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Ming Li Yee,Raphael Hau,Alison Taylor,Mark Guerra,Peter Guerra,Peteris Darzins,Christopher Gilfillan 대한골다공증학회 2020 Osteoporosis and Sarcopenia Vol.6 No.3
Objectives: Sarcopenia is a decline in skeletal muscle mass and function. It is associated with adverse outcomes and increased mortality. Sarcopenia is also reported to be prevalent in the hip fracture population. Our aims in this study are to compare the hormonal profile in women with hip fracture to controls, and to assess the relationship between hormonal biomarkers to skeletal muscle mass and function in these women. Methods: A cross sectional study was performed enrolling women above age 60 years old with hip fracture as a study group. For comparison healthy women from the community were recruited. Peripheral blood samples were obtained for analysis of hormonal profiles. Measures of skeletal muscle mass and function by muscle area on computed tomography, dual energy X-ray absorptiometry, bioelectrical impedance analysis, and grip strength was performed. Results: A high proportion of sarcopenic individuals were detected in the hip fracture group (60%). Women with hip fracture compared to controls were older (P ¼ 0.073), had lower serum albumin levels (P < 0.001), serum insulin-like growth factor-1 (IGF-1) (P < 0.001), insulin-like growth factor binding protein 3 (IGFBP-3) (P < 0.001), free testosterone levels (P ¼ 0.001), and impaired beta cell function by homeostasis model assessment (HOMA beta) (P ¼ 0.038). Conclusions: There is a high proportion of sarcopenic individuals in the hip fracture group. Lowered serum levels of IGF-1 and IGFBP-3, HOMA beta cell function, and free testosterone levels were detected in this group and may serve as potential biomarkers of sarcopenia.
( Ju-dong Li ),( Xin-fei Xu ),( Jiong-jie Yu ),( Zhen-li Li ),( Hao Xing ),( Han Wu ),( Han Zhang ),( Chao Li ),( Ming-da Wang ),( Meng-chao Wu ),( Wan-yee Lau ),( Tian Yang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: A family history of liver cancer is regarded as a risk factor for hepatocellular carcinoma (HCC) development. We investigated the association between family history and cancer recurrence and survival in patients with hepatitis B virus (HBV)- related HCC. Methods: Patients who underwent curative resection of HBV-related HCC between 2003 and 2013 from a tertiary hepatobiliary center in China were enrolled in this study. A family history was defined as a self-reported history of primary liver cancer in the first-degree relatives. Propensity score matching (PSM) and multivariable Cox-regression analyses were performed to compare the overall survival (OS) and recurrence-free survival (RFS) between patients with and without a family history of liver cancer. Results: Of 1,112 patients, 183 patients (16.5%) had a family history of liver cancer. A family history was not associated with OS and RFS (P=0.994 and 0.428) in the entire cohort. Using PSM, 179 pairs of patients with and without a family history but with comparable baseline characteristics and operative variables were created. A family history was associated with decreased OS and RFS (P=0.042 and 0.006) in the PSM cohort. On multivariable Cox-regression analyses, a family history was significantly associated with decreased OS (HR: 1.574, 95% CI: 1.171-2.116, P=0.003) and RFS (HR: 1.534, 95% CI: 1.176-2.002, P=0.002) after adjusting for other prognostic factors. Conclusions: A family history of liver cancer was associated with decreased OS and RFS rates after curative resection in patients with HBV-related HCC.
Doon-yee WONG,Kam-wah LI,Siu-ming YIP 아시아경찰학회 2006 Asia Pacific Journal of Police & Criminal Justice Vol.4 No.1
This paper is to examine how the cultural transformation of the Hong Kong Police Force (HKPF) from a quasi-military management style to a service quality (customer oriented) management style through a series of Living-the-Values Workshops takes place; and how the management culture change positively motivates its members. Although there were many attributors, such as advance in technology, better cooperation with the Mainland Public Security Bureau, higher education of new recruits, etc. for the outstanding performance of HKPF in the past decade, the successful cultural transformation, attitude and behaviour change of HKPF’s members no doubt played an essential role in the process. Police officers were observed to perform their duties in the most professional way even in times of adversities, such as reduction in manpower and salary (involuntarily), bleak promotion prospect, rising public demand on service quality and increasing workload. The current Living-the-Values Workshop (Wave V) “Serving with Care” will be examined in detail to show how the above process takes place.
( Tian Yang ),( Ming-da Wang ),( Chao Li ),( Lei Liang ),( Hao Xing ),( Li-yang Sun ),( Bing Quan ),( Han Wu ),( Xin-fei Xu ),( Timothy M ),( Pawlik ),( Wan Yee Lau ),( Feng Shen ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Survival after liver resection of hepatocellular carcinoma (HCC) remains poor due to a high incidence of recurrence. We sought to investigate risk factors, patterns, and long-term prognosis among patients with early and late recurrence after liver resection for hepatitis B virus (HBV)-associated HCC. Methods: Data of consecutive patients undergoing curative resection for HBV-associated HCC were analyzed. According to the time to recurrence after surgery, recurrence was divided into early (≤ 2 years) and late recurrence (> 2 years). Characteristics, patterns of initial recurrence and post-recurrence survival (PRS) were compared between patients with early and late recurrence. Risk factors of early and late recurrence, and predictors of PRS were identified by univariable and multivariable Cox-regression analyses. Results: mong 894 patients, 322 (36.0%) and 282 (31.5%) developed early and late recurrence, respectively. On multivariable analyses preoperative HBV-DNA>104 copies/ml was associated with both early and late recurrence, while postoperative no/ irregular antiviral therapy was associated with late recurrence. Compared with patients with late recurrence, patients with early recurrence had a lower proportion of intrahepatic only recurrence (72.0% vs. 91.1%, P<0.001), as well as a lower chance of receiving potentially-curative treatments for recurrence (33.9% vs. 50.7%, P<0.001) and a worse median PRS (19.1 vs. 37.5 months, P<0.001). Multivariable analysis demonstrated that early recurrence was independently associated with worse PRS (HR 1.361, 95%CI 1.094-1.692, P=0.006). Conclusions: Although risk factors associated with early recurrence and late recurrence were different, a high preoperative HBV-DNA load was an independent hepatitis-related risk for both early and late recurrence. Early recurrence was associated with
The SAME Project: A Hong Kong Experience in Enhancing Accessibility of the Central Curriculum
( Alison Man Ching Li ),( Andrew Chung Yee Tse ),( Ming Gon John Lian ) 대구대학교 특수교육문제연구소 2009 한국특수교육문제연구소 학술대회발표자료집 Vol.2009 No.-
Special schools, along with an increasing number of mainstream schools that implement inclusive education in Hong Kong, have been making efforts to develop their own school-based curriculum to echo the spirit of "one curriculum for all" since the Education Bureau’s (EDB) Curriculum Development Council (CDC) released the consultation document on education reform (CDC, 2001 Lian, 2001a, 2001b). However, several concerns surfaced in the processof developing an appropriate and effective curriculum: (a) it was difficult to help students with special education needs (SEN) access the central (i.e., mainstream) curriculum due to the lack of guidance; (b) a common language, as well as a teaching and evaluation system, has not been used with agreed-upon performance standards to describe students’ learning progress and attainment; and (c) the phenomena of having low expectations for children with learning difficulties (CWLD) is common due to high emphasis on skills training-oriented education, a lack of direction inteaching and the understanding of the key learning areas. This paper is, therefore, in an attempt to (a) review the trends and related studies on "access to central curriculum" from international experiences; (b) discuss the concerns on assessment and curriculum development for improving access to central curriculum for students with SEN in Hong Kong with respect to "one curriculum for all" and (c) describe a project (the SAME project) in Hong Kong and to highlight the accomplishment of the Phase 1 of the project. The implications to the field are also discussed.
SAME 프로젝트: 공통(중앙)교육과정의 접근을 향상시키기 위한 홍콩의 경험
( Alison Man Ching Li ),( Andrew Chung Yee Tse ),( Ming Gon John Lian ) 대구대학교 특수교육문제연구소 2009 한국특수교육문제연구소 학술대회발표자료집 Vol.2009 No.-
홍콩 교육부의 교과과정 개발위원회가 교육개혁에 대한 협의안을 발표한 이후, 완전통합교육을 실행하는 홍콩의 mainstream 학교들은 그 수가 증가했으며, 이와 더불어 특수학교들도 “one curriculum for all"의 정신을 반영하는 그들 자체의 교육과정을 개발하기 위해 노력해왔다 (CDC, 2001; Lian, 2001a, 2001b). 하지만, 적절하고 효과적인 교육과정을 개발하는 도중 다음과 같은 여러 가지 문제들이 생겨났다: (a) 특수교육을 요구 하는 학생들의 공통(i.e., mainstream)교과과정에 대한 접근을 도와주기위한 지도가 부족하다; (b) 교수와 평가시스템은 물론 학생들의 학습 진전과 성취를 기술하는 협의된 성취기준들을 갖춘 합의된 언어가 사용되어 오지 못했다; 그리고 (c) 기술훈련 위주의 교육을 중시하고 주요 학습 분야에 대한 지도방향과 이해의 부족으로 학습곤란 아동들에 대한 기대가 일반적으로 낮은 현상이 있다. 따라서 본 논문의 목적은 (a) "공통교과과정에의 접근”에 대한 추세와 관련 연구들을 국제적 경험을 통해 재검토하고, (b) 특수교육을 필요로 하는 홍콩학생들이 “one curriculum for all"을 토대로 공통교과과정에 보다 용이하게 접근할 수 있도록 하기 위하여 평가와 교과과정 개발상의 문제점들을 논의하며; 그리고 (c) 홍콩의 the SAME 프로젝트에 대해 언급하고 프로젝트의 1 단계에서 성취한 결과들을 주요 설명하는 것이다. 또한, 관련분야에 대한 논의도 포함되어있다.