conclusion : Many papers of experimental studies, clinical experiments and documentary researches related Bojungikki-tang are included in domestic journals. Bojungikki-tang is being researched variously in immune enhancing effect, nerve and mental system, radiation protection effect, anti-allergy, anti-inflammatory, anti-cancer, remedy of diabetes, skin protection and so on. However, more clinical studies on Bojungikki-tang are needed.