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선인장 양심실 보조장치의 설계 및 임상적용을 위한 평가
민병구,박찬영,최재순,이혁수,황창모,김삼성,윤걸중,김종원,선경,이경갑,정종태,김원곤 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.1
현재 개발되고 있는 맥동형 이식형 인공심장은 완전이식형 인공심장과 좌심실보조장치 뿐이다. 좌심실보조장치를 장착한 환자의 10~15%가 우심실의 보조를 필요로하고 완전이식형 인공심장의 장착을 위해서는 자연심장을 제거해야하는 상황에서 이식형 양심실보조장치에 대한 필요성이 대두되고 있다. 본 연구진은 완전이식형 인공심장으로 개발된 한국형 인공심장을 개선하여 양심 실 보조장치를 개발하였다. 양심실보조장치는 이동형 작동기식 미케니즘을 이용하고 있으며 에너지 변환장치와 감속기로 구성된 작동기와 혈액주머니, 그리고 내장형 제어기로 구성되어 있다. 선인장 펌프로 명명된 KAH350은 캐뉼라의 연결을 위한 커넥터를 포함하여 길이 177mm, 폭 164mm, 높이 67 이고 무게 780g이며 최대 심박출량은 5L/min 이다. 양심실보조장치로 개발된 선인장펌프는 좌심실보조장치로도 응용이 가능하다. 이식적합성과 생체적합성을 평가하기 위하여 좌심실보조장치로 5회, 양싱실보조장치로 6회의 동물실험을 수행하였다. 각각 최장 28일간 생존하였으며 11회의 동물실험중 장치의 결함에 의한 것이 3회 있었는데 이들은 모두 전자장치의 결함과 방수처리문제였다. 현재 이식적합성과 일박출량을 향상시킨 KAH400모델이 개발중이다. The types of pulsatile implantable artificial hearts that are on the way of development and have been developed are totally implantable artificial heart and implantable left ventricular assist device (LVAD). Approximately 10% to 15% of all patients Implanted with wearable VADs have required right heart support with another device. And it is reluctant to patient who should remove his or her own heart to be implanted with total artificial heart. These situations drive the development of implantable bi-ventricular assist device (BVAD). The Korean BVAD was develophed by modifying the moving actuator type Korean artificial heart. This electro-mechanical BVAD comprises actuator including energy converter and reduction gear train, blood sacs, and internal motor and energy controllers. The KAH350 which is named as 'Cactus Pump' is 177mm in length, 164mm in width, and 67mm in thickness including connectors and nuts. The weight and maximum cardiac output of Cactus Pump is 780g and 5L/min, respectively. The Cactus Pump that was developed as BVAD could be used as LVAD by attaching compliance caps on the 2 ports of one ventricle. The animal experiments were undergone 5 times for LVAD, and 6 times for BVAD. The best records were 28 days survival in both applications. There were 3 times of device failure and they were all associated with electrical connection and hermetic sealing. The KAH400 that has improved anatomical fitting characterisitcs and stroke volume is on development.
Kim Min-Gul,Kim Suin,Jeon Ji-Young,Moon Seol Ju,Kwak Yong-Geun,Na Joo Young,Lee SeungHwan,Park Kyung-Mi,Kim Hyo-Jin,Lee Sang-Min,Choi Seo-Yeon,Shin Kwang-Hee 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.2
This study aimed to identify metabolic biomarkers and investigate changes in intestinal microbiota in the feces of healthy participants following administration of Lactococcus lactis GEN-001. GEN-001 is a single-strain L. lactis strain isolated from the gut of a healthy human volunteer. The study was conducted as a parallel, randomized, phase 1, open design trial. Twenty healthy Korean males were divided into five groups according to the GEN-001 dosage and dietary control. Groups A, B, C, and D1 received 1, 3, 6, and 9 GEN-001 capsules (1 × 1011 colony forming units), respectively, without dietary adjustment, whereas group D2 received 9 GEN-001 capsules with dietary adjustment. All groups received a single dose. Fecal samples were collected 2 days before GEN-001 administration to 7 days after for untargeted metabolomics and gut microbial metagenomic analyses; blood samples were collected simultaneously for immunogenicity analysis. Levels of phenylalanine, tyrosine, cholic acid, deoxycholic acid, and tryptophan were significantly increased at 5–6 days after GEN-001 administration when compared with predose levels. Compared with predose, the relative abundance (%) of Parabacteroides and Alistipes significantly decreased, whereas that of Lactobacillus and Lactococcus increased; Lactobacillus and tryptophan levels were negatively correlated. A single administration of GEN-001 shifted the gut microbiota in healthy volunteers to a more balanced state as evidenced by an increased abundance of beneficial bacteria, including Lactobacillus, and higher levels of the metabolites that have immunogenic properties.
김민석(Min-Seok Kim),김민규(Min-Kyu Kim),박용걸(Yong-Gul Park),이종우(Jong-Woo Lee) 대한전기학회 2011 전기학회논문지 Vol.60 No.1
Main characteristic in railroad is the guided movement of the wheel by the track through a metal-to-metal contact, conferring to the rail vehicle a single degree of freedom. There are defects such as head check, shelling, corrugation, squats etc in surface of the rail by interface between the wheel and rail. These defects bring about reducing the life-cycle of rails and track components and increasing noises. In case of bad conditions, it is possible to happen to full-scale accident such as derailment. Recently, the track capacity has been increased for increasing speed and operation efficiency. So, maintenance and indirect cost have been increased. Currently, a coating method of rail construction is proposed by using the ceramics in Korea. Rails are used as the earth in electrical railroad systems. Currently traction return current is flowed through wheels of trains. In case of rails coated, problems are caused in the contact power between wheel and coating material of spray. In this paper, electric model is presented in the AT feeding method. In case of rails coated, electric model is presented. Also, standard resistance of the ceramic is demonstrated by contact power between wheel and coating material of spray.
변형률 에너지 해방률에 기반한 Carbon/Epoxy 직교적층판의 모드 I 층간 및 층내 파괴 특성 분석
강민송 ( Min-song Kang ),전민혁 ( Min-hyeok Jeon ),김인걸 ( In-gul Kim ),우경식 ( Kyeong-sik Woo ) 한국복합재료학회 2019 Composites research Vol.32 No.1
본 논문에서는 Cross-ply 탄소섬유/에폭시 복합재 적층판의 모드 I 층간분리 특성을 분석하였다. 이를 위하여 Cross-ply 시편에 대한 Double-Cantilever Beam(DCB) 시험을 수행하였다. Cross-ply DCB 시편의 경우 층간 및 층내 파괴를 포함한 복합적인 균열 성장과 기하학적 대변형에 의한 비선형성을 수반하였다. 따라서 변형률 에너지 해방률과 유한요소해석을 기반으로 비선형성을 수반한 DCB 시험에서도 적용되는 모드 I 층간 파괴인성 평가 방법을 제안하고 기존의 선형이론으로 구한 결과와 비교 분석하였다. 본 연구에서 제안한 방법으로 Cross-ply DCB 시편의 모드 I 층간 파괴인성과 모드 I 층내 파괴인성을 분류하였고 모드 I 층내 파괴인성이 더욱 낮음을 확인하였다. This paper describes the characteristics for mode I interlaminar and intralaminar fractures of cross-ply carbon/epoxy composite laminates. We obtained mode I interlaminar fracture toughness and mode I intralaminar fracture toughness based on energy release rate and Finite Element Analysis (FEA). For this purpose, the Double- Cantilever Beam (DCB) test and FEA were performed for cross-ply DCB specimens. Also, the behavior of loaddisplacement curve at the interlaminar and intralaminar crack was analyzed. The results show that mode I intralaminar fracture toughness was lower than mode I interlaminar fracture toughness in the cross-ply DCB specimen.